Theodossis Athanassios Theodossiou

  • Senior Researcher, Marie Curie IntraEuropean Fellow
  • +47 22 78 1987

Team leader, senior researcher in project LUMIBLAST sponsored by FET open Horizon 2020


Publications 2023

Ménard M, Ali LMA, Vardanyan A, Charnay C, Raehm L, Cunin F, Bessière A, Oliviero E, Theodossiou TA, Seisenbaeva GA, Gary-Bobo M, Durand JO (2023)
Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation
Nanomaterials (Basel), 13 (24)
DOI 10.3390/nano13243155, PubMed 38133052

Panagiotakis S, Mavroidi B, Athanasopoulos A, Gonçalves AR, Bugnicourt-Moreira L, Regagnon T, Boukos N, Charalambidis G, Coutsolelos AG, Grigalavicius M, Theodossiou TA, Berg K, Ladavière C, Pelecanou M, Yannakopoulou K (2023)
Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles
Carbohydr Polym, 306, 120579
DOI 10.1016/j.carbpol.2023.120579, PubMed 36746578

Publications 2022

Ali M, Fulci G, Grigalavicius M, Pulli B, Li A, Wojtkiewicz GR, Wang C, Hsieh KL, Linnoila JJ, Theodossiou TA, Chen JW (2022)
Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy
Neoplasia, 26, 100779
DOI 10.1016/j.neo.2022.100779, PubMed 35247801

Grigalavicius M, Ezzatpanah S, Papakyriakou A, Raabe TTH, Yannakopoulou K, Theodossiou TA (2022)
5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
Cancers (Basel), 14 (16)
DOI 10.3390/cancers14164003, PubMed 36010996

Publications 2021

Christopoulos PF, Grigalavicius M, Corthay A, Berg K, Theodossiou TA (2021)
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants (Basel), 10 (7)
DOI 10.3390/antiox10071149, PubMed 34356382

Gorgen A, Guttormsen M, Larsen AC, Siem S, Adli E, Edin NFJ, Gjersdal H, Henriksen G, Malinen E, Modamio V, Schoultz B, Sobas PA, Theodossiou TA, Wikne JC (2021)
The Oslo Cyclotron Laboratory
Eur. Phys. J. Plus, 136 (2), 181
DOI 10.1140/epjp/s13360-021-01150-3

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2021)
Publisher Correction: Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 12 (1), 7073
DOI 10.1038/s41467-021-27175-x, PubMed 34848706

Publications 2020

Grigalavicius M, Mastrangelopoulou M, Arous D, Juzeniene A, Ménard M, Skarpen E, Berg K, Theodossiou TA (2020)
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Photochem Photobiol, 96 (3), 699-707
DOI 10.1111/php.13257, PubMed 32125700

Jerjes W, Theodossiou TA, Hirschberg H, Høgset A, Weyergang A, Selbo PK, Hamdoon Z, Hopper C, Berg K (2020)
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J Clin Med, 9 (2)
DOI 10.3390/jcm9020528, PubMed 32075165

Li X, Salzano G, Qiu J, Menard M, Berg K, Theodossiou T, Ladavière C, Gref R (2020)
Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
Front Bioeng Biotechnol, 8, 1027
DOI 10.3389/fbioe.2020.01027, PubMed 33042960

Mastrangelopoulou M, Grigalavicius M, Raabe TH, Skarpen E, Juzenas P, Peng Q, Berg K, Theodossiou TA (2020)
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), 5 (12), e1278
DOI 10.1002/cnr2.1278, PubMed 32737955

Publications 2019

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929

Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre MR, Fåne A, Gaudernack G, Kvalheim G, Myklebust JH, Inderberg EM, Wälchli S (2019)
NK cells specifically TCR-dressed to kill cancer cells
EBioMedicine, 40, 106-117
DOI 10.1016/j.ebiom.2019.01.031, PubMed 30665853

Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Wälchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194

Publications 2018

Christensen T, de Gruijl F, Hamblin M, Ishibashi Y, Kamada K, Sage E, Saltiel J, Sliwa M, Theodossiou T, Wu SP, Bassani D, Nonell S, Shore A (2018)
Outstanding Reviewers for Photochemical and Photobiological Sciences in 2017
Photochem. Photobiol. Sci., 17 (5), 533
DOI 10.1039/c8pp90021c

Mastrangelopoulou M, Grigalavicius M, Berg K, Ménard M, Theodossiou TA (2018)
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem Photobiol, 95 (1), 387-396
DOI 10.1111/php.12997, PubMed 30107033

Sideratou Z, Agathokleous M, Theodossiou TA, Tsiourvas D (2018)
Functionalized Hyperbranched Polyethylenimines as Thermosensitive Drug Delivery Nanocarriers with Controlled Transition Temperatures
Biomacromolecules, 19 (2), 315-328
DOI 10.1021/acs.biomac.7b01325, PubMed 29313672

Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, Inderberg EM, Smeland EB, Myklebust JH, Oksvold MP (2018)
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389

Publications 2017

Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhász G, Bilder D, Brech A, Stenmark H, Rusten TE (2017)
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876

Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K (2017)
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn Ther, 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761

Theodossiou TA, Olsen CE, Jonsson M, Kubin A, Hothersall JS, Berg K (2017)
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol, 12, 191-197
DOI 10.1016/j.redox.2017.02.018, PubMed 28254657

Publications 2015

Pefkianakis EK, Theodossiou TA, Toubanaki DK, Karagouni E, Falaras P, Papadopoulos K, Vougioukalakis GC (2015)
A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
Photochem Photobiol, 91 (5), 1191-202
DOI 10.1111/php.12485, PubMed 26118404

Theodossiou TA, Wälchli S, Olsen CE, Skarpen E, Berg K (2015)
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462

Publications 2014

Aggelidou C, Theodossiou TA, Gonçalves AR, Lampropoulou M, Yannakopoulou K (2014)
A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry
Beilstein J Org Chem, 10, 2414-20
DOI 10.3762/bjoc.10.251, PubMed 25383111

Paleos CM, Sideratou Z, Theodossiou TA, Tsiourvas D (2014)
Carboxylated hydroxyethyl starch: a novel polysaccharide for the delivery of doxorubicin
Chem Biol Drug Des, 85 (5), 653-8
DOI 10.1111/cbdd.12447, PubMed 25303215

Publications 2013

Aggelidou C, Theodossiou TA, Yannakopoulou K (2013)
Protoporphyrin IX-β-cyclodextrin bimodal conjugate: nanosized drug transporter and potent phototoxin
Photochem Photobiol, 89 (5), 1011-9
DOI 10.1111/php.12127, PubMed 23819797

Fraix A, Gonçalves AR, Cardile V, Graziano AC, Theodossiou TA, Yannakopoulou K, Sortino S (2013)
A multifunctional bichromophoric nanoaggregate for fluorescence imaging and simultaneous photogeneration of RNOS and ROS
Chem Asian J, 8 (11), 2634-41
DOI 10.1002/asia.201300463, PubMed 23788396

Piras L, Theodossiou TA, Manouilidou MD, Lazarou YG, Sortino S, Yannakopoulou K (2013)
S-nitroso-β-cyclodextrins as new bimodal carriers: preparation, detailed characterization, nitric-oxide release, and molecular encapsulation
Chem Asian J, 8 (11), 2768-78
DOI 10.1002/asia.201300543, PubMed 23894118

Theodossiou TA, Sideratou Z, Katsarou ME, Tsiourvas D (2013)
Mitochondrial delivery of doxorubicin by triphenylphosphonium-functionalized hyperbranched nanocarriers results in rapid and severe cytotoxicity
Pharm Res, 30 (11), 2832-42
DOI 10.1007/s11095-013-1111-7, PubMed 23921486

Publications 2012

Theodossiou TA, Yannakopoulou K, Aggelidou C, Hothersall JS (2012)
Tamoxifen subcellular localization; observation of cell-specific cytotoxicity enhancement by inhibition of mitochondrial ETC complexes I and III
Photochem Photobiol, 88 (4), 1016-22
DOI 10.1111/j.1751-1097.2012.01144.x, PubMed 22428931

Publications 2011

Theodossiou TA, Sideratou Z, Tsiourvas D, Paleos CM (2011)
A novel mitotropic oligolysine nanocarrier: Targeted delivery of covalently bound D-Luciferin to cell mitochondria
Mitochondrion, 11 (6), 982-6
DOI 10.1016/j.mito.2011.08.004, PubMed 21856448

Publications 2010

Sideratou Z, Tsiourvas D, Theodossiou T, Fardis M, Paleos CM (2010)
Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI
Bioorg Med Chem Lett, 20 (14), 4177-81
DOI 10.1016/j.bmcl.2010.05.055, PubMed 20621729

Publications 2009

Theodossiou TA, Hothersall JS, De Witte PA, Pantos A, Agostinis P (2009)
The multifaceted photocytotoxic profile of hypericin
Mol Pharm, 6 (6), 1775-89
DOI 10.1021/mp900166q, PubMed 19739671

Theodossiou TA, Tsiourvas D, Hothersall JS (2009)
Hypericin hydroquinone: potential as a red-far red photosensitizer?
Photochem Photobiol, 86 (1), 18-22
DOI 10.1111/j.1751-1097.2009.00668.x, PubMed 20003155

