Welcome to Lars Eide's group Mitogroup

Lars EideGroup leader
Lars Eide
Group leader

Nuclear and mitochondrial genomes (nDNA and mtDNA, respectively) are subjected to dynamic modifications. There is a crosstalk between mitochondrial metabolism and mtDNA modifications, and abnormal metabolism (as in disease) can be identified as altered mtDNA. We have and are developing in-house techniques to evaluate mtDNA modifications that include mutations and other modifications (“damage”).

Huntington’s disease (HD) is a neurodegenerative disorder, with strong association to mitochondrial dysfunction.

Maple Syrup Urine Disease (MSUD) is another rare, inborn disease caused by deficient degradation of branched chain amino acids. The deficient, mitochondrial protein is identified as a constituent of the “mitochondrial chromatin”.

Research projects

  • Deep sequencing analyses of mtDNA/mtRNA. Prediction of bioenergetics score
  • Mitochondrial dysfunction in Huntington’s Disease. Comparative studies of mitochondrial biomarkers in HD and HD models
  • Exploring Maple Syrup Urine Disease: targeting BCAT transaminase and branched fatty acids

Contact information:
Group leader Lars Eide, Department of Medical Biochemistry,
Tel: +47 23071062/93241242, E-mail: lars.eide@medisin.uio.no.