Welcome to Lars Eide's group Mitogroup

Lars Eide
Group leader

We focus on function of mitochondria in relation to oxidative stress and mtDNA repair. Oxidative stress damages mitochondrial macromolecules including mtDNA, but also serves important regulatory role of metabolic processes in the mitochondrial matrix. We are investigating how mitochondrial respiration, respirasome organization and metabolic activity correlate with mtDNA processes in different cellular models.

Challenges:

Nuclear and mitochondrial genomes are subjected to dynamic modifications. These modifications are taken care of by DNA glycosylases. We have found that modifications in the DNA in nucleus and mitochondria serve distinct roles in cellular regulation of metabolism. Thus, we believe that these modifications, traditionally known as damages, can be considered intracellular signals. We combine our developed high-resolution methods to quantify site-specific DNA modifications with mitochondrial and metabolic measurements to study the (mitochondrial) DNA- metabolic relation.

Research projects

  • Deep sequencing analyses of mitochondrial mutagenesis. Prediction of bioenergetics score.
     
  • Mitochondrial dysfunction in Huntingtons Disease. Comparative studies of mitochondrial biomarkers in HD and HD models.
     
  • Exploring Maple Syrup Urine Disease: targeting BCAT transaminase and branched fatty acids.

Contact information:
Group leader Lars Eide, Department of Medical Biochemistry,
Tel: +47 23071062/93241242, E-mail: lars.eide@medisin.uio.no.