Gunhild Trøen

  • Engineer; PhD
 

Publications 2024

Małecka A, Østlie I, Trøen G, Małecki J, Delabie J, Tierens A, Munthe LA, Berentsen S, Tjønnfjord GE (2024)
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease
Clin Exp Immunol, 216 (1), 45-54
DOI 10.1093/cei/uxad135, PubMed 38133636

Publications 2022

Farooq A, Trøen G, Delabie J, Wang J (2022)
Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma
Comput Struct Biotechnol J, 20, 1726-1742
DOI 10.1016/j.csbj.2022.03.023, PubMed 35495111

Przybyła W, Gjersvoll Paulsen KM, Mishra CK, Nygård S, Engebretsen S, Ruud E, Trøen G, Beiske K, Baumbusch LO (2022)
Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants
PLoS One, 17 (8), e0273280
DOI 10.1371/journal.pone.0273280, PubMed 36037157

Publications 2021

Małecka A, Trøen G, Delabie J, Małecki J, Østlie I, Tierens A, Randen U, Berentsen S, Tjønnfjord GE (2021)
The mutational landscape of cold agglutinin disease: CARD11 and CXCR4 mutations are correlated with lower hemoglobin levels
Am J Hematol, 96 (8), E279-E283
DOI 10.1002/ajh.26205, PubMed 33891703

Publications 2020

Małecka A, Delabie J, Østlie I, Tierens A, Randen U, Berentsen S, Tjønnfjord GE, Trøen G (2020)
Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18
Blood Adv, 4 (6), 993-996
DOI 10.1182/bloodadvances.2020001608, PubMed 32168377

Siaw JT, Javanmardi N, Van den Eynden J, Lind DE, Fransson S, Martinez-Monleon A, Djos A, Sjöberg RM, Östensson M, Carén H, Trøen G, Beiske K, Berbegall AP, Noguera R, Lai WY, Kogner P, Palmer RH, Hallberg B, Martinsson T (2020)
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma
Cell Rep, 32 (12), 108171
DOI 10.1016/j.celrep.2020.108171, PubMed 32966799

Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878

Publications 2019

Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Øy GF, Trøen G, Flørenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A (2019)
MX 2 is a novel regulator of cell cycle in melanoma cells
Pigment Cell Melanoma Res, 33 (3), 446-457
DOI 10.1111/pcmr.12837, PubMed 31660681

Publications 2018

Holte H, Beiske K, Boyle M, Trøen G, Blaker YN, Myklebust J, Kvaløy S, Rosenwald A, Lingjaerde OC, Rimsza LM, Smeland EB, Scott DW, Kolstad A (2018)
The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy
Br J Haematol, 183 (2), 225-234
DOI 10.1111/bjh.15518, PubMed 30080252

Publications 2017

Małecka A, Trøen G, Tierens A, Østlie I, Małecki J, Randen U, Wang J, Berentsen S, Tjønnfjord GE, Delabie JMA (2017)
Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease
Br J Haematol, 183 (5), 838-842
DOI 10.1111/bjh.15063, PubMed 29265349

Mantaka P, Malecka A, Trøen G, Helsing P, Gjersvik P, Beiske K, Delabie J (2017)
Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?
Acta Derm Venereol, 97 (9), 1081-1086
DOI 10.2340/00015555-2722, PubMed 28597017

Publications 2016

Małecka A, Trøen G, Tierens A, Østlie I, Małecki J, Randen U, Berentsen S, Tjønnfjord GE, Delabie JM (2016)
Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity
Haematologica, 101 (9), e361-4
DOI 10.3324/haematol.2016.146126, PubMed 27198717

Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, Wälchli S, Green MR, Trøen G, Liestøl K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R (2016)
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling
Blood, 129 (6), 759-770
DOI 10.1182/blood-2016-05-718494, PubMed 28011673

Publications 2015

Bassarova A, Trøen G, Spetalen S, Micci F, Tierens A, Delabie J (2015)
Lymphoplasmacytic lymphoma and marginal zone lymphoma in the bone marrow: paratrabecular involvement as an important distinguishing feature
Am J Clin Pathol, 143 (6), 797-806
DOI 10.1309/AJCP6ZODWV1CIDME, PubMed 25972321

Malecka A, Tierens A, Østlie I, Schmitz R, Trøen G, Spetalen S, Staudt LM, Smeland E, Holte H, Delabie J (2015)
Primary diffuse large B-cell lymphoma associated with clonally-related monoclonal B lymphocytosis indicates a common precursor cell
Haematologica, 100 (10), e415-8
DOI 10.3324/haematol.2015.126656, PubMed 26001788

Wang J, Malecka A, Trøen G, Delabie J (2015)
Comprehensive genome-wide transcription factor analysis reveals that a combination of high affinity and low affinity DNA binding is needed for human gene regulation
BMC Genomics, 16 Suppl 7 (Suppl 7), S12
DOI 10.1186/1471-2164-16-S7-S12, PubMed 26099425

