![](https://www.ous-research.no/ergo/images/people/B-Hassel.jpg)
Bjørnar Hassel
- Consultant, Professor II
- +47 22 11 91 44
Publications 2023
Bacterial Brain Abscesses Expand Despite Effective Antibiotic Treatment: A Process Powered by Osmosis Due to Neutrophil Cell Death
Neurosurgery, 94 (5), 1079-87 (in press)
DOI 10.1227/neu.0000000000002792, PubMed 38084989
The spectrum of pyridoxine dependent epilepsy across the age span: A nationwide retrospective observational study
Epilepsy Res, 190, 107099
DOI 10.1016/j.eplepsyres.2023.107099, PubMed 36731270
Corrigendum to "The spectrum of pyridoxine dependent epilepsy across the age span: A nationwide retrospective observational study" [Epilepsy Res. 190 (2023) 107099]
Epilepsy Res, 198, 107113
DOI 10.1016/j.eplepsyres.2023.107113, PubMed 36906427
Heart rate monitoring to detect acute pain in non-verbal patients: a study protocol for a randomized controlled clinical trial
BMC Psychiatry, 23 (1), 252
DOI 10.1186/s12888-023-04757-1, PubMed 37060049
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients
J Clin Invest, 133 (2)
DOI 10.1172/JCI163472, PubMed 36409557
Publications 2022
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors
Fluids Barriers CNS, 19 (1), 45
DOI 10.1186/s12987-022-00333-z, PubMed 35659255
Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma
Front Oncol, 12, 846674
DOI 10.3389/fonc.2022.846674, PubMed 35965529
ADHD symptoms and use of anabolic androgenic steroids among male weightlifters
Sci Rep, 12 (1), 9479
DOI 10.1038/s41598-022-12977-w, PubMed 35676515
Improvement of attention deficit/hyperactivity disorder (ADHD) in three adult men during testosterone treatment: a case series
J Med Case Rep, 16 (1), 425
DOI 10.1186/s13256-022-03651-w, PubMed 36397172
People with intellectual disabilities and harmful sexual behaviour: Professionals' views on the barriers to prevent harm
J Appl Res Intellect Disabil, 36 (1), 176-185
DOI 10.1111/jar.13048, PubMed 36385724
Publications 2021
Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood
JCI Insight, 6 (9)
DOI 10.1172/jci.insight.147063, PubMed 33822769
Cerebrospinal fluid catecholamines in delirium and dementia
Brain Commun, 3 (3), fcab121
DOI 10.1093/braincomms/fcab121, PubMed 34423298
Increased heart rate functions as a signal of acute distress in non-communicating persons with intellectual disability
Sci Rep, 11 (1), 6479
DOI 10.1038/s41598-021-86023-6, PubMed 33742078
Publications 2020
Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis
Cells, 9 (7)
DOI 10.3390/cells9071686, PubMed 32668809
β-Amyloid may accumulate in the human brain after focal bacterial infection: An 18 F-flutemetamol positron emission tomography study
Eur J Neurol, 28 (3), 877-883
DOI 10.1111/ene.14622, PubMed 33131195
Sudden death in epilepsy and ectopic neurohypophysis in Joubert syndrome 23 diagnosed using SNVs/indels and structural variants pipelines on WGS data: a case report
BMC Med Genet, 21 (1), 96
DOI 10.1186/s12881-020-01024-y, PubMed 32381069
Novel aspects of glutamine synthetase in ammonia homeostasis
Neurochem Int, 140, 104809
DOI 10.1016/j.neuint.2020.104809, PubMed 32758585
Publications 2019
Intellectual Disability Associated With Pyridoxine-Responsive Epilepsies: The Need to Protect Cognitive Development
Front Psychiatry, 10, 116
DOI 10.3389/fpsyt.2019.00116, PubMed 30930802
Uncovering health and social care needs among myotonic dystrophy patients: Utility of the Needs and Provisions Complexity Scale
Acta Neurol Scand, 139 (6), 526-532
DOI 10.1111/ane.13086, PubMed 30848487
The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity
Cereb Cortex, 29 (12), 5166-5179
