Publications 2023

Bråten LCH, Gjefsen E, Gervin K, Pripp AH, Skouen JS, Schistad E, Pedersen LM, Wigemyr M, Selmer KK, Aass HCD, Goll G, Brox JI, Espeland A, Grøvle L, Zwart JA, Storheim K, AIM-study group (2023)
Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study)
J Pain Res, 16, 1713-1724
DOI 10.2147/JPR.S406079, PubMed 37252109

Gjefsen E, Gervin K, Bråten LCH, Goll GL, Aass HCD, Schistad EI, Wigemyr M, Pedersen LM, Skouen JS, Vigeland MD, Selmer KK, Storheim K, Zwart JA (2023)
Longitudinal changes of serum cytokines in patients with chronic low back pain and Modic changes
Osteoarthritis Cartilage, 31 (4), 543-547
DOI 10.1016/j.joca.2023.01.001, PubMed 36640896

Publications 2022

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Kristoffersen PM, Vetti N, Wigemyr M, Bråten LCH, Gjefsen E, Schistad EI, Haugen AJ, Froholdt A, Skouen JS, Zwart JA, Storheim K, Pedersen LM, Lie BA, AIM Study Group (2022)
Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
Sci Rep, 12 (1), 215
DOI 10.1038/s41598-021-04189-5, PubMed 34997115

Publications 2021

Gjefsen E, Gervin K, Goll G, Bråten LCH, Wigemyr M, Aass HCD, Vigeland MD, Schistad E, Pedersen LM, Pripp AH, Storheim K, Selmer KK, Zwart JA (2021)
Macrophage migration inhibitory factor: a potential biomarker for chronic low back pain in patients with Modic changes
RMD Open, 7 (2)
DOI 10.1136/rmdopen-2021-001726, PubMed 34344830

Publications 2020

Bråten LCH, Grøvle L, Espeland A, Pripp AH, Grotle M, Helllum C, Haugen AJ, Froholdt A, Rolfsen MP, Nygaard ØP, Lutro O, Kristoffersen PM, Anke A, Schistad EI, Skouen JS, Brox JI, Zwart JA, Storheim K, AIM-study group (2020)
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study)
BMC Musculoskelet Disord, 21 (1), 458
DOI 10.1186/s12891-020-03422-y, PubMed 32660517

Bråten LCH, Schistad EI, Espeland A, Kristoffersen PM, Haugen AJ, Marchand GH, Vetti N, Pripp AH, Kadar TI, Skouen JS, Grotle M, Grøvle L, Zwart JA, Brox JI, Storheim K, AIM-study group (2020)
Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM-study
BMC Musculoskelet Disord, 21 (1), 368
DOI 10.1186/s12891-020-03381-4, PubMed 32522268

Gjefsen E, Bråten LCH, Goll GL, Wigemyr M, Bolstad N, Valberg M, Schistad EI, Marchand GH, Granviken F, Selmer KK, Froholdt A, Haugen AJ, Dagestad MH, Vetti N, Bakland G, Lie BA, Haavardsholm EA, Nilsen AT, Holmgard TE, Kadar TI, Kvien T, Skouen JS, Grøvle L, Brox JI, Espeland A et al. (2020)
The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
BMC Musculoskelet Disord, 21 (1), 698
DOI 10.1186/s12891-020-03720-5, PubMed 33087100

Publications 2019

Bjorland S, Gjerstad J, Schistad E, Swanson DM, Røe C (2019)
Persistent lumbar radicular and low back pain; impact of genetic variability versus emotional distress
BMC Res Notes, 12 (1), 547
DOI 10.1186/s13104-019-4592-6, PubMed 31455415

Bråten LCH, Rolfsen MP, Espeland A, Wigemyr M, Aßmus J, Froholdt A, Haugen AJ, Marchand GH, Kristoffersen PM, Lutro O, Randen S, Wilhelmsen M, Winsvold BS, Kadar TI, Holmgard TE, Vigeland MD, Vetti N, Nygaard ØP, Lie BA, Hellum C, Anke A, Grotle M, Schistad EI, Skouen JS, Grøvle L et al. (2019)
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
BMJ, 367, l5654
DOI 10.1136/bmj.l5654, PubMed 31619437

Hasvik E, Schjølberg T, Jacobsen DP, Haugen AJ, Grøvle L, Schistad EI, Gjerstad J (2019)
Up-regulation of circulating microRNA-17 is associated with lumbar radicular pain following disc herniation
Arthritis Res Ther, 21 (1), 186
DOI 10.1186/s13075-019-1967-y, PubMed 31409426

Publications 2018

Schistad EI, Bjorland S, Røe C, Gjerstad J, Vetti N, Myhre K, Espeland A (2018)
Five-year development of lumbar disc degeneration-a prospective study
Skeletal Radiol, 48 (6), 871-879
DOI 10.1007/s00256-018-3062-x, PubMed 30255192

