Weiwen Yang

  • Department engineer; PhD
  • +47-22781318/+46-707874196

Positions

  • 2009→            Bio-engineer. Department of Immunology, Institute of Cancer Research, Oslo University Hospital
  • 2007 - 2008    Post doctor (funded by JSPS, JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE), Dept. of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
  • 2006 -2007     Assistant professor Dept. of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan
  • 2004 - 2005    Post doctor Dept. of Medical Chemistry and Cell Biology, Institute of Biomedicine, Göterborg University, Göterborg, Sweden
  • 1994 - 1996    Visiting Scientist. Dept. of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Göterborg University, Göterborg, Sweden
  • 1989 -1993     Research assistant. Dept of Biochemistry, Institute of Virology, Chinese Academy of Preventive medicine, Beijing, China

Education

  • 1997 - 2003    Philosophiae doctor (PhD), Dept. of Medical Chemistry and Cell Biology, Institute of Biomedicine, Göterborg University, Göterborg, Sweden
  • 1985 - 1989    Bachelor of Science (BSc), Dept of Biochemistry, Peking University, Beijing, China

Scientific Publications

  • Ph.D. Thesis Transcription Regulation of Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) Gene in B Cells 2003 (ISBN 91-628-5748-7)
  • 15 articles in international peer-reviewed scientific journals
  • > 20 posters / presentations at national / international scientific conventions

Scientific Supervision

  • 1996-2003   Teaching assistant for Ph.D course "Molecular Biology methods in studying transcription regulation", Göterborg University, Göterborg, Sweden

  • 2006-2007   Teacher for neuronal anatomy in Dept of Anatomy and Neurobiology, Kagawa University, Faculty of Medicine, Kagawa, Japan

Publications

  1. Sébastien Wälchi, Geir-Åge Løset, Shraddha Kumari, Jorunn Nergård Johansen, Weiwen Yang, Inger Sandlie, Johanna Olweus A practical approach to T-cell Receptor cloning and expression PLoS ONE PONE-D-11-13484R1 10.1371/journal.pone.0027930
  2. Yang Weiwen, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, Itoh S, Kato M. Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2. Cancer Sci. 2011 Jul 1. doi: 10.1111/j.1349-7006.2011.02022.x. [Epub ahead of print]
  3. Muna Elmi, Yoshiki Matsumoto, Weiwen Yang, and Keiko Funa  Nuclear Receptor TLX Promotes Neuronal Differentiation in Adult Hippocampus-derived Progenitor Cells. Mol Cell Neurosci. 2010 Oct;45(2):121-31. Epub 2010 Jun 18.
  4. Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang Weiwen, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M. TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins in TGF-β signaling.  Mol Cell. 2010 Jan 15;37(1):123-34.
  5. Weiwen Yang, Daniel Wetterskog, Yoshiki Matsumoto, and Keiko Funa  Kinetics of repression by modified p53 on the PDGF b-receptor promoter. Int J Cancer. 2008 Aug 11;123(9):2020-2030.
  6. Masaharu Kaneko*, Weiwen Yang*, Yoshiki Matsumoto*, Fujiko Watt, and Keiko Funa Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma.  Exp Cell Res. 2006 Jul 1;312(11):2028-39. Epub 2006 Apr 19. *they contributed equally. 
  7. Muna Elmi, Rolan Figle*, Weiwen Yang*, Erica Rosenqvist, and Keiko Funa. Mechanism of MASH1 induction by ASK1 and ATRA in adult neural progenitors. Mol Cell Neurosci. 2007 Oct;36(2):248-59. *they contributed equally.
  8. Fujiko Watt, Rie Watanable, Weiwen Yang, Yvonne Arvidsson, and Keiko Funa A novel MASH1 enhancer with N-myc and CREB-binding sites is active in neuroblastoma. Cancer Gene Ther. 2007 Mar;14(3):287-96.
  9. Takanori Miki, Toshifumi Yokoyama, Kazunori Sumitani, Zhi-Yu Wang, Weiwen Yang, Takashi Kusaka, Yoshiki Matsumoto, Nam-Seob Lee and Yoshiki Takeuchi The effect of prenatal X- irradiation on the developing cerebral cortex of rats. II: A quantitative assessment of glial cells in the somatosensory cortex. Int J Dev Neurosci. 2007 Aug;25(5):293-7. Epub 2007 May 17.
  10. Kazutoshi Fusumada, Toshifumi Yokoyama, Takanori Miki, Zhi-Yu Wang, Weiwen Yang, Nam-Seob Lee, Endo Yoko and Yoshiki Takeuchi c-Fos Expression in the Periaqueductal Gray Induced By Electrocupuncture, with Possible Reference to GABAergic Neurons in the Rat Okajimas Folia Anat Jpn. 2007 May;84(1):1-9.
  11. Ann Jansson, Pegal Johansson,  Weiwen Yang, Lars Palmqvist, Anna Sjöblom-Hallén and Lars Rymo Role of a consensus AP-2 regulatory sequence within the Epstein - Barr virus LMP1 promoter in EBNA2 mediated transactivation. Virus Genes. 2007 Oct;35(2):203-14.
  12. Anna Sjöblom-Hallén, Weiwen Yang, Ann Jansson and Lars Rymo Silencing of the Epstein-Barr Virus (EBV) Latent Membrane Protein (LMP1) Gene by the Max/Mad1/mSin3A Modulator of Chromatin Structure   Journal of Virology, 1999, 73:2983-2993.
  13. Anna Sjöblom, Weiwen Yang, Lars Palmqvist, Ann Jansson and Lars Rymo An ATF/CRE Element Mediates both EBNA2 Dependent and EBNA2 Independent Activation of the Epstein-Barr virus LMP1 Promoter Journal of Virology, 1998,72:1365-1376
  14. Cuomo, L., P. Trivedi, U de Grazia, A. Calogero, M. D'Onofrio, Weiwen Yang, L. Frati, A. Faggioni, L. Rymo, G. Ragona Upregulation of Epstein-Barr Virus-Encoded Latent Membrane Protein by Human Herpesvirus 6 Superinfection of EBV-Carring Burkitt Lymphoma Cells Journal of Medical Virology, 55:219-226(1998)
  15. Anna Sjöblom, Ann Jansson, Weiwen Yang, Sonia Lain, Tina Nilsson and Lars Rymo PU box-binding transcription factors and a POU domain protein cooperate in the Epstein-Barr virus (EBV) nuclear antigen 2-induced transactivation of the EBV latent membrane protein 1 promoter. Journal of General Virology, 1995, 76, 2679-2692
 

