
Marius Trøseid
- Group leader, ass. professor; MD, PhD
- +47 23 07 18 98
Publications 2021
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol
DOI 10.1080/00365521.2021.1880627, PubMed 33583308
Alterations in the kynurenine pathway of tryptophan metabolism are associated with depression in people living with HIV
J Acquir Immune Defic Syndr (in press)
DOI 10.1097/QAI.0000000000002664, PubMed 33633032
Publications 2020
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus
J Infect Dis, 221 (3), 419-427
DOI 10.1093/infdis/jiz465, PubMed 31538186
Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions
Clin Infect Dis, 71 (8), e359-e367
DOI 10.1093/cid/ciz1235, PubMed 31894240
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med
DOI 10.1111/joim.13178, PubMed 32976665
Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection
Open Forum Infect Dis, 7 (2), ofaa033
DOI 10.1093/ofid/ofaa033, PubMed 32055642
Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals
J Infect Dis, 221 (4), 506-509
DOI 10.1093/infdis/jiz253, PubMed 31077280
No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers
BMC Infect Dis, 20 (1), 882
DOI 10.1186/s12879-020-05594-3, PubMed 33238950
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology (in press)
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943
HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa714, PubMed 33216130
Elevated serum ferritin is not only a sign of liver failure
Tidsskr Nor Laegeforen, 140 (8)
DOI 10.4045/tidsskr.20.0376, PubMed 32463199
Probiotics to manage inflammation in HIV infection
Curr Opin Infect Dis, 33 (1), 34-43
DOI 10.1097/QCO.0000000000000612, PubMed 31789692
Independent Association of Interleukin 6 With Low Dynamic Lung Function and Airflow Limitation in Well-Treated People With Human Immunodeficiency Virus
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa600, PubMed 33141877
When COVID-19 meets the African health service
Tidsskr Nor Laegeforen, 140 (7)
DOI 10.4045/tidsskr.20.0283, PubMed 32378852
The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions
EBioMedicine, 52, 102649
DOI 10.1016/j.ebiom.2020.102649, PubMed 32062353
Experimental treatment for COVID-19 should be undertaken in randomised studies
Tidsskr Nor Laegeforen, 140 (7)
DOI 10.4045/tidsskr.20.0282, PubMed 32378863
Publications 2019
Effects of dietary intervention and n-3 PUFA supplementation on markers of gut-related inflammation and their association with cardiovascular events in a high-risk population
Atherosclerosis, 286, 53-59
DOI 10.1016/j.atherosclerosis.2019.05.004, PubMed 31100620
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167
DOI 10.1038/s41598-018-35367-7, PubMed 30655568
Reply: Potential risk associated with direct modulation of the gut flora in patients with heart failure
ESC Heart Fail, 6 (3), 557-558
DOI 10.1002/ehf2.12437, PubMed 31034162
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
AIDS, 33 (7), 1117-1129
DOI 10.1097/QAD.0000000000002173, PubMed 30789356
Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals
AIDS, 33 (4), 645-653
DOI 10.1097/QAD.0000000000002087, PubMed 30531315
Bone Marrow Transplantation - a cure for HIV?
Tidsskr. Nor. Laegeforen., 139 (7), 580
Bone marrow transplantation – a cure for HIV?
