Chloé B. Steen

  • Researcher; PhD


Associated member in Alizadeh and Newman labs at Stanford University


Publications 2023

Steen CB, Luca BA, Alizadeh AA, Gentles AJ, Newman AM (2023)
Profiling Cellular Ecosystems at Single-Cell Resolution and at Scale with EcoTyper
Methods Mol Biol, 2629, 43-71
DOI 10.1007/978-1-0716-2986-4_4, PubMed 36929073

Vahid MR, Brown EL, Steen CB, Zhang W, Jeon HS, Kang M, Gentles AJ, Newman AM (2023)
High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE
Nat Biotechnol (in press)
DOI 10.1038/s41587-023-01697-9, PubMed 36879008

Publications 2022

Esfahani MS, Hamilton EG, Mehrmohamadi M, Nabet BY, Alig SK, King DA, Steen CB, Macaulay CW, Schultz A, Nesselbush MC, Soo J, Schroers-Martin JG, Chen B, Binkley MS, Stehr H, Chabon JJ, Sworder BJ, Hui AB, Frank MJ, Moding EJ, Liu CL, Newman AM, Isbell JM, Rudin CM, Li BT et al. (2022)
Inferring gene expression from cell-free DNA fragmentation profiles
Nat Biotechnol, 40 (4), 585-597
DOI 10.1038/s41587-022-01222-4, PubMed 35361996

Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM (2022)
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma
Nat Med, 28 (2), 353-362
DOI 10.1038/s41591-021-01623-z, PubMed 35027754

Sikandar SS, Gulati GS, Antony J, Fetter I, Kuo AH, Ho WHD, Haro-Acosta V, Das S, Steen CB, Pereira TA, Qian D, Beachy PA, Dirbas F, Red-Horse K, Rabbitts TH, Thiery JP, Newman AM, Clarke MF (2022)
Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis
Sci Adv, 8 (45), eabm3548
DOI 10.1126/sciadv.abm3548, PubMed 36351009

Publications 2021

Luca BA, Steen CB, Matusiak M, Azizi A, Varma S, Zhu C, Przybyl J, Espín-Pérez A, Diehn M, Alizadeh AA, van de Rijn M, Gentles AJ, Newman AM (2021)
Atlas of clinically distinct cell states and ecosystems across human solid tumors
Cell, 184 (21), 5482-5496.e28
DOI 10.1016/j.cell.2021.09.014, PubMed 34597583

Steen CB, Luca BA, Esfahani MS, Azizi A, Sworder BJ, Nabet BY, Kurtz DM, Liu CL, Khameneh F, Advani RH, Natkunam Y, Myklebust JH, Diehn M, Gentles AJ, Newman AM, Alizadeh AA (2021)
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma
Cancer Cell, 39 (10), 1422-1437.e10
DOI 10.1016/j.ccell.2021.08.011, PubMed 34597589

Publications 2020

Nabet BY, Esfahani MS, Moding EJ, Hamilton EG, Chabon JJ, Rizvi H, Steen CB, Chaudhuri AA, Liu CL, Hui AB, Almanza D, Stehr H, Gojenola L, Bonilla RF, Jin MC, Jeon YJ, Tseng D, Liu C, Merghoub T, Neal JW, Wakelee HA, Padda SK, Ramchandran KJ, Das M, Plodkowski AJ et al. (2020)
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition
Cell, 183 (2), 363-376.e13
DOI 10.1016/j.cell.2020.09.001, PubMed 33007267

Steen CB, Liu CL, Alizadeh AA, Newman AM (2020)
Profiling Cell Type Abundance and Expression in Bulk Tissues with CIBERSORTx
Methods Mol Biol, 2117, 135-157
DOI 10.1007/978-1-0716-0301-7_7, PubMed 31960376

Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878

Publications 2019

Liu CC, Steen CB, Newman AM (2019)
Computational approaches for characterizing the tumor immune microenvironment
Immunology, 158 (2), 70-84
DOI 10.1111/imm.13101, PubMed 31347163

Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, Diehn M, Alizadeh AA (2019)
Determining cell type abundance and expression from bulk tissues with digital cytometry
Nat Biotechnol, 37 (7), 773-782
DOI 10.1038/s41587-019-0114-2, PubMed 31061481

Steen CB, Leich E, Myklebust JH, Lockmer S, Wise JF, Wahlin BE, Østenstad B, Liestøl K, Kimby E, Rosenwald A, Smeland EB, Holte H, Lingjærde OC, Brodtkorb M (2019)
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
Haematologica, 104 (10), e460-e464
DOI 10.3324/haematol.2018.209080, PubMed 30846496

Publications 2018

Lockmer S, Østenstad B, Hagberg H, Holte H, Johansson AS, Wahlin BE, Wader KF, Steen CB, Meyer P, Maisenhølder M, Smedby KE, Brown P, Kimby E (2018)
Chemotherapy-Free Initial Treatment of Advanced Indolent Lymphoma Has Durable Effect With Low Toxicity: Results From Two Nordic Lymphoma Group Trials With More Than 10 Years of Follow-Up
J Clin Oncol, 36 (33), 3315-+
DOI 10.1200/JCO.18.00262, PubMed 30285560

Våtsveen TK, Myhre MR, Steen CB, Wälchli S, Lingjærde OC, Bai B, Dillard P, Theodossiou TA, Holien T, Sundan A, Inderberg EM, Smeland EB, Myklebust JH, Oksvold MP (2018)
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389

Publications 2017

Josefsson SE, Huse K, Kolstad A, Beiske K, Pende D, Steen CB, Inderberg EM, Lingjærde OC, Østenstad B, Smeland EB, Levy R, Irish JM, Myklebust JH (2017)
T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling
Clin Cancer Res, 24 (4), 870-881
DOI 10.1158/1078-0432.CCR-17-2337, PubMed 29217528

Publications 2016

Knudsen MD, de Lange T, Botteri E, Nguyen DH, Evensen H, Steen CB, Hoff G, Bernklev T, Hjartåker A, Berstad P (2016)
Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia
World J Gastroenterol, 22 (27), 6276-86
DOI 10.3748/wjg.v22.i27.6276, PubMed 27468217

Publications 2015

Eikenes ÅH, Malerød L, Christensen AL, Steen CB, Mathieu J, Nezis IP, Liestøl K, Huynh JR, Stenmark H, Haglund K (2015)
ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo
PLoS Genet, 11 (1), e1004904
DOI 10.1371/journal.pgen.1004904, PubMed 25635693

Publications 2013

Randen U, Trøen G, Tierens A, Steen C, Warsame A, Beiske K, Tjønnfjord GE, Berentsen S, Delabie J (2013)
Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma
Haematologica, 99 (3), 497-504
DOI 10.3324/haematol.2013.091702, PubMed 24143001

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