Bjørn Dalhus
Position: Research scientist, PhD
Phone: 230 70908
Structure group

Author network for Bjørn Dalhus by COREMINE medical

Publications 2017

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17) (in press)
PubMed 28878121

Lång A, Eriksson J, Schink KO, Lång E, Blicher P, Połeć A, Brech A, Dalhus B, Bøe SO (2017)
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
PubMed 28402725

Publications 2016

Forsberg Z, Nelson CE, Dalhus B, Mekasha S, Loose JS, Crouch LI, Røhr ÅK, Gardner JG, Eijsink VG, Vaaje-Kolstad G (2016)
Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus
J Biol Chem, 291 (14), 7300-12
PubMed 26858252

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
PubMed 26962230

Nawaz MS, Vik ES, Berges N, Fladeby C, Bjørås M, Dalhus B, Alseth I (2016)
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
PubMed 27573237

Nawaz MS, Vik ES, Ronander ME, Solvoll AM, Blicher P, Bjørås M, Alseth I, Dalhus B (2016)
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
PubMed 27108838

Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Øyan AM, Zhang W, Kalland KH, Ke X (2016)
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Proc Natl Acad Sci U S A, 113 (33), 9339-44
PubMed 27482107

Publications 2015

Dalhus B, Alseth I, Bjørås M (2015)
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V
Prog Biophys Mol Biol, 117 (2-3), 134-42
PubMed 25824682

Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR (2015)
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
PubMed 26668322

Heimdal K, Dalhus B, Rødningen OK, Kroken M, Eiklid K, Dheyauldeen S, Røysland T, Andersen R, Kulseth MA (2015)
Mutation analysis in Norwegian families with hereditary hemorrhagic telangiectasia: founder mutations in ACVRL1
Clin Genet, 89 (2), 182-6
PubMed 25970827

Mahajan TR, Ytre-Arne ME, Strøm-Andersen P, Dalhus B, Gundersen LL (2015)
Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1
Molecules, 20 (9), 15944-65
PubMed 26364627

Mekasha S, Forsberg Z, Dalhus B, Bacik JP, Choudhary S, Schmidt-Dannert C, Vaaje-Kolstad G, Eijsink VG (2015)
Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans
FEBS Lett, 590 (1), 34-42
PubMed 26763108

Naas AE, MacKenzie AK, Dalhus B, Eijsink VG, Pope PB (2015)
Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus
Sci Rep, 5, 11666
PubMed 26133573

Publications 2014

Alseth I, Dalhus B, Bjørås M (2014)
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
PubMed 25173738

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
PubMed 24652290

Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K (2014)
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
PubMed 24619930

Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
PubMed 25344603

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
PubMed 24764301

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
PubMed 25336645

Publications 2013

Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M (2013)
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
PubMed 23623903

Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Fleming AM, Burrows CJ, Dalhus B, Bjørås M (2013)
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
DNA Repair (Amst), 12 (12), 1159-64
PubMed 23755964

Rosnes I, Rowe AD, Vik ES, Forstrøm RJ, Alseth I, Bjørås M, Dalhus B (2013)
Structural basis of DNA loop recognition by endonuclease V
Structure, 21 (2), 257-65
PubMed 23313664

Simonelli V, Camerini S, Mazzei F, Van Loon B, Allione A, D'Errico M, Barone F, Minoprio A, Ricceri F, Guarrera S, Russo A, Dalhus B, Crescenzi M, Hübscher U, Bjørås M, Matullo G, Dogliotti E (2013)
Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies
Free Radic Biol Med, 63, 401-9
PubMed 23726996

Vik ES, Nawaz MS, Strøm Andersen P, Fladeby C, Bjørås M, Dalhus B, Alseth I (2013)
Endonuclease V cleaves at inosines in RNA
Nat Commun, 4, 2271
PubMed 23912683

