Sigrid Børte

  • MD, PhD
  • +47 928 50 480

Background: Sigrid Børte has a medical doctor degree from the University of Oslo. She finished her internship before starting her Ph.D.

Research Project: Sigrid Børte is working with the Ph.D project “Genetic and environmental causes of migraine, a large-scale family-based analysis”, using the Nord-Trøndelag Health Study, a large population cohort from Trøndelag, Norway. In addition, she is involved in the HUNT-All-in neuropsychiatry group.    

(Main supervisor/Co supervisor): Bendik S. Winsvold (main supervisor) and John-Anker Zwart (co supervisor)

Methodology and interests: Epidemiology, genetics, mitochondrial genetics

Publications

  1. Børte, S., Winsvold, B. S., Stensland, S. Ø., Sm, C., & Zwart, J. (2017). The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood . The HUNT Study, 1–12.
  2. Johnsen, M. B., Winsvold, B. S., Børte, S., Vie, G., Pedersen, L. M., Storheim, K., … Zwart, J. A. (2018). The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study. European Journal of Neurology, 25(9), 1148-e102. https://doi.org/10.1111/ene.13675
  3. Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Tune, H., … Lee, P. H. (2016). Meta-analysis of 375 , 000 individuals identifies 38 susceptibility loci for migraine, 1–29.
  4. Gormley, P., Kurki, M., Hiekkala, M. E., Veerapen, K., Häppölä, P., Mitchell, A. A., … Ripatti, S. (2018). Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron, 98(4), 743–753.e4. https://doi.org/10.1016/j.neuron.2018.04.014
 

Publications 2024

Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C et al. (2024)
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nat Genet (in press)
DOI 10.1038/s41588-024-01707-9, PubMed 38637617

Publications 2023

Jacobsen KK, Børte S, Laborie LB, Kristiansen H, Schäfer A, HUNT All-In Pain, Gundersen T, Zayats T, Slagsvold Winsvold BK, Rosendahl K (2023)
COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study
Osteoarthr Cartil Open, 6 (1), 100424
DOI 10.1016/j.ocarto.2023.100424, PubMed 38283578

Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JR, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babic D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C et al. (2023)
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
medRxiv
DOI 10.1101/2023.08.31.23294915, PubMed 37693460

Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Børte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O'Connor E, Bjornsdottir G, Häppölä P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgård FJ, Heinze K, Lund N, Thomas LF et al. (2023)
Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor
Ann Neurol, 94 (4), 713-726
DOI 10.1002/ana.26743, PubMed 37486023

Publications 2022

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R et al. (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries
Nature, 611 (7934), 115-123
DOI 10.1038/s41586-022-05165-3, PubMed 36180795

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R et al. (2022)
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
Nature, 612 (7938), E7
DOI 10.1038/s41586-022-05492-5, PubMed 36376532

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, Nielsen JB, Fritsche LG, Thomas LF, Pedersen LM, Gabrielsen ME, Johnsen MB, Meisingset TW, Zhou W, Proitsi P, Hodges A et al. (2022)
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 54 (7), 1062
DOI 10.1038/s41588-022-01126-8, PubMed 35726068

Publications 2021

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O et al. (2021)
Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 53 (2), 254
DOI 10.1038/s41588-020-00760-4, PubMed 33353957

Freidin MB, Tsepilov YA, Stanaway IB, Meng W, Hayward C, Smith BH, Khoury S, Parisien M, Bortsov A, Diatchenko L, Børte S, Winsvold BS, Brumpton BM, Zwart JA, Aulchenko YS, Suri P, Williams FMK, HUNT All-In Pain (2021)
Sex- and age-specific genetic analysis of chronic back pain
Pain, 162 (4), 1176-1187
DOI 10.1097/j.pain.0000000000002100, PubMed 33021770

Harder AVE, Winsvold BS, Noordam R, Vijfhuizen LS, Børte S, Kogelman LJA, de Boer I, Tronvik E, Rosendaal FR, Willems van Dijk K, O'Connor E, Fourier C, Thomas LF, Kristoffersen ES, Cluster Headache Genetics Working Group, Fronczek R, Pozo-Rosich P, Jensen RH, Ferrari MD, Hansen TF, Zwart JA, Terwindt GM, van den Maagdenberg AMJM (2021)
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Ann Neurol, 90 (2), 203-216
DOI 10.1002/ana.26146, PubMed 34180076

Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH et al. (2021)
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Nat Genet, 53 (6), 817-829
DOI 10.1038/s41588-021-00857-4, PubMed 34002096

Rahman MS, Winsvold BS, Chavez Chavez SO, Børte S, Tsepilov YA, Sharapov SZ, HUNT All-In Pain, Aulchenko YS, Hagen K, Fors EA, Hveem K, Zwart JA, van Meurs JB, Freidin MB, Williams FM (2021)
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
Ann Rheum Dis, 80 (9), 1227-1235
DOI 10.1136/annrheumdis-2020-219624, PubMed 33926923

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, Nielsen JB, Fritsche LG, Thomas LF, Pedersen LM, Gabrielsen ME, Johnsen MB, Meisingset TW, Zhou W, Proitsi P, Hodges A et al. (2021)
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 53 (9), 1276-1282
DOI 10.1038/s41588-021-00921-z, PubMed 34493870

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, Nielsen JB, Fritsche LG, Thomas LF, Pedersen LM, Gabrielsen ME, Johnsen MB, Meisingset TW, Zhou W, Proitsi P, Hodges A et al. (2021)
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 53 (12), 1722
DOI 10.1038/s41588-021-00977-x, PubMed 34773122

Publications 2020

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O et al. (2020)
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 52 (12), 1303-1313
DOI 10.1038/s41588-020-00725-7, PubMed 33199917

Børte S, Zwart JA, Skogholt AH, Gabrielsen ME, Thomas LF, Fritsche LG, Surakka I, Nielsen JB, Zhou W, Wolford BN, Vigeland MD, Hagen K, Kristoffersen ES, Nyholt DR, Chasman DI, Brumpton BM, Willer CJ, Winsvold BS (2020)
Mitochondrial genome-wide association study of migraine - the HUNT Study
Cephalalgia, 40 (6), 625-634
DOI 10.1177/0333102420906835, PubMed 32056457

Kristoffersen ES, Børte S, Hagen K, Zwart JA, Winsvold BS (2020)
Migraine, obesity and body fat distribution - a population-based study
J Headache Pain, 21 (1), 97
DOI 10.1186/s10194-020-01163-w, PubMed 32762643

Kristoffersen ES, Børte S, Hagen K, Zwart JA, Winsvold BS (2020)
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study
BMJ Open, 10 (11), e040685
DOI 10.1136/bmjopen-2020-040685, PubMed 33208331

Publications 2019

Børte S, Zwart JA, Stensland SØ, Hagen K, Winsvold BS (2019)
Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
Cephalalgia, 39 (7), 854-862
DOI 10.1177/0333102419828989, PubMed 30714392

Kogelman LJA, Esserlind AL, Christensen AF, Awasthi S, Ripke S, Ingason A, Davidsson OB, Erikstrup C, Hjalgrim H, Ullum H, Olesen J, Hansen TF, Gudbjartsson D, Gastafsson O, Stefansson K, Stefansson H, Porsteinsdottir U, Andersen S, Banasik K, Brunak S, Buil A, Burgdorf K, Gregor J, Jennum P, Nielsen KR et al. (2019)
Migraine polygenic risk score associates with efficacy of migraine-specific drugs
Neurol.-Genet., 5 (6), e364
DOI 10.1212/NXG.0000000000000364

Publications 2018

Johnsen MB, Winsvold BS, Børte S, Vie GÅ, Pedersen LM, Storheim K, Skorpen F, Hagen K, Bjørngaard JH, Åsvold BO, Zwart JA (2018)
The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study
Eur J Neurol, 25 (9), 1148-e102
DOI 10.1111/ene.13675, PubMed 29747220

Publications 2017

Børte S, Winsvold BS, Stensland SØ, Småstuen MC, Zwart JA (2017)
The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study
PLoS One, 12 (4), e0175908
DOI 10.1371/journal.pone.0175908, PubMed 28410431

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