DOI 10.1093/cercor/bhz055, PubMed 31050701
Potential metabolic markers in glaucoma and their regulation in response to hypoxia
Acta Ophthalmol, 97 (6), 567-576
DOI 10.1111/aos.14021, PubMed 30690927
Publications 2018
CSF sodium at toxic levels precedes delirium in hip fracture patients
Neurotoxicology, 69, 11-16
DOI 10.1016/j.neuro.2018.08.010, PubMed 30149051
Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine
J Histochem Cytochem, 66 (3), 189-202
DOI 10.1369/0022155417749828, PubMed 29303644
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia
Biochem J, 475 (4), 749-758
DOI 10.1042/BCJ20170814, PubMed 29339464
Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration
Neurochem Int, 123, 22-33
DOI 10.1016/j.neuint.2018.07.009, PubMed 30053506
Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus
Neurochem Int, 123, 101-113
DOI 10.1016/j.neuint.2018.03.006, PubMed 29530756
Publications 2017
Cyst Fluid From Cystic, Malignant Brain Tumors: A Reservoir of Nutrients, Including Growth Factor-Like Nutrients, for Tumor Cells
Neurosurgery, 80 (6), 917-924
DOI 10.1093/neuros/nyw101, PubMed 28327992
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus
J Neurosurg, 129 (3), 829-837
DOI 10.3171/2017.4.JNS17284, PubMed 29053067
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783
Publications 2016
A New Approach for Epilepsy
Cerebrum, 2016
PubMed 27408679
Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport
Brain, 139 (Pt 12), 3109-3120
DOI 10.1093/brain/aww244, PubMed 27742667
Hyperosmolar sodium chloride is toxic to cultured neurons and causes reduction of glucose metabolism and ATP levels, an increase in glutamate uptake, and a reduction in cytosolic calcium
Neurotoxicology, 54, 34-43
DOI 10.1016/j.neuro.2016.03.005, PubMed 26994581
Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
BMC Geriatr, 16, 149
DOI 10.1186/s12877-016-0324-0, PubMed 27484129
Publications 2015
Toxic levels of ammonia in human brain abscess
J Neurosurg, 124 (3), 854-60
DOI 10.3171/2015.1.JNS142582, PubMed 26274996
High extracellular levels of potassium and trace metals in human brain abscess
Neurochem Int, 82, 28-32
DOI 10.1016/j.neuint.2015.02.003, PubMed 25684071
Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro
Neurotoxicology, 48, 61-7
DOI 10.1016/j.neuro.2015.03.001, PubMed 25757835
Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro
J Neurochem, 133 (4), 572-81
DOI 10.1111/jnc.13079, PubMed 25708447
[Posterior cortical atrophy]
Tidsskr Nor Laegeforen, 135 (10), 949-52
DOI 10.4045/tidsskr.14.1127, PubMed 26037756
Publications 2014
High extracellular concentration of excitatory amino acids glutamate and aspartate in human brain abscess
Neurochem Int, 69, 41-7
DOI 10.1016/j.neuint.2014.03.001, PubMed 24632003
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715
Publications 2013
Tetanus: pathophysiology, treatment, and the possibility of using botulinum toxin against tetanus-induced rigidity and spasms
Toxins (Basel), 5 (1), 73-83
DOI 10.3390/toxins5010073, PubMed 23299659
Publications 2012
[A description of early hydrocephalus with macrocephaly, cerebral palsy, epilepsy, intellectual disability, and growth retardation by Norwegian novelist Amalie Skram (1846-1905)]
Tidsskr Nor Laegeforen, 132 (23-24), 2632-5
DOI 10.4045/tidsskr.12.0912, PubMed 23338097
Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents
J Biol Chem, 287 (42), 35733-35746
DOI 10.1074/jbc.M112.368175, PubMed 22896705
Publications 2010
Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin
Epilepsia, 51 (9), 1714-20
DOI 10.1111/j.1528-1167.2010.02545.x, PubMed 20345932