Weel-Sneve R, Kristiansen KI, Odsbu I, Dalhus B, Booth J, Rognes T, Skarstad K, Bjørås M (2013)
Single transmembrane peptide DinQ modulates membrane-dependent activities
PLoS Genet, 9 (2), e1003260
PubMed 23408903

Publications 2012

Andersen JT, Dalhus B, Cameron J, Daba MB, Plumridge A, Evans L, Brennan SO, Gunnarsen KS, Bjørås M, Sleep D, Sandlie I (2012)
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
PubMed 22215085

Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M (2012)
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2
Structure, 21 (1), 154-166
PubMed 23245849

Fladeby C, Vik ES, Laerdahl JK, Gran Neurauter C, Heggelund JE, Thorgaard E, Strøm-Andersen P, Bjørås M, Dalhus B, Alseth I (2012)
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
PubMed 23139746

Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (2012)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
Mol Cell, 49 (2), 339-45
PubMed 23246433

Payne CM, Baban J, Horn SJ, Backe PH, Arvai AS, Dalhus B, Bjørås M, Eijsink VG, Sørlie M, Beckham GT, Vaaje-Kolstad G (2012)
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases
J Biol Chem, 287 (43), 36322-30
PubMed 22952223

Vik ES, Alseth I, Forsbring M, Helle IH, Morland I, Luna L, Bjørås M, Dalhus B (2012)
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
PubMed 22858590

Publications 2011

Belova NV, Dalhus B, Girichev GV, Giricheva NI, Haaland A, Kuzmima NP, Zhukova TA (2011)
The molecular structure of tris-2,2,6,6-tetramethyl-heptane-3,5-dione aluminium: gas-phase electron diffraction, quantum chemical calculations and X-ray crystallography
Struct. Chem., 22 (2), 393-399

Dalhus B, Forsbring M, Helle IH, Vik ES, Forstrøm RJ, Backe PH, Alseth I, Bjørås M (2011)
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
PubMed 21220122

Lauritzen KH, Dalhus B, Storm JF, Bjørås M, Klungland A (2011)
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
Mech Ageing Dev, 132 (8-9), 424-8
PubMed 21354441

Vaaje-Kolstad G, Bøhle LA, Gåseidnes S, Dalhus B, Bjørås M, Mathiesen G, Eijsink VG (2011)
Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme
J Mol Biol, 416 (2), 239-54
PubMed 22210154

Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M (2011)
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
PubMed 21570366

Publications 2010

Görbitz CH, Dalhus B, Day GM (2010)
Pseudoracemic amino acid complexes: blind predictions for flexible two-component crystals
Phys Chem Chem Phys, 12 (30), 8466-77
PubMed 20461256

Johnsen L, Flåtten I, Morigen, Dalhus B, Bjørås M, Waldminghaus T, Skarstad K (2010)
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication
Mol Microbiol, 79 (2), 433-46
PubMed 21219462

Publications 2009

Dalhus B, Arvai AS, Rosnes I, Olsen ØE, Backe PH, Alseth I, Gao H, Cao W, Tainer JA, Bjørås M (2009)
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
PubMed 19136958

Dalhus B, Laerdahl JK, Backe PH, Bjørås M (2009)
DNA base repair--recognition and initiation of catalysis
FEMS Microbiol Rev, 33 (6), 1044-78
PubMed 19659577

Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
PubMed 19443904

Hol J, Küchler AM, Johansen FE, Dalhus B, Haraldsen G, Oynebråten I (2009)
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies
J Biol Chem, 284 (35), 23532-9
PubMed 19578117

Publications 2007

Dalhus B, Helle IH, Backe PH, Alseth I, Rognes T, Bjørås M, Laerdahl JK (2007)
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
PubMed 17395642

Publications 2006

Hoell IA, Dalhus B, Heggset EB, Aspmo SI, Eijsink VG (2006)
Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes
FEBS J, 273 (21), 4889-900
PubMed 17010167

