SKIN MICROCIRCULATION

Finger pulp blood flow in systemic sclerosis patients with digital ulcers treated with sympathetic blockade

We aim to study impact of Botulinum toxin A (Botox®) and plexus blockade on blood perfusion of the finger, the effect of Botox as treatment on ulcer healing and recurrence. Measurements of skin perfusion are made using Laser Doppler flux immediate before treatment, and 4 weeks after treatment.

Project leader: Tone Kristin Bergersen. Collaborators: Department of Rheumatology.

 

Treatment of pyoderma gangrenosum at the Department of Dermatology, Oslo University Hospital

We aim to study local and systemic treatment of pyoderma gangrenosum in a retrospective cohort study designed as student project.

Project leader: Tone Kristin Bergersen. Others: Katrine Ness Johnsen, medical student.

 

Erythromelalgia – clinical, genetic and functional studies

Throughout the last 30 years, almost 300 patients have been diagnosed with erythromelalgia at the Department of Dermatology, Oslo University Hospital, of whom five have had limb-threatening erythromelalgi. We wish to publish this series of patients to document that erythromelalgia may lead to loss of limbs. 35 patients with primary erythromelalgia have been tested for mutations in the SCN9A gene.

Phd project: Mari S. Kvernebo. Main supervisor: Knut Kvernebo. Co-supervisors: Petter Gjersvik, Cato Mørk. Collaborators: Xenon Pharmaceuticals (genetical testing)

 

Sturge-Weber syndrome

Sturge-Weber syndrome (SWS) is believed to result from somatic mutations in endothelial cells. In this study, we search for possible causative somatic mutations by sequencing DNA from skin biopsies of port wine stains and non-affected tissues in patients with SWS.

Project leader: Olav Sundnes. Others: Jan Sitek. Collaborators: Kaja Selmer og Roar Fjær (geneticists).