Publications 2022

Berge-Seidl S, Nielsen NV, Rodriguez Alfonso AA, Etscheid M, Kandanur SPS, Haug BE, Stensland M, Thiede B, Karacan M, Preising N, Wiese S, Ständker L, Declerck PJ, Løset GÅ, Kanse SM (2022)
Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation
ACS Chem Biol, 17 (9), 2631-2642
DOI 10.1021/acschembio.2c00538, PubMed 36070465

Cui XY, Stavik B, Thiede B, Sandset PM, Kanse SM (2022)
FSAP Protects against Histone-Mediated Increase in Endothelial Permeability In Vitro
Int J Mol Sci, 23 (22)
DOI 10.3390/ijms232213706, PubMed 36430180

Etscheid M, Hanschmann KM, Sandset PM, Kanse SM (2022)
Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis
Thromb Res, 220, 24-34
DOI 10.1016/j.thromres.2022.09.027, PubMed 36265411

Harjen HJ, Hellum M, Rørtveit R, Oscarson M, Anfinsen KP, Moldal ER, Solbak S, Kanse SM, Henriksson CE (2022)
Persistent hypercoagulability in dogs envenomated by the European adder (Vipera berus berus)
PLoS One, 17 (2), e0263238
DOI 10.1371/journal.pone.0263238, PubMed 35180240

Kim JY, Manna D, Etscheid M, Leergaard TB, Kanse SM (2022)
Factor VII activating protease (FSAP) inhibits the outcome of ischemic stroke in mouse models
FASEB J, 36 (10), e22564
DOI 10.1096/fj.202200828R, PubMed 36165219

Publications 2021

Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM (2021)
Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice
Pflugers Arch, 474 (2), 217-229
DOI 10.1007/s00424-021-02639-7, PubMed 34870751

Cui XY, Tjønnfjord GE, Kanse SM, Dahm AEA, Iversen N, Myklebust CF, Sun L, Jiang ZX, Ueland T, Campbell JJ, Ho M, Sandset PM (2021)
Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia
Sci Rep, 11 (1), 5127
DOI 10.1038/s41598-021-84695-8, PubMed 33664415

Gramstad OR, Kandanur SPS, Etscheid M, Nielsen EW, Kanse SM (2021)
Factor VII activating protease (FSAP) is not essential in the pathophysiology of angioedema in patients with C1 inhibitor deficiency
Mol Immunol, 142, 95-104
DOI 10.1016/j.molimm.2021.11.019, PubMed 34973499

Uhl B, A Mittmann L, Dominik J, Hennel R, Smiljanov B, Haring F, B Schaubächer J, Braun C, Padovan L, Pick R, Canis M, Schulz C, Mack M, Gutjahr E, Sinn P, Heil J, Steiger K, Kanse SM, Weichert W, Sperandio M, Lauber K, Krombach F, Reichel CA (2021)
uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils
EMBO Mol Med, 13 (6), e13110
DOI 10.15252/emmm.202013110, PubMed 33998175

Publications 2020

Byskov K, Etscheid M, Kanse SM (2020)
Cellular effects of factor VII activating protease (FSAP)
Thromb Res, 188, 74-78
DOI 10.1016/j.thromres.2020.02.010, PubMed 32087413

Kara E, Nielsen NV, Eggertsdottir B, Thiede B, Kanse SM, Løset GÅ (2020)
Design and Characterization of a New pVII Combinatorial Phage Display Peptide Library for Protease Substrate Mining Using Factor VII Activating Protease (FSAP) as Model
Chembiochem, 21 (13), 1875-1884
DOI 10.1002/cbic.201900705, PubMed 32180321

Parahuleva MS, Worsch M, Euler G, Choukeir M, Mardini A, Parviz B, Kanse SM, Portig I, Khayrutdinov E, Schieffer B, Markus B (2020)
Factor VII Activating Protease Expression in Human Platelets and Accumulation in Symptomatic Carotid Plaque
J Am Heart Assoc, 9 (17), e016445
DOI 10.1161/JAHA.120.016445, PubMed 32856552

Publications 2019

Byskov K, Le Gall SM, Thiede B, Camerer E, Kanse SM (2019)
Protease activated receptors (PAR)-1 and -2 mediate cellular effects of factor VII activating protease (FSAP)
FASEB J, 34 (1), 1079-1090
DOI 10.1096/fj.201801986RR, PubMed 31914657

