Torbjørn Elvsåshagen
- Group leader and postdoctoral researcher; MD, PhD
- +47 991 55 282
Senior consultant at the Department of Neurology, OUH, researcher at the Norwegian Centre for Mental Disorders Research, OUH, and professor II at the Institute of Basic Medical Sciences, UiO
Publications 2024
The genetic landscape of basal ganglia and implications for common brain disorders
Nat Commun, 15 (1), 8476
DOI 10.1038/s41467-024-52583-0, PubMed 39353893
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
Mol Psychiatry (in press)
DOI 10.1038/s41380-024-02784-2, PubMed 39501059
Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity
Hum Brain Mapp, 45 (8), e26682
DOI 10.1002/hbm.26682, PubMed 38825977
Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling
Proc Natl Acad Sci U S A, 121 (34), e2312511121
DOI 10.1073/pnas.2312511121, PubMed 39141354
Mismatch negativity and polygenic risk scores for schizophrenia and bipolar disorder
Schizophr Res, 264, 314-326
DOI 10.1016/j.schres.2024.01.013, PubMed 38215567
Publications 2023
Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness
Schizophr Bull, 49 (3), 635-645
DOI 10.1093/schbul/sbac191, PubMed 36462169
Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
Psychol Med, 53 (14), 6743-6753
DOI 10.1017/S0033291723000223, PubMed 36846964
Telomere length and verbal learning in bipolar disorders
J Affect Disord, 339, 555-560
DOI 10.1016/j.jad.2023.07.087, PubMed 37459977
Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity
Schizophr Res, 261, 80-93
DOI 10.1016/j.schres.2023.09.012, PubMed 37716205
Relationship between function and structure in the visual cortex in healthy individuals and in patients with severe mental disorders
Psychiatry Res Neuroimaging, 332, 111633
DOI 10.1016/j.pscychresns.2023.111633, PubMed 37028226
Auditory Cortex Thickness Is Associated With N100 Amplitude in Schizophrenia Spectrum Disorders
Schizophr Bull Open, 4 (1), sgad015
DOI 10.1093/schizbullopen/sgad015, PubMed 38812720
The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
medRxiv
DOI 10.1101/2023.07.21.23292993, PubMed 37503175
Corrigendum to "Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling"
Neuroimage, 270, 119939
DOI 10.1016/j.neuroimage.2023.119939, PubMed 36841108
Baseline long-term potentiation-like cortical plasticity is associated with longitudinal cortical thinning in healthy adults and in adults with bipolar disorder type II
Eur J Neurosci, 58 (3), 2824-2837
DOI 10.1111/ejn.16038, PubMed 37163975
Publications 2022
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Nat Neurosci, 25 (4), 421-432
DOI 10.1038/s41593-022-01042-4, PubMed 35383335
Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study
Schizophr Bull, 48 (1), 37-46
DOI 10.1093/schbul/sbab106, PubMed 34499169
A family study of symbolic learning and synaptic plasticity in autism spectrum disorder
Front Hum Neurosci, 16, 950922
DOI 10.3389/fnhum.2022.950922, PubMed 36504626
Long-Term Potentiation-Like Visual Synaptic Plasticity Is Negatively Associated With Self-Reported Symptoms of Depression and Stress in Healthy Adults
Front Hum Neurosci, 16, 867675
DOI 10.3389/fnhum.2022.867675, PubMed 35601905
Long term potentiation-like neural plasticity and performance-based memory function
Neurobiol Learn Mem, 196, 107696
DOI 10.1016/j.nlm.2022.107696, PubMed 36368635
Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation
Biol Psychiatry, 93 (2), 187-196
DOI 10.1016/j.biopsych.2022.06.029, PubMed 36182530
Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation
Transl Psychiatry, 12 (1), 161
DOI 10.1038/s41398-022-01909-x, PubMed 35422097
Publications 2021
Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group
Biol Psychiatry, 91 (6), 582-592
DOI 10.1016/j.biopsych.2021.09.008, PubMed 34809987
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
Psychol Med, 53 (4), 1479-1488
DOI 10.1017/S0033291721003056, PubMed 35387700
Telomeres are shorter and associated with number of suicide attempts in affective disorders
J Affect Disord, 295, 1032-1039
DOI 10.1016/j.jad.2021.08.135, PubMed 34706411
The genetic architecture of the human thalamus and its overlap with ten common brain disorders
