Pierre Chymkowitch

  • Project Group Leader PhD
  • +47 916 31 231

Mini CV

Name: Pierre Chymkowitch
Date of birth: 27.05.1979
Nationality: French
Researcher unique identifier: ORCID ID

EDUCATION

2008 PhD: 21.11.2008
University of Strasbourg/IGBMC, Illkirch, France.
Adviser: Prof. Jean-Marc EGLY
2004 MSc molecular and structural biology
University of Strasbourg/IGBMC, Illkirch, France.
Supervisor: Prof. Jean-Marc EGLY

 CURRENT AND PREVIOUS POSITIONS

Current position Project Group leader
Dept. of Microbiology, Division of Clinical Laboratory Medicine, Oslo Univ. Hospital, Norway
2013 - 2016
Senior scientist
Independent project funded by the Research Council of Norway
Dept. of Molecular Cell Biology, Institute for Cancer Research, Oslo Univ. Hospital, Norway.
2009 - 2012
Post-doctoral researcher
Dept. of Microbiology, Division of Clinical Laboratory Medicine, Oslo University Hospital, Norway AND Center for Molecular Biology and Neuroscience (CMBN), Oslo, Norway.
2005 - 2008
PhD student (Employed by the French government)
IGBMC, Illkirch, France. Adviser: J-M Egly.

RESEARCH FOCUS
Signal-induced remodeling of chromatin landscape
Impact of mitotic chromatin on mitotic gene expression
Regulation of gene expression by the Small Ubiquitin-like Modifier (Sumo)
The role of Sumo during cellular differentiation

FELLOWSHIPS AND AWARDS

2017
Anders Jarhe grant for medical scientists
2016 - Researcher grant (Helse Sør Øst)
- SkatteFUNN Tax Incentive Scheme (Norwegian gov. and the Research Council of Norway)
- Anders Jarhe grant for medical scientists
2015 Oslo University Hospital's prize for best original article.
Chymkowitch et al, Genome Research 2015 (6):897:906
2014 Oslo University Hospital's prize for best original article.
Zimmermann et al, Cell Reports 5 (4), 1036-46
2013 Independent research project grant (FRIPRO). The Research Council of Norway.
2012 Anders Jarhe grant for medical scientists.
2008 Fondation Recherche Medicale (FRM) scholarship “fin de thèse scientifique”.
2005 - 2007 PhD fellowship “allocation de recherche et de moniteur de l’enseignement supérieur”.

OTHER PROFESSIONAL ACTIVITIES
Co-founder, member of the board of directors and CSO, Hemispherian AS, Oslo, Norway. Partially funded by SKATEFUNN and the ResearchCouncil of Norway (2015-present).

 

Author network for Pierre Chymkowitch by COREMINE medical


Publications 2018

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res (in press)
PubMed 30247619

Kruitwagen T, Chymkowitch P, Denoth-Lippuner A, Enserink J, Barral Y (2018)
Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
Cell, 175 (3), 780-795.e15
PubMed 30318142

Publications 2017

Chymkowitch P, Enserink JM (2017)
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
Biochim Biophys Acta Gene Regul Mech, 1861 (4), 310-319
PubMed 29127063

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
PubMed 28096404

Chymkowitch P, P AN, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2017)
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 27 (2), 334
PubMed 28148563

Enserink J, Nguéa P A, Chymkowitch P (2017)
Anabolic transcription: Secrets of the sumo diet
Cell Cycle, 16 (7), 593-594
PubMed 28278057

Zimmermann C, Garcia I, Omerzu M, Chymkowitch P, Zhang B, Enserink JM (2017)
Mapping the Synthetic Dosage Lethality Network of <i>CDK1/CDC28</i>
G3 (Bethesda), 7 (6), 1753-1766
PubMed 28428242

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2017)
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
Cell Rep, 18 (8), 2073-2074
PubMed 28228270

Publications 2015

Chymkowitch P, Nguéa P A, Enserink JM (2015)
SUMO-regulated transcription: challenging the dogma
Bioessays, 37 (10), 1095-105
PubMed 26354225

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
PubMed 25800674

Publications 2013

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2013)
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
Cell Rep, 5 (4), 1036-46
PubMed 24239358

Publications 2012

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
PubMed 22689984

Chymkowitch P, Enserink JM (2012)
The cell cycle rallies the transcription cycle: Cdc28/Cdk1 is a cell cycle-regulated transcriptional CDK
Transcription, 4 (1), 3-6
PubMed 23131667

Publications 2011

Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM (2011)
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
PubMed 22042866

Publications 2010

Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM (2010)
The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process
EMBO J, 30 (3), 468-79
PubMed 21157430

Publications 2007

Ito S, Kuraoka I, Chymkowitch P, Compe E, Takedachi A, Ishigami C, Coin F, Egly JM, Tanaka K (2007)
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients
Mol Cell, 26 (2), 231-43
PubMed 17466625

Publications 2004

Drané P, Compe E, Catez P, Chymkowitch P, Egly JM (2004)
Selective regulation of vitamin D receptor-responsive genes by TFIIH
Mol Cell, 16 (2), 187-97
PubMed 15494306

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