Espen W. Remme
- Group leader, Senior scientist; M.Sc., Dr. Ing.
- +47 230 71413
Espen Remme leads the research group of Integrated Cardiovascular Function at the Institute of Surgical Research/Department of Cardiology.
His research is focused on cardiac mechanics, hemodynamics, myocardial deformation, diastolic function, echocardiography, blood speckle tracking, dyssynchrony, cardiac resynchronization therapy, mathematical simulation models of the heart, machine learning, and cardiac motion sensors. He has developed and teaches the course ‘MF9145 – Cardiac mechanics’ for PhD fellows and cardiac researchers at University of Oslo.
Espen Remme completed his doctoral of engineering degree in 2004. The PhD thesis involved finite element simulation models of the left ventricle which was conducted at the Norwegian University of Science and Technology (Department of Engineering Cybernetics and Department of Circulation and Medical Imaging) and at the Auckland Bioengineering Institute, University of Auckland, New Zealand. He also holds an M.Sc. in cybernetics/biomedical engineering from the Norwegian University of Science and Technology and a B.Eng. in electrical engineering from Telemark Institute of Technology.
Besides the position at the Institute for Surgical Research, he also has a senior scientist position at the Intervention Center in the Section for Medical Cybernetics and Image Processing.
Publications 2024
Cardiac Valve Event Timing in Echocardiography Using Deep Learning and Triplane Recordings
IEEE J Biomed Health Inform, 28 (5), 2759-2768
DOI 10.1109/JBHI.2024.3373124, PubMed 38442058
Echocardiographic Evaluation of Left Ventricular Filling Pressure in Patients With Pulmonary Hypertension
JACC Cardiovasc Imaging, 17 (5), 566-567
DOI 10.1016/j.jcmg.2023.12.004, PubMed 38340138
Evaluation of left ventricular filling pressure by echocardiography in patients with atrial fibrillation
Echo Res Pract, 11 (1), 14
DOI 10.1186/s44156-024-00048-x, PubMed 38825684
Association between myocardial work indices and cardiovascular events according to hypertension in the general population
Eur Heart J Cardiovasc Imaging, 25 (3), 413-424
DOI 10.1093/ehjci/jead292, PubMed 37930752
Non-invasive myocardial work in aortic stenosis: validation and improvement in left ventricular pressure estimation
Eur Heart J Cardiovasc Imaging, 25 (2), 201-212
DOI 10.1093/ehjci/jead227, PubMed 37672652
Myocardial Strain Imaging: Theory, Current Practice, and the Future
JACC Cardiovasc Imaging (in press)
DOI 10.1016/j.jcmg.2024.07.011, PubMed 39269417
Publications 2023
Machine learning in diastolic dysfunction: Left atrial strain trace superior to single points for estimation of filling pressure†
Eur Heart J Cardiovasc Imaging, 25 (1), 27-28
DOI 10.1093/ehjci/jead257, PubMed 37818845
Mental Stress Reduces Left Ventricular Strain: Can It Lead to Misinterpretation of Cancer Therapy-Related Cardiac Dysfunction?