Dahm AEA, Jacobsen EM, Wik HS, Jacobsen AF, Mollnes TE, Kanse SM, Sandset PM (2019)
Elevated Complement C3 and C4 Levels are Associated with Postnatal Pregnancy-Related Venous Thrombosis
Thromb Haemost, 119 (9), 1481-1488
DOI 10.1055/s-0039-1692426, PubMed 31254974

Nielsen NV, Roedel E, Manna D, Etscheid M, Morth JP, Kanse SM (2019)
Characterization of the enzymatic activity of the serine protease domain of Factor VII activating protease (FSAP)
Sci Rep, 9 (1), 18990
DOI 10.1038/s41598-019-55531-x, PubMed 31831842

Rut W, Nielsen NV, Czarna J, Poreba M, Kanse SM, Drag M (2019)
Fluorescent activity-based probe for the selective detection of Factor VII activating protease (FSAP) in human plasma
Thromb Res, 182, 124-132
DOI 10.1016/j.thromres.2019.08.016, PubMed 31479940

Uslu Ö, Herold J, Kanse SM (2019)
VEGF-A-Cleavage by FSAP and Inhibition of Neo-Vascularization
Cells, 8 (11)
DOI 10.3390/cells8111396, PubMed 31698750

Publications 2018

Etscheid M, Subramaniam S, Lochnit G, Zabczyk M, Undas A, Lang IM, Hanschmann KM, Kanse SM (2018)
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP)
Biochim Biophys Acta Mol Basis Dis, 1864 (10), 3397-3406
DOI 10.1016/j.bbadis.2018.07.030, PubMed 30076961

Olsson M, Stanne TM, Pedersen A, Lorentzen E, Kara E, Martinez-Palacian A, Rønnow Sand NP, Jacobsen AF, Sandset PM, Sidelmann JJ, Engström G, Melander O, Kanse SM, Jern C (2018)
Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity
J Thromb Haemost, 16 (10), 2024-2034
DOI 10.1111/jth.14258, PubMed 30070759

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H (2018)
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCF^FBXW7 function
EMBO J, 37 (6)
DOI 10.15252/embj.201899170, PubMed 29545456

Subramaniam S, Kanse SM, Kothari H, Reinhardt C, Fletcher C (2018)
Post-transcriptional, post-translational and pharmacological regulation of tissue factor pathway inhibitor
Blood Coagul Fibrinolysis, 29 (8), 668-682
DOI 10.1097/MBC.0000000000000775, PubMed 30439766

Publications 2017

Byskov K, Boettger T, Ruehle PF, Nielsen NV, Etscheid M, Kanse SM (2017)
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells
Atherosclerosis, 265, 133-139
DOI 10.1016/j.atherosclerosis.2017.08.029, PubMed 28881271

Grasso S, Neumann A, Lang IM, Etscheid M, von Köckritz-Blickwede M, Kanse SM (2017)
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs)
Thromb Res, 161, 36-42
DOI 10.1016/j.thromres.2017.11.012, PubMed 29178989

Herold J, Nowak S, Kostin S, Daniel JM, Francke A, Subramaniam S, Braun-Dullaeus RC, Kanse SM (2017)
Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model
Am J Transl Res, 9 (6), 3084-3095
PubMed 28670395

Sperling C, Maitz MF, Grasso S, Werner C, Kanse SM (2017)
A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP)
ACS Appl Mater Interfaces, 9 (46), 40107-40116
DOI 10.1021/acsami.7b14281, PubMed 29091393

Publications 2016

Bustamante A, Díaz-Fernández B, Giralt D, Boned S, Pagola J, Molina CA, García-Berrocoso T, Kanse SM, Montaner J (2016)
Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke
Int J Stroke, 11 (6), 646-55
DOI 10.1177/1747493016641949, PubMed 27073188

Cheng YC, Stanne TM, Giese AK, Ho WK, Traylor M, Amouyel P, Holliday EG, Malik R, Xu H, Kittner SJ, Cole JW, O'Connell JR, Danesh J, Rasheed A, Zhao W, Engelter S, Grond-Ginsbach C, Kamatani Y, Lathrop M, Leys D, Thijs V, Metso TM, Tatlisumak T, Pezzini A, Parati EA et al. (2016)
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2
Stroke, 47 (2), 307-16
DOI 10.1161/STROKEAHA.115.011328, PubMed 26732560

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz ARM, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E (2016)
Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function
Cell Rep, 16 (8), 2197-2207
DOI 10.1016/j.celrep.2016.07.040, PubMed 27524614

