Publications

Publications from OUS - Dept. of Microbiology, Cellular Responses to DNA Damage (Bjørås)

316 publications found

Publications 2023

Bali N, Brennhaug SJ, Bjørås M, Bandyopadhyay S, Manaf A (2023)
Optimized synthesis of polyacrylic acid-coated magnetic nanoparticles for high-efficiency DNA isolation and size selection
RSC Adv, 13 (42), 29109-29120
DOI 10.1039/d3ra04687g, PubMed 37800135
Lin X, Wang W, Yang M, Damseh N, de Sousa MML, Jacob F, Lång A, Kristiansen E, Pannone M, Kissova M, Almaas R, Kuśnierczyk A, Siller R, Shahrour M, Al-Ashhab M, Abu-Libdeh B, Tang W, Slupphaug G, Elpeleg O, Bøe SO, Eide L, Sullivan GJ, Rinholm JE, Song H, Ming GL et al. (2023)
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
Genome Biol, 24 (1), 216
DOI 10.1186/s13059-023-03037-1, PubMed 37773136
Misceo D, Lirussi L, Strømme P, Sumathipala D, Guerin A, Wolf NI, Server A, Stensland M, Dalhus B, Tolun A, Kroes HY, Nyman TA, Nilsen HL, Frengen E (2023)
A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
Brain, 146 (8), 3513-3527
DOI 10.1093/brain/awad086, PubMed 36917474
Quiles-Jiménez A, Sousa MML, Huse C, Dyrhol-Riise AM, Holter JC, Christensen EE, Tonby K, Holten AR, Aukrust P, Bjørås M, Dahl TB, Halvorsen B (2023)
Severely ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome
J Infect, 86 (6), 593-595
DOI 10.1016/j.jinf.2023.03.002, PubMed 36889510
Radenkovic S, Laerdahl JK, Backe PH, Morava E (2023)
The role of PGM1isoform 2 in PGM1-CDG: One step closer to genotype-phenotype correlation?
J Inherit Metab Dis, 46 (2), 159-160
DOI 10.1002/jimd.12601, PubMed 36843136
Ramos-Alonso L, Holland P, Le Gras S, Zhao X, Jost B, Bjørås M, Barral Y, Enserink JM, Chymkowitch P (2023)
Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase
Proc Natl Acad Sci U S A, 120 (4), e2210593120
DOI 10.1073/pnas.2210593120, PubMed 36656860
Ravlo E, Ianevski A, Starheim E, Wang W, Ji P, Lysvand H, Smura T, Kivi G, Voolaid ML, Plaan K, Ustav M, Ustav M, Zusinaite E, Tenson T, Kurg R, Oksenych V, Walstad K, Nordbø SA, Kaarbø M, Ernits K, Bjørås M, Kainov DE, Fenstad MH (2023)
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study
Int J Infect Dis, 137, 75-78 (in press)
DOI 10.1016/j.ijid.2023.10.011, PubMed 37852599
Ravlo E, Sousa MML, Andersen LL, Holberg-Petersen M, Klundby I, Aas PA, Hagen L, Erlandsen SE, Malmring JF, Ali Z, Sharma A, Ottesen V, Bandyopadhyay S, Bjørås M (2023)
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles
Sci Rep, 13 (1), 11714
DOI 10.1038/s41598-023-38743-0, PubMed 37474666
Starheim EJ, Ravlo E, Schjølberg JO, Solvang V, Wang W, Scrimgeour NR, Manaf A, Erlandsen SE, Aas PA, Hagen L, de Sousa MML, Bjørås M (2023)
NAxtra magnetic nanoparticles for low-cost, efficient isolation of mammalian DNA and RNA
Sci Rep, 13 (1), 20836
DOI 10.1038/s41598-023-46868-5, PubMed 38012172
Sæbø IP, Bjørås M, Franzyk H, Helgesen E, Booth JA (2023)
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Int J Mol Sci, 24 (3)
DOI 10.3390/ijms24032914, PubMed 36769243
Tangeraas T, Constante JR, Backe PH, Oyarzábal A, Neugebauer J, Weinhold N, Boemer F, Debray FG, Ozturk-Hism B, Evren G, Tuba EF, Ummuhan O, Footitt E, Davison J, Martinez C, Bueno C, Machado I, Rodríguez-Pombo P, Al-Sannaa N, De Los Santos M, López JM, Ozturkmen-Akay H, Karaca M, Tekin M, Pajares S et al. (2023)
BCKDK deficiency: a treatable neurodevelopmental disease amenable to newborn screening
Brain, 146 (7), 3003-3013
DOI 10.1093/brain/awad010, PubMed 36729635
Thorfinnsdottir LB, Bø GH, Booth JA, Bruheim P (2023)
Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions
Front Microbiol, 14, 1149978
DOI 10.3389/fmicb.2023.1149978, PubMed 36970700
Yang M, Ali O, Bjørås M, Wang J (2023)
Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data
iScience, 26 (8), 107266
DOI 10.1016/j.isci.2023.107266, PubMed 37520692