J Am Soc Echocardiogr, 37 (5), 564-566
DOI 10.1016/j.echo.2023.11.010, PubMed 37981246
Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy
Europace, 25 (3), 1183-1192
DOI 10.1093/europace/euad013, PubMed 36734281
Publications 2022
A high-throughput study of visceral organs in CT-scanned pigs
Sci Rep, 12 (1), 9154
DOI 10.1038/s41598-022-13253-7, PubMed 35650423
Myocardial Work in Patients Hospitalized With COVID-19: Relation to Biomarkers, COVID-19 Severity, and All-Cause Mortality
J Am Heart Assoc, 11 (19), e026571
DOI 10.1161/JAHA.122.026571, PubMed 36129046
Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS
Circ Cardiovasc Imaging, 15 (5), e013712
DOI 10.1161/CIRCIMAGING.121.013712, PubMed 35535593
Instant contractility, just apply a single beat
J Physiol, 600 (22), 4775-4776
DOI 10.1113/JP283843, PubMed 36285355
Order of tricuspid and mitral valve opening as an index of left ventricular filling pressure and prognosis
Eur Heart J Cardiovasc Imaging, 23 (5), 627-628
DOI 10.1093/ehjci/jeab239, PubMed 34791146
Tracking Early Systolic Motion for Assessing Acute Response to Cardiac Resynchronization Therapy in Real Time
Front Physiol, 13, 903784
DOI 10.3389/fphys.2022.903784, PubMed 35721553
Automatic Detection of Aortic Valve Events Using Deep Neural Networks on Cardiac Signals From Epicardially Placed Accelerometer
IEEE J Biomed Health Inform, 26 (9), 4450-4461
DOI 10.1109/JBHI.2022.3181148, PubMed 35679388
Publications 2021
Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure
Eur Heart J Cardiovasc Imaging, 23 (1), 61-70
DOI 10.1093/ehjci/jeaa415, PubMed 33496314
Corrigendum to: Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure
Eur Heart J Cardiovasc Imaging, 23 (1), 136
DOI 10.1093/ehjci/jeab194, PubMed 34608485
Continuous Estimation of Acute Changes in Preload Using Epicardially Attached Accelerometers
IEEE Trans Biomed Eng, 68 (7), 2067-2075
DOI 10.1109/TBME.2020.3020358, PubMed 32866091
Myocardial Strain Measured by Epicardial Transducers-Comparison Between Velocity Estimators
Ultrasound Med Biol, 47 (5), 1377-1396
DOI 10.1016/j.ultrasmedbio.2021.01.012, PubMed 33593489
Shortening of time-to-peak left ventricular pressure rise (Td) in cardiac resynchronization therapy
ESC Heart Fail, 8 (6), 5222-5236
DOI 10.1002/ehf2.13601, PubMed 34514746
Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block
JACC Cardiovasc Imaging, 14 (11), 2059-2069
DOI 10.1016/j.jcmg.2021.04.017, PubMed 34147454
Publications 2020
Left bundle branch block increases left ventricular diastolic pressure during tachycardia due to incomplete relaxation
J Appl Physiol (1985), 128 (4), 729-738
DOI 10.1152/japplphysiol.01002.2018, PubMed 31999529
The 'Digital Twin' to enable the vision of precision cardiology
Eur Heart J, 41 (48), 4556-4564
DOI 10.1093/eurheartj/ehaa159, PubMed 32128588
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 13 (7), 1475-1484
DOI 10.1016/j.jcmg.2019.11.016, PubMed 31954643
Automatic detection of valve events by epicardial accelerometer allows estimation of the left ventricular pressure trace and pressure-displacement loop area
Sci Rep, 10 (1), 20088
DOI 10.1038/s41598-020-76637-7, PubMed 33208784
Publications 2019
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study
Europace, 21 (2), 347-355
DOI 10.1093/europace/euy221, PubMed 30418572
Dynamic gravity compensation does not increase detection of myocardial ischemia in combined accelerometer and gyro sensor measurements
Sci Rep, 9 (1), 2671
DOI 10.1038/s41598-018-35630-x, PubMed 30804438
Detection of Regional Mechanical Activation of the Left Ventricular Myocardium Using High Frame Rate Ultrasound Imaging
IEEE Trans Med Imaging, 38 (11), 2665-2675
DOI 10.1109/TMI.2019.2909358, PubMed 30969919
Comparison of two methods for mechanical activation detection using high frame rate ultrasound imaging
IEEE INT ULTRA SYM, 1410-1413
Estimating Regional Myocardial Contraction Using Miniature Transducers on the Epicardium