Daniel JM, Reichel CA, Schmidt-Woell T, Dutzmann J, Zuchtriegel G, Krombach F, Herold J, Bauersachs J, Sedding DG, Kanse SM (2016)
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation
J Thromb Haemost, 14 (10), 2058-2067
DOI 10.1111/jth.13417, PubMed 27431088

Leiting S, Seidl S, Martinez-Palacian A, Muhl L, Kanse SM (2016)
Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes
J Biol Chem, 291 (40), 21020-21028
DOI 10.1074/jbc.M116.744631, PubMed 27462075

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H (2016)
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function
EMBO J, 36 (3), 260-273
DOI 10.15252/embj.201694795, PubMed 28007894

Publications 2015

Joshi AU, Orset C, Engelhardt B, Baumgart-Vogt E, Gerriets T, Vivien D, Kanse SM (2015)
Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice
Eur J Neurosci, 41 (7), 965-75
DOI 10.1111/ejn.12830, PubMed 25615590

Reichel CA, Hessenauer ME, Pflieger K, Rehberg M, Kanse SM, Zahler S, Krombach F, Berghaus A, Strieth S (2015)
Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects
PLoS One, 10 (2), e0116883
DOI 10.1371/journal.pone.0116883, PubMed 25658820

Publications 2014

Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R, Kanse SM (2014)
Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men (vol 58, pg 104, 2013)
J. Hepatol., 61 (4), 967
DOI 10.1016/j.jhep.2014.06.021

Martinez-Palacian A, Kanse SM, Weiskirchen R (2014)
Factor VII activating protease (FSAP): a novel protective factor in liver fibrosis
Proteomics Clin Appl, 8 (5-6), 438-46
DOI 10.1002/prca.201300078, PubMed 24497464

Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset PM, Nieswandt B, Etscheid M, Kanse SM (2014)
Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP)
Thromb Haemost, 113 (4), 870-80
DOI 10.1160/TH14-06-0519, PubMed 25427855

Publications 2013

Parahuleva MS, Maj R, Hölschermann H, Parviz B, Abdallah Y, Erdogan A, Tillmanns H, Kanse SM (2013)
Regulation of monocyte/macrophage function by factor VII activating protease (FSAP)
Atherosclerosis, 230 (2), 365-72
DOI 10.1016/j.atherosclerosis.2013.08.007, PubMed 24075769

Roedel EK, Schwarz E, Kanse SM (2013)
The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2)
J Biol Chem, 288 (10), 7193-203
DOI 10.1074/jbc.M112.433029, PubMed 23341458

Publications 2012

Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R, Kanse SM (2012)
Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men
J Hepatol, 58 (1), 104-11
DOI 10.1016/j.jhep.2012.09.007, PubMed 22989567

Etscheid M, Muhl L, Pons D, Jukema JW, König H, Kanse SM (2012)
The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity
Thromb Res, 130 (6), 935-41
DOI 10.1016/j.thromres.2012.07.023, PubMed 22906531

Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse SM, Philippe M, Benzakour O (2012)
The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner
Blood, 120 (25), 5073-83
DOI 10.1182/blood-2012-05-429183, PubMed 23065156

Hanson E, Kanse SM, Joshi A, Jood K, Nilsson S, Blomstrand C, Jern C (2012)
Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke
J Thromb Haemost, 10 (5), 848-56
DOI 10.1111/j.1538-7836.2012.04692.x, PubMed 22409238

Huber-Lang M, Denk S, Fulda S, Erler E, Kalbitz M, Weckbach S, Schneider EM, Weiss M, Kanse SM, Perl M (2012)
Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro
Mol Immunol, 50 (1-2), 60-5
DOI 10.1016/j.molimm.2011.12.005, PubMed 22244896

Kanse SM, Gallenmueller A, Zeerleder S, Stephan F, Rannou O, Denk S, Etscheid M, Lochnit G, Krueger M, Huber-Lang M (2012)
Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a
J Immunol, 188 (6), 2858-65
DOI 10.4049/jimmunol.1103029, PubMed 22308306

Parahuleva MS, Ball N, Parviz B, Zandt D, Abdallah Y, Tillmanns H, Hoelschermann H, Kanse SM (2012)
Factor seven activating protease (FSAP) expression in human placenta and its role in trophoblast migration
Eur J Obstet Gynecol Reprod Biol, 167 (1), 34-40
DOI 10.1016/j.ejogrb.2012.10.035, PubMed 23218959

