Øyvind Haugen Lie
- Group leader and Consultant interventional cardiologist; MD, PhD
Øyvind Haugen Lie, MD, PhD, Department of Cardiology, Rikshospitalet, Oslo University Hospital
Øyvind Haugen Lie successfully defended his PhD thesis "Risk stratification and management of patients with right ventricular arrhythmias" in December 2018. His supervisors were Associate Professor Kristina Hermann Haugaa, MD, PhD and Professor Thor Edvardsen, MD, PhD.
During his fellowship Lie was awarded with Prof. J. Roelandt’s Young Investigator Award for best original work in clinical science at the 2017 EuroEcho-Imaging Congress. The award was given in recognition of the work “Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy”.
Lie also won the best poster prize in the session for “Diagnostic and therapeutical strategies for cardiac disease” at the annual Center for Heart Failure Research Symposium two years in a row. He was give the prize in recognition of the work “How many are too many – Frequent premature ventricular contractions and left ventricular function” and "V-3 QRS-duration of premature ventricular contractions relates to ventricular tachycardia in patients with outflow tract arrhythmia", respectively.
Lie, together with his colleagues, discovered that the threshold ectopy burden associated with impaired left ventricular function was lower than previously assumed when accurate and sensitive echocardiographic tools were used. Patients with frequent premature ventricular contractions of right ventricular outflow tract origin may contract an ectopy-induced cardiomyopathy, those with more than 8000 premature ventricular contractions per 24 hours may benefit from antiarrhythmic therapy.
Higher exercise intensity is a strong and independent marker of adverse outcome in patients with arrhythmogenic cardiomyopathy, irrespective of longer exercise duration. Together with ECG-abnormalities and subtle left ventricular contraction abnormalities, information on exercise intensity at study entry yielded precise risk stratification that may be useful in the challenging selection of patients with arrhythmogenic cardiomyopathy who may benefit from a primary preventive implantable cardioverter-defibrillator.
Publications 2024
No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes
Sci Rep, 14 (1), 6581
DOI 10.1038/s41598-024-57233-5, PubMed 38503845
Left ventricular mechanical dispersion as a predictor of the need for pacemaker implantation after transcatheter aortic valve implantation: MeDiPace TAVI study
Eur Heart J Cardiovasc Imaging, 25 (4), 539-547
DOI 10.1093/ehjci/jead315, PubMed 37976177
Differentiation of Myocardial Properties in Physiological Athletic Cardiac Remodeling and Mild Hypertrophic Cardiomyopathy
Biomedicines, 12 (2)
DOI 10.3390/biomedicines12020420, PubMed 38398022
Changes in electrical delay is associated with the hemodynamic response to cardiac pacing
Heart Rhythm O2, 5 (5), 338-340
DOI 10.1016/j.hroo.2024.03.013, PubMed 38840764
Publications 2023
An investigator-sponsored pragmatic randomized controlled trial of AntiCoagulation vs AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation: Rationale and design of ACASA-TAVI
Am Heart J, 265, 225-232
DOI 10.1016/j.ahj.2023.08.010, PubMed 37634655
The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy
Eur Heart J Cardiovasc Imaging, 24 (12), 1710-1718
DOI 10.1093/ehjci/jead174, PubMed 37474315
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum
J Am Coll Cardiol, 82 (9), 785-797
DOI 10.1016/j.jacc.2023.05.065, PubMed 37612010
Mortality in Patients with Acute Coronary Syndrome-A Prospective 5-Year Follow-Up Study
J Clin Med, 12 (20)
DOI 10.3390/jcm12206598, PubMed 37892735
Disease progression rate is a strong predictor of ventricular arrhythmias in patients with cardiac laminopathies: a primary prevention cohort study
Europace, 25 (2), 634-642
DOI 10.1093/europace/euac192, PubMed 36352512
Ventricular arrhythmias in arrhythmic mitral valve syndrome-a prospective continuous long-term cardiac monitoring study
Europace, 25 (2), 506-516
DOI 10.1093/europace/euac182, PubMed 36256597
Publications 2022
Integrating Exercise Into Personalized Ventricular Arrhythmia Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy
Circ Arrhythm Electrophysiol, 15 (2), e010221
DOI 10.1161/CIRCEP.121.010221, PubMed 35089054
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Eur Heart J, 43 (32), e1-e9
DOI 10.1093/eurheartj/ehac180, PubMed 35441664
Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive
J Am Heart Assoc, 11 (8), e024960
DOI 10.1161/JAHA.121.024960, PubMed 35434999
Electrical markers and arrhythmic risk associated with myocardial fibrosis in mitral valve prolapse
Europace, 24 (7), 1156-1163
DOI 10.1093/europace/euac017, PubMed 35226070
Effect of continuous positive airway pressure therapy on recurrence of atrial fibrillation after pulmonary vein isolation in patients with obstructive sleep apnea: A randomized controlled trial
Heart Rhythm, 19 (9), 1433-1441
DOI 10.1016/j.hrthm.2022.06.016, PubMed 35716856
Timing of cardioverter-defibrillator implantation in patients with cardiac laminopathies-External validation of the LMNA-risk ventricular tachyarrhythmia calculator
