Finger pulp blood flow in systemic sclerosis patients with digital ulcers treated with sympathetic blockade
We aim to study impact of Botulinum toxin A (Botox®) and plexus blockade on blood perfusion of the finger, the effect of Botox as treatment on ulcer healing and recurrence. Measurements of skin perfusion are made using Laser Doppler flux immediate before treatment, and 4 weeks after treatment.
Project leader: Tone Kristin Bergersen. Collaborators: Department of Rheumatology.
Erythromelalgia clinical, genetic and functional studies
Throughout the last 30 years, almost 300 patients have been diagnosed with erythromelalgia at the Department of Dermatology, Oslo University Hospital, of whom five have had limb-threatening erythromelalgi. We wish to publish this series of patients to document that erythromelalgia may lead to loss of limbs. 35 patients with primary erythromelalgia have been tested for mutations in the SCN9A gene.
Phd project: Mari S. Kvernebo. Main supervisor: Knut Kvernebo. Co-supervisors: Petter Gjersvik, Cato Mørk. Collaborators: Xenon Pharmaceuticals (genetical testing)