Parahuleva MS, Hölschermann H, Zandt D, Pons-Kühnemann J, Parviz B, Weiskirchen R, Staubitz A, Tillmanns H, Erdogan A, Kanse SM (2012)
Circulating factor VII activating protease (FSAP) is associated with clinical outcome in acute coronary syndrome
Circ J, 76 (11), 2653-61
DOI 10.1253/circj.cj-11-1502, PubMed 22850287

Parahuleva MS, Langanke E, Hölschermann H, Parviz B, Abdallah Y, Stracke S, Tillmanns H, Kanse SM (2012)
Nicotine modulation of factor VII activating protease (FSAP) expression in human monocytes
J Atheroscler Thromb, 19 (11), 962-9
DOI 10.5551/jat.9589, PubMed 22878700

Reichel CA, Kanse SM, Krombach F (2012)
At the interface of fibrinolysis and inflammation: the role of urokinase-type plasminogen activator in the leukocyte extravasation cascade
Trends Cardiovasc Med, 22 (7), 192-6
DOI 10.1016/j.tcm.2012.07.019, PubMed 23062972

Publications 2011

Kanse SM, Declerck PJ, Ruf W, Broze G, Etscheid M (2011)
Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor
Arterioscler Thromb Vasc Biol, 32 (2), 427-33
DOI 10.1161/ATVBAHA.111.238394, PubMed 22116096

Kanse SM, Etscheid M (2011)
Factor VII activating protease. Single nucleotide polymorphisms light the way
Hamostaseologie, 31 (3), 174-6, 177-8
DOI 10.5482/ha-1159, PubMed 21655671

Kanse SM, Etscheid M (2011)
Factor VII activating protease
Hamostaseologie, 31 (3), 174-178
DOI 10.5482/ha-1159, PubMed 29589358

Trompet S, Pons D, Kanse SM, de Craen AJ, Ikram MA, Verschuren JJ, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, Slagboom PE, Westendorp RG, Jukema JW (2011)
Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality
Stroke Res Treat, 2011, 424759
DOI 10.4061/2011/424759, PubMed 21789270

Publications 2010

Baeten KM, Richard MC, Kanse SM, Mutch NJ, Degen JL, Booth NA (2010)
Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets
J Thromb Haemost, 8 (6), 1313-22
DOI 10.1111/j.1538-7836.2010.03813.x, PubMed 20180903

Parahuleva MS, Hölschermann H, Erdogan A, Langanke E, Prickartz I, Parviz B, Weiskirchen R, Tillmanns H, Kanse SM (2010)
Factor seven ativating potease (FSAP) levels during normal pregnancy and in women using oral contraceptives
Thromb Res, 126 (1), e36-40
DOI 10.1016/j.thromres.2010.03.003, PubMed 20381831

Publications 2009

Kanse SM, Etscheid M (2009)
Factor VII activating protease (FSAP): caught in the cross-fire between polycations and polyanions
J Thromb Haemost, 8 (3), 556-8
DOI 10.1111/j.1538-7836.2009.03718.x, PubMed 19995407

Muhl L, Galuska SP, Oörni K, Hernández-Ruiz L, Andrei-Selmer LC, Geyer R, Preissner KT, Ruiz FA, Kovanen PT, Kanse SM (2009)
High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease
FEBS J, 276 (17), 4828-39
DOI 10.1111/j.1742-4658.2009.07183.x, PubMed 19664058

Muhl L, Hersemeyer K, Preissner KT, Weimer T, Kanse SM (2009)
Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions
FEBS Lett, 583 (12), 1994-8
DOI 10.1016/j.febslet.2009.05.012, PubMed 19446554

Wasmuth HE, Tag CG, Van de Leur E, Hellerbrand C, Mueller T, Berg T, Puhl G, Neuhaus P, Samuel D, Trautwein C, Kanse SM, Weiskirchen R (2009)
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB
Hepatology, 49 (3), 775-80
DOI 10.1002/hep.22707, PubMed 19105210

Publications 2008

Kanse SM, Parahuleva M, Muhl L, Kemkes-Matthes B, Sedding D, Preissner KT (2008)
Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis
Thromb Haemost, 99 (2), 286-9
DOI 10.1160/TH07-10-0640, PubMed 18278176

Roderfeld M, Weiskirchen R, Atanasova S, Gressner AM, Preissner KT, Roeb E, Kanse SM (2008)
Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells
Liver Int, 29 (5), 686-91
DOI 10.1111/j.1478-3231.2008.01897.x, PubMed 19018983