Publications 2005

Fimland G, Johnsen L, Dalhus B, Nissen-Meyer J (2005)
Pediocin-like antimicrobial peptides (class IIa bacteriocins) and their immunity proteins: biosynthesis, structure, and mode of action
J Pept Sci, 11 (11), 688-96
PubMed 16059970

Johnsen L, Dalhus B, Leiros I, Nissen-Meyer J (2005)
1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A
J Biol Chem, 280 (19), 19045-50
PubMed 15753083

Publications 2004

Bjørk A, Dalhus B, Mantzilas D, Sirevåg R, Eijsink VG (2004)
Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface
J Mol Biol, 341 (5), 1215-26
PubMed 15321717

Fooladi E, Dalhus B, Tilset M (2004)
Synthesis and characterization of half-sandwich N-heterocyclic carbene complexes of cobalt and rhodium
Dalton Trans (22), 3909-17
PubMed 15540136

Helle IH, Løkken CV, Görbitz CH, Dalhus B (2004)
Acta Crystallogr C, 60 (Pt 10), o771-2
PubMed 15467155

Moen A, Frøseth M, Görbitz CH, Dalhus B (2004)
A non-planar peptide bond in L-seryl-L-valine
Acta Crystallogr C, 60 (Pt 8), o564-5
PubMed 15295188

Publications 2003

Bjørk A, Dalhus B, Mantzilas D, Eijsink VG, Sirevåg R (2003)
Stabilization of a tetrameric malate dehydrogenase by introduction of a disulfide bridge at the dimer-dimer interface
J Mol Biol, 334 (4), 811-21
PubMed 14636605

Dalhus B, Johnsen L, Nissen-Meyer J (2003)
Crystallization and preliminary X-ray data investigation of the bacterial enterocin A immunity protein at 1.65 A resolution
Acta Crystallogr D Biol Crystallogr, 59 (Pt 7), 1291-3
PubMed 12832790

Publications 2002

Dalhus B, Saarinen M, Sauer UH, Eklund P, Johansson K, Karlsson A, Ramaswamy S, Bjørk A, Synstad B, Naterstad K, Sirevåg R, Eklund H (2002)
Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases
J Mol Biol, 318 (3), 707-21
PubMed 12054817

Fooladi E, Dalhus B, Rømming C, Tilset M (2002)
An organometallic RhIII complex with a distorted octahedral structure: (acetonitrile-kappaN)dimethyl(1,4,7-trimethyl-1,4,7-triazacyclononane-kappa3N,N',N")rhodium(III) tetraphenylborate
Acta Crystallogr C, 58 (Pt 12), m567-9
PubMed 12466599

Publications 2001

Hersleth HP, Dalhus B, Görbitz CH, Andersson KK (2001)
An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2
J Biol Inorg Chem, 7 (3), 299-304
PubMed 11935353

Publications 2000

Dalhus B, Gorbitz CH (2000)
Structural relationships in crystals accommodating different stereoisomers of 2-amino-3-methylpentanoic acid
Acta Crystallogr B, 56 (Pt 4), 720-7
PubMed 10944265

Dalhus B, Görbitz CH (2000)
Non-centrosymmetric racemates: space-group frequencies and conformational similarities between crystallographically independent molecules
Acta Crystallogr B, 56 (Pt 4), 715-9
PubMed 10944264

Publications 1999

Dalhus B, Görbitz CH (1999)
Molecular aggregation in crystalline 1:1 complexes of hydrophobic D- and L-amino acids. I. The L-isoleucine series
Acta Crystallogr B, 55 (Pt 3), 424-431
PubMed 10927385

Publications 1996

Dalhus B, Görbitz CH (1996)
Glycyl-L-leucyl-L-tyrosine dihydrate 2-propanol solvate
Acta Crystallogr C, 52 ( Pt 8), 2087-90
PubMed 8819306