Publications 2014

Bethge N, Honne H, Andresen K, Hilden V, Trøen G, Liestøl K, Holte H, Delabie J, Lind GE, Smeland EB (2014)
A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma
PLoS One, 9 (9), e104249
DOI 10.1371/journal.pone.0104249, PubMed 25226156

Mantaka P, Malecka A, Trøen G, Helsing P, Gjersvik P, Delabie J (2014)
Multiple distinct T-cell clones in folliculotropic mycosis fungoides
Am J Dermatopathol, 36 (12), 972-6
DOI 10.1097/DAD.0000000000000095, PubMed 25140661

Publications 2013

Bethge N, Honne H, Hilden V, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma
PLoS One, 8 (11), e79602
DOI 10.1371/journal.pone.0079602, PubMed 24260260

Bethge N, Lothe RA, Honne H, Andresen K, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
Epigenetics, 9 (3), 428-36
DOI 10.4161/epi.27554, PubMed 24362313

Brodtkorb M, Lingjærde OC, Huse K, Trøen G, Hystad M, Hilden VI, Myklebust JH, Leich E, Rosenwald A, Delabie J, Holte H, Smeland EB (2013)
Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma
Blood, 123 (7), 1051-4
DOI 10.1182/blood-2013-07-512392, PubMed 24357726

Randen U, Trøen G, Tierens A, Steen C, Warsame A, Beiske K, Tjønnfjord GE, Berentsen S, Delabie J (2013)
Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma
Haematologica, 99 (3), 497-504
DOI 10.3324/haematol.2013.091702, PubMed 24143001

Trøen G, Warsame A, Delabie J (2013)
CD79B and MYD88 Mutations in Splenic Marginal Zone Lymphoma
ISRN Oncol, 2013, 252318
DOI 10.1155/2013/252318, PubMed 23378931

Publications 2012

Warsame A, Delabie J, Malecka A, Wang J, Trøen G, Tierens A (2012)
Monocytoid B cells: an enigmatic B cell subset showing evidence of extrafollicular immunoglobulin gene somatic hypermutation
Scand J Immunol, 75 (5), 500-9
DOI 10.1111/j.1365-3083.2012.02688.x, PubMed 22486786

Publications 2011

Nyquist KB, Thorsen J, Zeller B, Haaland A, Trøen G, Heim S, Micci F (2011)
Identification of the TAF15-ZNF384 fusion gene in two new cases of acute lymphoblastic leukemia with a t(12;17)(p13;q12)
Cancer Genet, 204 (3), 147-52
DOI 10.1016/j.cancergen.2011.01.003, PubMed 21504714

Warsame AA, Aasheim HC, Nustad K, Trøen G, Tierens A, Wang V, Randen U, Dong HP, Heim S, Brech A, Delabie J (2011)
Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
Blood, 118 (12), 3331-9
DOI 10.1182/blood-2011-03-341651, PubMed 21725051

Publications 2010

Eide MB, Liestøl K, Lingjaerde OC, Hystad ME, Kresse SH, Meza-Zepeda L, Myklebost O, Trøen G, Aamot HV, Holte H, Smeland EB, Delabie J (2010)
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
DOI 10.1182/blood-2010-03-272278, PubMed 20505157

Publications 2009

Bassarova A, Trøen G, Fosså A, Ikonomou IM, Beiske K, Nesland JM, Delabie J (2009)
Transformation of B cell lymphoma to histiocytic sarcoma: somatic mutations of PAX-5 gene with loss of expression cannot explain transdifferentiation
J Hematop, 2 (3), 135-41
DOI 10.1007/s12308-009-0031-2, PubMed 19669194

Holte H, Kvaløy S, Delabie J, Trøen G, Smeland EB (2009)
[Molecular diagnosis of malignant lymphomas]
Tidsskr Nor Laegeforen, 129 (22), 2352-6
DOI 10.4045/tidsskr.09.0704, PubMed 19935935

Publications 2008

Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Goldschmidt N, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, Kyle A, May L, Gascoyne RD, Connors JM, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G et al. (2008)
Stromal gene signatures in large-B-cell lymphomas
N Engl J Med, 359 (22), 2313-23
DOI 10.1056/NEJMoa0802885, PubMed 19038878

Slipicevic A, Jørgensen K, Skrede M, Rosnes AK, Trøen G, Davidson B, Flørenes VA (2008)
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells
BMC Cancer, 8, 276
DOI 10.1186/1471-2407-8-276, PubMed 18826602

Trøen G, Wlodarska I, Warsame A, Hernández Llodrà S, De Wolf-Peeters C, Delabie J (2008)
NOTCH2 mutations in marginal zone lymphoma
Haematologica, 93 (7), 1107-9
DOI 10.3324/haematol.11635, PubMed 18508802

