Kidney transplant research group

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Kidney Transplantation

The group initiates and participates in studies focusing on renal transplant patients. The research is clinically oriented towards these patients.

About the group

The research group carries out epidemiological and clinical outcome studies in kidney transplantation, pancreas transplantation and islet transplantation.

Data from the Norwegian Renal Registry (which is updated yearly) together with data from a local biobank are generated, together with RCTs and observational studies.

The studies focus on immunotherapy, pharmacokinetics, pharmacotherapeutic modelling and metabolism, in particular metabolism in post-transplant diabetes (PTDM).

Clinical studies are oriented on outcomes and complications after kidney and pancreas transplantation including epidemiological studies, RCT’s and explanatory studies of mechanisms and pathogenesis.

The studies include immunotherapy and pharmacokinetics and pharmacotherapeutic modelling. For epidemiological studies local biobank and follow up via Norwegian Renal Registry are essential.

Projects

  • Covid-19 vaccine study among kidney transplant recipients
  • EVITA (Epstein-Barr virus infection monitoring in renal transplant recipients) 
  • BONTRAX – 10 years follow-up of bisphosphonate treatment in kidney transplant recipients
  • Hypomagnesemia as a risk factor for development of posttransplant diabetes mellitus (PhD project Rasmus Kirkeskov Carlsen).
  • The microbiome and gut metabolism of mycophenolate acid. 
  • Post-transplant diabetes
  • Kidney rejection and immunity
  • Osteoporosis after transplantation
  • Individualization of immunosuppression, also with home based blood sampling (MitraTip®)
  • Biomarkers of outcomes after transplantation
  • Measured GFR by iohexol plasma clearance vs. estimated glomerular filtration rate
  • Evaluation and follow-up of kidney donors (ALDON Study)
     

Cooperation

Internal

  • Section of Endocrinology
  • Section of Transplant surgery
  • Department of Pathology
  • Department of Immunology
  • Department of Pediatrics

National

  • University of Oslo, AHUS - Renal research Group
  • University of Tromsø- Renal research Group
  • University of Bergen- Department of nephrology
  • University of Stavanger, Department of nephrology
  • School of Pharmacy, UiO
  • Department of Nutrition, UiO

International

  • Laboratory for Applied Pharmacokinetics and Bioinformatics, University of Southern California
  • Professor Esteban Porini, La Laguna University, Tenerife, Spain
  • Professor Manfred Hecking, Medical Universtiy of Vienna, Austria
  • CHU Limoges, Department of Pharmacology and Toxicology, Limoges, France
  • Andreas Paasch, Caltec, Basel
  • Professor Filip Knop, Center for Diabetes Research, Gentofte Hospital, Copenhagen
  • Professor Bo Feldt-Rasmussen, Department of Nephrology, Rigshospitalet, Copenhagen

Publications

  • Åsberg A, Bjerre A, Almaas R, Luis-Lima S, Robertsen I, Porrini E, Schwartz G, Hartmann A, Bergan S. Measured GFR by utilizing population pharmacokinetic methods to determine iohexol clearance. KI Reports 2020; 5(2), 189-198.
  • Gustavsen MT, Midtvedt K, Robertsen I, Woillard J-B, Debord J, Klaasen RA, Vethe NT, Bergan S, Åsberg A. Fasting status and circadian variation must be considered when performing AUC-based therapeutic drug monitoring of tacrolimus in renal transplant recipients. Clin Translat Sci 2020;13(6): 1327-1335.
  • Pihlstrøm HK, Ueland T, Michelsen AE, Aukrust P, Gatti F, Hammarström C, Kasprzycka M, Wang J, Haraldsen G, Mjøen G, Dahle DO, Midtvedt K, Eide IA, Hartmann A, Holdaas H. Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients. PLoS One. 2020; 15(12): e0243759.
  • Haugen AJ, Hallan S, Langberg NE, Dahle DO, Pihlstrøm H, Birkeland KI, Reisaeter A, Midtvedt K, Hartmann A, Holdaas H, Mjøen G. Increased long-term risk for hypertension in kidney donors - a retrospective cohort study. Transpl Int. 2020; 33(5): 536-543.
Published Aug. 14, 2018 10:36 AM - Last modified June 1, 2021 2:47 PM

Contact

Group leader

Participants

Detailed list of participants

 

 

 
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