Shibamiya A, Hersemeyer K, Schmidt Wöll T, Sedding D, Daniel JM, Bauer S, Koyama T, Preissner KT, Kanse SM (2008)
A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
Blood, 113 (3), 714-22
DOI 10.1182/blood-2008-02-137901, PubMed 18971420

Publications 2007

Muhl L, Nykjaer A, Wygrecka M, Monard D, Preissner KT, Kanse SM (2007)
Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP
Biochem J, 404 (2), 191-6
DOI 10.1042/BJ20061630, PubMed 17298300

Parahuleva MS, Kanse SM, Parviz B, Barth A, Tillmanns H, Bohle RM, Sedding DG, Hölschermann H (2007)
Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques
Atherosclerosis, 196 (1), 164-171
DOI 10.1016/j.atherosclerosis.2007.03.042, PubMed 17482622

Petzinger J, Saltel F, Hersemeyer K, Daniel JM, Preissner KT, Wehrle-Haller B, Kanse SM (2007)
Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins
Cell Commun Adhes, 14 (4), 137-55
DOI 10.1080/15419060701557487, PubMed 17957530

Shibamiya A, Muhl L, Tannert-Otto S, Preissner KT, Kanse SM (2007)
Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
Biochem J, 404 (1), 45-50
DOI 10.1042/BJ20070166, PubMed 17300216

Tag CG, Mengsteab S, Weiskirchen R, Kanse SM (2007)
Rapid genotyping of the G534E polymorphism (Marburg I) of the gene encoding the factor VII-activating protease (FSAP) by LightCycler PCR
Clin Biochem, 40 (13-14), 1063-4
DOI 10.1016/j.clinbiochem.2007.05.007, PubMed 17574227

Wygrecka M, Morty RE, Markart P, Kanse SM, Andreasen PA, Wind T, Guenther A, Preissner KT (2007)
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
J Biol Chem, 282 (30), 21671-82
DOI 10.1074/jbc.M610748200, PubMed 17540775

Publications 2006

Altincicek B, Shibamiya A, Trusheim H, Tzima E, Niepmann M, Linder D, Preissner KT, Kanse SM (2006)
A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding
Biochem J, 394 (Pt 3), 687-92
DOI 10.1042/BJ20051563, PubMed 16332249

Sedding D, Daniel JM, Muhl L, Hersemeyer K, Brunsch H, Kemkes-Matthes B, Braun-Dullaeus RC, Tillmanns H, Weimer T, Preissner KT, Kanse SM (2006)
The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation
J Exp Med, 203 (13), 2801-7
DOI 10.1084/jem.20052546, PubMed 17145954

Publications 2005

Kanse SM, Liang O, Schubert U, Haas H, Preissner KT, Doenhoff MJ, Dennis RD (2005)
Characterisation and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor
Mol Biochem Parasitol, 144 (1), 76-85
DOI 10.1016/j.molbiopara.2005.08.001, PubMed 16169609

Publications 2004

Kannemeier C, Al-Fakhri N, Preissner KT, Kanse SM (2004)
Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells
FASEB J, 18 (6), 728-30
DOI 10.1096/fj.03-0898fje, PubMed 14977886

Kanse SM, Chavakis T, Kuo A, Bdeir K, Cines DB, Preissner KT (2004)
Variability in the expression of urokinase receptor (CD87) mutants on cells: relevance to cell adhesion
Cell Biochem Funct, 22 (4), 257-64
DOI 10.1002/cbf.1098, PubMed 15248186

Kanse SM, Matz RL, Preissner KT, Peter K (2004)
Promotion of leukocyte adhesion by a novel interaction between vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18)
Arterioscler Thromb Vasc Biol, 24 (12), 2251-6
DOI 10.1161/01.ATV.0000146529.68729.8b, PubMed 15458976

Publications 2003

Deindl E, Ziegelhöffer T, Kanse SM, Fernandez B, Neubauer E, Carmeliet P, Preissner KT, Schaper W (2003)
Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis
FASEB J, 17 (9), 1174-6
DOI 10.1096/fj.02-0800fje, PubMed 12692088

Kanse SM, Chavakis T, Al-Fakhri N, Hersemeyer K, Monard D, Preissner KT (2003)
Reciprocal regulation of urokinase receptor (CD87)-mediated cell adhesion by plasminogen activator inhibitor-1 and protease nexin-1
J Cell Sci, 117 (Pt 3), 477-85
DOI 10.1242/jcs.00861, PubMed 14679304

