Mathis Korseberg Stokke

  • Group leader; MD, PhD

Mathis Korseberg Stokke is group leader for Research group for Translational arrhythmology and electrophysiology at Institute for Experimental Medical Research. He is Associate Professor I at the University of Oslo, and senior consultant at the Arrhythmia unit of the Department of Cardiology, Oslo University Hospital Rikshospitalet.

Stokke did his PhD at IEMR in collaboration with David Eisners` research group at the University of Manchester, UK, and defended his thesis entitled SERCA2-RyR2 interplay at the heart of Ca2+ wave development in 2011. He continued his research at IEMR as a Postdoctoral fellow and supervisor, and spent his second period as a Postdoctoral fellow at the Department of Cardiology, OUS Rikshospitalet.

From 2008-2019, Stokke was part of the administration of the Center for Heart Failure Research, and acted as head of CHFR in 2018-2019. He has been Deputy Director of NORHEART – The Norwegian PhD School of Heart Research since 2013.

 

Publications 2020

Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjöbacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V et al. (2020)
Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Circ Arrhythm Electrophysiol, 13 (3), e007471
DOI 10.1161/CIRCEP.119.007471, PubMed 32063070

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2020)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686

Stokke MK, Castrini AI, Aneq MÅ, Jensen HK, Madsen T, Hansen J, Bundgaard H, Gilljam T, Platonov PG, Svendsen JH, Edvardsen T, Haugaa KH (2020)
Absence of ECG Task Force Criteria does not rule out structural changes in genotype positive ARVC patients
Int J Cardiol (in press)
DOI 10.1016/j.ijcard.2020.05.095, PubMed 32504717

Publications 2019

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

Conte G, Belhassen B, Lambiase P, Ciconte G, de Asmundis C, Arbelo E, Schaer B, Frontera A, Burri H, Calo' L, Letsas KP, Leyva F, Porter B, Saenen J, Zacà V, Berne P, Ammann P, Zardini M, Luani B, Rordorf R, Sarquella Brugada G, Medeiros-Domingo A, Geller JC, de Potter T, Stokke MK et al. (2019)
Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry
Europace, 21 (11), 1670-1677
DOI 10.1093/europace/euz221, PubMed 31504477

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765

Tazmini K, Fraz MSA, Nymo SH, Stokke MK, Louch WE, Øie E (2019)
Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial
Am Heart J, 221, 114-124
DOI 10.1016/j.ahj.2019.12.014, PubMed 31986288

Publications 2018

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK (2018)
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100, PubMed 30399185

Dejgaard LA, Skjølsvik ET, Lie ØH, Ribe M, Stokke MK, Hegbom F, Scheirlynck ES, Gjertsen E, Andresen K, Helle-Valle TM, Hopp E, Edvardsen T, Haugaa KH (2018)
The Mitral Annulus Disjunction Arrhythmic Syndrome
J Am Coll Cardiol, 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070, PubMed 30261961

Haugaa KH, Stokke MK (2018)
Cardiac electrical and mechanical alterations - united in the long QT syndrome
Int J Cardiol, 274, 190-191
DOI 10.1016/j.ijcard.2018.09.048, PubMed 30236503

Lie ØH, Dejgaard LA, Saberniak J, Rootwelt C, Stokke MK, Edvardsen T, Haugaa KH (2018)
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC Clin Electrophysiol, 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010, PubMed 29929667

Lie ØH, Rootwelt-Norberg C, Dejgaard LA, Leren IS, Stokke MK, Edvardsen T, Haugaa KH (2018)
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017, PubMed 30031702

Publications 2017

Lie ØH, Saberniak J, Dejgaard LA, Stokke MK, Hegbom F, Anfinsen OG, Edvardsen T, Haugaa KH (2017)
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594
DOI 10.1002/ehf2.12180, PubMed 29154430

Publications 2016

Logantha SJ, Stokke MK, Atkinson AJ, Kharche SR, Parveen S, Saeed Y, Sjaastad I, Sejersted OM, Dobrzynski H (2016)
Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front Physiol, 7, 197
DOI 10.3389/fphys.2016.00197, PubMed 27313537

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK (2016)
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Cardiovasc Res, 111 (3), 295-306
DOI 10.1093/cvr/cvw095, PubMed 27161030

Sadredini M, Danielsen TK, Aronsen JM, Manotheepan R, Hougen K, Sjaastad I, Stokke MK (2016)
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887, PubMed 27096943

Publications 2014

Aronsen JM, Skogestad J, Lewalle A, Louch WE, Hougen K, Stokke MK, Swift F, Niederer S, Smith NP, Sejersted OM, Sjaastad I (2014)
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299

Manotheepan R, Saberniak J, Danielsen TK, Edvardsen T, Sjaastad I, Haugaa KH, Stokke MK (2014)
Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1
Am J Cardiol, 113 (11), 1829-33
DOI 10.1016/j.amjcard.2014.03.012, PubMed 24837260

Publications 2013

Stokke MK, Tovsrud N, Louch WE, Øyehaug L, Hougen K, Sejersted OM, Swift F, Sjaastad I (2013)
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation
Cardiovasc Res, 98 (2), 315-25
DOI 10.1093/cvr/cvt037, PubMed 23417043

Publications 2012

Louch WE, Stokke MK, Sjaastad I, Christensen G, Sejersted OM (2012)
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754

Stokke MK, Rivelsrud F, Sjaastad I, Sejersted OM, Swift F (2012)
From global to local: a new understanding of cardiac electromechanical coupling
Tidsskr Nor Laegeforen, 132 (12-13), 1457-60
DOI 10.4045/tidsskr.11.1353, PubMed 22766818

Publications 2011

Stokke MK, Briston SJ, Jølle GF, Manzoor I, Louch WE, Øyehaug L, Christensen G, Eisner DA, Trafford AW, Sejersted OM, Sjaastad I (2011)
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164

Publications 2010

Hougen K, Aronsen JM, Stokke MK, Enger U, Nygard S, Andersson KB, Christensen G, Sejersted OM, Sjaastad I (2010)
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136

Publications 2009

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW (2009)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150

Page visits: 481