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.19.0199, PubMed 30969050
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J Heart Lung Transplant, 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003, PubMed 31301965
Publications 2018
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals
J Acquir Immune Defic Syndr, 78 (4), 450-457
DOI 10.1097/QAI.0000000000001693, PubMed 29874201
Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: a cross-sectional study
Diabetol Metab Syndr, 10, 59
DOI 10.1186/s13098-018-0360-3, PubMed 30038669
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Liver Int, 39 (2), 371-381
DOI 10.1111/liv.13979, PubMed 30269440
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction
Sci Rep, 8 (1), 6725
DOI 10.1038/s41598-018-25168-3, PubMed 29712976
Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts
J Am Coll Cardiol, 71 (10), 1184-1186
DOI 10.1016/j.jacc.2017.12.057, PubMed 29519360
Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial
ESC Heart Fail, 5 (5), 977-984
DOI 10.1002/ehf2.12332, PubMed 30088346
The microbial metabolite trimethylamine-N-oxide in association with inflammation and microbial dysregulation in three HIV cohorts at various disease stages
AIDS, 32 (12), 1589-1598
DOI 10.1097/QAD.0000000000001813, PubMed 29620717
Tendering for HIV drugs is not clinically justified
Tidsskr Nor Laegeforen, 138 (20)
DOI 10.4045/tidsskr.18.0808, PubMed 30539614
Tenders for HIV medicines are not academically justified
Tidsskr. Nor. Laegeforen., 138 (20), 1912-1913
Publications 2017
Tryptophan catabolism and immune activation in primary and chronic HIV infection
BMC Infect Dis, 17 (1), 349
DOI 10.1186/s12879-017-2456-z, PubMed 28511640
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect Dis, 17 (1), 445
DOI 10.1186/s12879-017-2547-x, PubMed 28645263
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation
BMC Infect Dis, 17 (1), 234
DOI 10.1186/s12879-017-2334-8, PubMed 28356058
Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals
Scand J Clin Lab Invest, 77 (8), 628-633
DOI 10.1080/00365513.2017.1393691, PubMed 29069988
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J Card Fail, 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
PLoS One, 12 (5), e0176527
DOI 10.1371/journal.pone.0176527, PubMed 28464042
Gut microbiota and acute coronary syndromes: ready for use in the emergency room?
Eur Heart J, 38 (11), 825-827
DOI 10.1093/eurheartj/ehx005, PubMed 28159962
Publications 2016
Marker of Endothelial Dysfunction Asymmetric Dimethylarginine Is Elevated in HIV Infection but Not Associated With Subclinical Atherosclerosis
J Acquir Immune Defic Syndr, 73 (5), 507-513
DOI 10.1097/QAI.0000000000001148, PubMed 27509250
Microbiota-Dependent Marker TMAO Is Elevated in Silent Ischemia but Is Not Associated With First-Time Myocardial Infarction in HIV Infection
J Acquir Immune Defic Syndr, 71 (2), 130-6
DOI 10.1097/QAI.0000000000000843, PubMed 26413854
Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected patients: a retrospective cross-sectional study
BMC Infect Dis, 16, 176
DOI 10.1186/s12879-016-1510-6, PubMed 27103116
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597
[A man in his 20s with abdominal pain and heart murmurs]
Tidsskr Nor Laegeforen, 136 (3), 238-40
DOI 10.4045/tidsskr.15.0790, PubMed 26860384
Microbiota-Dependent Marker TMAO is Not Associated With Decreased Myocardial Perfusion in Well-Treated HIV-Infected Patients as Assessed by 82Rubidium PET/CT
J Acquir Immune Defic Syndr, 72 (4), e83-5
DOI 10.1097/QAI.0000000000001044, PubMed 27152465
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816
Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function
United European Gastroenterol J, 5 (4), 532-541
DOI 10.1177/2050640616663453, PubMed 28588885
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-9
DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery
Metab Syndr Relat Disord, 14 (4), 197-201
DOI 10.1089/met.2015.0120, PubMed 27081744
Publications 2015
T-cell homeostasis in chronic HCV-infected patients treated with interferon and ribavirin or an interferon-free regimen
APMIS, 123 (10), 903-11
DOI 10.1111/apm.12429, PubMed 26279289
Personalised medicine targeting the gut microbiota?
Tidsskr Nor Laegeforen, 135 (7), 624
DOI 10.4045/tidsskr.14.1431, PubMed 25899345
Personalized intestinal flora medicine?
