Welcome to the home page Mimi Stokke Opdal's group: Therapeutic Drug Monitoring
Clinical Pharmacology is the study of kinetics (absorption, distribution, protein binding, metabolism and excretion) and response of drugs in the human body. A considerable individual variation in both the kinetics and effects/response of the drug is common. A goal in treatment is to achieve optimal drug effects and to avoid harmful side effects. The effects/side effects of many drugs are concentration dependent, hence it may be useful to measure the total drug concentration in serum/plasma, also called therapeutic drug monitoring (TDM). Gene variants in genes encoding proteins participating in metabolism, transport and drug actions may explain some of the dose response variability. The research group is working on the optimization of drug therapy using TDM, pharmacogenetic analyses and other outcome measures.