Mette-Elise Estensen

  • Consultant cardiologist; MD, PhD

Mette-Elise Estensen, MD, PhD, Consultant Cardiologist, Department of Cardiology, Oslo University Hospital, Rikshospitalet

Dr. Estensen defended her PhD thesis "Left ventricular function and systemic arterial properties in normal and preeclamptic pregnancy" in January 2013.

Preeclampsia occurs in 3-8% of all pregnancies and can have serious consequences for the mother and child. Research has shown that women who have undergone preeclampsia have a significantly increased risk of developing cardiovascular disease later in life.

Cardiologist and researcher Mette-Elise Estensen studied how the heart and the large vessels function during normal pregnancies in healthy women, and compared the change in healthy women with the changes that occur in women who develop preeclampsia.

In her dissertation, Estensen and colleagues found that the pumping function of the heart reduced somewhat during pregnancy, both in healthy subjects and in those with preeclampsia. Heart function is normalized in both groups after childbirth. However, Estensen found that during pregnancy women with preeclampsia have more rigid vessels compared to healthy women, this is persistent even after pregnancy and is shown in women who are controlled 3 years after undergone preeclampsia.

Estensen concluded that women who have undergone preeclampsia have persistent cardiovascular changes that last up to three years after childbirth, which can help explain the increased incidence of cardiovascular disease in these women.

 

Original articles

Ueland T, Estensen ME, Grindheim G, Bollerslev J, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Lekva T (2020)
Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies
J Hypertens (in press)
DOI 10.1097/HJH.0000000000002362, PubMed 31990902

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

Aulie HA, Estensen ME, Selvaag AM, Lilleby V, Flatø B, Aakhus S (2018)
Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls
Pediatr Rheumatol Online J, 16 (1), 85
DOI 10.1186/s12969-018-0302-5, PubMed 30594204

Erikssen G, Aboulhosn J, Lin J, Liestøl K, Estensen ME, Gjesdal O, Skulstad H, Døhlen G, Lindberg HL (2018)
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology
Open Heart, 5 (2), e000902
DOI 10.1136/openhrt-2018-000902, PubMed 30364544

Tarp JB, Sørgaard MH, Christoffersen C, Jensen AS, Sillesen H, Celermajer D, Eriksson P, Estensen ME, Nagy E, Holstein-Rathlou NH, Engstrøm T, Søndergaard L (2018)
Subclinical atherosclerosis in patients with cyanotic congenital heart disease
Int J Cardiol, 277, 97-103
DOI 10.1016/j.ijcard.2018.08.104, PubMed 30228018

Riise N, Lindberg BR, Kulseth MA, Fredwall SO, Lundby R, Estensen ME, Drolsum L, Merckoll E, Krohg-Sørensen K, Paus B (2018)
Clinical diagnosis of Larsen syndrome, Stickler syndrome and Loeys-Dietz syndrome in a 19-year old male: a case report
BMC Med Genet, 19 (1), 155
DOI 10.1186/s12881-018-0671-0, PubMed 30170566

Hjortshøj CMS, Kempny A, Jensen AS, Sørensen K, Nagy E, Dellborg M, Johansson B, Rudiene V, Hong G, Opotowsky AR, Budts W, Mulder BJ, Tomkiewicz-Pajak L, D'Alto M, Prokšelj K, Diller GP, Dimopoulos K, Estensen ME, Holmstrøm H, Turanlahti M, Thilén U, Gatzoulis MA, Søndergaard L (2017)
Past and current cause-specific mortality in Eisenmenger syndrome
Eur Heart J, 38 (26), 2060-2067
DOI 10.1093/eurheartj/ehx201, PubMed 28430906

Hjortshøj CS, Jensen AS, Sørensen K, Nagy E, Johansson B, Kronvall T, Dellborg M, Estensen ME, Holmstrøm H, Turanlahti M, Thilén U, Søndergaard L (2017)
Epidemiological changes in Eisenmenger syndrome in the Nordic region in 1977-2012
Heart, 103 (17), 1353-1358
DOI 10.1136/heartjnl-2016-310979, PubMed 28450553