Rhee JS, Santoso S, Herrmann M, Bierhaus A, Kanse SM, May AE, Nawroth PP, Colman RW, Preissner KT, Chavakis T (2003)
New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products
Curr Mol Med, 3 (4), 387-92
DOI 10.2174/1566524033479753, PubMed 12776993

Publications 2002

Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M, Preissner KT (2002)
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
Nat Med, 8 (7), 687-93
DOI 10.1038/nm728, PubMed 12091905

Chavakis T, Kanse SM, May AE, Preissner KT (2002)
Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation
Biochem Soc Trans, 30 (2), 168-73
PubMed 12023845

May AE, Schmidt R, Kanse SM, Chavakis T, Stephens RW, Schömig A, Preissner KT, Neumann FJ (2002)
Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction
Blood, 100 (10), 3611-7
DOI 10.1182/blood-2002-03-0778, PubMed 12393744

Schoppet M, Chavakis T, Al-Fakhri N, Kanse SM, Preissner KT (2002)
Molecular interactions and functional interference between vitronectin and transforming growth factor-beta
Lab Invest, 82 (1), 37-46
DOI 10.1038/labinvest.3780393, PubMed 11796824

Publications 2001

Chavakis T, Kanse SM, Pixley RA, May AE, Isordia-Salas I, Colman RW, Preissner KT (2001)
Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen
FASEB J, 15 (13), 2365-76
DOI 10.1096/fj.01-0201com, PubMed 11689462

Chavakis T, Willuweit AK, Lupu F, Preissner KT, Kanse SM (2001)
Release of soluble urokinase receptor from vascular cells
Thromb Haemost, 86 (2), 686-93
PubMed 11522023

Liang OD, Chavakis T, Kanse SM, Preissner KT (2001)
Ligand binding regions in the receptor for urokinase-type plasminogen activator
J Biol Chem, 276 (31), 28946-53
DOI 10.1074/jbc.m011347200, PubMed 11501527

Publications 2000

Chavakis T, Kanse SM, Lupu F, Hammes HP, Müller-Esterl W, Pixley RA, Colman RW, Preissner KT (2000)
Different mechanisms define the antiadhesive function of high molecular weight kininogen in integrin- and urokinase receptor-dependent interactions
Blood, 96 (2), 514-22
PubMed 10887113

Preissner KT, Kanse SM, May AE (2000)
Urokinase receptor: a molecular organizer in cellular communication
Curr Opin Cell Biol, 12 (5), 621-8
DOI 10.1016/s0955-0674(00)00141-1, PubMed 10978899

Preissner KT, Nawroth PP, Kanse SM (2000)
Vascular protease receptors: integrating haemostasis and endothelial cell functions
J Pathol, 190 (3), 360-72
DOI 10.1002/(SICI)1096-9896(200002)190:3<360::AID-PATH574>3.0.CO;2-8, PubMed 10685070

Publications 1999

Chavakis T, May AE, Preissner KT, Kanse SM (1999)
Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta2-integrins
Blood, 93 (9), 2976-83
PubMed 10216093

Klouche M, May AE, Hemmes M, Messner M, Kanse SM, Preissner KT, Bhakdi S (1999)
Enzymatically modified, nonoxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell monolayers
Arterioscler Thromb Vasc Biol, 19 (3), 784-93
DOI 10.1161/01.atv.19.3.784, PubMed 10073987

Preissner KT, Kanse SM, Chavakis T, May AE (1999)
The dual role of the urokinase receptor system in pericellular proteolysis and cell adhesion: implications for cardiovascular function
Basic Res Cardiol, 94 (5), 315-21
DOI 10.1007/s003950050157, PubMed 10543306

Wohn KD, Schmidt T, Kanse SM, Yutzy B, Germer M, Morgenstern E, Preissner KT (1999)
The role of plasminogen activator inhibitor-1 as inhibitor of platelet and megakaryoblastic cell adhesion
Br J Haematol, 104 (4), 901-8
DOI 10.1046/j.1365-2141.1999.01242.x, PubMed 10192457

Publications 1998

Chavakis T, Kanse SM, Yutzy B, Lijnen HR, Preissner KT (1998)
Vitronectin concentrates proteolytic activity on the cell surface and extracellular matrix by trapping soluble urokinase receptor-urokinase complexes
Blood, 91 (7), 2305-12
PubMed 9516128