Publications 2022

Ali O, Farooq A, Yang M, Jin VX, Bjørås M, Wang J (2022)
abc4pwm: affinity based clustering for position weight matrices in applications of DNA sequence analysis
BMC Bioinformatics, 23 (1), 83
DOI 10.1186/s12859-022-04615-z, PubMed 35240993
Egiazarian MA, Strømstad S, Sakshaug T, Nunez-Nescolarde AB, Bethge N, Bjørås M, Scheffler K (2022)
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med, 193 (Pt 2), 685-693
DOI 10.1016/j.freeradbiomed.2022.11.020, PubMed 36395955
Frick R, Høydahl LS, Hodnebrug I, Vik ES, Dalhus B, Sollid LM, Gray JJ, Sandlie I, Løset GÅ (2022)
Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
Protein Eng Des Sel, 35
DOI 10.1093/protein/gzac005, PubMed 35871543
Ianevski A, Simonsen RM, Myhre V, Tenson T, Oksenych V, Bjørås M, Kainov DE (2022)
DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)
Nucleic Acids Res, 50 (W1), W272-W275
DOI 10.1093/nar/gkac348, PubMed 35610052
Karlsen TR, Olsen MB, Kong XY, Yang K, Quiles-Jiménez A, Kroustallaki P, Holm S, Lines GT, Aukrust P, Skarpengland T, Bjørås M, Dahl TB, Nilsen H, Gregersen I, Halvorsen B (2022)
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length
Biochem Biophys Rep, 29, 101211
DOI 10.1016/j.bbrep.2022.101211, PubMed 35079641
Kennedy L, Glesaaen ER, Palibrk V, Pannone M, Wang W, Al-Jabri A, Suganthan R, Meyer N, Austbø ML, Lin X, Bergersen LH, Bjørås M, Rinholm JE (2022)
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia
Elife, 11
DOI 10.7554/eLife.76451, PubMed 35942676
Kaarbø M, Yang M, Hov JR, Holm K, de Sousa MML, Macpherson ME, Reims HM, Kran AB, Halvorsen B, Karlsen TH, Aukrust P, Lundin KEA, Fevang B, Bjørås M, Jørgensen SF (2022)
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400
Li M, Klungland A, Dalhus B (2022)
Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST)
Methods Mol Biol, 2528, 239-251
DOI 10.1007/978-1-0716-2477-7_15, PubMed 35704195
Olsen MB, Huse C, de Sousa MML, Murphy SL, Sarno A, Obermann TS, Yang K, Holter JC, Jørgensen MJ, Christensen EE, Wang W, Ji P, Heggelund L, Hoel H, Dyrhol-Riise AM, Gregersen I, Aukrust P, Bjørås M, Halvorsen B, Dahl TB (2022)
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
J Inflamm Res, 15, 6629-6644
DOI 10.2147/JIR.S379331, PubMed 36514358
Olsen MB, Sannes AC, Yang K, Nielsen MB, Einarsen SV, Christensen JO, Pallesen S, Bjørås M, Gjerstad J (2022)
Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions
iScience, 25 (9), 104953
DOI 10.1016/j.isci.2022.104953, PubMed 36060062
Quiles-Jiménez A, Dahl TB, Bjørås M, Alseth I, Halvorsen B, Gregersen I (2022)
Epitranscriptome in Ischemic Cardiovascular Disease: Potential Target for Therapies
Stroke, 53 (6), 2114-2122
DOI 10.1161/STROKEAHA.121.037581, PubMed 35240858
Sumathipala D, Strømme P, Fattahi Z, Lüders T, Sheng Y, Kahrizi K, Einarsen IH, Sloan JL, Najmabadi H, van den Heuvel L, Wevers RA, Guerrero-Castillo S, Mørkrid L, Valayannopoulos V, Backe PH, Venditti CP, van Karnebeek CD, Nilsen H, Frengen E, Misceo D (2022)
ZBTB11 dysfunction: spectrum of brain abnormalities, biochemical signature and cellular consequences
Brain, 145 (7), 2602-2616
DOI 10.1093/brain/awac034, PubMed 35104841
Ørstavik K, Arntzen KA, Mathisen P, Backe PH, Tangeraas T, Rasmussen M, Kristensen E, Van Ghelue M, Jonsrud C, Bliksrud YT (2022)
Novel mutations in the HADHB gene causing a mild phenotype of mitochondrial trifunctional protein (MTP) deficiency
JIMD Rep, 63 (3), 193-198
DOI 10.1002/jmd2.12276, PubMed 35433169

