Grethe Skretting
Position: Group leader, Senior scientist, MSc, PhD
Phone: +47 23 07 33 48

Author network for Grethe Skretting by COREMINE medical

Publications 2017

Andresen MS, Ali HO, Myklebust CF, Sandset PM, Stavik B, Iversen N, Skretting G (2017)
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1
Mol Cell Endocrinol, 443, 80-88
PubMed 28088469

Cui XY, Skretting G, Tinholt M, Stavik B, Dahm AEA, Sahlberg KK, Kanse S, Iversen N, Sandset PM (2017)
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7
Thromb Res, 157, 111-116
PubMed 28734156

Espada S, Stavik B, Holm S, Sagen EL, Bjerkeli V, Skjelland M, Dahl TB, Espevik T, Kanse S, Sandset PM, Skretting G, Halvorsen B (2017)
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
PubMed 28712870

Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B (2017)
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
PubMed 28482260

Publications 2016

Ali HO, Arroyo AB, González-Conejero R, Stavik B, Iversen N, Sandset PM, Martínez C, Skretting G (2016)
The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor α
J Thromb Haemost, 14 (6), 1226-37
PubMed 26999003

Ali HO, Stavik B, Myklebust CF, Andersen E, Dahm AE, Iversen N, Sandset PM, Skretting G (2016)
Oestrogens Downregulate Tissue Factor Pathway Inhibitor through Oestrogen Response Elements in the 5'-Flanking Region
PLoS One, 11 (3), e0152114
PubMed 26999742

Cui XY, Tinholt M, Stavik B, Dahm AE, Kanse S, Jin Y, Seidl S, Sahlberg KK, Iversen N, Skretting G, Sandset PM (2016)
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer
J Thromb Haemost, 14 (2), 387-96
PubMed 26598923

Stavik B, Espada S, Cui XY, Iversen N, Holm S, Mowinkel MC, Halvorsen B, Skretting G, Sandset PM (2016)
EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
Biochim Biophys Acta, 1862 (4), 670-8
PubMed 26826018

Tinholt M, Sandset PM, Mowinckel MC, Garred Ø, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Jacobsen AF, Skretting G, Iversen N (2016)
Determinants of acquired activated protein C resistance and D-dimer in breast cancer
Thromb Res, 145, 78-83
PubMed 27505249

Tiscia GL, Dørum E, Myklebust CF, Grandone E, Sandset PM, Skretting G (2016)
Functional characterization of annexin A5 gene promoter allelic variants
Thromb Res, 144, 93-9
PubMed 27318245

Publications 2015

Chollet ME, Skarpen E, Iversen N, Sandset PM, Skretting G (2015)
The chemical chaperone sodium 4-phenylbutyrate improves the secretion of the protein CA267T mutant in CHO-K1 cells trough the GRASP55 pathway
Cell Biosci, 5, 57
PubMed 26457178

Dahm AE, Tiscia G, Holmgren A, Jacobsen AF, Skretting G, Grandone E, Sandset PM (2015)
Genetic variations in the annexin A5 gene and the risk of pregnancy-related venous thrombosis
J Thromb Haemost, 13 (3), 409-13
PubMed 25495894

Iversen PO, Dahm A, Skretting G, Mowinckel MC, Stranda A, Østerud B, Sandset PM, Kostovski E (2015)
Reduced peak, but no diurnal variation, in thrombin generation upon melatonin supplementation in tetraplegia. A randomised, placebo-controlled study
Thromb Haemost, 114 (5), 964-8
PubMed 26202881

Kostovski E, Dahm AE, Mowinckel MC, Stranda A, Skretting G, Østerud B, Sandset PM, Iversen PO (2015)
Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin
Spinal Cord, 53 (4), 285-90
PubMed 25644388

Tinholt M, Stavik B, Louch W, Carlson CR, Sletten M, Ruf W, Skretting G, Sandset PM, Iversen N (2015)
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
PLoS One, 10 (1), e0117404
PubMed 25617766

Publications 2014

Ali HO, Stavik B, Dørum E, Iversen N, Sandset PM, Skretting G (2014)
Oestrogen induced downregulation of TFPI expression is mediated by ERα
Thromb Res, 134 (1), 138-43
PubMed 24785473

Tinholt M, Viken MK, Dahm AE, Vollan HK, Sahlberg KK, Garred O, Børresen-Dale AL, Jacobsen AF, Kristensen V, Bukholm I, Kåresen R, Schlichting E, Skretting G, Lie BA, Sandset PM, Iversen N (2014)
Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study
BMC Cancer, 14, 845
PubMed 25407022

Publications 2013

Cui XY, Skretting G, Jing Y, Sun H, Sandset PM, Sun L (2013)
Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells
Blood Cells Mol Dis, 51 (3), 177-84
PubMed 23725749

Stavik B, Tinholt M, Sletten M, Skretting G, Sandset PM, Iversen N (2013)
TFPIα and TFPIβ are expressed at the surface of breast cancer cells and inhibit TF-FVIIa activity
J Hematol Oncol, 6, 5
PubMed 23320987