Germer M, Kanse SM, Kirkegaard T, Kjøller L, Felding-Habermann B, Goodman S, Preissner KT (1998)
Kinetic analysis of integrin-dependent cell adhesion on vitronectin--the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptides
Eur J Biochem, 253 (3), 669-74
DOI 10.1046/j.1432-1327.1998.2530669.x, PubMed 9654064

May AE, Kanse SM, Lund LR, Gisler RH, Imhof BA, Preissner KT (1998)
Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo
J Exp Med, 188 (6), 1029-37
DOI 10.1084/jem.188.6.1029, PubMed 9743521

Publications 1997

Kanse SM, Benzakour O, Kanthou C, Kost C, Lijnen HR, Preissner KT (1997)
Induction of vascular SMC proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders
Arterioscler Thromb Vasc Biol, 17 (11), 2848-54
DOI 10.1161/01.atv.17.11.2848, PubMed 9409265

Kjøller L, Kanse SM, Kirkegaard T, Rodenburg KW, Rønne E, Goodman SL, Preissner KT, Ossowski L, Andreasen PA (1997)
Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation
Exp Cell Res, 232 (2), 420-9
DOI 10.1006/excr.1997.3540, PubMed 9168821

Preissner KT, Kanse SM, Hammes HP (1997)
Integrin chatter and vascular function in diabetic retinopathy
Horm Metab Res, 29 (12), 643-5
DOI 10.1055/s-2007-979118, PubMed 9497904

Preissner KT, May AE, Wohn KD, Germer M, Kanse SM (1997)
Molecular crosstalk between adhesion receptors and proteolytic cascades in vascular remodelling
Thromb Haemost, 78 (1), 88-95
PubMed 9198134

Ständker L, Schrader M, Kanse SM, Jürgens M, Forssmann WG, Preissner KT (1997)
Isolation and characterization of the circulating form of human endostatin
FEBS Lett, 420 (2-3), 129-33
DOI 10.1016/s0014-5793(97)01503-2, PubMed 9459295

Wohn KD, Kanse SM, Deutsch V, Schmidt T, Eldor A, Preissner KT (1997)
The urokinase-receptor (CD87) is expressed in cells of the megakaryoblastic lineage
Thromb Haemost, 77 (3), 540-7
PubMed 9066008

Publications 1996

Benzakour O, Kanthou C, Kanse SM, Scully MF, Kakkar VV, Cooper DN (1996)
Evidence for cultured human vascular smooth muscle cell heterogeneity: isolation of clonal cells and study of their growth characteristics
Thromb Haemost, 75 (5), 854-8
PubMed 8725736

Kanse SM, Kost C, Wilhelm OG, Andreasen PA, Preissner KT (1996)
The urokinase receptor is a major vitronectin-binding protein on endothelial cells
Exp Cell Res, 224 (2), 344-53
DOI 10.1006/excr.1996.0144, PubMed 8612711

Kanthou C, Kanse SM, Kakkar VV, Benzakour O (1996)
Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells
Cell Signal, 8 (1), 59-66
DOI 10.1016/0898-6568(95)02018-7, PubMed 8777142

Publications 1995

Benzakour O, Kanthou C, Newman P, Kakkar VV, Kanse SM (1995)
Long-term chemotaxis studies on adherent cells: effect of platelet-derived growth factor-BB on human vascular smooth muscle cell migration
Anal Biochem, 230 (2), 215-23
DOI 10.1006/abio.1995.1466, PubMed 7503410

Hess S, Kanse SM, Kost C, Preissner KT (1995)
The versatility of adhesion receptor ligands in haemostasis: morpho-regulatory functions of vitronectin
Thromb Haemost, 74 (1), 258-65
PubMed 8578469

Kanse SM, Wijelath E, Kanthou C, Newman P, Kakkar VV (1995)
The proliferative responsiveness of human vascular smooth muscle cells to endothelin correlates with endothelin receptor density
Lab Invest, 72 (3), 376-82
PubMed 7898056

Kanthou C, Kanse SM, Newman P, Kakkar VV, Benzakour O (1995)
Variability in the proliferative responsiveness of cultured human vascular smooth muscle cells to alpha-thrombin
Blood Coagul Fibrinolysis, 6 (8), 753-60
DOI 10.1097/00001721-199512000-00010, PubMed 8825227

Newman P, Kakkar VV, Kanse SM (1995)
Modulation of endothelin receptor expression in human vascular smooth muscle cells by interleukin-1 beta
FEBS Lett, 363 (1-2), 161-4
DOI 10.1016/0014-5793(95)00308-v, PubMed 7729539