Ultrasound Med Biol, 45 (11), 2958-2969
DOI 10.1016/j.ultrasmedbio.2019.07.416, PubMed 31447239
Monitoring cardiac function by accelerometer - detecting start systole from the acceleration signal makes additional ECG recordings for R-peak detection redundant
Annu Int Conf IEEE Eng Med Biol Soc, 2019, 4922-4925
DOI 10.1109/EMBC.2019.8856417, PubMed 31946964
Monitoring cardiac function by accelerometer - detecting start systole from the acceleration signal makes additional ECG recordings for R-peak detection redundant
IEEE ENG MED BIO, 4922-4925
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar
JACC Cardiovasc Imaging, 12 (12), 2402-2413
DOI 10.1016/j.jcmg.2018.11.030, PubMed 30772230
Publications 2018
Validation of a Holographic Display for Quantification of Mitral Annular Dynamics by Three-Dimensional Echocardiography
J Am Soc Echocardiogr, 32 (2), 303-316.e4
DOI 10.1016/j.echo.2018.08.010, PubMed 30293779
Reply: Interaction Between Longitudinal, Circumferential, and Radial Deformations and Their Contributions to Ejection Fraction
J Am Coll Cardiol, 71 (2), 257-258
DOI 10.1016/j.jacc.2017.10.090, PubMed 29325649
Reply: Left Ventricular Twist: An Often Ignored But Crucial Determinant of Left Ventricular Function
J Am Coll Cardiol, 71 (5), 584-585
DOI 10.1016/j.jacc.2017.12.002, PubMed 29406870
Dysfunction of the systemic right ventricle after atrial switch: physiological implications of altered septal geometry and load
J Appl Physiol (1985), 125 (5), 1482-1489
DOI 10.1152/japplphysiol.00255.2018, PubMed 30188795
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC Cardiovasc Imaging, 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025, PubMed 29361486
Publications 2017
Estimating Left Ventricular Filling Pressure by Echocardiography
J Am Coll Cardiol, 69 (15), 1937-1948
DOI 10.1016/j.jacc.2017.01.058, PubMed 28408024
Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements
Ann Biomed Eng, 45 (5), 1292-1304
DOI 10.1007/s10439-017-1798-4, PubMed 28116541
Velocity Resolution Improvement for High Temporal Resolution Ultrasonic Transducer
IEEE INT ULTRA SYM
Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain
J Am Coll Cardiol, 70 (8), 942-954
DOI 10.1016/j.jacc.2017.06.046, PubMed 28818204
Publications 2015
Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 16 (11), 1247-55
DOI 10.1093/ehjci/jev078, PubMed 25851329
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
DOI 10.1016/j.preghy.2015.09.003, PubMed 26597749
Continuous monitoring of cardiac function by 3-dimensional accelerometers in a closed-chest pig model
Interact Cardiovasc Thorac Surg, 21 (5), 573-82
DOI 10.1093/icvts/ivv191, PubMed 26254463
Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue: Electrophysiological Simulation Study
Circ Arrhythm Electrophysiol, 8 (5), 1164-72
DOI 10.1161/CIRCEP.115.002677, PubMed 26136400
Factors determining the magnitude of the pre-ejection leftward septal motion in left bundle branch block
Europace, 18 (12), 1905-1913
DOI 10.1093/europace/euv381, PubMed 26612883
Publications 2014
Cardiac responses to left ventricular pacing in hearts with normal electrical conduction: beneficial effect of improved filling is counteracted by dyssynchrony
Am J Physiol Heart Circ Physiol, 307 (3), H370-8
DOI 10.1152/ajpheart.00089.2014, PubMed 24906920
Assessment of 3D motion increases the applicability of accelerometers for monitoring left ventricular function
Interact Cardiovasc Thorac Surg, 20 (3), 329-37
DOI 10.1093/icvts/ivu404, PubMed 25472979
Advantages of strain echocardiography in assessment of myocardial function in severe sepsis: an experimental study
Crit Care Med, 42 (6), e432-40
DOI 10.1097/CCM.0000000000000310, PubMed 24633187
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018
Early systolic lengthening may identify minimal myocardial damage in patients with non-ST-elevation acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 15 (10), 1152-60
DOI 10.1093/ehjci/jeu101, PubMed 24866900
