Sebastian Patzke's project group: Centrosome and Cell Division Cycle
Publications 2023
CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins
J Cell Sci, 136 (3)
DOI 10.1242/jcs.260327, PubMed 36606424
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side
J Cell Biol, 222 (4)
DOI 10.1083/jcb.202208062, PubMed 36752787
Publications 2022
3D-Structured Illumination Microscopy of Centrosomes in Human Cell Lines
Bio Protoc, 12 (6), e4360
DOI 10.21769/BioProtoc.4360, PubMed 35434191
Anti-CD37 radioimmunotherapy with 177Lu-NNV003 synergizes with the PARP inhibitor olaparib in treatment of non-Hodgkin's lymphoma in vitro
PLoS One, 17 (4), e0267543
DOI 10.1371/journal.pone.0267543, PubMed 35486574
Publications 2021
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
Elife, 10
DOI 10.7554/eLife.63731, PubMed 34259627
Publications 2020
Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome
Hum Mutat, 41 (12), 2179-2194
DOI 10.1002/humu.24127, PubMed 33131181
177Lu-Lilotomab Satetraxetan Has the Potential to Counteract Resistance to Rituximab in Non-Hodgkin Lymphoma
J Nucl Med, 61 (10), 1468-1475
DOI 10.2967/jnumed.119.237230, PubMed 32245896
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965
Publications 2019
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Cell Rep, 28 (7), 1907-1922.e6
DOI 10.1016/j.celrep.2019.07.025, PubMed 31412255
The therapeutic effectiveness of 177Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest
Leukemia, 34 (5), 1315-1328
DOI 10.1038/s41375-019-0677-4, PubMed 31836849
The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines
Front Oncol, 9, 1301
DOI 10.3389/fonc.2019.01301, PubMed 31850205
Publications 2018
Combined MR Imaging of Oxygen Consumption and Supply Reveals Tumor Hypoxia and Aggressiveness in Prostate Cancer Patients
Cancer Res, 78 (16), 4774-4785
DOI 10.1158/0008-5472.CAN-17-3806, PubMed 29945958
The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia
Mol Biol Cell, 29 (13), 1542-1554
DOI 10.1091/mbc.E17-04-0248, PubMed 29742019
Publications 2017
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn Ther, 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761
Publications 2016
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779
Publications 2015
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy
Oncogene, 34 (44), 5582-92
DOI 10.1038/onc.2015.15, PubMed 25684137
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Cell Cycle, 14 (20), 3248-60
DOI 10.1080/15384101.2015.1085137, PubMed 26312527
New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX
Cell Cycle, 14 (20), 3261-9
DOI 10.1080/15384101.2015.1087617, PubMed 26317799
Targeted Cancer Therapy with a Novel Anti-CD37 Beta-Particle Emitting Radioimmunoconjugate for Treatment of Non-Hodgkin Lymphoma
PLoS One, 10 (6), e0128816
DOI 10.1371/journal.pone.0128816, PubMed 26066655
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
DOI 10.1371/journal.pone.0134789, PubMed 26241740
Publications 2014
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule
Radiother Oncol, 110 (2), 355-61
DOI 10.1016/j.radonc.2013.12.014, PubMed 24502970
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
DOI 10.1038/bjc.2014.297, PubMed 24901235
Publications 2012
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
Mol Cell Biol, 32 (20), 4226-36
DOI 10.1128/MCB.00412-12, PubMed 22907750
Publications 2011
Three independent mechanisms for arrest in G2 after ionizing radiation
Cell Cycle, 10 (5), 819-29
DOI 10.4161/cc.10.5.14968, PubMed 21325885
Publications 2010
CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation
Mol Biol Cell, 21 (15), 2555-67
DOI 10.1091/mbc.e09-06-0503, PubMed 20519441
Publications 2007
Characterization of the FAM110 gene family
Genomics, 90 (1), 14-27
DOI 10.1016/j.ygeno.2007.03.002, PubMed 17499476
Publications 2006
CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization
J Cell Physiol, 209 (1), 199-210
DOI 10.1002/jcp.20725, PubMed 16826565
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
Publications 2005
Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization
Oncogene, 24 (7), 1159-73
DOI 10.1038/sj.onc.1208267, PubMed 15580290
Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis
Biochim Biophys Acta, 1723 (1-3), 1-7
DOI 10.1016/j.bbagen.2005.01.011, PubMed 15777695
Publications 2004
Characterization of a novel immunoglobulin-like domain containing receptor
Biochem Biophys Res Commun, 323 (3), 970-8
DOI 10.1016/j.bbrc.2004.08.188, PubMed 15381095
Publications 2002
Characterization of a novel human endogenous retrovirus, HERV-H/F, expressed in human leukemia cell lines
Virology, 303 (1), 164-73
DOI 10.1006/viro.2002.1615, PubMed 12482668
Codon-anticodon interaction at the P site is a prerequisite for tRNA interaction with the small ribosomal subunit
J Biol Chem, 277 (21), 19095-105
DOI 10.1074/jbc.M108902200, PubMed 11867615
Publications 2000
Periodic conformational changes in rRNA: monitoring the dynamics of translating ribosomes
Mol Cell, 6 (1), 159-71
PubMed 10949037
Publications 1998
Protection patterns of tRNAs do not change during ribosomal translocation
J Biol Chem, 273 (49), 32793-800
DOI 10.1074/jbc.273.49.32793, PubMed 9830024