Morten Milek Nielsen

  • Post doc
  • +47 22 78 13 17
 

Publications 2019

Viuff M, Skakkebaek A, Nielsen MM, Chang S, Gravholt CH (2019)
Epigenetics and genomics in Turner syndrome
Am J Med Genet C Semin Med Genet, 181 (1), 68-75
DOI 10.1002/ajmg.c.31683, PubMed 30811826

Publications 2018

Bertl J, Guo Q, Juul M, Besenbacher S, Nielsen MM, Hornshøj H, Pedersen JS, Hobolth A (2018)
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
BMC Bioinformatics, 19 (1), 147
DOI 10.1186/s12859-018-2141-2, PubMed 29673314

Hornshøj H, Nielsen MM, Sinnott-Armstrong NA, Świtnicki MP, Juul M, Madsen T, Sallari R, Kellis M, Ørntoft T, Hobolth A, Pedersen JS (2018)
Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
NPJ Genom Med, 3, 1
DOI 10.1038/s41525-017-0040-5, PubMed 29354286

Jacobsen KM, Villadsen NL, Tørring T, Nielsen CB, Salomón T, Nielsen MM, Tsakos M, Sibbersen C, Scavenius C, Nielsen R, Christensen EI, Guerra PF, Bross P, Pedersen JS, Enghild JJ, Johannsen M, Frøkiær J, Overgaard J, Horsman MR, Busk M, Poulsen TB (2018)
APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
Cell Chem Biol, 25 (11), 1337-1349.e12
DOI 10.1016/j.chembiol.2018.07.010, PubMed 30122371

Nielsen MM, Ruzanski C, Krucewicz K, Striebeck A, Cenci U, Ball SG, Palcic MM, Cuesta-Seijo JA (2018)
Crystal Structures of the <b>C</b>atalytic <b>D</b>omain of Arabidopsis thaliana Starch Synthase IV, of Granule Bound Starch Synthase From CLg1 and of Granule Bound Starch Synthase I of Cyanophora paradoxa Illustrate Substrate Recognition in Starch Synthases
Front Plant Sci, 9, 1138
DOI 10.3389/fpls.2018.01138, PubMed 30123236

Nielsen MM, Tataru P, Madsen T, Hobolth A, Pedersen JS (2018)
Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments
Algorithms Mol Biol, 13, 17
DOI 10.1186/s13015-018-0135-2, PubMed 30555524

Skakkebæk A, Nielsen MM, Trolle C, Vang S, Hornshøj H, Hedegaard J, Wallentin M, Bojesen A, Hertz JM, Fedder J, Østergaard JR, Pedersen JS, Gravholt CH (2018)
DNA hypermethylation and differential gene expression associated with Klinefelter syndrome
Sci Rep, 8 (1), 13740
DOI 10.1038/s41598-018-31780-0, PubMed 30213969

Publications 2017

Hebelstrup KH, Nielsen MM, Carciofi M, Andrzejczak O, Shaik SS, Blennow A, Palcic MM (2017)
Waxy and non-waxy barley cultivars exhibit differences in the targeting and catalytic activity of GBSS1a
J Exp Bot, 68 (5), 931-941
DOI 10.1093/jxb/erw503, PubMed 28199682

Juul M, Bertl J, Guo Q, Nielsen MM, Świtnicki M, Hornshøj H, Madsen T, Hobolth A, Pedersen JS (2017)
Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
Elife, 6
DOI 10.7554/eLife.21778, PubMed 28362259

Nielsen MM, Schmidt JD, Christensen JP, Geisler C, Johansen JD, Bonefeld CM (2017)
Detection of local inflammation induced by repeated exposure to contact allergens by use of IVIS SpectrumCT analyses
Contact Dermatitis, 76 (4), 210-217
DOI 10.1111/cod.12746, PubMed 28120518

Nielsen MM, Witherden DA, Havran WL (2017)
γδ T cells in homeostasis and host defence of epithelial barrier tissues
Nat Rev Immunol, 17 (12), 733-745
DOI 10.1038/nri.2017.101, PubMed 28920588

Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS (2017)
Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
NPJ Genom Med, 2, 36
DOI 10.1038/s41525-017-0038-z, PubMed 29263845

Seitz AK, Christensen LL, Christensen E, Faarkrog K, Ostenfeld MS, Hedegaard J, Nordentoft I, Nielsen MM, Palmfeldt J, Thomson M, Jensen MT, Nawroth R, Maurer T, Ørntoft TF, Jensen JB, Damgaard CK, Dyrskjøt L (2017)
Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer
Sci Rep, 7 (1), 395
DOI 10.1038/s41598-017-00327-0, PubMed 28341852

Publications 2016

Christensen LL, True K, Hamilton MP, Nielsen MM, Damas ND, Damgaard CK, Ongen H, Dermitzakis E, Bramsen JB, Pedersen JS, Lund AH, Vang S, Stribolt K, Madsen MR, Laurberg S, McGuire SE, Ørntoft TF, Andersen CL (2016)
SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism
Mol Oncol, 10 (8), 1266-82
DOI 10.1016/j.molonc.2016.06.003, PubMed 27396952

Damas ND, Marcatti M, Côme C, Christensen LL, Nielsen MM, Baumgartner R, Gylling HM, Maglieri G, Rundsten CF, Seemann SE, Rapin N, Thézenas S, Vang S, Ørntoft T, Andersen CL, Pedersen JS, Lund AH (2016)
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
Nat Commun, 7, 13875
DOI 10.1038/ncomms13875, PubMed 28004750

Dyring-Andersen B, Nielsen MM, Geisler C, Bonefeld CM, Skov L (2016)
IL-17A- and IFNγ-Producing T Cells in Healthy Skin
Scand J Immunol, 83 (4), 297-9
DOI 10.1111/sji.12412, PubMed 26808020

Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MBH, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R et al. (2016)
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
Cancer Cell, 30 (1), 27-42
DOI 10.1016/j.ccell.2016.05.004, PubMed 27321955

Rasmussen MH, Lyskjær I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, Pedersen JS, Hansen TP, Hansen F, Olsen JV, Pfeiffer P, Ørntoft TF, Andersen CL (2016)
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Nat Commun, 7, 12436
DOI 10.1038/ncomms12436, PubMed 27526785

Schmidt JD, Ahlström MG, Johansen JD, Dyring-Andersen B, Agerbeck C, Nielsen MM, Poulsen SS, Woetmann A, Ødum N, Thomsen AR, Geisler C, Bonefeld CM (2016)
Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8+ T cells
Contact Dermatitis, 76 (4), 218-227
DOI 10.1111/cod.12715, PubMed 27873334

Trolle C, Nielsen MM, Skakkebæk A, Lamy P, Vang S, Hedegaard J, Nordentoft I, Ørntoft TF, Pedersen JS, Gravholt CH (2016)
Widespread DNA hypomethylation and differential gene expression in Turner syndrome
Sci Rep, 6, 34220
DOI 10.1038/srep34220, PubMed 27687697

Publications 2015

Bonefeld CM, Nielsen MM, Vennegaard MT, Johansen JD, Geisler C, Thyssen JP (2015)
Nickel acts as an adjuvant during cobalt sensitization
Exp Dermatol, 24 (3), 229-31
DOI 10.1111/exd.12634, PubMed 25580744

Christensen B, Nellemann B, Thorsen K, Nielsen MM, Pedersen SB, Ornstrup MJ, JØrgensen JO, Jessen N (2015)
Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle
Muscle Nerve, 51 (4), 554-61
DOI 10.1002/mus.24355, PubMed 25088500

Cockburn D, Nielsen MM, Christiansen C, Andersen JM, Rannes JB, Blennow A, Svensson B (2015)
Surface binding sites in amylase have distinct roles in recognition of starch structure motifs and degradation
Int J Biol Macromol, 75, 338-45
DOI 10.1016/j.ijbiomac.2015.01.054, PubMed 25661878

