Espen S. Bækkevold
- Senior scientist; PhD
- +47 23 07 14 93
Publications 2024
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Cell Oncol (Dordr), 47 (4), 1267-1276
DOI 10.1007/s13402-024-00926-w, PubMed 38407700
Publications 2023
Human small intestine contains 2 functionally distinct regulatory T-cell subsets
J Allergy Clin Immunol, 152 (1), 278-289.e6
DOI 10.1016/j.jaci.2023.02.030, PubMed 36893861
A Roadmap for the Human Gut Cell Atlas
Nat Rev Gastroenterol Hepatol, 20 (9), 597-614
DOI 10.1038/s41575-023-00784-1, PubMed 37258747
Publications 2022
Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease
Nat Commun, 13 (1), 4920
DOI 10.1038/s41467-022-32691-5, PubMed 35995787
RvD1n-3 DPA Downregulates the Transcription of Pro-Inflammatory Genes in Oral Epithelial Cells and Reverses Nuclear Translocation of Transcription Factor p65 after TNF-α Stimulation
Int J Mol Sci, 23 (23)
DOI 10.3390/ijms232314878, PubMed 36499208
Expression and function of resolvin RvD1n-3 DPA receptors in oral epithelial cells
Eur J Oral Sci, 130 (4), e12883
DOI 10.1111/eos.12883, PubMed 35808844
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets
J Exp Med, 219 (3)
DOI 10.1084/jem.20211846, PubMed 35139155
Cellsnake: a user-friendly tool for single-cell RNA sequencing analysis
Gigascience, 12
DOI 10.1093/gigascience/giad091, PubMed 37889009
Calprotectin Expressing Donor-Derived Macrophages Increase in Acute Gastrointestinal Graft-Versus-Host Disease
Transplant Cell Ther, 28 (5), 248.e1-248.e8
DOI 10.1016/j.jtct.2022.01.028, PubMed 35144036
Publications 2021
Response to Lauro and Zorzetti
Mucosal Immunol, 14 (6), 1395-1396
DOI 10.1038/s41385-021-00454-y, PubMed 34535772
Lung CD4+ T-cells in patients with lung fibrosis produce pro-fibrotic interleukin-13 together with interferon-γ
Eur Respir J, 57 (3)
DOI 10.1183/13993003.00983-2020, PubMed 33154027
Origin of langerin (CD207)-expressing antigen presenting cells in the normal oral mucosa and in oral lichen planus lesions
Eur J Oral Sci, 130 (1), e12835
DOI 10.1111/eos.12835, PubMed 34935212
Publications 2020
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile
Mucosal Immunol, 14 (2), 402-410
DOI 10.1038/s41385-020-0315-5, PubMed 32572129
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
J Clin Invest, 130 (9), 4624-4636
DOI 10.1172/JCI129965, PubMed 32516138
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Publications 2019
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737
Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates
Cancer Immunol Immunother, 68 (4), 687-697
DOI 10.1007/s00262-019-02302-2, PubMed 30684003
Immune Cell Composition in Human Non-small Cell Lung Cancer
Front Immunol, 9, 3101
DOI 10.3389/fimmu.2018.03101, PubMed 30774636
Publications 2018
Monocytes accumulate in the airways of children with fatal asthma
Clin Exp Allergy, 48 (12), 1631-1639
DOI 10.1111/cea.13265, PubMed 30184280
Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers
Arterioscler Thromb Vasc Biol, 38 (4), 854-869
DOI 10.1161/ATVBAHA.117.310388, PubMed 29449332
Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestine
Mucosal Immunol, 11 (5), 1512-1523
DOI 10.1038/s41385-018-0060-1, PubMed 30038215
Publications 2017
Transcriptional and functional profiling defines human small intestinal macrophage subsets
J Exp Med, 215 (2), 441-458
DOI 10.1084/jem.20170057, PubMed 29273642
The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes
Scand J Immunol, 87 (2), 80-87
DOI 10.1111/sji.12636, PubMed 29194752
Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
J Immunol, 198 (7), 2785-2795
DOI 10.4049/jimmunol.1601881, PubMed 28228559
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812
Publications 2016
Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa
PLoS One, 11 (2), e0148826
DOI 10.1371/journal.pone.0148826, PubMed 26866695
Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects
J Allergy Clin Immunol, 137 (6), 1872-1881.e12
DOI 10.1016/j.jaci.2015.11.025, PubMed 26851967
Long-term persistence of human donor alveolar macrophages in lung transplant recipients
Thorax, 71 (11), 1006-1011
DOI 10.1136/thoraxjnl-2016-208292, PubMed 27329043
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
PLoS One, 11 (6), e0157387