Publications 1993

Dosso AA, Brooks RA, Beltramo E, Molinatti PA, Kanse SM, Kohner EM, Porta M (1993)
A study of the effects of human blood derivatives and individual growth factors on [3H]thymidine uptake in bovine retinal pericytes and endothelial cells
Acta Diabetol, 30 (4), 207-13
DOI 10.1007/BF00569931, PubMed 7514054

Publications 1992

Propato-Mussafiri R, Kanse SM, Ghatei MA, Bloom SR (1992)
Pituitary adenylate cyclase-activating polypeptide releases 7B2, adrenocorticotrophin, growth hormone and prolactin from the mouse and rat clonal pituitary cell lines AtT-20 and GH3
J Endocrinol, 132 (1), 107-13
DOI 10.1677/joe.0.1320107, PubMed 1310712

Publications 1991

Jamal H, Jones PM, Byrne J, Suda K, Ghatei MA, Kanse SM, Bloom SR (1991)
Peptide contents of neuropeptide Y, vasoactive intestinal polypeptide, and beta-calcitonin gene-related peptide and their messenger ribonucleic acids after dexamethasone treatment in the isolated rat islets of Langerhans
Endocrinology, 129 (6), 3372-80
DOI 10.1210/endo-129-6-3372, PubMed 1954911

Kanse SM, Takahashi K, Lam HC, Rees A, Warren JB, Porta M, Molinatti P, Ghatei M, Bloom SR (1991)
Cytokine stimulated endothelin release from endothelial cells
Life Sci, 48 (14), 1379-84
DOI 10.1016/0024-3205(91)90434-d, PubMed 1901127

Kanse SM, Takahashi K, Warren JB, Ghatei M, Bloom SR (1991)
Glucocorticoids induce endothelin release from vascular smooth muscle cells but not endothelial cells
Eur J Pharmacol, 199 (1), 99-101
DOI 10.1016/0014-2999(91)90641-3, PubMed 1893930

Kanse SM, Takahashi K, Warren JB, Perera T, Porta M, Ghatei M, Bloom SR (1991)
Production of endothelin by vascular smooth muscle cells
J Cardiovasc Pharmacol, 17 Suppl 7, S113-6
DOI 10.1097/00005344-199100177-00029, PubMed 1725301

Lam HC, Takahashi K, Ghatei MA, Suda K, Kanse SM, Bloom SR (1991)
Presence of immunoreactive endothelin in human saliva and rat parotid gland
Peptides, 12 (4), 883-5
DOI 10.1016/0196-9781(91)90151-e, PubMed 1788150

Publications 1990

Calvo JJ, Gonzalez R, De Carvalho LF, Takahashi K, Kanse SM, Hart GR, Ghatei MA, Bloom SR (1990)
Release of substance P from rat hypothalamus and pituitary by endothelin
Endocrinology, 126 (5), 2288-95
DOI 10.1210/endo-126-5-2288, PubMed 1691695

Lam HC, Takahashi K, Ghatei MA, Kanse SM, Polak JM, Bloom SR (1990)
Binding sites of a novel neuropeptide pituitary-adenylate-cyclase-activating polypeptide in the rat brain and lung
Eur J Biochem, 193 (3), 725-9
DOI 10.1111/j.1432-1033.1990.tb19392.x, PubMed 2249690

Takahashi K, Jones PM, Kanse SM, Lam HC, Spokes RA, Ghatei MA, Bloom SR (1990)
Endothelin in the gastrointestinal tract. Presence of endothelinlike immunoreactivity, endothelin-1 messenger RNA, endothelin receptors, and pharmacological effect
Gastroenterology, 99 (6), 1660-7
DOI 10.1016/0016-5085(90)90472-d, PubMed 2172072

Publications 1989

Kanse SM, Ghatei MA, Bloom SR (1989)
Endothelin binding sites in porcine aortic and rat lung membranes
Eur J Biochem, 182 (1), 175-9
DOI 10.1111/j.1432-1033.1989.tb14814.x, PubMed 2543571

Takahashi K, Brooks RA, Kanse SM, Ghatei MA, Kohner EM, Bloom SR (1989)
Production of endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes
Diabetes, 38 (9), 1200-2
DOI 10.2337/diab.38.9.1200, PubMed 2548910

Publications 1988

Kanse SM, Kreymann B, Ghatei MA, Bloom SR (1988)
Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung
FEBS Lett, 241 (1-2), 209-12
DOI 10.1016/0014-5793(88)81063-9, PubMed 2848722