Tidsskr. Nor. Laegeforen., 135 (7), 624
Gut microbiota diversity predicts immune status in HIV-1 infection
AIDS, 29 (18), 2409-18
DOI 10.1097/QAD.0000000000000869, PubMed 26355675
Lower Self-Reported Quality of Life in HIV-Infected Patients on cART and With Low Comorbidity Compared With Healthy Controls
J Acquir Immune Defic Syndr, 70 (1), 16-22
DOI 10.1097/QAI.0000000000000697, PubMed 26017659
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
J Acquir Immune Defic Syndr, 70 (4), 329-37
DOI 10.1097/QAI.0000000000000784, PubMed 26258571
[Antiretroviral drugs against HIV infections]
Tidsskr Nor Laegeforen, 135 (11), 1054
DOI 10.4045/tidsskr.15.0156, PubMed 26080783
AIDS epidemic Defeats, victories and new challenges
Tidsskr. Nor. Laegeforen., 135 (11), 1059
Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients
Metab Syndr Relat Disord, 13 (3), 119-24
DOI 10.1089/met.2014.0111, PubMed 25562385
Publications 2014
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers
PLoS One, 9 (1), e85604
DOI 10.1371/journal.pone.0085604, PubMed 24416431
Plasma lipopolysaccharide and triglycerides are independently associated and both markers correlate with the development of metabolic syndrome in HIV infection
J Acquir Immune Defic Syndr, 65 (4), e158-61
DOI 10.1097/QAI.0000000000000055, PubMed 24577189
Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART
J Acquir Immune Defic Syndr, 67 (4), 370-4
DOI 10.1097/QAI.0000000000000339, PubMed 25226210
Antiretroviral treatment failure predicts mortality in rural Tanzania
Int J STD AIDS, 26 (9), 633-9
DOI 10.1177/0956462414548460, PubMed 25122578
Reduced trunk fat and triglycerides after strength training are associated with reduced LPS levels in HIV-infected individuals
J Acquir Immune Defic Syndr, 66 (2), e52-4
DOI 10.1097/QAI.0000000000000132, PubMed 24608893
Microbial translocation and cardiometabolic risk factors in HIV infection
AIDS Res Hum Retroviruses, 30 (6), 514-22
DOI 10.1089/aid.2013.0280, PubMed 24521167
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J Intern Med, 277 (6), 717-26
DOI 10.1111/joim.12328, PubMed 25382824
Publications 2013
Soluble markers of the Toll-like receptor 4 pathway differentiate between active and latent tuberculosis and are associated with treatment responses
PLoS One, 8 (7), e69896
DOI 10.1371/journal.pone.0069896, PubMed 23875007
Discrepant coagulation profile in HIV infection: elevated D-dimer but impaired platelet aggregation and clot initiation
AIDS, 27 (17), 2749-58
DOI 10.1097/01.aids.0000432462.21723.ed, PubMed 23842126
Markers of microbial translocation predict hypertension in HIV-infected individuals
HIV Med, 14 (6), 354-61
DOI 10.1111/hiv.12015, PubMed 23332095
Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction
J Acquir Immune Defic Syndr, 64 (5), 425-33
DOI 10.1097/QAI.0b013e31829f919d, PubMed 23797689
Plasma lipopolysaccharide is closely associated with glycemic control and abdominal obesity: evidence from bariatric surgery
Diabetes Care, 36 (11), 3627-32
DOI 10.2337/dc13-0451, PubMed 23835694
Publications 2012
Low nadir CD4 cell count predicts sustained hypertension in HIV-infected individuals
J Clin Hypertens (Greenwich), 15 (2), 101-6
DOI 10.1111/jch.12029, PubMed 23339727
Impact of HMGB1/TLR Ligand Complexes on HIV-1 Replication: Possible Role for Flagellin during HIV-1 Infection
Int J Microbiol, 2012, 263836
DOI 10.1155/2012/263836, PubMed 22719767
High levels of HMGB1 in plasma may be due to ex vivo cell necrosis
Anticancer Res, 32 (9), 4067-9
PubMed 22993362
Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: possible implication for TLR4-signalling and chronic immune activation
Innate Immun, 19 (3), 290-7
DOI 10.1177/1753425912461042, PubMed 23070967
Publications 2011
p24 antigen detection on dried blood spots is a feasible and reliable test for infant HIV infection in rural Tanzania
Int J STD AIDS, 22 (12), 719-21
DOI 10.1258/ijsa.2009.009382, PubMed 22174052
[The fight against HIV--two scenarios]
Tidsskr Nor Laegeforen, 131 (23), 2331
DOI 10.4045/tidsskr.11.1213, PubMed 22139097
High mobility group box protein-1 in HIV-1 infection
Curr HIV Res, 9 (1), 6-10
DOI 10.2174/157016211794582632, PubMed 21198433
Adipose tissue expression of interleukin-18 mRNA is elevated in subjects with metabolic syndrome and independently associated with fasting glucose
Wien Klin Wochenschr, 123 (21-22), 650-4
DOI 10.1007/s00508-011-0028-6, PubMed 21842238
Publications 2010
Studies on inflammation and atherosclerosis in the metabolic syndrome
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 920, 1 b. (flere pag.)
BIBSYS 100892027, ISBN 978-82-8072-581-3
[The battle against HIV can be won, but there is not enough money!]