DOI 10.1371/journal.pone.0157387, PubMed 27311059
Publications 2015
IL-5 production by resident mucosal allergen-specific T cells in an explant model of allergic rhinitis
Clin Exp Allergy, 45 (8), 1296-304
DOI 10.1111/cea.12543, PubMed 25817862
Publications 2014
The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide
Mucosal Immunol, 8 (1), 49-56
DOI 10.1038/mi.2014.41, PubMed 24850429
A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa
Mucosal Immunol, 8 (1), 107-14
DOI 10.1038/mi.2014.46, PubMed 24917456
A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa
J Allergy Clin Immunol, 134 (3), 613-621.e7
DOI 10.1016/j.jaci.2014.05.010, PubMed 24958565
Increased tartrate-resistant Acid phosphatase expression in osteoblasts and osteocytes in experimental osteoporosis in rats
Calcif Tissue Int, 94 (5), 510-21
DOI 10.1007/s00223-013-9834-3, PubMed 24395179
Publications 2013
The skeletal phenotype of chondroadherin deficient mice
PLoS One, 8 (6), e63080
DOI 10.1371/journal.pone.0063080, PubMed 23755099
Publications 2011
Enhanced transfection of cell lines from Atlantic salmon through nucoleofection and antibiotic selection
BMC Res Notes, 4, 136
DOI 10.1186/1756-0500-4-136, PubMed 21548922
Publications 2010
Gene expression and distribution of key bone turnover markers in the callus of estrogen-deficient, vitamin D-depleted rats
Calcif Tissue Int, 87 (1), 77-89
DOI 10.1007/s00223-010-9371-2, PubMed 20495792
Publications 2009
Analysis of host- and strain-dependent cell death responses during infectious salmon anemia virus infection in vitro
Virol J, 6, 91
DOI 10.1186/1743-422X-6-91, PubMed 19566966
Publications 2008
Molecular and functional characterization of two infectious salmon anaemia virus (ISAV) proteins with type I interferon antagonizing activity
Virus Res, 133 (2), 228-38
DOI 10.1016/j.virusres.2008.01.008, PubMed 18304672
Publications 2005
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations
J Exp Med, 201 (7), 1045-51
DOI 10.1084/jem.20041059, PubMed 15795234
Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules
Blood, 106 (2), 444-6
DOI 10.1182/blood-2004-11-4353, PubMed 15863780
Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils
Blood, 106 (2), 593-600
DOI 10.1182/blood-2004-12-4630, PubMed 15827133
Publications 2004
The traffic of mucosal lymphocytes to extraintestinal sites
J Pediatr Gastroenterol Nutr, 39 Suppl 3, S725-6
DOI 10.1097/00005176-200406003-00004, PubMed 15167361
Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
Blood, 104 (10), 3021-7
DOI 10.1182/blood-2004-02-0701, PubMed 15284119
Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment
Blood, 103 (11), 4164-72
DOI 10.1182/blood-2003-10-3537, PubMed 14976058
Publications 2003
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
Am J Pathol, 163 (1), 69-79
DOI 10.1016/S0002-9440(10)63631-0, PubMed 12819012
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
Proc Natl Acad Sci U S A, 100 (14), 8389-94
DOI 10.1073/pnas.1433000100, PubMed 12829791
Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis
J Immunol, 170 (9), 4638-48
DOI 10.4049/jimmunol.170.9.4638, PubMed 12707342
Publications 2002
B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue
Gut, 51 (3), 364-71
DOI 10.1136/gut.51.3.364, PubMed 12171958
Publications 2001
The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment
J Exp Med, 193 (9), 1105-12
DOI 10.1084/jem.193.9.1105, PubMed 11342595
From B to A the mucosal way
Nat Immunol, 2 (12), 1093-4
DOI 10.1038/ni1201-1093, PubMed 11725295
Publications 1999
Culture characterization of differentiated high endothelial venule cells from human tonsils
Lab Invest, 79 (3), 327-36
PubMed 10092069
Regional specialization in the mucosal immune system: what happens in the microcompartments?
Immunol Today, 20 (3), 141-51
DOI 10.1016/s0167-5699(98)01413-3, PubMed 10203706
Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules
Proc Natl Acad Sci U S A, 96 (22), 12772-7
DOI 10.1073/pnas.96.22.12772, PubMed 10535998
Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization
Am J Pathol, 155 (6), 2043-55
DOI 10.1016/S0002-9440(10)65523-X, PubMed 10595934
Publications 1998
Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase
FASEB J, 12 (7), 603-12
DOI 10.1096/fasebj.12.7.603, PubMed 9576487