
Ståle Nygård
- Elixir helpdesk leader; Ph.D.
- +47 951 29 127
Competencies: Statistics, transcriptomics, functional genomics
Publications 2021
Proteomic analyses Identify Major Vault Protein as a Prognostic Biomarker for Fatal Prostate Cancer
Carcinogenesis (in press)
DOI 10.1093/carcin/bgab015, PubMed 33609362
Publications 2020
Late-Gadolinium Enhancement Interface Area and Electrophysiological Simulations Predict Arrhythmic Events in Patients With Nonischemic Dilated Cardiomyopathy
JACC Clin Electrophysiol, 7 (2), 238-249
DOI 10.1016/j.jacep.2020.08.036, PubMed 33602406
Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants
Open Heart, 7 (2)
DOI 10.1136/openhrt-2020-001278, PubMed 32675298
Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study
Eur J Clin Nutr, 74 (12), 1707-1717
DOI 10.1038/s41430-020-0641-4, PubMed 32341488
Gene expression profile in cases of infectious death in infancy
Pediatr Res
DOI 10.1038/s41390-020-0896-4, PubMed 32299088
A framework to assess the quality and impact of bioinformatics training across ELIXIR
PLoS Comput Biol, 16 (7), e1007976
DOI 10.1371/journal.pcbi.1007976, PubMed 32702016
Muscle activity in children with spastic unilateral cerebral palsy when walking with ankle-foot orthoses: an explorative study
Gait Posture, 80, 31-36
DOI 10.1016/j.gaitpost.2020.05.011, PubMed 32485421
National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - a prospective cohort study
Scand J Trauma Resusc Emerg Med, 28 (1), 66
DOI 10.1186/s13049-020-00764-3, PubMed 32660623
Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study
Eur Heart J Cardiovasc Imaging, 21 (5), 501-507
DOI 10.1093/ehjci/jeaa004, PubMed 32031593
Publications 2019
Circulating Secretoneurin Concentrations After Cardiac Surgery: Data From the FINNish Acute Kidney Injury Heart Study
Crit Care Med, 47 (5), e412-e419
DOI 10.1097/CCM.0000000000003670, PubMed 30730440
Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: secondary analysis of a randomized controlled trial, a 7-year follow-up study
Vasc Health Risk Manag, 15, 11-18
DOI 10.2147/VHRM.S191873, PubMed 30799926
Predictors for Favorable Cognitive Outcome Post-Stroke: A-Seven-Year Follow-Up Study
Dement Geriatr Cogn Disord, 48 (1-2), 45-55
DOI 10.1159/000501850, PubMed 31461703
Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study
J Alzheimers Dis, 70 (4), 1041-1049
DOI 10.3233/JAD-190327, PubMed 31306128
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
Sci Rep, 9 (1), 9206
DOI 10.1038/s41598-019-45651-9, PubMed 31235849
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995
Diagnosing adenomyosis with MRI: a prospective study revisiting the junctional zone thickness cutoff of 12 mm as a diagnostic marker
Eur Radiol, 29 (12), 6971-6981
DOI 10.1007/s00330-019-06308-3, PubMed 31264010
Noninvasive Diagnosis of Adenomyosis: A Structured Review and Meta-analysis of Diagnostic Accuracy in Imaging
J Minim Invasive Gynecol, 27 (2), 408-418.e3
DOI 10.1016/j.jmig.2019.11.001, PubMed 31712162
Publications 2018
Signalling pathways identified in salivary glands from primary Sjögren's syndrome patients reveal enhanced adipose tissue development
Autoimmunity, 51 (3), 135-146
DOI 10.1080/08916934.2018.1446525, PubMed 29504848
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 118 (6), e11
DOI 10.1038/bjc.2017.470, PubMed 29462127
The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients
Clin Biochem, 53, 65-71
DOI 10.1016/j.clinbiochem.2018.01.012, PubMed 29371002
Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study
J Am Heart Assoc, 7 (10)
DOI 10.1161/JAHA.118.008562, PubMed 29739796
Norwegian e-Infrastructure for Life Sciences (NeLS)
F1000Res, 7
DOI 10.12688/f1000research.15119.1, PubMed 30271575
Development of a clinical prediction model for diagnosing adenomyosis
Fertil Steril, 110 (5), 957-964.e3
DOI 10.1016/j.fertnstert.2018.06.009, PubMed 30316443
Publications 2017
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy
Br J Cancer, 117 (11), 1656-1664
DOI 10.1038/bjc.2017.346, PubMed 28972967
Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study
Liver Int, 37 (10), 1554-1561
DOI 10.1111/liv.13402, PubMed 28267887
Antibodies to Signaling Molecules and Receptors in Alzheimer's Disease are Associated with Psychomotor Slowing, Depression, and Poor Visuospatial Function
J Alzheimers Dis, 59 (3), 929-939
DOI 10.3233/JAD-170245, PubMed 28697567
Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study
Biomarkers, 22 (8), 775-781
DOI 10.1080/1354750X.2016.1269200, PubMed 28049363
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study
Respir Res, 18 (1), 184
DOI 10.1186/s12931-017-0665-z, PubMed 29100503
Publications 2016
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome
Pediatr Res, 80 (1), 77-84
DOI 10.1038/pr.2016.45, PubMed 26959483
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816
Gender, High-Sensitivity Troponin I, and the Risk of Cardiovascular Events (from the Nord-Trøndelag Health Study)
Am J Cardiol, 118 (6), 816-821
DOI 10.1016/j.amjcard.2016.06.043, PubMed 27453509
Impact of Smoking on Circulating Cardiac Troponin I Concentrations and Cardiovascular Events in the General Population: The HUNT Study (Nord-Trøndelag Health Study)
Circulation, 134 (24), 1962-1972
DOI 10.1161/CIRCULATIONAHA.116.023726, PubMed 27815376
Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study
Clin Chem, 62 (10), 1380-9
DOI 10.1373/clinchem.2016.258764, PubMed 27540029
PBX3 is a putative biomarker of aggressive prostate cancer
Int J Cancer, 139 (8), 1810-20
DOI 10.1002/ijc.30220, PubMed 27273830
Prognostic Value of Secretoneurin in Critically Ill Patients With Infections
Crit Care Med, 44 (10), 1882-90
DOI 10.1097/CCM.0000000000001832, PubMed 27414477
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939
Publications 2015
[Diagnostic accuracy for heart failure – data from the Akershus Cardiac Examination 2 Study]
Tidsskr Nor Laegeforen, 135 (19), 1738-44
DOI 10.4045/tidsskr.14.1174, PubMed 26486668
Mapping the global mRNA transcriptome during development of the murine first molar
Front Genet, 6, 47
DOI 10.3389/fgene.2015.00047, PubMed 25852735
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252
Teachers' Experiences Using KODU as a Teaching Tool
PROC EUR CONF GAME, 416-422
Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: the HUNT study
Clin Chem, 61 (4), 646-56
DOI 10.1373/clinchem.2014.234369, PubMed 25695851
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
DOI 10.2147/CEG.S70119, PubMed 25624769
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells
Oncotarget, 6 (28), 26192-215
DOI 10.18632/oncotarget.4613, PubMed 26295306
Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis
Hepatology, 62 (1), 188-97
DOI 10.1002/hep.27825, PubMed 25833813
Publications 2014
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
Immunogenetics, 67 (2), 73-84
DOI 10.1007/s00251-014-0819-9, PubMed 25502872
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol (Oxf), 213 (2), 492-504
DOI 10.1111/apha.12376, PubMed 25182570
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699
Hypoxia-reoxygenation affects whole-genome expression in the newborn eye
Invest Ophthalmol Vis Sci, 55 (3), 1393-401
DOI 10.1167/iovs.13-13159, PubMed 24458145
Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
Life Sci, 97 (2), 145-54
DOI 10.1016/j.lfs.2013.12.030, PubMed 24398041
Publications 2013
Predicting physical interactions between protein complexes
Mol Cell Proteomics, 12 (6), 1723-34
DOI 10.1074/mcp.O112.019828, PubMed 23438732
Expansion of multipotent stem cells from the adult human brain
PLoS One, 8 (8), e71334
DOI 10.1371/journal.pone.0071334, PubMed 23967194
The Genomic HyperBrowser: an analysis web server for genome-scale data
Nucleic Acids Res, 41 (Web Server issue), W133-41
DOI 10.1093/nar/gkt342, PubMed 23632163
Lack of pro-inflammatory cytokine mobilization predicts poor prognosis in patients with acute heart failure
