Welcome to Lars Eide's group

Mitogroup

 
Lars Eide<br>Group leader
Lars Eide
Group leader

We focus on function of mitochondria in relation to oxidative stress and mtDNA repair. Oxidative stress damages mitochondrial macromolecules including mtDNA, but also serves important regulatory role of metabolic processes in the mitochondrial matrix. We are investigating how mitochondrial respiration, respirasome organization and metabolic activity correlate with mtDNA processes in different cellular models.

Challenges:

Nuclear and mitochondrial genomes are subjected to dynamic modifications. These modifications are taken care of by DNA glycosylases. We have found that modifications in the DNA in nucleus and mitochondria serve distinct roles in cellular regulation of metabolism. Thus, we believe that these modifications, traditionally known as damages, can be considered intracellular signals. We combine our developed high-resolution methods to quantify site-specific DNA modifications with mitochondrial and metabolic measurements to study the (mitochondrial) DNA- metabolic relation.

 
 

Research projects

 
  • Deep sequencing analyses of mitochondrial mutagenesis. Novel techniques measure mtDNA mutation frequency to one per million. This allows backtracing of mtDNA migration in the tissue.

  • Mitochondrial dysfunction in Huntingtons Disease. We focus on genomic alteration in patients and mouse/pig models of HD, to investigate the impact on mitochondrial function.

  • Mitochondrial epigenetics: we investigate putative role of non-methylation modification of mtDNA in the regulation of mitochondrial activity. 

 
 
 

Contact information:
Group leader Lars Eide, Department of Medical Biochemistry,
Tel: +47 23071062/93241242, E-mail: lars.eide@medisin.uio.no.