Welcome to Lars Eide's group Mitogroup

Lars EideGroup leader
Lars Eide
Group leader

Nuclear and mitochondrial genomes (nDNA and mtDNA, respectively) are subjected to dynamic modifications. There is a crosstalk between mitochondrial metabolism and mtDNA modifications.

Our aim is to understand how modifications on mtDNA influence/regulate mitochondrial metabolism.

Relevant diseases are:

  • Maple Syrup Urine Disease (MSUD); a rare, inborn disease caused by deficient degradation of branched chain amino acids. This degradation is rate-limited by a large branched-chain keto acid dehydrogenase complex, whose core subunit is also a constituent of the “mitochondrial chromatin”.
  • Pancreatic Ductal adenocarcinoma (PDAC) has reprogrammed energy metabolism towards branched-chain amino acid metabolism.
  • Huntington’s disease (HD) is a neurodegenerative disorder, with strong association to mitochondrial dysfunction. We have found that nuclear DNA integrity is a peripheral biomarker that correlates with disease progression, and speculate that individual mitochondrial capacity dictates age of onset.
  • Branched-chain amino acids are precursors for branched-chain fatty acids; with unknown function but present from gestation and throughout life, and positively associated with glucose homeostasis.

Research projects

  • Deep sequencing analyses of mtDNA/mtRNA. Prediction of bioenergetics score 
  • Mitochondrial dysfunction in Huntington’s Disease. Comparative studies of mitochondrial biomarkers in HD and HD models 
  • Exploring MSUD and PDAC: targeting branched-chain amino acid metabolism.
  • Mitochondrial quality markers in retinal epithelial cell transplantation

Contact information:
Group leader Lars Eide, Department of Medical Biochemistry,
Tel: +47 23071062/93241242, E-mail: lars.eide@medisin.uio.no.