
Marine Jeanmougin
- Ass. Group leader, Scientist; PhD
- +47 22 78 1730
Previous positions
Jan. 2013 - July 2015 - Post-doc in Biostatistics.
Immunity and Cancer Department, Institut Curie, Paris, France.
Jan. 2010 - Dec. 2012 – PhD student in Applied Mathematics (CNRS grant).
Statistics and Genome Laboratory (renamed “LaMME” in 2014), Evry, France.
Biostatistics and Bioinformatics department, Pharnext, Issy-les-Moulineaux, France.
Feb. 2009 - July 2009 – Research training.
Leung Lab, McGill University, Montreal, Canada.
Sept. 2008 - Jan 2009 – Research training.
CIT program, Ligue Nationale contre le Cancer, Paris, France.
Education
2012 - PhD in Applied Mathematics, University of Evry-Val-d’Essonne, Paris, France.
Title: Statistical methods for robust analysis of transcriptome data by integration of biological prior knowledge.
2009 – Engineer degree in Bioinformatics and Mathematical Modeling, INSA, Lyon, France.
Research area of interest
My area of expertise is Biostatistics and my interests are in both (i) applications to cancer biomedicine and (ii) statistical methodology.
More specifically, my current projects include the analysis of an intriguing subgroup of colorectal tumors, which have unusually little promoter hypermethylation. Using high-throughput methylome sequencing data, we aim at characterizing this novel subgroup at multiple levels and improve our understanding of the DNA methylation machinery and its association with cancer development. On the methodological side, my work spans several areas of statistics such as hypothesis testing approaches, variable selection, classification or network inference.
My motivation
“I keep saying that the sexy job in the next 10 years will be statisticians, and I’m not kidding,” (2009) Hal Varian, Chief Economist at Google.
Selected publications
Selected first or co-first authorship papers.
Jeanmougin M, Guedj M, Ambroise C (2012)
Defining a robust biological prior from Pathway Analysis to drive Network Inference
J-SFdS, Vol 152(2).
Dillies MA*, Rau A*, Aubert J*, Hennequet-Antier C*, Jeanmougin M*, Servant N, Keime C*, Marot G, Castel D, Estelle J, Guernec G, Jagla B, Jouneau L, Laloë D, Le Gall C, Schaëffer B, Le Crom S, Guedj M, Jaffrézic F, French StatOmique Consortium (2012)
A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis
Brief Bioinform, 14 (6), 671-83
PubMed 22988256
* These authors have contributed equally to this work.
Jeanmougin M, de Reynies A, Marisa L, Paccard C, Nuel G, Guedj M (2010)
Should we abandon the t-test in the analysis of gene expression microarray data: a comparison of variance modeling strategies
PLoS One, 5 (9), e12336
PubMed 20838429
Publications 2023
PoDCall: positive droplet calling and normalization of droplet digital PCR DNA methylation data
Bioinformatics, 39 (1)
DOI 10.1093/bioinformatics/btac766, PubMed 36448696
Publications 2022
Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
Mod Pathol, 35 (9), 1236-1246
DOI 10.1038/s41379-022-01086-8, PubMed 35484226
BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients
Clin Epigenetics, 14 (1), 115
DOI 10.1186/s13148-022-01335-2, PubMed 36115961
Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus
Clin Epigenetics, 14 (1), 77
DOI 10.1186/s13148-022-01287-7, PubMed 35701814
Publications 2021
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Hepatology, 75 (1), 59-73
DOI 10.1002/hep.32125, PubMed 34435693
Publications 2020
Multiregional assessment of CIMP in primary colorectal cancers: Phenotype concordance but marker variability
Int J Cancer, 148 (7), 1652-1657
DOI 10.1002/ijc.33425, PubMed 33284993
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051
Publications 2019
Microbe-host interplay in atopic dermatitis and psoriasis
Nat Commun, 10 (1), 4703
DOI 10.1038/s41467-019-12253-y, PubMed 31619666
Publications 2018
A robust internal control for high-precision DNA methylation analyses by droplet digital PCR
Clin Epigenetics, 10, 24
DOI 10.1186/s13148-018-0456-5, PubMed 29484034
Publications 2017
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
Clin Epigenetics, 9, 97
DOI 10.1186/s13148-017-0397-4, PubMed 28878843
CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
Int J Cancer, 141 (5), 967-976
DOI 10.1002/ijc.30796, PubMed 28542846
Publications 2016
Experimental factors affecting the robustness of DNA methylation analysis
Sci Rep, 6, 33936
DOI 10.1038/srep33936, PubMed 27671843
Publications 2015
Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes
Cancer Res, 75 (14), 2775-87
DOI 10.1158/0008-5472.CAN-14-2386, PubMed 25977333
Publications 2014
Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β
Blood, 124 (15), 2411-20
DOI 10.1182/blood-2014-04-568311, PubMed 25114264
Publications 2012
Multiple testing in large-scale genetic studies
Methods Mol Biol, 888, 213-33
DOI 10.1007/978-1-61779-870-2_13, PubMed 22665284
A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis
Brief Bioinform, 14 (6), 671-83
DOI 10.1093/bib/bbs046, PubMed 22988256
Publications 2010
Should we abandon the t-test in the analysis of gene expression microarray data: a comparison of variance modeling strategies
PLoS One, 5 (9), e12336
DOI 10.1371/journal.pone.0012336, PubMed 20838429