Cuesta-Seijo JA, Nielsen MM, Ruzanski C, Krucewicz K, Beeren SR, Rydhal MG, Yoshimura Y, Striebeck A, Motawia MS, Willats WG, Palcic MM (2015)
In vitro Biochemical Characterization of All Barley Endosperm Starch Synthases
Front Plant Sci, 6, 1265
DOI 10.3389/fpls.2015.01265, PubMed 26858729

Montes M, Nielsen MM, Maglieri G, Jacobsen A, Højfeldt J, Agrawal-Singh S, Hansen K, Helin K, van de Werken HJG, Pedersen JS, Lund AH (2015)
The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence
Nat Commun, 6, 6967
DOI 10.1038/ncomms7967, PubMed 25908244

Nielsen MM, Dyring-Andersen B, Schmidt JD, Witherden D, Lovato P, Woetmann A, Ødum N, Poulsen SS, Havran WL, Geisler C, Bonefeld CM (2015)
NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity
J Invest Dermatol, 135 (5), 1311-1319
DOI 10.1038/jid.2015.23, PubMed 25634359

Skryhan K, Cuesta-Seijo JA, Nielsen MM, Marri L, Mellor SB, Glaring MA, Jensen PE, Palcic MM, Blennow A (2015)
The Role of Cysteine Residues in Redox Regulation and Protein Stability of Arabidopsis thaliana Starch Synthase 1
PLoS One, 10 (9), e0136997
DOI 10.1371/journal.pone.0136997, PubMed 26367870

Publications 2014

Boding L, Hansen AK, Nielsen MM, Meroni G, Braunstein TH, Woetmann A, Ødum N, Bonefeld CM, Geisler C (2014)
Midline 1 controls polarization and migration of murine cytotoxic T cells
Immun Inflamm Dis, 2 (4), 262-71
DOI 10.1002/iid3.44, PubMed 25866633

Bonefeld CM, Nielsen MM, Gimenéz-Arnau E, Lang M, Vennegaard MT, Geisler C, Johansen JD, Lepoittevin JP (2014)
An immune response study of oakmoss absolute and its constituents atranol and chloroatranol
Contact Dermatitis, 70 (5), 282-90
DOI 10.1111/cod.12177, PubMed 24460794

Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM, Christophersen NS, Christensen LL, Borre M, Sørensen KD, Andersen LD, Andersen CL, Hulleman E, Wurdinger T, Ralfkiær E, Helin K, Grønbæk K, Ørntoft T, Waszak SM, Dahan O, Pedersen JS, Lund AH, Pilpel Y (2014)
A dual program for translation regulation in cellular proliferation and differentiation
Cell, 158 (6), 1281-1292
DOI 10.1016/j.cell.2014.08.011, PubMed 25215487

Nielsen MM, Lovato P, MacLeod AS, Witherden DA, Skov L, Dyring-Andersen B, Dabelsteen S, Woetmann A, Ødum N, Havran WL, Geisler C, Bonefeld CM (2014)
IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity
J Immunol, 192 (7), 2975-83
DOI 10.4049/jimmunol.1301689, PubMed 24600030

Schmidt JD, Johansen JD, Nielsen MM, Zimersson E, Svedman C, Bruze M, Engkilde K, Poulsen SS, Geisler C, Bonefeld CM (2014)
Immune responses to hair dyes containing toluene-2,5-diamine
Br J Dermatol, 170 (2), 352-9
DOI 10.1111/bjd.12676, PubMed 24124869

Vennegaard MT, Dyring-Andersen B, Skov L, Nielsen MM, Schmidt JD, Bzorek M, Poulsen SS, Thomsen AR, Woetmann A, Thyssen JP, Johansen JD, Odum N, Menné T, Geisler C, Bonefeld CM (2014)
Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway
Contact Dermatitis, 71 (4), 224-32
DOI 10.1111/cod.12270, PubMed 25040758

