Welcome to Marit Inngjerdingen's research group:Innate lymphocyte group

Marit InngjerdingenGroup leader
Marit Inngjerdingen
Group leader

Background

Our group studies innate lymphocytes, with a particular focus on how NK cells are regulated at steady-state or during allo-transplantation or hematological malignancies.

 

Projects

  • Longitudinal studies of NK cells in pediatric patients with ALL or AML in collaboration with the Department of Children, Oslo University Hospital, aiming at correlating NK cell responses and/or receptor repertoires with disease outcome.
  • In-depth mechanistic studies of how leukemia blasts evade and suppress the immune system using in vivo rat models of T-ALL and AML. Projects include tailoring NK cells for immunotherapy, and investigations on how soluble ligands and exosomes released from leukemic blasts affect NK cell tumor immunosurveillance.
  • Developmental and functional characterization of NK cell subsets and ILCs in different tissues in the rat, and their regulation of inflammation
  • Evaluation of exosomes as early prognostic markers for risk stratification of pediatric acute leukemia.
  • Characterization of intracellular signaling cascades in human T cells and NK cells in health and disease.
 

Contact information:
Marit Inngjerdingen, PhD                          
Department of Immunology
E-mail: mariti@medisin.uio.no
Tel: +47 23 07 37 69 / 95 06 39 29



 
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