PDX models

Patient derived xenograft (PDX) models are established by implanting tumor tissue from patients into mice, and are a valuable tool to investigate drug response. We have established 9 patient derived xenograft (PDX) models from patients with peritoneal metastasis from colorectal cancer and pseudomyxoma peritonei. 

Our PDX are established by implanting tumor tissue from patients with peritoneal metastasis in the peritoneal cavity in mice. By implanting it intraperitoneally we have a similar microenvironment as is present in patients. We have now established nine models from patients with pseudomyxoma peritonei and colorectal. The models have different mutations, common for their cancer of origin and are therefore good models to investigate treatment response and if that can be associated with mutations or other characteristics. Our models established from PMP and colorectal cancer has mucinous phenotype which is difficult to treat in patients. We are currently working on establishing more models from PMP and ovarian cancer.

Published articles:

Ito I et al 2023

Hyldbakk et al 2023

Fleten KG et al 2022

Andersson Y et al 2021

Fleten KG et al 2020

Flatmark K et al 2013

Flatmark K et al 2010

Flatmark K et al 2007

 
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