Publications 2013
Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study
Am J Hypertens, 26 (4), 549-56
DOI 10.1093/ajh/hps067, PubMed 23467210
Publications 2012
Inflow typology and ventricular geometry determine efficiency of filling in the hypoplastic left heart
Ann Thorac Surg, 94 (5), 1562-9
DOI 10.1016/j.athoracsur.2012.05.122, PubMed 22858280
Systemic arterial response and ventriculo-arterial interaction during normal pregnancy
Am J Hypertens, 25 (6), 672-7
DOI 10.1038/ajh.2012.29, PubMed 22460202
TRANSMURAL STRAIN DISTRIBUTION ACROSS THE CARDIAC WALL AND ITS DEPENDENCY ON MEASUREMENT SITE
IEEE INT ULTRA SYM
DOI 10.1109/ULTSYM.2012.0271
EFFECT OF MYOCARDIAL PERFUSION ON END-SYSTOLIC RADIAL STRAIN AT THE APEX
IEEE INT ULTRA SYM
DOI 10.1109/ULTSYM.2012.0272
Myocardial relaxation, restoring forces, and early-diastolic load are independent determinants of left ventricular untwisting rate
Circulation, 126 (12), 1441-51
DOI 10.1161/CIRCULATIONAHA.111.080861, PubMed 22865889
Simulation model of cardiac three dimensional accelerometer measurements
Med Eng Phys, 34 (7), 990-8
DOI 10.1016/j.medengphy.2012.04.015, PubMed 22633656
A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work
Eur Heart J, 33 (6), 724-33
DOI 10.1093/eurheartj/ehs016, PubMed 22315346
Publications 2011
Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block
Circ Cardiovasc Imaging, 4 (3), 264-73
DOI 10.1161/CIRCIMAGING.110.961417, PubMed 21393502
Transmural Myocardial Strain Distribution Measured at High Spatial and Temporal Resolution
IEEE INT ULTRA SYM, 696-699
DOI 10.1109/ULTSYM.2011.0169
Mechanics of left ventricular relaxation, early diastolic lengthening, and suction investigated in a mathematical model
Am J Physiol Heart Circ Physiol, 300 (5), H1678-87
DOI 10.1152/ajpheart.00165.2010, PubMed 21317306
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am J Physiol Heart Circ Physiol, 301 (6), H2334-43
DOI 10.1152/ajpheart.00644.2011, PubMed 21984549
Publications 2010
Comments on point: Counterpoint: Left ventricular volume during diastasis is/is not the physiological in vivo equilibrium volume and is/is not related to diastolic suction
J Appl Physiol (1985), 109 (2), 612
DOI 10.1152/japplphysiol.00558.2010, PubMed 21312417
Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: a novel method that differentiates between electrical and mechanical etiologies
Circ Cardiovasc Imaging, 3 (4), 405-14
DOI 10.1161/CIRCIMAGING.109.905539, PubMed 20494943
Publications 2009
The effect of including myocardial anisotropy in simulated ultrasound images of the heart
IEEE Trans Ultrason Ferroelectr Freq Control, 56 (2), 326-33
DOI 10.1109/TUFFC.2009.1041, PubMed 19251519
Automatic real-time detection of myocardial ischemia by epicardial accelerometer
J Thorac Cardiovasc Surg, 139 (4), 1026-32
DOI 10.1016/j.jtcvs.2009.05.031, PubMed 19717169
Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones
Am J Physiol Heart Circ Physiol, 297 (1), H257-67
DOI 10.1152/ajpheart.01116.2008, PubMed 19395547
Fast ultrasound imaging simulation in K-space
IEEE Trans Ultrason Ferroelectr Freq Control, 56 (6), 1159-67
DOI 10.1109/TUFFC.2009.1158, PubMed 19574124
A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign
Am J Physiol Heart Circ Physiol, 296 (3), H645-54
DOI 10.1152/ajpheart.00313.2008, PubMed 19122168
Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load
Circulation, 119 (19), 2578-86
DOI 10.1161/CIRCULATIONAHA.108.791681, PubMed 19414640
Validation of cardiac accelerometer sensor measurements
Physiol Meas, 30 (12), 1429-44
DOI 10.1088/0967-3334/30/12/010, PubMed 19907074
Response to Letter Regarding Article, "Mechanisms of Preejection and Postejection Velocity Spikes in Left Ventricular Myocardium: Interaction Between Wall Deformation and Valve Events"
Circulation, 119 (6), E205
DOI 10.1161/CIRCULATIONAHA.108.823716
Pacing in heart failure patients with narrow QRS: is there more to gain than resynchronization?
