Bioinformatics: The role of non-coding RNAs in disease
The primary research interest in the group is the role of non-coding RNAs in genetically inherited diseases. We have a specific interest in miRNAs but, rather than using the conventional approach that assumes there is a one-to-one mapping between a miRNA and its target mRNA (which produces a perturbation to phenotype) we are interested in the one-to-many mapping between miRNAs and mRNA which form more complex miRNA-mRNA gene regulation networks. To this end we are developing theoretical, computational and experimental methodologies to investigate how the topology of these networks change with ethnicity and amongst disease conditions. We are also applying these platforms to the studies of Rheumatoid Arthritis and Type II Diabetes.