Cytokine, 61 (3), 962-9
DOI 10.1016/j.cyto.2013.01.006, PubMed 23415671
Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mTOR signaling pathway, DNA repair, and JNK-pathway regulation
Pediatr Res, 74 (5), 536-44
DOI 10.1038/pr.2013.140, PubMed 23999071
Transcriptome profiling of the newborn mouse brain after hypoxia-reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes
Pediatr Res, 75 (4), 517-26
DOI 10.1038/pr.2013.249, PubMed 24375083
Publications 2012
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts
Mol Oncol, 6 (4), 418-27
DOI 10.1016/j.molonc.2012.03.006, PubMed 22521242
New insight into the pathogenesis of retinopathy of prematurity: assessment of whole-genome expression
Pediatr Res, 73 (4 Pt 1), 476-83
DOI 10.1038/pr.2012.195, PubMed 23269122
Prognostic value of chromogranin A in severe sepsis: data from the FINNSEPSIS study
Intensive Care Med, 38 (5), 820-9
DOI 10.1007/s00134-012-2546-8, PubMed 22491939
Diagnostic utility of a single-epitope sandwich B-type natriuretic peptide assay in stable coronary artery disease: data from the Akershus Cardiac Examination (ACE) 1 Study
Clin Biochem, 45 (16-17), 1269-75
DOI 10.1016/j.clinbiochem.2012.05.010, PubMed 22609895
Cardiac troponin T levels and exercise stress testing in patients with suspected coronary artery disease: the Akershus Cardiac Examination (ACE) 1 study
Clin Sci (Lond), 122 (12), 599-606
DOI 10.1042/CS20110557, PubMed 22239123
Transient hyperosmolality modulates expression of cardiac aquaporins
Biochem Biophys Res Commun, 425 (1), 70-5
DOI 10.1016/j.bbrc.2012.07.052, PubMed 22820194
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload
Matrix Biol, 32 (2), 133-42
DOI 10.1016/j.matbio.2012.11.011, PubMed 23220517
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle
J Appl Physiol (1985), 112 (8), 1372-82
DOI 10.1152/japplphysiol.01350.2011, PubMed 22345433
Publications 2011
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway
PLoS One, 6 (12), e28302
DOI 10.1371/journal.pone.0028302, PubMed 22164265
Sequential Monte Carlo multiple testing
Bioinformatics, 27 (23), 3235-41
DOI 10.1093/bioinformatics/btr568, PubMed 21998154
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668, PubMed 21533157
Publications 2010
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload
Eur Heart J, 32 (2), 236-45
DOI 10.1093/eurheartj/ehq166, PubMed 20525982
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136
Circulating cytokine levels in mice with heart failure are etiology dependent
J Appl Physiol (1985), 108 (5), 1357-64
DOI 10.1152/japplphysiol.01084.2009, PubMed 20224000
Publications 2009
Survival prediction from clinico-genomic models--a comparative study
BMC Bioinformatics, 10, 413
DOI 10.1186/1471-2105-10-413, PubMed 20003386
Cardiac troponin I degradation in serum of patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation
Cardiology, 114 (3), 167-73
DOI 10.1159/000226596, PubMed 19571537
Gene expression profiles reflect sclerosing cholangitis activity in abcb4 (-/-) mice
Scand J Gastroenterol, 44 (2), 211-8
DOI 10.1080/00365520802400867, PubMed 18785065
Publications 2008
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J Mol Cell Cardiol, 45 (2), 261-9
DOI 10.1016/j.yjmcc.2008.05.009, PubMed 18585734
Statistical modeling of complex time-dependent data in genomics and ecology
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, nr. 811, 1 b. (flere pag.)
BIBSYS 082909911
Partial least squares Cox regression for genome-wide data
Lifetime Data Anal, 14 (2), 179-95
DOI 10.1007/s10985-007-9076-7, PubMed 18188699
Publications 2007
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis
Scand J Gastroenterol, 42 (10), 1245-55
DOI 10.1080/00365520701320521, PubMed 17852852
Publications 2002
Estimering av aldersavhengig overlevelse basert på fangst-/gjenfangst og gjenfunnsdata med anvendelser på havørndata
S. Nygård, [Trondheim], 111 s.
BIBSYS 030682711