Rita Pinto

  • Post.doc; PhD

Current main line of research:

Epigenetic heterogeneity of gastrointestinal cancers.

Academic degrees:

2015 - PhD in Biomedicine, University of Porto, Portugal
Title: CDX2 homeobox gene in cancer glycoproteome regulation
Host institutions: Institute of Molecular Pathology and Immunology of the University of Porto and Copenhagen Center for Glycomics, University of Copenhagen

2012 - MSc in Biochemistry, University of Porto, Portugal
Title: Cancer glycoproteome alterations – is there a role for CDX2?
Host institution: Institute of Molecular Pathology and Immunology of the University of Porto

 

Publications 2021

Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, Weirich S, Kikuchi M, Olsen JV, Dohmae N, Umehara T, Sodeoka M, Siino V, McDonough MA, Eijkelkamp N, Schofield CJ et al. (2021)
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Nat Commun, 12 (1), 891
DOI 10.1038/s41467-020-20670-7, PubMed 33563959

Małecki JM, Odonohue MF, Kim Y, Jakobsson ME, Gessa L, Pinto R, Wu J, Davydova E, Moen A, Olsen JV, Thiede B, Gleizes PE, Leidel SA, Falnes PØ (2021)
Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function
Nucleic Acids Res, 49 (6), 3185-3203
DOI 10.1093/nar/gkab088, PubMed 33693809

Publications 2020

Flatin BTB, Vedeld HM, Pinto R, Langerud J, Lind GE, Lothe RA, Sveen A, Jeanmougin M (2020)
Multiregional assessment of CIMP in primary colorectal cancers: Phenotype concordance but marker variability
Int J Cancer, 148 (7), 1652-1657
DOI 10.1002/ijc.33425, PubMed 33284993

Lopes N, Bergsland C, Bruun J, Bjørnslett M, Vieira AF, Mesquita P, Pinto R, Gomes R, Cavadas B, Bennett E, Pereira L, Lothe RA, Almeida R, David L (2020)
A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis
Gastric Cancer, 23 (5), 811-823
DOI 10.1007/s10120-020-01064-6, PubMed 32215766

Pinto R, Vågbø CB, Jakobsson ME, Kim Y, Baltissen MP, O'Donohue MF, Guzmán UH, Małecki JM, Wu J, Kirpekar F, Olsen JV, Gleizes PE, Vermeulen M, Leidel SA, Slupphaug G, Falnes PØ (2020)
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA
Nucleic Acids Res, 48 (2), 830-846
DOI 10.1093/nar/gkz1147, PubMed 31799605

Publications 2019

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ (2019)
Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration
J Biol Chem, 294 (31), 11654-11664
DOI 10.1074/jbc.RA119.009045, PubMed 31213526

Publications 2018

Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ (2018)
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
Nat Commun, 9 (1), 3411
DOI 10.1038/s41467-018-05646-y, PubMed 30143613

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Kjønstad IF, Burgering BMT, Zwartkruis F, Eijkelkamp N, Falnes PØ (2018)
Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase
J Biol Chem, 294 (4), 1128-1141
DOI 10.1074/jbc.RA118.005473, PubMed 30530489

Publications 2017

Pinto R, Hansen L, Hintze J, Almeida R, Larsen S, Coskun M, Davidsen J, Mitchelmore C, David L, Troelsen JT, Bennett EP (2017)
Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression
Nucleic Acids Res, 45 (13), e123
DOI 10.1093/nar/gkx371, PubMed 28472465

Publications 2015

Pinto R, Barros R, Pereira-Castro I, Mesquita P, da Costa LT, Bennett EP, Almeida R, David L (2015)
CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia
Lab Invest, 95 (7), 718-27
DOI 10.1038/labinvest.2015.52, PubMed 25867765

Publications 2014

Ricardo S, Marcos-Silva L, Pereira D, Pinto R, Almeida R, Söderberg O, Mandel U, Clausen H, Felix A, Lunet N, David L (2014)
Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours
Mol Oncol, 9 (2), 503-12
DOI 10.1016/j.molonc.2014.10.005, PubMed 25454345

Publications 2012

Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L (2012)
Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation
J Cell Mol Med, 16 (7), 1474-84
DOI 10.1111/j.1582-4934.2011.01436.x, PubMed 21883895

Sousa SF, Coimbra JT, Paramos D, Pinto R, Guimarães RS, Teixeira V, Fernandes PA, Ramos MJ (2012)
Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif
J Mol Model, 19 (2), 673-88
DOI 10.1007/s00894-012-1590-1, PubMed 23011608

Publications 2011

de Oliveira JT, de Matos AJ, Santos AL, Pinto R, Gomes J, Hespanhol V, Chammas R, Manninen A, Bernardes ES, Albuquerque Reis C, Rutteman G, Gärtner F (2011)
Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking
Int J Dev Biol, 55 (7-9), 823-34
DOI 10.1387/ijdb.113359jt, PubMed 22161838

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