Metastases in bones, lymph nodes and lungs are common challenges among oncology patients (e.g. breast cancer, prostate cancer, osteosarcoma) and are the primary cause of death. Efficacious new treatment options are sorely needed. Alpha-particle emitting radionuclides being highly cytotoxic may fulfil this critical need. We study a novel technology with potentially broad therapeutic applications for cancer micrometastases by means of dual targeted alpha particle radiation. The treatment involves administration of a bone-seeking, alpha-particle emitting radionuclide 224Ra and its daughter radionuclide 212Pb solution containing chelator-labelled new and existing molecular ligands and tumour-associated monoclonal antibodies (mAb) as carriers for the daughter radionuclide. Pb-212 is a source of highly cytotoxic alpha particles via its decay to 212Bi daughter.
Contact information Asta Juzeniene, Scientist, Ph.D. Department of Radiation Biology, Institute for Cancer Research The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway Tel. +47 22 78 12 00, Fax +47 22 78 12 07
Berge LAM, Andreassen BK, Stenehjem JS, Larsen IK, Furu K, Juzeniene A, Roscher I, Heir T, Green A, Veierød MB, Robsahm TE(2019) Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study BMJ Open, 9(2), e025246 DOI 10.1136/bmjopen-2018-025246, PubMed 30787091
Mastrangelopoulou M, Grigalavicius M, Berg K, Ménard M, Theodossiou TA(2018) Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines Photochem Photobiol, 95(1), 387-396 DOI 10.1111/php.12997, PubMed 30107033
Juzeniene A, Bernoulli J, Suominen M, Halleen J, Larsen RH(2018) Antitumor Activity of Novel Bone-seeking, α-emitting 224Ra-solution in a Breast Cancer Skeletal Metastases Model Anticancer Res, 38(4), 1947-1955 DOI 10.21873/anticanres.12432, PubMed 29599310