Mette-Elise Estensen

  • Consultant cardiologist; MD, PhD

Mette-Elise Estensen, MD, PhD, Consultant Cardiologist, Department of Cardiology, Oslo University Hospital, Rikshospitalet

Dr. Estensen defended her PhD thesis "Left ventricular function and systemic arterial properties in normal and preeclamptic pregnancy" in January 2013.

Preeclampsia occurs in 3-8% of all pregnancies and can have serious consequences for the mother and child. Research has shown that women who have undergone preeclampsia have a significantly increased risk of developing cardiovascular disease later in life.

Cardiologist and researcher Mette-Elise Estensen studied how the heart and the large vessels function during normal pregnancies in healthy women, and compared the change in healthy women with the changes that occur in women who develop preeclampsia.

In her dissertation, Estensen and colleagues found that the pumping function of the heart reduced somewhat during pregnancy, both in healthy subjects and in those with preeclampsia. Heart function is normalized in both groups after childbirth. However, Estensen found that during pregnancy women with preeclampsia have more rigid vessels compared to healthy women, this is persistent even after pregnancy and is shown in women who are controlled 3 years after undergone preeclampsia.

Estensen concluded that women who have undergone preeclampsia have persistent cardiovascular changes that last up to three years after childbirth, which can help explain the increased incidence of cardiovascular disease in these women.

 

Publications 2024

Kovacs AH, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Estensen ME, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Jameson SM, Callus E, Kutty S, Oechslin E et al. (2024)
Anxiety and Depression in Adults With Congenital Heart Disease
J Am Coll Cardiol, 83 (3), 430-441
DOI 10.1016/j.jacc.2023.10.043, PubMed 38233017

Langen I, Langesæter E, Gunnes N, Almaas VM, Haugen G, Estensen ME, Sørbye IK (2024)
Hypertensive disorders of pregnancy among women with cardiovascular disease in Norway: A historical cohort study
Acta Obstet Gynecol Scand (in press)
DOI 10.1111/aogs.14841, PubMed 38597240

Wifstad SV, Kildahl HA, Grenne B, Holte E, Hauge SW, Sæbø S, Mekonnen D, Nega B, Haaverstad R, Estensen ME, Dalen H, Lovstakken L (2024)
Mitral Valve Segmentation and Tracking from Transthoracic Echocardiography Using Deep Learning
Ultrasound Med Biol, 50 (5), 661-670
DOI 10.1016/j.ultrasmedbio.2023.12.023, PubMed 38341361

Publications 2023

Erikssen G, Liestøl K, Aboulhosn J, Wik G, Holmstrøm H, Døhlen G, Gjesdal O, Birkeland S, Hoel TN, Saatvedt KJ, Seem E, Thaulow E, Estensen ME, Lindberg HL (2023)
Preoperative versus postoperative survival in patients with univentricular heart: a nationwide, retrospective study of patients born in 1990-2015
BMJ Open, 13 (7), e069531
DOI 10.1136/bmjopen-2022-069531, PubMed 37491095

Gronningsaeter L, Estensen ME, Skulstad H, Langesaeter E, Edvardsen E (2023)
Cardiorespiratory fitness in women after severe pre-eclampsia
Hypertens Pregnancy, 42 (1), 2245054
DOI 10.1080/10641955.2023.2245054, PubMed 37559403

Gronningsaeter L, Langesaeter E, Sørbye IK, Quattrone A, Almaas VM, Skulstad H, Estensen ME (2023)
High prevalence of pre-eclampsia in women with coarctation of the aorta
Eur Heart J Open, 3 (4), oead072
DOI 10.1093/ehjopen/oead072, PubMed 37559925

Hauge SW, Estensen ME, Persson R, Abebe S, Mekonnen D, Nega B, Solholm A, Graven T, Salvesen O, Farstad M, Vikenes K, Haaverstad R, Dalen H (2023)
The importance of concomitant mitral regurgitation for estimates of mitral valve area by pressure half time in patients with chronic rheumatic heart disease
Int J Cardiol, 398, 131600
DOI 10.1016/j.ijcard.2023.131600, PubMed 37996013

