About the group
The clinical effectiveness group at the University of Oslo and Oslo University Hospital was established in 2012 by Michael Bretthauer and Mette Kalager. The young and dynamic group performs top research in diagnostic and therapeutic interventions in several clinical areas. The current portfolio of the group includes more than 300,000 patients in clinical trials. In addition, the group runs large observational studies and tests new new statistical methods in medicine.
Signature studies of the group include the Norwegian Colorectal Cancer Prevention trial (NORCCAP), the Nordic-European Initiative on Colorectal Cancer NordICC, and the European Polyp Surveillance trials EPoS.
The group wants to move barriers in clinical research and aims at improving clinical practices. The work is team-based and inclusive. Click here for news and publications.
News
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Clinical Effectiveness Research Group co-publish new legal and ethical framework for artificial intelligence in gastrointestinal endoscopy Dec. 15, 2025 3:19 PM
A new international guideline explains how artificial intelligence (AI) should be used in gastrointestinal (GI) endoscopy so patients get the benefits without added risks. Members of the OperA project — led by the Clinical Effectiveness Research Group at the University of Oslo — coordinated a global expert panel to produce the recommendations.
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Continuous exposure to AI might reduce the skills of the endoscopist Aug. 13, 2025 10:51 AM
The ACCEPT team, part of the UiO OperA EU project, published a paper this week in the Lancet Gastroenterology and Hepatology that may generate controversy in the field of AI and colonoscopy.
Funding
The group receives research grants from many entitiescome out their amongst the Norwegian research Council, the European Union, the Norwegian cancer society, the southeast NORWAY health region, and others.
Collaboration
Collaboration: the group is running the regional network for clinical effectiveness in gastroenterology in South-East Norway which is a collaboration between researchers at Oslo University Hospital and the University of Oslo, Sørlandet Hospital in Arendal and Kristiansand, Telemark Hospital, Vestfold Hospital, Bærum Hospital Vestre Viken, Østfold Hospital and Innlandet Hospital.
The research group has a formal collaboration with these and other academic institutions abroad:
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Harvard T.H Chan School of Public Health, Boston, USA
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Karolinska Instituttet, Stockholm, Sweden
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Erasmus Medical Centre, Rotterdam, Netherlands
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Marie Curie Sklodowska Cancer Center, Warsawa, Poland
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Sloan Kettering Memorial Cancer Center, New York City, USA
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Uppsala University Hospital, Uppsala, Sweden
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Landspitali University Hospital, Reykjavik, Iceland
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Showa University Northern Yokohama Hospital, Yokohama
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King's College Hospital, London