John M. Aalen
- Postdoc and cardiology fellow; MD, PhD
John Aalen graduated as MD from University of Oslo in 2012. Since then he has been working at Vestfold Hospital Trust (Sentralsykehuset i Vestfold), first as a part of his internship and the last year as resident in internal medicine. He joined our research group in April 2014.
His PhD work "Contractile Reserve in Dyssynchrony (CRID): A novel principle to identify candidates for cardiac resynchronization therapy" focuses on identifying candidates for cardiac resynchronization therapy and the effect of increased afterload on the left ventricle during left bundle branch block. He successfully defended his PhD thesis in May 2021.
Aalen has published several research papers and presented numerous abstracts at international and national conferences and has also won prizes for his work, including the Young Investigator Award for Basic Science at EuroEcho-Imaging Congress in Lisboa in 2017.”
PhD thesis:
Insights into left ventricular dyssynchrony: Consequences for myocardial function and response to cardiac resynchronization therapys (duo.uio.no)
Publications 2024
Association between myocardial work indices and cardiovascular events according to hypertension in the general population
Eur Heart J Cardiovasc Imaging, 25 (3), 413-424
DOI 10.1093/ehjci/jead292, PubMed 37930752
Publications 2023
Mechanical Dyssynchrony Combined with Septal Scarring Reliably Identifies Responders to Cardiac Resynchronization Therapy
J Clin Med, 12 (18)
DOI 10.3390/jcm12186108, PubMed 37763048
Cardiac Magnetic Resonance Identifies Responders to Cardiac Resynchronization Therapy with an Assessment of Septal Scar and Left Ventricular Dyssynchrony
J Clin Med, 12 (22)
DOI 10.3390/jcm12227182, PubMed 38002795
Mental Stress Reduces Left Ventricular Strain: Can It Lead to Misinterpretation of Cancer Therapy-Related Cardiac Dysfunction?
J Am Soc Echocardiogr, 37 (5), 564-566
DOI 10.1016/j.echo.2023.11.010, PubMed 37981246
Publications 2022
Visual Presence of Mechanical Dyssynchrony Combined With Septal Scarring Identifies Responders to Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 15 (12), 2151-2153
DOI 10.1016/j.jcmg.2022.06.020, PubMed 36481085
Left atrial strain is a predictor of left ventricular systolic and diastolic reverse remodelling in CRT candidates
Eur Heart J Cardiovasc Imaging, 23 (10), 1373-1382
DOI 10.1093/ehjci/jeab163, PubMed 34432006
Scar imaging in the dyssynchronous left ventricle: Accuracy of myocardial metabolism by positron emission tomography and function by echocardiographic strain
Int J Cardiol, 372, 122-129
DOI 10.1016/j.ijcard.2022.11.042, PubMed 36460211
Myocardial Work in Patients Hospitalized With COVID-19: Relation to Biomarkers, COVID-19 Severity, and All-Cause Mortality
J Am Heart Assoc, 11 (19), e026571
DOI 10.1161/JAHA.122.026571, PubMed 36129046
Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS
Circ Cardiovasc Imaging, 15 (5), e013712
DOI 10.1161/CIRCIMAGING.121.013712, PubMed 35535593
Publications 2021
Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders
Eur J Nucl Med Mol Imaging, 48 (8), 2437-2446
DOI 10.1007/s00259-020-05161-7, PubMed 33416956
Importance of Systematic Right Ventricular Assessment in Cardiac Resynchronization Therapy Candidates: A Machine Learning Approach
J Am Soc Echocardiogr, 34 (5), 494-502
DOI 10.1016/j.echo.2020.12.025, PubMed 33422667
Prognostic utility of the assessment of diastolic function in patients undergoing cardiac resynchronization therapy
Int J Cardiol, 331, 144-151
DOI 10.1016/j.ijcard.2021.01.046, PubMed 33535079
Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block
JACC Cardiovasc Imaging, 14 (11), 2059-2069
DOI 10.1016/j.jcmg.2021.04.017, PubMed 34147454
Right ventricular work: a step forward for non-invasive assessment of right ventricular function
Eur Heart J Cardiovasc Imaging, 22 (2), 153-154
DOI 10.1093/ehjci/jeaa296, PubMed 33279985
Heart failure and systolic function: time to leave diagnostics based on ejection fraction?
Eur Heart J, 42 (7), 786-788
DOI 10.1093/eurheartj/ehaa979, PubMed 33454774
Strain identifies pseudo-normalized right ventricular function in tricuspid regurgitation
Eur Heart J Cardiovasc Imaging, 22 (8), 876-877
DOI 10.1093/ehjci/jeab089, PubMed 34148090
Publications 2020
Left bundle branch block increases left ventricular diastolic pressure during tachycardia due to incomplete relaxation
J Appl Physiol (1985), 128 (4), 729-738
DOI 10.1152/japplphysiol.01002.2018, PubMed 31999529
Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodelling
Eur Heart J Cardiovasc Imaging, 21 (6), 619-628
DOI 10.1093/ehjci/jeaa003, PubMed 32031587
Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block
Eur Heart J Cardiovasc Imaging, 21 (2), 143-153
DOI 10.1093/ehjci/jez231, PubMed 31599327
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 13 (7), 1475-1484
DOI 10.1016/j.jcmg.2019.11.016, PubMed 31954643
Imaging predictors of response to cardiac resynchronization therapy: left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance
Eur Heart J, 41 (39), 3813-3823
DOI 10.1093/eurheartj/ehaa603, PubMed 32918449
Publications 2019
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study
Europace, 21 (2), 347-355
DOI 10.1093/europace/euy221, PubMed 30418572
Detection of Regional Mechanical Activation of the Left Ventricular Myocardium Using High Frame Rate Ultrasound Imaging
IEEE Trans Med Imaging, 38 (11), 2665-2675
DOI 10.1109/TMI.2019.2909358, PubMed 30969919
Comparison of two methods for mechanical activation detection using high frame rate ultrasound imaging
IEEE INT ULTRA SYM, 1410-1413
Limitations of hazard ratios in clinical trials
Eur Heart J, 40 (17), 1378-1383
DOI 10.1093/eurheartj/ehy770, PubMed 30500891
Myocardial Efficiency: A Fundamental Physiological Concept on the Verge of Clinical Impact
JACC Cardiovasc Imaging, 13 (7), 1564-1576
DOI 10.1016/j.jcmg.2019.08.030, PubMed 31864979
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar
JACC Cardiovasc Imaging, 12 (12), 2402-2413
DOI 10.1016/j.jcmg.2018.11.030, PubMed 30772230
Editorial commentary: Septal flash - what is behind the flashy name?
Trends Cardiovasc Med, 30 (2), 123-124
DOI 10.1016/j.tcm.2019.04.003, PubMed 31010721
Publications 2018
Mechanism of harm from left bundle branch block
Trends Cardiovasc Med, 29 (6), 335-342
DOI 10.1016/j.tcm.2018.10.012, PubMed 30401603
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC Cardiovasc Imaging, 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025, PubMed 29361486