Lekva T, Michelsen AE, Roland MCP, Norwitz ER, Estensen ME, Olstad OK, Akkouh IA, Henriksen T, Bollerslev J, Aukrust P, Ueland T (2023)
Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1)
J Intern Med, 295 (2), 181-195
DOI 10.1111/joim.13732, PubMed 37870937

McMahon CJ, Voges I, Jenkins P, Brida M, van der Bosch AE, Dellborg M, Heying R, Stein JI, Georgiev B, Mesihovic-Dinarevic S, Prokšelj K, Oskarsson G, Frogoudaki A, Karagöz T, Jossif A, Doros G, Nielsen D, Jalanko M, Sanchez Perez I, Alvares S, Estensen ME, Petropoulos A, Tagen R, Gumbienė L, Michel-Behnke I et al. (2023)
Adult congenital heart disease training in Europe: current status, disparities and potential solutions
Open Heart, 10 (2)
DOI 10.1136/openhrt-2023-002558, PubMed 38097363

Publications 2022

Castrini AI, Skjølsvik E, Estensen ME, Almaas VM, Skulstad H, Lyseggen E, Edvardsen T, Lie ØH, Picard KCI, Lakdawala NK, Haugaa KH (2022)
Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive
J Am Heart Assoc, 11 (8), e024960
DOI 10.1161/JAHA.121.024960, PubMed 35434999

Gronningsaeter L, Skulstad H, Quattrone A, Langesaeter E, Estensen ME (2022)
Reduced left ventricular function and sustained hypertension in women seven years after severe preeclampsia
Scand Cardiovasc J, 56 (1), 292-301
DOI 10.1080/14017431.2022.2099012, PubMed 35852091

Sørbye IK, Haualand R, Wiull H, Letting AS, Langesaeter E, Estensen ME (2022)
Maternal beta-blocker dose and risk of small-for gestational-age in women with heart disease
Acta Obstet Gynecol Scand, 101 (7), 794-802
DOI 10.1111/aogs.14363, PubMed 35467752

Publications 2021

Chivulescu M, Krohg-Sørensen K, Scheirlynck E, Lindberg BR, Dejgaard LA, Lie ØH, Helle-Valle T, Skjølsvik ET, Estensen ME, Edvardsen T, Lingaas PS, Haugaa KH (2021)
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur Heart J Cardiovasc Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324, PubMed 33280029

de Lange C, Quattrone A, Try K, Bakke AH, Borger Kvaslerud A, Haugaa K, Estensen ME (2021)
Is experienced pregnancy in women with repaired tetralogy of Fallot related to diffuse myocardial fibrosis?
Int J Cardiol, 344, 95-102
DOI 10.1016/j.ijcard.2021.09.033, PubMed 34555445

Hauge SW, Dalen H, Estensen ME, Persson RM, Abebe S, Mekonnen D, Nega B, Solholm A, Farstad M, Bogale N, Graven T, Nielssen NE, Brekke HK, Vikenes K, Haaverstad R (2021)
Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: an observational study
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001706, PubMed 34376574

Lekva T, Roland MCP, Estensen ME, Norwitz ER, Tilburgs T, Henriksen T, Bollerslev J, Normann KR, Magnus P, Olstad OK, Aukrust P, Ueland T (2021)
Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence
Sci Rep, 11 (1), 19735
DOI 10.1038/s41598-021-99140-z, PubMed 34611223

Lekva T, Roland MCP, Estensen ME, Norwitz ER, Tilburgs T, Henriksen T, Bollerslev J, Normann KR, Magnus P, Olstad OK, Aukrust P, Ueland T (2021)
Author Correction: Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence
Sci Rep, 11 (1), 22572
DOI 10.1038/s41598-021-00917-z, PubMed 34782619