Tidsskr Nor Laegeforen, 130 (16), 1599-600
DOI 10.4045/tidsskr.10.0705, PubMed 20805855
[A step in the right direction]
Tidsskr Nor Laegeforen, 130 (22), 2223
DOI 10.4045/tidsskr.10.1100, PubMed 21109841
Elevated plasma levels of lipopolysaccharide and high mobility group box-1 protein are associated with high viral load in HIV-1 infection: reduction by 2-year antiretroviral therapy
AIDS, 24 (11), 1733-7
DOI 10.1097/QAD.0b013e32833b254d, PubMed 20502315
The role of interleukin-18 in the metabolic syndrome
Cardiovasc Diabetol, 9, 11
DOI 10.1186/1475-2840-9-11, PubMed 20331890
Prediction of cardiovascular events by matrix metalloproteinase (MMP)-9 in elderly men
Thromb Haemost, 103 (3), 679-81
DOI 10.1160/TH09-05-0317, PubMed 20076844
Association between smoking and presence of mycoplasma pneumoniae in circulating leukocytes
Swiss Med Wkly, 140, w13105
DOI 10.4414/smw.2010.13105, PubMed 20927683
Publications 2009
Dried blood spots can expand access to virological monitoring of HIV treatment in resource-limited settings
J Antimicrob Chemother, 64 (6), 1126-9
DOI 10.1093/jac/dkp353, PubMed 19776036
Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men
Metabolism, 58 (11), 1543-9
DOI 10.1016/j.metabol.2009.04.031, PubMed 19595382
[Immune reconstitution inflammatory syndrome and treatment of HIV infection]
Tidsskr Nor Laegeforen, 129 (23), 2484-7
DOI 10.4045/tidsskr.09.0190, PubMed 19997137
The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome
Metab Syndr Relat Disord, 7 (6), 579-84
DOI 10.1089/met.2009.0003, PubMed 19900154
Arterial stiffness is independently associated with interleukin-18 and components of the metabolic syndrome
Atherosclerosis, 209 (2), 337-9
DOI 10.1016/j.atherosclerosis.2009.09.028, PubMed 19836750
Publications 2008
[Children with HIV--still a big challenge]
Tidsskr Nor Laegeforen, 128 (8), 952-3
PubMed 18459190
Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia
Diabetes Care, 32 (3), 486-92
DOI 10.2337/dc08-1710, PubMed 19092166
[Whooping cough vaccination should be re-evaluated]
Tidsskr Nor Laegeforen, 128 (2), 204
PubMed 18202739
Publications 2007
[Tuberculosis--the forgotten part of the HIV epidemic]
Tidsskr Nor Laegeforen, 127 (20), 2712-4
PubMed 17952165
Publications 2006
[Whooping cough--an increasing problem in Norway]
Tidsskr Nor Laegeforen, 126 (3), 305-8
PubMed 16440035
[Antiretroviral therapy in Poipet]
Tidsskr Nor Laegeforen, 126 (17), 2290-2
PubMed 16967084
Comparison of biochemical, functional and structural aspects of arterial wall properties in elderly men
Scand J Clin Lab Invest, 66 (2), 137-45
DOI 10.1080/00365510500474462, PubMed 16537247
Publications 2005
Statin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian family
APMIS, 113 (9), 635-7
DOI 10.1111/j.1600-0463.2005.apm_270.x, PubMed 16218940
Isolation of Bordetella pertussis in blood culture from a patient with multiple myeloma
J Infect, 52 (1), e11-3
DOI 10.1016/j.jinf.2005.04.014, PubMed 15936087
Changes in serum levels of E-selectin correlate to improved glycaemic control and reduced obesity in subjects with the metabolic syndrome
Scand J Clin Lab Invest, 65 (4), 283-90
DOI 10.1080/00365510510013811, PubMed 16076683
Publications 2004
Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
Eur Heart J, 25 (4), 349-55
DOI 10.1016/j.ehj.2003.12.006, PubMed 14984925
Publications 2002
[Reduced use of restricted-prescription preparations in general practice]
Tidsskr Nor Laegeforen, 122 (5), 482-3
PubMed 11961975
Publications 1999
[Parvovirus B19 as a cause of acute arthritis]
Tidsskr Nor Laegeforen, 119 (23), 3415-6
PubMed 10553337
Publications 1997
[Being a medical student in Michigan]
Tidsskr Nor Laegeforen, 117 (19), 2828-9
PubMed 9312879