Kempny A, Hjortshøj CS, Gu H, Li W, Opotowsky AR, Landzberg MJ, Jensen AS, Søndergaard L, Estensen ME, Thilén U, Budts W, Mulder BJ, Blok I, Tomkiewicz-Pająk L, Szostek K, D'Alto M, Scognamiglio G, Prokšelj K, Diller GP, Dimopoulos K, Wort SJ, Gatzoulis MA (2016)
Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study
Circulation, 135 (15), 1432-1440
DOI 10.1161/CIRCULATIONAHA.116.023033, PubMed 27979875

Estensen ME, Grindheim G, Remme EW, Godang K, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Ueland T (2015)
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
DOI 10.1016/j.preghy.2015.09.003, PubMed 26597749

Aulie HA, Estensen ME, Selvaag AM, Lilleby V, Murbraech K, Flatø B, Aakhus S (2015)
Cardiac Function in Adult Patients with Juvenile Idiopathic Arthritis
J Rheumatol, 42 (9), 1716-23
DOI 10.3899/jrheum.141351, PubMed 26178287

Ruys TP, Roos-Hesselink JW, Hall R, Subirana-Domènech MT, Grando-Ting J, Estensen M, Crepaz R, Fesslova V, Gurvitz M, De Backer J, Johnson MR, Pieper PG (2013)
Heart failure in pregnant women with cardiac disease: data from the ROPAC
Heart, 100 (3), 231-8
DOI 10.1136/heartjnl-2013-304888, PubMed 24293523

Estensen ME, Beitnes JO, Grindheim G, Aaberge L, Smiseth OA, Henriksen T, Aakhus S (2013)
Altered maternal left ventricular contractility and function during normal pregnancy
Ultrasound Obstet Gynecol, 41 (6), 659-66
DOI 10.1002/uog.12296, PubMed 23001841

Estensen ME, Remme EW, Grindheim G, Smiseth OA, Segers P, Henriksen T, Aakhus S (2013)
Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study
Am J Hypertens, 26 (4), 549-56
DOI 10.1093/ajh/hps067, PubMed 23467210

Estensen ME, Grindheim G, Remme EW, Swillens A, Smiseth OA, Segers P, Henriksen T, Aakhus S (2012)
Systemic arterial response and ventriculo-arterial interaction during normal pregnancy
Am J Hypertens, 25 (6), 672-7
DOI 10.1038/ajh.2012.29, PubMed 22460202

Grindheim G, Estensen ME, Langesaeter E, Rosseland LA, Toska K (2012)
Changes in blood pressure during healthy pregnancy: a longitudinal cohort study
J Hypertens, 30 (2), 342-50
DOI 10.1097/HJH.0b013e32834f0b1c, PubMed 22179091

Grindheim G, Toska K, Estensen ME, Rosseland LA (2011)
Changes in pulmonary function during pregnancy: a longitudinal cohort study
BJOG, 119 (1), 94-101
DOI 10.1111/j.1471-0528.2011.03158.x, PubMed 22004272

Estensen M, Gude E, Ekmehag B, Lommi J, Bjortuft O, Mortensen S, Nystrom UM, Simonsen S (2011)
Pregnancy in heart- and heart/lung recipients can be problematic
Scand Cardiovasc J, 45 (6), 349-53
DOI 10.3109/14017431.2011.605168, PubMed 21879798

Estensen ME, Hognestad A, Syversen U, Squire I, Ng L, Kjekshus J, Dickstein K, Omland T (2006)
Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction
Am Heart J, 152 (5), 927.e1-6
DOI 10.1016/j.ahj.2006.05.008, PubMed 17070161

Books

Craft N, Estensen M, Hagerup E (2002)
Fakta om kroppen din
Cappelen, [Oslo], 80 s.
BIBSYS 02086616x

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