Quattrone A, Lie OH, Nestaas E, de Lange C, Try K, Lindberg HL, Skulstad H, Erikssen G, Edvardsen T, Haugaa K, Estensen ME (2021)
Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001400, PubMed 33414183

Quattrone A, Lie OH, Nestaas E, de Lange C, Try K, Lindberg HL, Skulstad H, Erikssen G, Edvardsen T, Haugaa K, Estensen ME (2021)
Long-term follow-up and sex differences in adults operated for tetralogy of Fallot
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001738, PubMed 34663747

Publications 2020

Tarp JB, Clausen P, Celermajer D, Christoffersen C, Jensen AS, Sørensen K, Sillesen H, Estensen ME, Nagy E, Holstein-Rathlou NH, Engstrøm T, Feldt-Rasmussen B, Søndergaard L (2020)
Vascular function in adults with cyanotic congenital heart disease
Int J Cardiol Heart Vasc, 30, 100632
DOI 10.1016/j.ijcha.2020.100632, PubMed 32995473

Ueland T, Estensen ME, Grindheim G, Bollerslev J, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Lekva T (2020)
Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies
J Hypertens, 38 (7), 1347-1354
DOI 10.1097/HJH.0000000000002362, PubMed 31990902

Publications 2019

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

Publications 2018

Aulie HA, Estensen ME, Selvaag AM, Lilleby V, Flatø B, Aakhus S (2018)
Arterial properties in adults with long-lasting active juvenile idiopathic arthritis compared to healthy controls
Pediatr Rheumatol Online J, 16 (1), 85
DOI 10.1186/s12969-018-0302-5, PubMed 30594204

Erikssen G, Aboulhosn J, Lin J, Liestøl K, Estensen ME, Gjesdal O, Skulstad H, Døhlen G, Lindberg HL (2018)
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology
Open Heart, 5 (2), e000902
DOI 10.1136/openhrt-2018-000902, PubMed 30364544

Riise N, Lindberg BR, Kulseth MA, Fredwall SO, Lundby R, Estensen ME, Drolsum L, Merckoll E, Krohg-Sørensen K, Paus B (2018)
Clinical diagnosis of Larsen syndrome, Stickler syndrome and Loeys-Dietz syndrome in a 19-year old male: a case report
BMC Med Genet, 19 (1), 155
DOI 10.1186/s12881-018-0671-0, PubMed 30170566

Tarp JB, Sørgaard MH, Christoffersen C, Jensen AS, Sillesen H, Celermajer D, Eriksson P, Estensen ME, Nagy E, Holstein-Rathlou NH, Engstrøm T, Søndergaard L (2018)
Subclinical atherosclerosis in patients with cyanotic congenital heart disease
Int J Cardiol, 277, 97-103
DOI 10.1016/j.ijcard.2018.08.104, PubMed 30228018

Publications 2017

Hjortshøj CMS, Kempny A, Jensen AS, Sørensen K, Nagy E, Dellborg M, Johansson B, Rudiene V, Hong G, Opotowsky AR, Budts W, Mulder BJ, Tomkiewicz-Pajak L, D'Alto M, Prokšelj K, Diller GP, Dimopoulos K, Estensen ME, Holmstrøm H, Turanlahti M, Thilén U, Gatzoulis MA, Søndergaard L (2017)
Past and current cause-specific mortality in Eisenmenger syndrome
Eur Heart J, 38 (26), 2060-2067
DOI 10.1093/eurheartj/ehx201, PubMed 28430906

Hjortshøj CS, Jensen AS, Sørensen K, Nagy E, Johansson B, Kronvall T, Dellborg M, Estensen ME, Holmstrøm H, Turanlahti M, Thilén U, Søndergaard L (2017)
Epidemiological changes in Eisenmenger syndrome in the Nordic region in 1977-2012
Heart, 103 (17), 1353-1358
DOI 10.1136/heartjnl-2016-310979, PubMed 28450553

