Our goals
The group's long-term goal is to improve patients' clinical condition after anesthetic procedures. We can achieve this partly by optimizing aspects of the anesthetic procedure itself:
- Better dosage control
- Optimal medication and methods
- Physiological care
and partly by focusing on important post-anesthetic aspects like:
- Pain
- Fatigue
- Normothermia
- Safety and experienced quality
We also work on:
- Pharmacological modeling of Propofol in adipose tissue
- New analgesic methods postoperatively - drugs and nerve blockades
- Depth control of anaesthesia with EEG
- Expiratory Propofol measurement
- Pain relief after major trauma
- Postoperative pain
- Safety and quality in the post-operative care unit, on wards and after discharge (day surgery).
- Implementing results and initiating new research in areas with low resources like Lebanon, Palestine, Gaza.
Projects
- Postoperative fatigue after surgery- includes preparation and testing of mapping tools, testing on inhalation versus IV anesthesia, defining clinical cut-off values.
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Plexus brachialis optimization by over extremity surgery and injuries
Map the meaning of timing and adjuvant medication. Mapping of microcirculation.
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New model for Propofol pharmacokinetics in highly obese
Clinical Material with Large Plasma Samples and Pharmacokinetic Modeling for the Development of a New Dosage Model in Highly Obese.
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New algorithm for monitoring newly operated - electronic form and wireless monitoring. Develop new tool for rapid mapping of patient quality and safety for newly operated on bed post. This includes developing wireless monitoring of vital functions.
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Expiratory measurement of Propofol in exhaled air, and correlation to EEG, pharmacology and clinic.
Explore brand new technology for continuous monitoring of Propofol levels in plasma via expiratory Propofol measurement. Check out simultaneously modeled plasma concentration, EEG characteristics (new algorithms) and clinical effect in an experimental setting in patients in general anesthesia.
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Quality assurance of day surgery patients after discharge.
Establish registry for follow-up of day surgery patients after discharge and use large amounts of data to identify problem areas related to pain, nausea and fatigue.At next stage - try out targeted interventions against identified risk patients.
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Postoperative pain relief with tapentadol - testing of analgesic, tapentadol versus oxycodone. including developing algorithms to identify pre-operatively which patients are at increased risk of post-operative pain.
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Hypothermia prophylaxis perioperatively
Test out pre-warming, heat blanket, theme dressing in gynecological surgery patients. In addition, mapping the occurrence of perioperative hypothermia in cases of caesarean section, with a view to future interventions.
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Pain after Caesarean section
Identify the occurrence of pain after cesarean section.
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Prolonged pain after severe trauma
Identify the incidence and risk factors for pain and chronic pain after major trauma. Possibly design interventions and test these for high-risk patients.
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Erector spinae blockade perioperatively
Test out the erector spinae blockade for different types of surgery
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Day surgery and pain management in Lebanon and Gaza
Follow-up and mapping of success related to start-up projects for day surgery and pain management in Lebanon and Gaza.
Collaboration
Internal
- Professors Pål Aksel Næss and Christine Gaarder, Department of Traumatology, OUH
- Professor Tone Rustøen, Institute of Health and Society, UiO,
- Professor Torgeir Bruun Wyller, Oslo Delirium Research Group, UiO and OUH,
- Professor Hanne Storm, Pain Research Group, UiO
- Professor Audun Stubhaug and Dr. Lars Petter Granan, Department of Pain Management and Research, OUH,
- Professor Marit Lieng and Associate Professor Katariina Laine, Research Centre for Obstetrics and Gynecology
National
- The hospitals in Skien, Kalnes og Trondheim
- Professor Johan Kvalvik Stanghelle, Sunnaas Hospital
- Professor Petter C. Borchgrevink, St.Olav Hospital
- Associate Professor Ann-Chatrin Leonardsen, Østfold University College
- NORWAC: Norwegian Aid Committee for Palestinians
International
- Professor Michel Struys group, Groeningen, Belgium
- Professors Aneta Stefanovska and Peter McClintock, Braccia group, Lancaster, UK
- Professors Marc van der Velde,Esther Podgatzki-Zahn and Stephan Schug, Prospect group, ESRA
- Professor Lars Engebretsen and Dr. Brian Hainline, IOC,
- BBraun medical,Instrumentation (Edmon©) for exhaled propofol measurements