Heart Rhythm, 20 (3), 423-429
DOI 10.1016/j.hrthm.2022.11.024, PubMed 36494026
Flecainide in patients with arrhythmic mitral valve syndrome: A case series
Heart Rhythm, 20 (4), 635-636
DOI 10.1016/j.hrthm.2022.12.024, PubMed 36566890
Publications 2021
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur Heart J Cardiovasc Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324, PubMed 33280029
Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure
J Med Genet, 59 (9), 858-864
DOI 10.1136/jmedgenet-2021-107911, PubMed 34400560
Right Ventricular Functional Abnormalities in Arrhythmogenic Cardiomyopathy: Association With Life-Threatening Ventricular Arrhythmias
JACC Cardiovasc Imaging, 14 (5), 900-910
DOI 10.1016/j.jcmg.2020.12.028, PubMed 33582062
Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
J Am Heart Assoc, 10 (8), e018680
DOI 10.1161/JAHA.120.018680, PubMed 33821670
Left Ventricular Rupture
N Engl J Med, 384 (2), e4
DOI 10.1056/NEJMicm2020871, PubMed 33502833
Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001400, PubMed 33414183
Long-term follow-up and sex differences in adults operated for tetralogy of Fallot
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001738, PubMed 34663747
Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy
Europace, 23 (7), 1084-1091
DOI 10.1093/europace/euab077, PubMed 33829244
Tricuspid Annulus Disjunction: Novel Findings by Cardiac Magnetic Resonance in Patients With Mitral Annulus Disjunction
JACC Cardiovasc Imaging, 14 (8), 1535-1543
DOI 10.1016/j.jcmg.2021.01.028, PubMed 33744128
Publications 2020
Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration
Circ Arrhythm Electrophysiol, 14 (1), e008509
DOI 10.1161/CIRCEP.120.008509, PubMed 33296238
High penetrance and similar disease progression in probands and in family members with arrhythmogenic cardiomyopathy
Eur Heart J, 41 (14), 1401-1410
DOI 10.1093/eurheartj/ehz570, PubMed 31504415
The super healthy atrial fibrillation conundrum
Eur Heart J Cardiovasc Imaging, 21 (12), 1384-1385
DOI 10.1093/ehjci/jeaa217, PubMed 32810229
Cardiac Phenotypes and Markers of Adverse Outcome in Elite Athletes With Ventricular Arrhythmias
JACC Cardiovasc Imaging, 14 (1), 148-158
DOI 10.1016/j.jcmg.2020.07.039, PubMed 33129723
Worse Prognosis in Brugada Syndrome Patients With Arrhythmogenic Cardiomyopathy Features
JACC Clin Electrophysiol, 6 (11), 1353-1363
DOI 10.1016/j.jacep.2020.05.026, PubMed 33121663
Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype
J Am Heart Assoc, 9 (2), e012937
DOI 10.1161/JAHA.119.012937, PubMed 31957533
Publications 2019
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Eur Heart J, 40 (23), 1850-1858
DOI 10.1093/eurheartj/ehz103, PubMed 30915475
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777
Reply: Arrhythmic Mitral Annulus Disjunction and Mitral Valve Prolapse: Components of the Same Clinical Spectrum?
J Am Coll Cardiol, 73 (6), 739-740
DOI 10.1016/j.jacc.2018.12.008, PubMed 30765047
Cardiac amyloidosis: can imaging shed light on mechanisms and prognosis?
Eur Heart J Cardiovasc Imaging, 20 (5), 500-501
DOI 10.1093/ehjci/jez009, PubMed 30726891
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block
Eur Heart J Cardiovasc Imaging, 20 (3), 271-278
DOI 10.1093/ehjci/jey127, PubMed 30247533
Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Am J Cardiol, 123 (7), 1156-1162
DOI 10.1016/j.amjcard.2018.12.049, PubMed 30678832
Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias
Open Heart, 6 (1), e001016
DOI 10.1136/openhrt-2019-001016, PubMed 31168386
Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias
Int J Cardiol, 299, 147-152
DOI 10.1016/j.ijcard.2019.06.074, PubMed 31281045
Speckle tracking echocardiography data in Brugada syndrome patients
Data Brief, 25, 104330
DOI 10.1016/j.dib.2019.104330, PubMed 31453301
Publications 2018
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int J Cardiol, 250, 157-163
DOI 10.1016/j.ijcard.2017.07.015, PubMed 29169752
The Mitral Annulus Disjunction Arrhythmic Syndrome
J Am Coll Cardiol, 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070, PubMed 30261961
Reveal the Concealed: The Quest for Early Disease Detection in Family Members at Risk of Developing Arrhythmogenic Cardiomyopathy
JACC Cardiovasc Imaging, 12 (3), 456-457
DOI 10.1016/j.jcmg.2018.02.007, PubMed 29550321
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC Clin Electrophysiol, 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010, PubMed 29929667
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017, PubMed 30031702
Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center
Int J Cardiol, 279, 79-83
DOI 10.1016/j.ijcard.2018.12.066, PubMed 30638987
Publications 2017
Right ventricular remodeling in athletes and in arrhythmogenic cardiomyopathy
Scand Cardiovasc J, 52 (1), 13-19
DOI 10.1080/14017431.2017.1416158, PubMed 29254378
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
DOI 10.1016/j.dib.2017.08.018, PubMed 28971120
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594
DOI 10.1002/ehf2.12180, PubMed 29154430