Publications 2016

Kempny A, Hjortshøj CS, Gu H, Li W, Opotowsky AR, Landzberg MJ, Jensen AS, Søndergaard L, Estensen ME, Thilén U, Budts W, Mulder BJ, Blok I, Tomkiewicz-Pająk L, Szostek K, D'Alto M, Scognamiglio G, Prokšelj K, Diller GP, Dimopoulos K, Wort SJ, Gatzoulis MA (2016)
Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study
Circulation, 135 (15), 1432-1440
DOI 10.1161/CIRCULATIONAHA.116.023033, PubMed 27979875

Publications 2015

Aulie HA, Estensen ME, Selvaag AM, Lilleby V, Murbraech K, Flatø B, Aakhus S (2015)
Cardiac Function in Adult Patients with Juvenile Idiopathic Arthritis
J Rheumatol, 42 (9), 1716-23
DOI 10.3899/jrheum.141351, PubMed 26178287

Estensen ME, Grindheim G, Remme EW, Godang K, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Ueland T (2015)
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
DOI 10.1016/j.preghy.2015.09.003, PubMed 26597749

Publications 2013

Estensen ME, Beitnes JO, Grindheim G, Aaberge L, Smiseth OA, Henriksen T, Aakhus S (2013)
Altered maternal left ventricular contractility and function during normal pregnancy
Ultrasound Obstet Gynecol, 41 (6), 659-66
DOI 10.1002/uog.12296, PubMed 23001841

Estensen ME, Remme EW, Grindheim G, Smiseth OA, Segers P, Henriksen T, Aakhus S (2013)
Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study
Am J Hypertens, 26 (4), 549-56
DOI 10.1093/ajh/hps067, PubMed 23467210

Ruys TP, Roos-Hesselink JW, Hall R, Subirana-Domènech MT, Grando-Ting J, Estensen M, Crepaz R, Fesslova V, Gurvitz M, De Backer J, Johnson MR, Pieper PG (2013)
Heart failure in pregnant women with cardiac disease: data from the ROPAC
Heart, 100 (3), 231-8
DOI 10.1136/heartjnl-2013-304888, PubMed 24293523

Publications 2012

Estensen ME, Grindheim G, Remme EW, Swillens A, Smiseth OA, Segers P, Henriksen T, Aakhus S (2012)
Systemic arterial response and ventriculo-arterial interaction during normal pregnancy
Am J Hypertens, 25 (6), 672-7
DOI 10.1038/ajh.2012.29, PubMed 22460202

Grindheim G, Estensen ME, Langesaeter E, Rosseland LA, Toska K (2012)
Changes in blood pressure during healthy pregnancy: a longitudinal cohort study
J Hypertens, 30 (2), 342-50
DOI 10.1097/HJH.0b013e32834f0b1c, PubMed 22179091

Publications 2011

Estensen M, Gude E, Ekmehag B, Lommi J, Bjortuft O, Mortensen S, Nystrom UM, Simonsen S (2011)
Pregnancy in heart- and heart/lung recipients can be problematic
Scand Cardiovasc J, 45 (6), 349-53
DOI 10.3109/14017431.2011.605168, PubMed 21879798

Grindheim G, Toska K, Estensen ME, Rosseland LA (2011)
Changes in pulmonary function during pregnancy: a longitudinal cohort study
BJOG, 119 (1), 94-101
DOI 10.1111/j.1471-0528.2011.03158.x, PubMed 22004272

Publications 2006

Estensen ME, Hognestad A, Syversen U, Squire I, Ng L, Kjekshus J, Dickstein K, Omland T (2006)
Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarction
Am Heart J, 152 (5), 927.e1-6
DOI 10.1016/j.ahj.2006.05.008, PubMed 17070161

Publications 2002

Craft N, Estensen M, Hagerup E (2002)
Fakta om kroppen din
Cappelen, [Oslo], 80 s.
BIBSYS 02086616x

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