Nat Commun, 12 (1), 2909
DOI 10.1038/s41467-021-23175-z, PubMed 34006833
Characterisation of age and polarity at onset in bipolar disorder
Br J Psychiatry, 219 (6), 659-669
DOI 10.1192/bjp.2021.102, PubMed 35048876
Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals
Bipolar Disord, 24 (5), 509-520
DOI 10.1111/bdi.13172, PubMed 34894200
Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals
Mol Psychiatry, 26 (11), 6806-6819
DOI 10.1038/s41380-021-01098-x, PubMed 33863996
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Nat Genet, 53 (6), 817-829
DOI 10.1038/s41588-021-00857-4, PubMed 34002096
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
Transl Psychiatry, 11 (1), 407
DOI 10.1038/s41398-021-01527-z, PubMed 34301917
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Transl Psychiatry, 11 (1), 3
DOI 10.1038/s41398-020-01142-4, PubMed 33414458
Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity
Brain Behav, 11 (8), e02188
DOI 10.1002/brb3.2188, PubMed 34291596
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
Brain Behav Immun, 99, 299-306
DOI 10.1016/j.bbi.2021.10.017, PubMed 34758379
ENIGMA-Sleep: Challenges, opportunities, and the road map
J Sleep Res, 30 (6), e13347
DOI 10.1111/jsr.13347, PubMed 33913199
Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder
Schizophr Bull, 47 (6), 1751-1760
DOI 10.1093/schbul/sbab049, PubMed 33963856
Publications 2020
Heart rate variability is associated with disease severity in psychosis spectrum disorders
Prog Neuropsychopharmacol Biol Psychiatry, 111, 110108
DOI 10.1016/j.pnpbp.2020.110108, PubMed 32946948
Borderline patients have difficulties describing feelings; bipolar II patients describe difficult feelings. An alexithymia study
Acta Psychiatr Scand, 142 (3), 203-214
DOI 10.1111/acps.13204, PubMed 32594515
What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
Hum Brain Mapp, 43 (1), 56-82
DOI 10.1002/hbm.25098, PubMed 32725849
Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study
BMC Psychiatry, 20 (1), 582
DOI 10.1186/s12888-020-02968-4, PubMed 33287748
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Nat Commun, 11 (1), 4016
DOI 10.1038/s41467-020-17376-1, PubMed 32782260
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Mol Psychiatry, 26 (9), 5124-5139
DOI 10.1038/s41380-020-0754-0, PubMed 32424236
In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group
Hum Brain Mapp, 43 (1), 385-398
DOI 10.1002/hbm.25249, PubMed 33073925
Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 23 (2), 295
DOI 10.1038/s41593-019-0553-6, PubMed 31848485
Do visual and auditory stimulus-specific response modulation reflect different mechanisms of neocortical plasticity?
Eur J Neurosci, 53 (4), 1072-1085
DOI 10.1111/ejn.14964, PubMed 32897598
Exploring neurophysiological markers of visual perspective taking: Methodological considerations
Int J Psychophysiol, 161, 1-12
DOI 10.1016/j.ijpsycho.2020.12.006, PubMed 33388368
Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals
Neuroimage, 223, 117302
DOI 10.1016/j.neuroimage.2020.117302, PubMed 32828930
Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling
Neuroimage, 226, 117540
DOI 10.1016/j.neuroimage.2020.117540, PubMed 33186715
Evidence for wakefulness-related changes to extracellular space in human brain white matter from diffusion-weighted MRI
Neuroimage, 212, 116682
DOI 10.1016/j.neuroimage.2020.116682, PubMed 32114147
Publications 2019
Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder
Acta Psychiatr Scand, 139 (3), 256-268
DOI 10.1111/acps.12997, PubMed 30552759
Equivalence Class Formation and the N400: Methodological Issues
Psychol. Rec., 69 (2), 175-191
DOI 10.1007/s40732-019-00332-x
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Nat Neurosci, 22 (10), 1617-1623
DOI 10.1038/s41593-019-0471-7, PubMed 31551603
Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders
Front Psychiatry, 10, 534
DOI 10.3389/fpsyt.2019.00534, PubMed 31440172
Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations
Cereb Cortex, 29 (2), 875-891
DOI 10.1093/cercor/bhy291, PubMed 30475994
Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade
Acta Psychiatr Scand, 139 (4), 348-360
DOI 10.1111/acps.13008, PubMed 30697685
Genome-wide association study identifies 30 loci associated with bipolar disorder
Nat Genet, 51 (5), 793-803
DOI 10.1038/s41588-019-0397-8, PubMed 31043756
Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II
Bipolar Disord, 21 (6), 525-538
DOI 10.1111/bdi.12771, PubMed 30864260
Telomere length is associated with childhood trauma in patients with severe mental disorders
Transl Psychiatry, 9 (1), 97
DOI 10.1038/s41398-019-0432-7, PubMed 30898995
Publications 2018
Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation
Neuroimage, 186, 497-509
DOI 10.1016/j.neuroimage.2018.11.032, PubMed 30471387
Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
Mol Psychiatry, 25 (9), 2130-2143
DOI 10.1038/s41380-018-0228-9, PubMed 30171211
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
Transl Psychiatry, 8 (1), 103
DOI 10.1038/s41398-018-0151-5, PubMed 29795193
Publications 2017
Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation
Neuroimage, 156, 214-223
DOI 10.1016/j.neuroimage.2017.05.027, PubMed 28526620
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
Mol Psychiatry, 23 (4), 932-942
DOI 10.1038/mp.2017.73, PubMed 28461699
Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders
Front Neuroendocrinol, 45, 1-10
DOI 10.1016/j.yfrne.2016.12.004, PubMed 28049009
Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults
PLoS One, 12 (2), e0170921
DOI 10.1371/journal.pone.0170921, PubMed 28151944
Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial
Transl Psychiatry, 7 (5), e1136
DOI 10.1038/tp.2017.103, PubMed 28534875
Publications 2016
Dentate gyrus-cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross-sectional analyses
Bipolar Disord, 18 (8), 657-668
DOI 10.1111/bdi.12457, PubMed 27995733
Subcortical volumetric abnormalities in bipolar disorder
Mol Psychiatry, 21 (12), 1710-1716
DOI 10.1038/mp.2015.227, PubMed 26857596
Publications 2015
Widespread changes in white matter microstructure after a day of waking and sleep deprivation
PLoS One, 10 (5), e0127351
DOI 10.1371/journal.pone.0127351, PubMed 26020651
The brain functional connectome is robustly altered by lack of sleep
Neuroimage, 127, 324-332
DOI 10.1016/j.neuroimage.2015.12.028, PubMed 26712339
Publications 2014
Different impulsivity profiles in borderline personality disorder and bipolar II disorder
J Affect Disord, 170, 104-11
DOI 10.1016/j.jad.2014.08.033, PubMed 25237733
Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder
J Psychiatry Neurosci, 39 (2), 127-34
DOI 10.1503/jpn.130070, PubMed 24309162
The surface area of early visual cortex predicts the amplitude of the visual evoked potential
Brain Struct Funct, 220 (2), 1229-36
DOI 10.1007/s00429-013-0703-7, PubMed 24415060
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Brain Imaging Behav, 8 (2), 153-82
DOI 10.1007/s11682-013-9269-5, PubMed 24399358
Publications 2013
Regional cortical thinning may be a biological marker for borderline personality disorder
Acta Psychiatr Scand, 130 (3), 193-204
DOI 10.1111/acps.12234, PubMed 24571788
Evidence for reduced dentate gyrus and fimbria volume in bipolar II disorder
Bipolar Disord, 15 (2), 167-76
DOI 10.1111/bdi.12046, PubMed 23317454
Bipolar II disorder is associated with thinning of prefrontal and temporal cortices involved in affect regulation
Bipolar Disord, 15 (8), 855-64
DOI 10.1111/bdi.12117, PubMed 23980618
Publications 2011
Evidence for impaired neocortical synaptic plasticity in bipolar II disorder
Biol Psychiatry, 71 (1), 68-74
DOI 10.1016/j.biopsych.2011.09.026, PubMed 22036034
The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
J Affect Disord, 135 (1-3), 43-50
DOI 10.1016/j.jad.2011.08.006, PubMed 21880373
Publications 2009
[Neurofibromatosis type 2 and auditory brainstem implantation]
Tidsskr Nor Laegeforen, 129 (15), 1469-73
DOI 10.4045/tidsskr.08.0151, PubMed 19690597
Publications 2008
[Structural plasticity in the adult central nervous system]
Tidsskr Nor Laegeforen, 128 (3), 298-302
PubMed 18264154
[A 58-year-old woman with stroke, elevated troponin and hypercoagulability]
Tidsskr Nor Laegeforen, 128 (6), 706-8
PubMed 18365333