Publications 2017

Bjorland S, Røe C, Moen A, Schistad E, Mahmood A, Gjerstad J (2017)
Genetic predictors of recovery in low back and lumbar radicular pain
Pain, 158 (8), 1456-1460
DOI 10.1097/j.pain.0000000000000934, PubMed 28471875

Moen GH, Moen A, Schistad EI, Gjerstad J (2017)
Local up-regulation of interferon-γ (IFN-γ) following disc herniation is involved in the inflammatory response underlying acute lumbar radicular pain
Cytokine, 97, 181-186
DOI 10.1016/j.cyto.2017.06.005, PubMed 28651128

Schistad EI, Stubhaug A, Furberg AS, Engdahl BL, Nielsen CS (2017)
C-reactive protein and cold-pressor tolerance in the general population: the Tromsø Study
Pain, 158 (7), 1280-1288
DOI 10.1097/j.pain.0000000000000912, PubMed 28420008

Storheim K, Espeland A, Grøvle L, Skouen JS, Aßmus J, Anke A, Froholdt A, Pedersen LM, Haugen AJ, Fors T, Schistad E, Lutro O, Marchand GH, Kadar T, Vetti N, Randen S, Nygaard ØP, Brox JI, Grotle M, Zwart JA (2017)
Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial
Trials, 18 (1), 596
DOI 10.1186/s13063-017-2306-8, PubMed 29246188

Publications 2016

Bjorland S, Moen A, Schistad E, Gjerstad J, Røe C (2016)
Genes associated with persistent lumbar radicular pain; a systematic review
BMC Musculoskelet Disord, 17 (1), 500
DOI 10.1186/s12891-016-1356-5, PubMed 27964712

Publications 2015

Pedersen LM, Schistad E, Jacobsen LM, Røe C, Gjerstad J (2015)
Serum levels of the pro-inflammatory interleukins 6 (IL-6) and -8 (IL-8) in patients with lumbar radicular pain due to disc herniation: A 12-month prospective study
Brain Behav Immun, 46, 132-6
DOI 10.1016/j.bbi.2015.01.008, PubMed 25653193

Publications 2014

Moen A, Schistad EI, Rygh LJ, Røe C, Gjerstad J (2014)
Role of IL1A rs1800587, IL1B rs1143627 and IL1RN rs2234677 genotype regarding development of chronic lumbar radicular pain; a prospective one-year study
PLoS One, 9 (9), e107301
DOI 10.1371/journal.pone.0107301, PubMed 25207923

Schistad EI, Espeland A, Pedersen LM, Sandvik L, Gjerstad J, Røe C (2014)
Association between baseline IL-6 and 1-year recovery in lumbar radicular pain
Eur J Pain, 18 (10), 1394-401
DOI 10.1002/j.1532-2149.2014.502.x, PubMed 24692238

Schistad EI, Espeland A, Rygh LJ, Røe C, Gjerstad J (2014)
The association between Modic changes and pain during 1-year follow-up in patients with lumbar radicular pain
Skeletal Radiol, 43 (9), 1271-9
DOI 10.1007/s00256-014-1928-0, PubMed 24965739

Schistad EI, Jacobsen LM, Røe C, Gjerstad J (2014)
The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity and decreased pressure pain thresholds in patients with lumbar radicular pain
Clin J Pain, 30 (10), 869-74
DOI 10.1097/AJP.0000000000000048, PubMed 24300227

Publications 2013

Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Espeland A, Rygh LJ, Røe C, Gjerstad J (2013)
The MMP1 rs1799750 2G allele is associated with increased low back pain, sciatica, and disability after lumbar disk herniation
Clin J Pain, 29 (11), 967-71
DOI 10.1097/AJP.0b013e31827df7fd, PubMed 23370084

Publications 2012

Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Rygh LJ, Røe C, Gjerstad J (2012)
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation
Eur J Pain, 16 (7), 1064-9
DOI 10.1002/j.1532-2149.2011.00102.x, PubMed 22337560

Olsen MB, Jacobsen LM, Schistad EI, Pedersen LM, Rygh LJ, Røe C, Gjerstad J (2012)
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction
J Neurosci, 32 (29), 9831-4
DOI 10.1523/JNEUROSCI.1742-12.2012, PubMed 22815498

Publications 2010

Iordanova E, Røe C, Keller A, Skouen JS, Rygh LJ, Espeland A, Gjerstad J (2010)
[Long-lasting low back pain and MRI changes in the intervertebral discs]
Tidsskr Nor Laegeforen, 130 (22), 2260-3
DOI 10.4045/tidsskr.09.0122, PubMed 21109850