Publications 2023

Foldvari Z, Knetter C, Yang W, Gjerdingen TJ, Bollineni RC, Tran TT, Lund-Johansen F, Kolstad A, Drousch K, Klopfleisch R, Leisegang M, Olweus J (2023)
A systematic safety pipeline for selection of T-cell receptors to enter clinical use
NPJ Vaccines, 8 (1), 126
DOI 10.1038/s41541-023-00713-y, PubMed 37607971

Giannakopoulou E, Lehander M, Virding Culleton S, Yang W, Li Y, Karpanen T, Yoshizato T, Rustad EH, Nielsen MM, Bollineni RC, Tran TT, Delic-Sarac M, Gjerdingen TJ, Douvlataniotis K, Laos M, Ali M, Hillen A, Mazzi S, Chin DWL, Mehta A, Holm JS, Bentzen AK, Bill M, Griffioen M, Gedde-Dahl T et al. (2023)
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Nat Cancer, 4 (10), 1474-1490
DOI 10.1038/s43018-023-00642-8, PubMed 37783807

Meyer S, Blaas I, Bollineni RC, Delic-Sarac M, Tran TT, Knetter C, Dai KZ, Madssen TS, Vaage JT, Gustavsen A, Yang W, Nissen-Meyer LSH, Douvlataniotis K, Laos M, Nielsen MM, Thiede B, Søraas A, Lund-Johansen F, Rustad EH, Olweus J (2023)
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Cell Rep, 42 (1), 111995
DOI 10.1016/j.celrep.2023.111995, PubMed 36656713

Publications 2021

Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT et al. (2021)
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Nat Biotechnol, 40 (4), 488-498
DOI 10.1038/s41587-021-01089-x, PubMed 34873326

Publications 2020

Bartok O, Pataskar A, Nagel R, Laos M, Goldfarb E, Hayoun D, Levy R, Körner PR, Kreuger IZM, Champagne J, Zaal EA, Bleijerveld OB, Huang X, Kenski J, Wargo J, Brandis A, Levin Y, Mizrahi O, Alon M, Lebon S, Yang W, Nielsen MM, Stern-Ginossar N, Altelaar M, Berkers CR et al. (2020)
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature, 590 (7845), 332-337
DOI 10.1038/s41586-020-03054-1, PubMed 33328638

Publications 2019

Ali M, Foldvari Z, Giannakopoulou E, Böschen ML, Strønen E, Yang W, Toebes M, Schubert B, Kohlbacher O, Schumacher TN, Olweus J (2019)
Induction of neoantigen-reactive T cells from healthy donors
Nat Protoc, 14 (6), 1926-1943
DOI 10.1038/s41596-019-0170-6, PubMed 31101906

Publications 2018

Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte JA, Malmberg KJ (2018)
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol Res, 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477

Publications 2016

Mensali N, Ying F, Sheng VO, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J (2016)
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199, PubMed 27467957

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN (2016)
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
DOI 10.1126/science.aaf2288, PubMed 27198675

Publications 2015

Tadesse FG, Mensali N, Fallang LE, Walseng E, Yang W, Olweus J, Wälchli S (2015)
Unpredicted phenotypes of two mutants of the TcR DMF5
J Immunol Methods, 425, 37-44
DOI 10.1016/j.jim.2015.06.006, PubMed 26079729

Walseng E, Wälchli S, Fallang LE, Yang W, Vefferstad A, Areffard A, Olweus J (2015)
Soluble T-cell receptors produced in human cells for targeted delivery
PLoS One, 10 (4), e0119559
DOI 10.1371/journal.pone.0119559, PubMed 25875651

Publications 2013

Kumari S, Wälchli S, Fallang LE, Yang W, Lund-Johansen F, Schumacher TN, Olweus J (2013)
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Proc Natl Acad Sci U S A, 111 (1), 403-8
DOI 10.1073/pnas.1306549111, PubMed 24344295

Wälchli S, Kumari S, Fallang LE, Sand KM, Yang W, Landsverk OJ, Bakke O, Olweus J, Gregers TF (2013)
Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation
Eur J Immunol, 44 (3), 774-84
DOI 10.1002/eji.201343671, PubMed 24293164

Publications 2011

Wälchli S, Løset GÅ, Kumari S, Johansen JN, Yang W, Sandlie I, Olweus J (2011)
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
DOI 10.1371/journal.pone.0027930, PubMed 22132171

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