Publications 2008

Galanou MC, Theodossiou TA, Tsiourvas D, Sideratou Z, Paleos CM (2008)
Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition
Photochem Photobiol, 84 (5), 1073-83
DOI 10.1111/j.1751-1097.2008.00392.x, PubMed 18627515

Kontoyianni C, Sideratou Z, Theodossiou T, Tziveleka LA, Tsiourvas D, Paleos CM (2008)
A novel micellar PEGylated hyperbranched polyester as a prospective drug delivery system for paclitaxel
Macromol Biosci, 8 (9), 871-81
DOI 10.1002/mabi.200800015, PubMed 18484566

Theodossiou TA, Galanou MC, Paleos CM (2008)
Novel amiodarone-doxorubicin cocktail liposomes enhance doxorubicin retention and cytotoxicity in DU145 human prostate carcinoma cells
J Med Chem, 51 (19), 6067-74
DOI 10.1021/jm800493j, PubMed 18783209

Theodossiou TA, Pantos A, Tsogas I, Paleos CM (2008)
Guanidinylated dendritic molecular transporters: prospective drug delivery systems and application in cell transfection
ChemMedChem, 3 (11), 1635-43
DOI 10.1002/cmdc.200800190, PubMed 18985650

Theodossiou TA, Papakyriakou A, Hothersall JS (2008)
Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors
Free Radic Biol Med, 45 (11), 1581-90
DOI 10.1016/j.freeradbiomed.2008.09.015, PubMed 18852042

Publications 2007

Tsogas I, Sideratou Z, Tsiourvas D, Theodossiou TA, Paleos CM (2007)
Interactive transport of guanidinylated poly(propylene imine)-based dendrimers through liposomal and cellular membranes
Chembiochem, 8 (15), 1865-76
DOI 10.1002/cbic.200700289, PubMed 17854019

Tsogas I, Theodossiou T, Sideratou Z, Paleos CM, Collet H, Rossi JC, Romestand B, Commeyras A (2007)
Interaction and transport of poly(L-lysine) dendrigrafts through liposomal and cellular membranes: the role of generation and surface functionalization
Biomacromolecules, 8 (10), 3263-70
DOI 10.1021/bm700668w, PubMed 17880235

Publications 2006

Theodossiou TA, Noronha-Dutra A, Hothersall JS (2006)
Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing
Int J Biochem Cell Biol, 38 (11), 1946-56
DOI 10.1016/j.biocel.2006.05.009, PubMed 16814590

Theodossiou TA, Thrasivoulou C, Ekwobi C, Becker DL (2006)
Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections
Biophys J, 91 (12), 4665-77
DOI 10.1529/biophysj.106.093740, PubMed 17130233

Publications 2004

Theodossiou T, Spiro MD, Jacobson J, Hothersall JS, Macrobert AJ (2004)
Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes
Photochem Photobiol, 80 (3), 438-43
DOI 10.1562/0031-8655(2004)080<0438:EFIAOH>2.0.CO;2, PubMed 15623327

Publications 2003

Mosse CA, Theodossiou T, Mills TN (2003)
A system to monitor for fibre breakage during photodynamic therapy with diffuser fibres
Lasers Med Sci, 18 (3), 162-4
DOI 10.1007/s10103-003-0270-x, PubMed 14505200

Theodossiou T, Hothersall JS, Woods EA, Okkenhaug K, Jacobson J, MacRobert AJ (2003)
Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells
Cancer Res, 63 (8), 1818-21
PubMed 12702568

Publications 2002

Theodossiou T, MacRobert AJ (2002)
Comparison of the photodynamic effect of exogenous photoprotoporphyrin and protoporphyrin IX on PAM 212 murine keratinocytes
Photochem Photobiol, 76 (5), 530-7
DOI 10.1562/0031-8655(2002)076<0530:cotpeo>;2, PubMed 12462649

Theodossiou T, Rapti GS, Hovhannisyan V, Georgiou E, Politopoulos K, Yova D (2002)
Thermally induced irreversible conformational changes in collagen probed by optical second harmonic generation and laser-induced fluorescence
Lasers Med Sci, 17 (1), 34-41
DOI 10.1007/s10103-002-8264-7, PubMed 11845366

Publications 2001

Theodossiou T, Georgiou E, Hovhannisyan V, Yova D (2001)
Visual observation of infrared laser speckle patterns at half their fundamental wavelength
Lasers Med Sci, 16 (1), 34-9
DOI 10.1007/pl00011334, PubMed 11486336

Yova D, Hovhannisyan V, Theodossiou T (2001)
Photochemical effects and hypericin photosensitized processes in collagen
J Biomed Opt, 6 (1), 52-7
DOI 10.1117/1.1331559, PubMed 11178580

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