Pierre Chymkowitch

  • Project Group Leader PhD
  • +47 91631231

Dr. Pierre CHYMKOWITCH

PhD in Biochemistry
Date of birth: 27.05.1979, Limoges, France
Current Address: Mortensrudveien 88, 1283 OSLO, Norway
Phone number: +47 91631231
E-mail: piechy@rr-research.no

EDUCATION AND EMPLOYMENT HISTORY
2017-now:Project Group Leader, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
2016-2017:Senior Scientist, Oslo University Hospital, The Radium Hospital, Oslo, Norway.
2014-now:Co-founder and Scientific advisor, Hemispherian AS, Oslo, Norway.
2013-2016:Scientist, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
2009-2012:Post-doctoral researcher, CMBN, Oslo, Norway.
2004-2008:PhD in Cell biology and Biochemistry, IGBMC, Strasbourg, France.
2002-2004:MSc in Cell biology and Biochemistry. University of Strasbourg, France.

RESEARCH TO DATE

Project Group Leader:

I am investigating the role of SUMO during stem cells differentiation with a primary focus on adipocyte differentiation.

Post-doc/Senior scientist:

I did my post-doc in J.M. Enserink’s group (CMBN, Oslo, Norway) where I later became a self-funded senior scientist. I was investigating the implication of cyclin-dependant kinases, chromatin compaction, epigenetics and SUMO in the transcription process in S. cerevisiae.

PhD thesis:
I did my PhD in the group of J-M Egly (IGBMC, Illkirch, France), which focuses on the role of TFIIH in nuclear receptor-mediated transcription, DNA repair and human rare diseases. I investigated the role of TFIIH kinase activity during cellular response to androgenic and estrogenic hormones in patients with Xeroderma pigmentosum and Cocayne syndrome. 

PREVIOUS FUNDING

  • Helse Sør Øst researcher grant, round 2016. NOK 4150000.
  • Research Council of Norway (NFR) SkatteFUNN Tax Incentive Scheme. GenomeStream: a global platform for Next Generation DNA sequencing analysis. NOK 280000.
  • Anders Jarhe grant for medical scientists, round 2016. NOK 35000.
  • Research Council of Norway (NFR) grant for independent research project, round 2012. NOK 4548000.
  • Anders Jarhe grant for medical scientists, round 2012. NOK 30000.
  • Fondation Recherche Medicale (FRM) grant “fin de thèse scientifique” round 2007. ~21000 euros.
  • French government grant “allocation de recherche et de moniteur de l’enseignement supérieur” round 2004. ~63000 euros.

ORAL COMMUNICATIONS (selected)

  • Chymkowitch P. and Enserink JM. TORC1-dependent sumoylation of Rpc82 promotes RNAPIII assembly and activity. The Ubiquitin Family. Apr 18-22, 2017, Cold Spring Harbor Laboratory, NY, USA. Selected Abstract.
  • Chymkowitch P. Nguéa P A., Robertson J., Aanes H, Klungland A. and Enserink JM. Nutrient availability shapes the Sumo proteome to control tRNA synthesis by RNA polymerase III. OddPols 2016: International Conference on Transcription by RNA Polymerases I, III, IV and V. June 24-27, 2016. The University of Michigan, Ann Arbor, MI, USA. Selected Abstract.
  • Chymkowitch P. and Enserink JM. Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. The Ubiquitin Family. Apr 21-25, 2015, Cold Spring Harbor Laboratory, NY, USA. Selected Abstract.
  • Chymkowitch P. and Enserink JM. Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Norwegian Genomics Consortium National Meeting 2014, RaumergårdenHotel, Oslo, Norway. Invited speaker.
  • Chymkowitch P. and Enserink JM. SUMO positively regulates tDNA and RP genes transcription. Nordic Mitosis Network Meeting 2013, Holmenkollen Hotel, Oslo, Norway.
  • Chymkowitch P., Zimmermann C. and Enserink JM. Regulation of transcription by the cyclin dependent kinase Cdk1. NBS Winter meeting 2010, Storefjell Resort Hotel, Norway, Jan 14-17 2010.
  • Chymkowitch P. and Egly J-M. A deficient expression of androgen responsive genes in Xeroderma pigmentosum cells. FP6 Integrated Project DNA repair, Third Annual Review Meeting, Hilton Rotterdam Hotel, The Netherlands, 16-18 April 2008.

 

AWARDS
2015    Oslo University Hospital's prize for best original article. Chymkowitch et al, Genome Research 2015 (6):897:906
2014    Oslo University Hospital's prize for best original article. Zimmermann et al, Cell Reports 5 (4), 1036-46

COURSES

EMBO Laboratory Management Courses. The art of leadership-fewer conflicts, more results. 12-15 June 2011, Heidelberg, Germany.

SUPERVISION

 

 

Jan 2013 - now: Co-supervision of a PhD student
June - Dec 2012: Supervision of a master student
Jan - June 2012: Supervision of a master student

 

Downlaod CV in Word format

 

Author network for Pierre Chymkowitch by COREMINE medical


Publications 2017

Chymkowitch P, Enserink JM (2017)
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
Biochim Biophys Acta, 1861 (4), 310-319
PubMed 29127063

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
PubMed 28096404

Chymkowitch P, P AN, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2017)
Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 27 (2), 334
PubMed 28148563

Enserink J, Nguéa P A, Chymkowitch P (2017)
Anabolic transcription: Secrets of the sumo diet
Cell Cycle, 16 (7), 593-594
PubMed 28278057

Zimmermann C, Garcia I, Omerzu M, Chymkowitch P, Zhang B, Enserink JM (2017)
Mapping the Synthetic Dosage Lethality Network of <i>CDK1/CDC28</i>
G3 (Bethesda), 7 (6), 1753-1766
PubMed 28428242

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2017)
TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
Cell Rep, 18 (8), 2073-2074
PubMed 28228270

Publications 2015

Chymkowitch P, Nguéa P A, Enserink JM (2015)
SUMO-regulated transcription: challenging the dogma
Bioessays, 37 (10), 1095-105
PubMed 26354225

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM (2015)
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes
Genome Res, 25 (6), 897-906
PubMed 25800674

Publications 2013

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2013)
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
Cell Rep, 5 (4), 1036-46
PubMed 24239358

Publications 2012

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
PubMed 22689984

Chymkowitch P, Enserink JM (2012)
The cell cycle rallies the transcription cycle: Cdc28/Cdk1 is a cell cycle-regulated transcriptional CDK
Transcription, 4 (1), 3-6
PubMed 23131667

Publications 2011

Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM (2011)
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
PubMed 22042866

Publications 2010

Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM (2010)
The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process
EMBO J, 30 (3), 468-79
PubMed 21157430

Publications 2007

Ito S, Kuraoka I, Chymkowitch P, Compe E, Takedachi A, Ishigami C, Coin F, Egly JM, Tanaka K (2007)
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients
Mol Cell, 26 (2), 231-43
PubMed 17466625

Publications 2004

Drané P, Compe E, Catez P, Chymkowitch P, Egly JM (2004)
Selective regulation of vitamin D receptor-responsive genes by TFIIH
Mol Cell, 16 (2), 187-97
PubMed 15494306

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