Maren-Helene Langeland Degnes

  • Researcher; PhD
Education
2023: PhD in applied biostatisics and obstetrics, University of Oslo and Oslo University Hospital 
2019: Master's degree in bioinformatics, Norwegian University of Life Sciences
2018: Bachelor's degree in biotechnology, Norwegian University of Life Sciences
 
Work
2025-today: Researcher II, Oslo University Hospital 
2024-2025: Post doctor, Oslo University Hospital 
2023-2024: Researcher III, University of Oslo and Oslo University Hospital 
2019-2023: PhD student, University of Oslo and Oslo University Hospital 
 
 
I work with biostatistical analyses of large-scale proteomics in plasma samples from pregnant women with or without preeclampsia diagnose. In my PhD I investigated the uptake and release of proteins by the placenta into maternal and fetal circulations, utilizing samples collected via the 4-vessel sampling method. Additionally, I examined protein trajectories throughout gestation using data from the longitudinal STORK cohort. This work has resulted in several potential biomarkers for preeclampsia.
 
Current work: Uptake and release of proteins from placenta between sexes. Movement of fatty acids between mother, placenta and the fetus utilizing 4-vessel samples in healthy pregnancies. Validation of suggested biomarkers of preeclampsia. 
 

Publications 2026

Sellevoll HB, Andresen IJ, Westerberg AC, Degnes ML, Ueland T, Zucknick M, Michelsen TM (2026)
Placental Protein Release and Uptake From the Fetal Circulation in Healthy Term Pregnancies-A Human In Vivo Exploratory Study
FASEB J, 40 (3), e71501
DOI 10.1096/fj.202503626R, PubMed 41615327

Publications 2025

Westerberg AC, Degnes ML, Andresen IJ, Sellevoll HB, Lekva T, Ueland T, Bergman L, Henriksen T, Roland MCP, Zucknick M, Michelsen TM (2025)
Placenta-Derived Proteins in Preeclampsia: A Human In Vivo Study
Hypertension, 82 (12), 2125-2139
DOI 10.1161/HYPERTENSIONAHA.125.24886, PubMed 41064898

Publications 2024

Andresen IJ, Zucknick M, Degnes ML, Angst MS, Aghaeepour N, Romero R, Roland MCP, Tarca AL, Westerberg AC, Michelsen TM (2024)
Prediction of late-onset preeclampsia using plasma proteomics: a longitudinal multi-cohort study
Sci Rep, 14 (1), 30813
DOI 10.1038/s41598-024-81277-2, PubMed 39730472

Degnes ML, Westerberg AC, Andresen IJ, Henriksen T, Roland MCP, Zucknick M, Michelsen TM (2024)
Protein biomarker signatures of preeclampsia - a longitudinal 5000-multiplex proteomics study
Sci Rep, 14 (1), 23654
DOI 10.1038/s41598-024-73796-9, PubMed 39390022

Westerberg AC, Degnes ML, Andresen IJ, Roland MCP, Michelsen TM (2024)
Angiogenic and vasoactive proteins in the maternal-fetal interface in healthy pregnancies and preeclampsia
Am J Obstet Gynecol, 231 (5), 550.e1-550.e22
DOI 10.1016/j.ajog.2024.03.012, PubMed 38494070

Publications 2022

Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM (2022)
Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?
BMC Med, 20 (1), 227
DOI 10.1186/s12916-022-02415-z, PubMed 35773701

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