Publications 2012

Dahm AE, Bezemer ID, Bergrem A, Jacobsen AF, Jacobsen EM, Skretting G, Rosendaal FR, Sandset PM (2012)
Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis
Br J Haematol, 157 (6), 753-61
PubMed 22533697

Dahm AE, Eilertsen AL, Goeman J, Olstad OK, Ovstebø R, Kierulf P, Mowinckel MC, Skretting G, Sandset PM (2012)
A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women
Thromb Res, 130 (1), 45-51
PubMed 22217510

Skretting G, Iversen N, Myklebust CF, Dahm AE, Sandset PM (2012)
Overexpression of tissue factor pathway inhibitor in CHO-K1 cells results in increased activation of NF-κB and apoptosis mediated by a caspase-3 independent pathway
Mol Biol Rep, 39 (12), 10089-96
PubMed 22932941

Stavik B, Skretting G, Olstad OK, Sletten M, Dehli Vigeland M, Sandset PM, Iversen N (2012)
TFPI alpha and beta regulate mRNAs and microRNAs involved in cancer biology and in the immune system in breast cancer cells
PLoS One, 7 (10), e47184
PubMed 23071754

Publications 2011

Stavik B, Skretting G, Aasheim HC, Tinholt M, Zernichow L, Sletten M, Sandset PM, Iversen N (2011)
Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility
BMC Cancer, 11, 357
PubMed 21849050

Tjeldhorn L, Iversen N, Sandvig K, Bergan J, Sandset PM, Skretting G (2011)
Protein C mutation (A267T) results in ER retention and unfolded protein response activation
PLoS One, 6 (8), e24009
PubMed 21901152

Publications 2010

Austbø L, Røed KH, Dolvik NI, Skretting G (2010)
Identification of differentially expressed genes associated with osteochondrosis in standardbred horses using RNA arbitrarily primed PCR
Anim Biotechnol, 21 (2), 135-9
PubMed 20379890

Opstad TB, Eilertsen AL, Høibraaten E, Skretting G, Sandset PM (2010)
Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy
Blood Coagul Fibrinolysis, 21 (6), 516-21
PubMed 20453636

Skretting G, Stavik B, Landvik NE, Myklebust CF, Iversen N, Zienolddiny S, Sandset PM (2010)
Functional characterization of polymorphisms in the human TFPI gene
Biochem Biophys Res Commun, 397 (1), 106-11
PubMed 20519147

Stavik B, Skretting G, Sletten M, Sandset PM, Iversen N (2010)
Overexpression of both TFPIα and TFPIβ induces apoptosis and expression of genes involved in the death receptor pathway in breast cancer cells
Mol Carcinog, 49 (11), 951-63
PubMed 20886581

Tjeldhorn L, Iversen N, Sandvig K, Bergan J, Sandset PM, Skretting G (2010)
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport
BMC Cell Biol, 11, 67
PubMed 20815936

Publications 2009

Sørby R, Austbø L, Press CM, Skretting G, Landsverk T, Espenes A (2009)
PrP expression, PrPSc accumulation and innervation of splenic compartments in sheep experimentally infected with scrapie
PLoS One, 4 (9), e6885
PubMed 19727393

Tjeldhorn L, Sandset PM, Haugbro K, Skretting G (2009)
Hereditary protein C deficiency caused by the Ala267Thr mutation in the protein C gene is associated with symptomatic and asymptomatic venous thrombosis
Thromb Res, 125 (3), 230-4
PubMed 19535131

Publications 2008

Austbø L, Kampmann A, Müller-Ladner U, Neumann E, Olsaker I, Skretting G (2008)
Identification of differentially expressed genes in ileal Peyer's patch of scrapie-infected sheep using RNA arbitrarily primed PCR
BMC Vet Res, 4, 12
PubMed 18373840

Skretting G, Lien T, Sandset PM, Iversen N (2008)
Expression of the V264M TFPI mutant in endothelial cell cultures may involve mRNA stability
Thromb Res, 123 (6), 851-5
PubMed 19007969

Publications 2007

Austbø L, Espenes A, Olsaker I, Press CM, Skretting G (2007)
Increased PrP mRNA expression in lymphoid follicles of the ileal Peyer's patch of sheep experimentally exposed to the scrapie agent
J Gen Virol, 88 (Pt 7), 2083-90
PubMed 17554044

Johannessen MK, Skretting G, Ytrehus B, Røed KH (2007)
Neonatal growth cartilage: equine tissue specific gene expression
Biochem Biophys Res Commun, 354 (4), 975-80
PubMed 17276390

Publications 2006

Austbø L, Espenes A, Olsaker I, Press CM, Skretting G (2006)
Lymphoid follicles of the ileal Peyer's patch of lambs express low levels of PrP, as demonstrated by quantitative real-time RT-PCR on microdissected tissue compartments, in situ hybridization and immunohistochemistry
J Gen Virol, 87 (Pt 11), 3463-71
PubMed 17030883

Roed KH, Hasle G, Midthjell V, Skretting G, Leinaas HP (2006)
Identification and characterization of 17 microsatellite primers for the tick, Ixodes ricinus, using enriched genomic libraries
Mol. Ecol. Notes, 6 (4), 1165-1167

