Cause-Specific Mortality in Patients During Long-Term Follow-Up After Atrial Switch for Transposition of the Great Arteries

Little is known about the cause of death (CoD) in patients with transposition of the great arteries palliated with a Mustard or Senning procedure. The aim was to describe the CoD for patients with the Mustard and Senning procedure.

This is a retrospective, descriptive multicenter cohort study including all Nordic patients (Denmark, Finland, Norway, and Sweden) who underwent a Mustard or Senning procedure between 1967 and 2003. Among patients corrected with Mustard or Senning transposition of the great arteries, the most common cause of death (CoD) is sudden cardiac death (SCD) followed by heart failure/heart transplantation. The CoD changes as the patients age, with SCD as the most common cause in adolescence and heart failure as the dominant cause in adulthood. Furthermore, the risk of all-cause mortality, SCD, and death attributable to heart failure or heart transplantation was increased in men >10 years after the Mustard/Senning operation.

Cause‐Specific Mortality in Patients During Long‐Term Follow‐Up After Atrial Switch for Transposition of the Great Arteries | Journal of the American Heart Association (ahajournals.org) ​
Multicenter Study. J Am Heart Assoc. 2022 Jul 19;11(14):e023921. 
Annette Schophuus Jensen, Troels Højsgaard Jørgensen, Christina Christersson, Edit Nagy, Juha Sinisalo, Eva Furenäs, Ola Gjesdal, Peter Eriksson, Niels Vejlstrup, Bengt Johansson, Joanna Hlebowicz, Gottfried Greve, Mikael Dellborg, Helge Skulstad, Per Kvidal, Eero Jokinen, Heikki Sairanen, Ulf Thilén, Lars Søndergaard 
PMID: 35861834 
PMCID: PMC9707826 
DOI: 10.1161/JAHA.121.023921

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