The objective of this project is to identify and functionally characterize E3 ubiquitin ligases involved in colorectal cancer development and to evaluate their potential as biomarkers and drug targets. We are focusing on the NEDD4 (neural precursor cell-expressed developmentally down-regulated 4) family of E3 ubiquitin ligases. This protein family comprises nine members in humans, and has important roles in the regulation of key signaling pathways implicated in cancer development, such as the phosphatidylinositol 3-kinase (PI3K)/Akt and the transforming growth factor-β (TGF-β) pathways. Several members of the NEDD4 E3 ubiquitin ligase family may act as proto-oncogenes or tumor suppressors and represent potential drug targets.
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
Cell Mol Life Sci, 77 (4), 573-591
Connexins in cancer: bridging the gap to the clinic
Oncogene, 38 (23), 4429-4451
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882