Skretting G, Austbø L, Olsaker I, Espenes A (2006)
Cloning and expression analysis of an ovine PAP-like protein cDNA, a gene differentially expressed in scrapie
Gene, 376 (1), 116-22
PubMed 16635555

Publications 2004

Skretting G, Espenes A, Ulvund MJ, Olsaker I (2004)
cDNA representational difference analysis of ileal Peyer's patches in lambs after oral inoculation with scrapie
Biochem Biophys Res Commun, 316 (1), 272-9
PubMed 15003541

Publications 2003

Iversen TG, Skretting G, van Deurs B, Sandvig K (2003)
Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA
Proc Natl Acad Sci U S A, 100 (9), 5175-80
PubMed 12682302

Publications 2001

Iversen TG, Skretting G, Llorente A, Nicoziani P, van Deurs B, Sandvig K (2001)
Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases
Mol Biol Cell, 12 (7), 2099-107
PubMed 11452006

Llorente A, Prydz K, Sprangers M, Skretting G, Kolset SO, Sandvig K (2001)
Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosis
J Cell Sci, 114 (Pt 2), 335-43
PubMed 11148135

Sandvig K, Grimmer S, Lauvrak SU, Torgersen ML, Skretting G, van Deurs B, Iversen TG (2001)
Pathways followed by ricin and Shiga toxin into cells
Histochem Cell Biol, 117 (2), 131-41
PubMed 11935289

Torgersen ML, Skretting G, van Deurs B, Sandvig K (2001)
Internalization of cholera toxin by different endocytic mechanisms
J Cell Sci, 114 (Pt 20), 3737-47
PubMed 11707525

Tranulis MA, Espenes A, Comincini S, Skretting G, Harbitz I (2001)
The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expression
Mamm Genome, 12 (5), 376-9
PubMed 11331946

Publications 1999

Rodal SK, Skretting G, Garred O, Vilhardt F, van Deurs B, Sandvig K (1999)
Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
Mol Biol Cell, 10 (4), 961-74
PubMed 10198050

Skretting G, Torgersen ML, van Deurs B, Sandvig K (1999)
Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
J Cell Sci, 112 ( Pt 22), 3899-909
PubMed 10547351

Publications 1997

Skretting G, Gjernes E, Prydz H (1997)
Sodium butyrate inhibits the expression of the human lecithin: cholesterol acyltransferase gene in HepG2 cells by a post-transcriptional mechanism
FEBS Lett, 404 (1), 105-10
PubMed 9074647

Publications 1995

Frengen E, Brede G, Larsen F, Skretting G, Prydz H (1995)
Physical linkage of the gene cluster containing the LCAT gene to the DNA marker D16S124 at human chromosome region 16q22.1
Cytogenet Cell Genet, 68 (3-4), 194-6
PubMed 7842735

Mehlum A, Staels B, Duverger N, Tailleux A, Castro G, Fievet C, Luc G, Fruchart JC, Olivecrona G, Skretting G (1995)
Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile
Eur J Biochem, 230 (2), 567-75
PubMed 7607230

Skretting G, Gjernes E, Prydz H (1995)
Regulation of lecithin:cholesterol acyltransferase by TGF-beta and interleukin-6
Biochim Biophys Acta, 1255 (3), 267-72
PubMed 7734442

Publications 1992

Jansen H, van Tol A, Auwerx J, Skretting G, Staels B (1992)
Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats
Biochim Biophys Acta, 1128 (2-3), 181-5
PubMed 1420288

Skretting G, Blomhoff JP, Solheim J, Prydz H (1992)
The genetic defect of the original Norwegian lecithin:cholesterol acyltransferase deficiency families
FEBS Lett, 309 (3), 307-10
PubMed 1516702

Skretting G, Prydz H (1992)
An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease
Biochem Biophys Res Commun, 182 (2), 583-7
PubMed 1571050

Staels B, van Tol A, Skretting G, Auwerx J (1992)
Lecithin:cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates
J Lipid Res, 33 (5), 727-35
PubMed 1619364

Publications 1987

Eskild W, Henriksen T, Skretting G, Blomhoff R, Berg T (1987)
Endocytosis of acetylated low-density lipoprotein, endothelial cell-modified low-density lipoprotein, and formaldehyde-treated serum albumin by rat liver endothelial cells. Evidence of uptake via a common receptor
Scand J Gastroenterol, 22 (10), 1263-9
PubMed 3433016

Henriksen T, Blomhoff R, Skretting G, Berg T, Eskild W (1987)
Tissue uptake of biologically modified low density lipoprotein in the rat
Scand J Clin Lab Invest, 47 (3), 269-75
PubMed 3589491

Rogne S, Skretting G, Larsen F, Myklebost O, Mevåg B, Carlson LA, Holmquist L, Gjone E, Prydz H (1987)
The isolation and characterisation of a cDNA clone for human lecithin:cholesterol acyl transferase and its use to analyse the genes in patients with LCAT deficiency and fish eye disease
Biochem Biophys Res Commun, 148 (1), 161-9
PubMed 2823801