Wang Z, Tropè CG, Suo Z, Trøen G, Yang G, Nesland JM, Holm R (2008)
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
BMC Cancer, 8, 308
DOI 10.1186/1471-2407-8-308, PubMed 18950492

Publications 2006

Ikonomou IM, Tierens A, Troen G, Aamot HV, Heim S, Lauritzsen GF, Vålerhaugen H, Delabie J (2006)
Peripheral T-cell lymphoma with involvement of the expanded mantle zone
Virchows Arch, 449 (1), 78-87
DOI 10.1007/s00428-005-0123-z, PubMed 16633785

Khnykin D, Troen G, Berner JM, Delabie J (2006)
The expression of fibroblast growth factors and their receptors in Hodgkin's lymphoma
J Pathol, 208 (3), 431-8
DOI 10.1002/path.1900, PubMed 16353171

Publications 2005

Korkmaz CG, Korkmaz KS, Kurys P, Elbi C, Wang L, Klokk TI, Hammarstrom C, Troen G, Svindland A, Hager GL, Saatcioglu F (2005)
Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer
Oncogene, 24 (31), 4934-45
DOI 10.1038/sj.onc.1208677, PubMed 15897894

Publications 2004

Trøen G, Nygaard V, Jenssen TK, Ikonomou IM, Tierens A, Matutes E, Gruszka-Westwood A, Catovsky D, Myklebost O, Lauritzsen G, Hovig E, Delabie J (2004)
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
J Mol Diagn, 6 (4), 297-307
DOI 10.1016/S1525-1578(10)60525-9, PubMed 15507668

Wu D, Qiao Y, Kristensen GB, Li S, Troen G, Holm R, Nesland JM, Suo Z (2004)
Prognostic significance of dysadherin expression in cervical squamous cell carcinoma
Pathol Oncol Res, 10 (4), 212-8
DOI 10.1007/BF03033763, PubMed 15619642

Wu D, Suo Z, Kristensen GB, Li S, Troen G, Holm R, Nesland JM (2004)
Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma
Gynecol Oncol, 94 (2), 312-9
DOI 10.1016/j.ygyno.2004.05.019, PubMed 15297167

Publications 2000

Brede G, Solheim J, Tröen G, Prydz H (2000)
Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization
Genomics, 70 (1), 82-92
DOI 10.1006/geno.2000.6365, PubMed 11087665

Eskild W, Troen G, Blaner WS, Nilsson A, Hansson V (2000)
Evidence for independent control at the mRNA and protein levels of cellular retinol binding protein 1 in rat Sertoli cells
J Reprod Fertil, 119 (1), 101-9
DOI 10.1530/jrf.0.1190101, PubMed 10864819

Publications 1999

Trøen G, Eskild W, Fromm SH, De Luca LM, Ong DE, Wardlaw SA, Reppe S, Blomhoff R (1999)
Vitamin A-sensitive tissues in transgenic mice expressing high levels of human cellular retinol-binding protein type I are not altered phenotypically
J Nutr, 129 (9), 1621-7
DOI 10.1093/jn/129.9.1621, PubMed 10460195

Publications 1997

Nilsson A, Trøen G, Petersen LB, Reppe S, Norum KR, Blomhoff R (1997)
Retinyl ester storage is altered in liver stellate cells and in HL60 cells transfected with cellular retinol-binding protein type I
Int J Biochem Cell Biol, 29 (2), 381-9
DOI 10.1016/s1357-2725(96)00068-4, PubMed 9147140

Publications 1996

Troen G, Eskild W, Fromm SH, Reppe S, Nilsson A, Norum KR, Blomhoff R (1996)
Retinyl ester storage is normal in transgenic mice with enhanced expression of cellular retinol-binding protein type I
J Nutr, 126 (11), 2709-19
DOI 10.1093/jn/126.11.2709, PubMed 8914940

Trøen G (1996)
Function of cellular retinol-binding protein I in metabolism of retinol
Institute for Nutrition Research and Department of Biochemistry, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 961594594, ISBN 82-992777-9-5

Publications 1994

Trøen G, Nilsson A, Norum KR, Blomhoff R (1994)
Characterization of liver stellate cell retinyl ester storage
Biochem J, 300 ( Pt 3) (Pt 3), 793-8
DOI 10.1042/bj3000793, PubMed 8010962

Publications 1993

Farrants AK, Nilsson A, Trøen G, Blomhoff R, Pedersen JI (1993)
The effect of retinoids and clofibric acid on the peroxisomal oxidation of palmitic acid and of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid in rat and rabbit hepatocytes
Biochim Biophys Acta, 1168 (1), 100-7
DOI 10.1016/0005-2760(93)90272-b, PubMed 8504135

Publications 1991

TROEN G, NORUM KR, BLOMHOFF R (1991)
RETINOL ESTERIFICATION IN RABBIT LIVER STELLATE CELLS
CELLS OF THE HEPATIC SINUSOID, VOL 3, 266-268

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