Publications 2013

Cuesta-Seijo JA, Nielsen MM, Marri L, Tanaka H, Beeren SR, Palcic MM (2013)
Structure of starch synthase I from barley: insight into regulatory mechanisms of starch synthase activity
Acta Crystallogr D Biol Crystallogr, 69 (Pt 6), 1013-25
DOI 10.1107/S090744491300440X, PubMed 23695246

Hansen S, Shanbhogue V, Folkestad L, Nielsen MM, Brixen K (2013)
Bone microarchitecture and estimated strength in 499 adult Danish women and men: a cross-sectional, population-based high-resolution peripheral quantitative computed tomographic study on peak bone structure
Calcif Tissue Int, 94 (3), 269-81
DOI 10.1007/s00223-013-9808-5, PubMed 24146226

Nielsen MM, Tehler D, Vang S, Sudzina F, Hedegaard J, Nordentoft I, Orntoft TF, Lund AH, Pedersen JS (2013)
Identification of expressed and conserved human noncoding RNAs
RNA, 20 (2), 236-51
DOI 10.1261/rna.038927.113, PubMed 24344320

Publications 2012

Carciofi M, Blennow A, Nielsen MM, Holm PB, Hebelstrup KH (2012)
Barley callus: a model system for bioengineering of starch in cereals
Plant Methods, 8 (1), 36
DOI 10.1186/1746-4811-8-36, PubMed 22958600

Skytthe A, Christiansen L, Kyvik KO, Bødker FL, Hvidberg L, Petersen I, Nielsen MM, Bingley P, Hjelmborg J, Tan Q, Holm NV, Vaupel JW, McGue M, Christensen K (2012)
The Danish Twin Registry: linking surveys, national registers, and biological information
Twin Res Hum Genet, 16 (1), 104-11
DOI 10.1017/thg.2012.77, PubMed 23084092

Publications 2011

Bonefeld CM, Nielsen MM, Rubin IM, Vennegaard MT, Dabelsteen S, Gimenéz-Arnau E, Lepoittevin JP, Geisler C, Johansen JD (2011)
Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens
Contact Dermatitis, 65 (6), 336-42
DOI 10.1111/j.1600-0536.2011.01945.x, PubMed 21767274

Nielsen MM, Suits MD, Yang M, Barry CS, Martinez-Fleites C, Tailford LE, Flint JE, Dumon C, Davis BG, Gilbert HJ, Davies GJ (2011)
Substrate and metal ion promiscuity in mannosylglycerate synthase
J Biol Chem, 286 (17), 15155-64
DOI 10.1074/jbc.M110.199844, PubMed 21288903

Zhang Z, Olsen EM, Kryger M, Voigt NV, Tørring T, Gültekin E, Nielsen M, MohammadZadegan R, Andersen ES, Nielsen MM, Kjems J, Birkedal V, Gothelf KV (2011)
A DNA tile actuator with eleven discrete states
Angew Chem Int Ed Engl, 50 (17), 3983-7
DOI 10.1002/anie.201007642, PubMed 21425422

Publications 2010

Boding L, Nielsen MW, Bonefeld CM, von Essen MR, Nielsen BL, Lauritsen JP, Hansen AK, Nielsen MM, Kongsbak M, Rubin M, Vennegaard MT, Odum N, Geisler C (2010)
Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation
Mol Immunol, 47 (15), 2450-7
DOI 10.1016/j.molimm.2010.06.012, PubMed 20638133

Jahn K, Olsen EM, Nielsen MM, Tørring T, MohammadZadegan R, Andersen ES, Gothelf KV, Kjems J (2010)
Site-specific chemical labeling of long RNA molecules
Bioconjug Chem, 22 (1), 95-100
DOI 10.1021/bc100422k, PubMed 21138255

Rubin IM, Dabelsteen S, Nielsen MM, White IR, Johansen JD, Geisler C, Bonefeld CM (2010)
Repeated exposure to hair dye induces regulatory T cells in mice
Br J Dermatol, 163 (5), 992-8
DOI 10.1111/j.1365-2133.2010.09988.x, PubMed 20716223