Circulation, 120 (17), 1651-3
DOI 10.1161/CIRCULATIONAHA.109.900381, PubMed 19822804
Publications 2008
3-D speckle tracking for assessment of regional left ventricular function
Ultrasound Med Biol, 35 (3), 458-71
DOI 10.1016/j.ultrasmedbio.2008.09.011, PubMed 19056164
Apical rotation by speckle tracking echocardiography: a simplified bedside index of left ventricular twist
J Am Soc Echocardiogr, 21 (10), 1121-8
DOI 10.1016/j.echo.2008.06.012, PubMed 18760568
Combining Edge Detection With Speckle-Tracking for Cardiac Strain Assessment in 3D echocardiography
ULTRASON, 1959-+
DOI 10.1109/ULTSYM.2008.0483
Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium: interaction between wall deformation and valve events
Circulation, 118 (4), 373-80
DOI 10.1161/CIRCULATIONAHA.107.748491, PubMed 18606917
Publications 2007
Characteristic strain pattern of moderately ischemic myocardium investigated in a finite element simulation model
LECT NOTES COMPUT SC, 4466, 330-+
Publications 2005
Parameter distribution models for estimation of population based left ventricular deformation using sparse fiducial markers
IEEE Trans Med Imaging, 24 (3), 381-8
DOI 10.1109/tmi.2004.842458, PubMed 15754988
Regional left ventricular electric and mechanical activation and relaxation
J Am Coll Cardiol, 47 (1), 173-4
DOI 10.1016/j.jacc.2005.10.039, PubMed 16386682
Publications 2004
A model-based approach for clinical evaluation of left ventricular deformation
In Doktoravhandlinger ved NTNU, Norges teknisk-naturvitenskapelige universitet, Trondheim, 2004:48, 1 b. (flere pag.)
BIBSYS 041446518
Development of an in vivo method for determining material properties of passive myocardium
J Biomech, 37 (5), 669-78
DOI 10.1016/j.jbiomech.2003.09.023, PubMed 15046996
Extraction and quantification of left ventricular deformation modes
IEEE Trans Biomed Eng, 51 (11), 1923-31
DOI 10.1109/TBME.2004.834283, PubMed 15536894
Publications 2003
Ventricular mechanics in diastole: material parameter sensitivity
J Biomech, 36 (5), 737-48
DOI 10.1016/s0021-9290(02)00452-9, PubMed 12695004
Publications 2000
Individualizing the aorto-radial pressure transfer function: feasibility of a model-based approach
Am J Physiol Heart Circ Physiol, 279 (2), H542-9
DOI 10.1152/ajpheart.2000.279.2.H542, PubMed 10924052
Publications 1998
Comparison of estimated central aortic blood pressure from carotid pulse curves obtained by arterial tonometry and volume distension recordings
[s.n.], [S.l.], [1] bl.
BIBSYS 990839664