Publications 2008
High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study
Neurochem Int, 53 (6-8), 193-8
DOI 10.1016/j.neuint.2008.06.008, PubMed 18674580
Early treatment of tetanus-induced trismus with botulinum toxin A
Anesth Analg, 106 (5), 1591
DOI 10.1213/ANE.0b013e31816a30f0, PubMed 18420892
Publications 2007
Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
Epilepsy Res, 74 (2-3), 232-6
DOI 10.1016/j.eplepsyres.2007.03.002, PubMed 17416486
Glutamate uptake is reduced in prefrontal cortex in Huntington's disease
Neurochem Res, 33 (2), 232-7
DOI 10.1007/s11064-007-9463-1, PubMed 17726644
High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study
Neurochem Int, 50 (5), 696-702
DOI 10.1016/j.neuint.2007.01.002, PubMed 17316904
Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain
Neurochem Int, 50 (5), 703-9
DOI 10.1016/j.neuint.2007.01.003, PubMed 17316901
Formation of glycerol from glucose in rat brain and cultured brain cells. Augmentation with kainate or ischemia
J Neurochem, 101 (6), 1694-700
DOI 10.1111/j.1471-4159.2006.04433.x, PubMed 17286586
Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia
J Neurochem, 101 (3), 806-14
DOI 10.1111/j.1471-4159.2006.04397.x, PubMed 17286595
Publications 2006
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
Ann Neurol, 60 (2), 223-35
DOI 10.1002/ana.20899, PubMed 16807920
Nicotinic mechanisms contribute to soman-induced symptoms and lethality
Neurotoxicology, 27 (4), 501-7
DOI 10.1016/j.neuro.2006.01.007, PubMed 16500708
High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study
Neurochem Int, 50 (2), 365-70
DOI 10.1016/j.neuint.2006.09.004, PubMed 17069932
Cerebral metabolism of glucose and pyruvate in soman poisoning. A 13C nuclear magnetic resonance spectroscopic study
Neurotoxicology, 28 (1), 13-8
DOI 10.1016/j.neuro.2006.09.007, PubMed 17087995
Publications 2005
Brain metabolism of exogenous pyruvate
J Neurochem, 95 (1), 284-93
DOI 10.1111/j.1471-4159.2005.03365.x, PubMed 16181432
Publications 2004
Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake
J Cereb Blood Flow Metab, 24 (11), 1226-34
DOI 10.1097/01.WCB.0000138666.25305.A7, PubMed 15545916
Publications 2003
Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study
J Neurochem, 87 (1), 230-7
DOI 10.1046/j.1471-4159.2003.01984.x, PubMed 12969269
Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol-3-phosphate dehydrogenase
J Neurochem, 85 (4), 831-42
DOI 10.1046/j.1471-4159.2003.01762.x, PubMed 12716415
Publications 2002
Cerebral dicarboxylate transport and metabolism studied with isotopically labelled fumarate, malate and malonate
J Neurochem, 82 (2), 410-9
DOI 10.1046/j.1471-4159.2002.00986.x, PubMed 12124442
Effects of potassium and glutamine on metabolism of glucose in astrocytes
Neurochem Res, 27 (1-2), 167-71
DOI 10.1023/a:1014827327690, PubMed 11926271
Effects of potassium and glutamine on metabolism of glucose in astrocytes
Plenum Publ. Corp., [New York], S. 167-171.
BIBSYS 030310288
Publications 1995
CNS neurotransmitters and neuromodulators: glutamate
CRC Press, Boca Raton, 6 bl., 380 s.
BIBSYS 951675583, ISBN 0-8493-7631-9
The cerebral metabolism of amino acids and related metabolites as studied by ¹³C and ¹⁴C labelling
Forsvarets forskningsinstitutt, Kjeller, 1 b. (flere pag.)
BIBSYS 952495198, ISBN 82-464-0032-0
The cerebral metabolism of amino acids and related metabolites as studied by ¹³C and ¹⁴C labelling
Department Group of Basic Medical Sciences Norwegian Defence Research Establishment, Division for Environmental Toxicology, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 960697608, ISBN 82-91061-65-3