Publications 2009

Andersen ES, Dong M, Nielsen MM, Jahn K, Subramani R, Mamdouh W, Golas MM, Sander B, Stark H, Oliveira CL, Pedersen JS, Birkedal V, Besenbacher F, Gothelf KV, Kjems J (2009)
Self-assembly of a nanoscale DNA box with a controllable lid
Nature, 459 (7243), 73-6
DOI 10.1038/nature07971, PubMed 19424153

Boding L, Bonefeld CM, Nielsen BL, Lauritsen JP, von Essen MR, Hansen AK, Larsen JM, Nielsen MM, Odum N, Geisler C (2009)
TCR down-regulation controls T cell homeostasis
J Immunol, 183 (8), 4994-5005
DOI 10.4049/jimmunol.0901539, PubMed 19801521

Nielsen MM, Bozonnet S, Seo ES, Mótyán JA, Andersen JM, Dilokpimol A, Abou Hachem M, Gyémánt G, Naested H, Kandra L, Sigurskjold BW, Svensson B (2009)
Two secondary carbohydrate binding sites on the surface of barley alpha-amylase 1 have distinct functions and display synergy in hydrolysis of starch granules
Biochemistry, 48 (32), 7686-97
DOI 10.1021/bi900795a, PubMed 19606835

Publications 2008

Andersen ES, Dong M, Nielsen MM, Jahn K, Lind-Thomsen A, Mamdouh W, Gothelf KV, Besenbacher F, Kjems J (2008)
DNA origami design of dolphin-shaped structures with flexible tails
ACS Nano, 2 (6), 1213-8
DOI 10.1021/nn800215j, PubMed 19206339

Jensen LT, Nielsen MM, Loeschcke V (2008)
New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF
Cell Stress Chaperones, 13 (2), 177-82
DOI 10.1007/s12192-008-0020-x, PubMed 18759003

Nielsen MM, Seo ES, Bozonnet S, Aghajari N, Robert X, Haser R, Svensson B (2008)
Multi-site substrate binding and interplay in barley alpha-amylase 1
FEBS Lett, 582 (17), 2567-71
DOI 10.1016/j.febslet.2008.06.027, PubMed 18588886

Publications 2007

Bozonnet S, Jensen MT, Nielsen MM, Aghajari N, Jensen MH, Kramhøft B, Willemoës M, Tranier S, Haser R, Svensson B (2007)
The 'pair of sugar tongs' site on the non-catalytic domain C of barley alpha-amylase participates in substrate binding and activity
FEBS J, 274 (19), 5055-67
DOI 10.1111/j.1742-4658.2007.06024.x, PubMed 17803687

Publications 2006

Nielsen MM, Sørensen JG, Kruhøffer M, Justesen J, Loeschcke V (2006)
Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance
Cell Stress Chaperones, 11 (4), 325-33
DOI 10.1379/csc-207.1, PubMed 17278881

Publications 2005

Nielsen MM, Jørgensen JS, Jacobsen BB, Hegedüs NR, Ryg J, Brixen KT (2005)
[Primary hyperparathyroidism in pregnancy]
Ugeskr Laeger, 167 (37), 3510-1
PubMed 16159462

Nielsen MM, Overgaard J, Sørensen JG, Holmstrup M, Justesen J, Loeschcke V (2005)
Role of HSF activation for resistance to heat, cold and high-temperature knock-down
J Insect Physiol, 51 (12), 1320-9
DOI 10.1016/j.jinsphys.2005.08.002, PubMed 16169555

Sørensen JG, Nielsen MM, Kruhøffer M, Justesen J, Loeschcke V (2005)
Full genome gene expression analysis of the heat stress response in Drosophila melanogaster
Cell Stress Chaperones, 10 (4), 312-28
DOI 10.1379/csc-128r1.1, PubMed 16333985

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