Bjarne Bogen's research group: Cellular and molecular immunology

Bjarne Bogen
Group leader
Bjarne Bogen
Group leader

The Bogen research group performs research within three areas:

(i) T-B cell collaboration and development of autoimmunity and B lymphomas

(ii) The role of CD4+ T cells in rejection of MHC II negative tumors

(iii) Development of new vaccines against influenza and other infectious diseases.

A common theme in these three research areas is T cell recognition of immunoglobulin variable regions, and how immunoglobulins can be used for construction of targeted DNA vaccines. The group is part of KG Jebsen Centre for Research on Influenza Vaccines (research area iii).

Link to home page at UiO

Projects

  • T-B cell collaboration where T cells recognize immunoglobulin variable region peptides (Id-peptides) on MHC II molecules on B cells. The importance of BCR (B cell receptor ligation) and T cell help in such Id-driven T-B collaboration. The relationship of chronic Id-driven T-B collaboration to development of autoimmunity and B cell lymphomas.
  • Studies on bystander killing effected by Id-specific CD4+ T cells. The mechanisms by which tumors can escape killing by CD4+ T cells.
  • Development of DNA vaccines that as proteins target fused antigen to antigen presenting cells for induction of strong immune responses against influenza virus (The Vaccibody principle).

Group Leader
Bjarne Bogen
Department of Immunology
Tel: +47 23073015
E-mail: bjarne.bogen@medisin.uio.no