Edward Leithe
Position: Project Leader, Senior Scientist, PhD
Phone: +47 2278 1737
Edward Leithe holds a M.Sc. from the Faculty of Mathematics and Natural Sciences, University of Oslo and a Ph.D. from the Faculty of Medicine, University of Oslo. He joined the Institute for Cancer Research in 2001 and has been a project leader since 2009.

Author network for Edward Leithe by COREMINE medical

Publications 2017

Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Cell Signal, 32, 1-11
PubMed 28077322

Leithe E, Mesnil M, Aasen T (2017)
The connexin 43 C-terminus: A tail of many tales
Biochim Biophys Acta (in press)
PubMed 28526583

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2017)
An update on minding the gap in cancer
Biochim Biophys Acta (in press)
PubMed 28655619

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
PubMed 28539123

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882
PubMed 28733455

Publications 2016

Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
Cell Cycle, 15 (21), 2943-2957
PubMed 27625181

Leithe E (2016)
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
Biochim Biophys Acta, 1865 (2), 133-46
PubMed 26855059

Publications 2015

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
PubMed 25910952

Publications 2014

Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2014)
Portrait of the PI3K/AKT pathway in colorectal cancer
Biochim Biophys Acta, 1855 (1), 104-21
PubMed 25450577

Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E (2014)
Connexins in colorectal cancer pathogenesis
Int J Cancer, 137 (1), 1-11
PubMed 24752574

Publications 2012

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E (2012)
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Cell Signal, 25 (1), 12-8
PubMed 22974840

Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
J Cell Sci, 125 (Pt 17), 3966-76
PubMed 22623726

Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E (2012)
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
J Biol Chem, 287 (19), 15851-61
PubMed 22411987

Publications 2011

Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E (2011)
Endocytosis and post-endocytic sorting of connexins
Biochim Biophys Acta, 1818 (8), 1870-9
PubMed 21996040

Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H (2011)
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
Traffic, 12 (9), 1211-26
PubMed 21564451

Mollerup S, Hofgaard JP, Braunstein TH, Kjenseth A, Leithe E, Rivedal E, Holstein-Rathlou NH, Nielsen MS (2011)
Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions
Cell Commun Adhes, 18 (4), 57-65
PubMed 21936631

Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
PubMed 21866551

Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE (2011)
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
Epigenetics, 6 (5), 602-9
PubMed 21406965

Publications 2010

Kjenseth A, Fykerud T, Rivedal E, Leithe E (2010)
Regulation of gap junction intercellular communication by the ubiquitin system
Cell Signal, 22 (9), 1267-73
PubMed 20206687

Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E (2010)
Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil
Toxicol Appl Pharmacol, 247 (1), 10-7
PubMed 20510257

Publications 2009

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
J Cell Sci, 122 (Pt 21), 3883-93
PubMed 19808888

Rivedal E, Witz G, Leithe E (2009)
Gap junction intercellular communication and benzene toxicity
Chem Biol Interact, 184 (1-2), 229-32
PubMed 19932693

Sirnes S, Kjenseth A, Leithe E, Rivedal E (2009)
Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication
Biochem Biophys Res Commun, 382 (1), 41-5
PubMed 19258009

Publications 2008

Rivedal E, Leithe E (2008)
The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43
Toxicol Appl Pharmacol, 232 (3), 463-8
PubMed 18723040

Sirnes S, Leithe E, Rivedal E (2008)
The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis
Biochem Biophys Res Commun, 373 (4), 597-601
PubMed 18601906

Publications 2007

Leithe E, Rivedal E (2007)
Ubiquitination of gap junction proteins
J Membr Biol, 217 (1-3), 43-51
PubMed 17657522

Publications 2006

Leithe E, Brech A, Rivedal E (2006)
Endocytic processing of connexin43 gap junctions: a morphological study
Biochem J, 393 (Pt 1), 59-67
PubMed 16162097

Leithe E, Sirnes S, Omori Y, Rivedal E (2006)
Downregulation of gap junctions in cancer cells
Crit Rev Oncog, 12 (3-4), 225-56
PubMed 17425504

Publications 2005

Rivedal E, Leithe E (2005)
Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells
Exp Cell Res, 302 (2), 143-52
PubMed 15561096

Publications 2004

Leithe E, Rivedal E (2004)
Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
J Cell Sci, 117 (Pt 7), 1211-20
PubMed 14970263

Leithe E, Rivedal E (2004)
Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment
J Biol Chem, 279 (48), 50089-96
PubMed 15371442

Publications 2003

Cruciani V, Leithe E, Mikalsen SO (2003)
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport
Exp Cell Res, 287 (1), 130-42
PubMed 12799189

Leithe E, Cruciani V, Sanner T, Mikalsen SO, Rivedal E (2003)
Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C
Carcinogenesis, 24 (7), 1239-45
PubMed 12807762

Publications 2002

Mallardo M, Leithe E, Schleich S, Roos N, Doglio L, Krijnse Locker J (2002)
Relationship between vaccinia virus intracellular cores, early mRNAs, and DNA replication sites
J Virol, 76 (10), 5167-83
PubMed 11967332