Publications 2021

Ahmadi A, Till K, Backe PH, Blicher P, Diekmann R, Schüttpelz M, Glette K, Tørresen J, Bjørås M, Rowe AD, Dalhus B (2021)
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Commun Biol, 4 (1), 876
DOI 10.1038/s42003-021-02400-x, PubMed 34267321
Andersen E, Chollet ME, Sletten M, Stavik B, Skarpen E, Backe PH, Thiede B, Glosli H, Henriksson CE, Iversen N (2021)
Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding
Thromb Haemost, 121 (12), 1588-1598
DOI 10.1055/a-1450-8568, PubMed 33742435
Aprigliano R, Aksu ME, Bradamante S, Mihaljevic B, Wang W, Rian K, Montaldo NP, Grooms KM, Fordyce Martin SL, Bordin DL, Bosshard M, Peng Y, Alexov E, Skinner C, Liabakk NB, Sullivan GJ, Bjørås M, Schwartz CE, van Loon B (2021)
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
Cell Rep Med, 2 (4), 100240
DOI 10.1016/j.xcrm.2021.100240, PubMed 33948573
Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, Kåsine T, Lund-Johansen F, Hoel H, Holten AR, Tveita A, Mathiessen A, Haugli M, Eiken R, Kildal AB, Berg Å, Johannessen A, Heggelund L, Dahl TB, Skåra KH, Mielnik P, Le LAK, Thoresen L, Ernst G, Hoff DAL, Skudal H, Kittang BR, Olsen RB et al. (2021)
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903
Blindheim FH, Malme AT, Dalhus B, Sundby E, Hoff BH (2021)
Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors
ChemistrySelect, 6 (45), 12852-12857
DOI 10.1002/slct.202103796
Carlson CR, Aronsen JM, Bergan-Dahl A, Moutty MC, Lunde M, Lunde PK, Jarstadmarken H, Wanichawan P, Pereira L, Kolstad TRS, Dalhus B, Subramanian H, Hille S, Christensen G, Müller OJ, Nikolaev V, Bers DM, Sjaastad I, Shen X, Louch WE, Klussmann E, Sejersted OM (2021)
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703
de Sousa MML, Ye J, Luna L, Hildrestrand G, Bjørås K, Scheffler K, Bjørås M (2021)
Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction
Int J Mol Sci, 22 (23)
DOI 10.3390/ijms222312924, PubMed 34884729
Fjær R, Marciniak K, Sundnes O, Hjorthaug H, Sheng Y, Hammarström C, Sitek JC, Vigeland MD, Backe PH, Øye AM, Fosse JH, Stav-Noraas TE, Uchiyama Y, Matsumoto N, Comi A, Pevsner J, Haraldsen G, Selmer KK (2021)
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome
Hum Mol Genet, 30 (21), 1919-1931
DOI 10.1093/hmg/ddab144, PubMed 34124757
Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kuśnierczyk A, Olsen AK, Gützkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Sætrom P, Luna L, Ye J, Scheffler K, Bjørås M (2021)
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice
Commun Biol, 4 (1), 1354
DOI 10.1038/s42003-021-02864-x, PubMed 34857879
Holm S, Kared H, Michelsen AE, Kong XY, Dahl TB, Schultz NH, Nyman TA, Fladeby C, Seljeflot I, Ueland T, Stensland M, Mjaaland S, Goll GL, Nissen-Meyer LS, Aukrust P, Skagen K, Gregersen I, Skjelland M, Holme PA, Munthe LA, Halvorsen B (2021)
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia
Eur Heart J, 42 (39), 4064-4072
DOI 10.1093/eurheartj/ehab506, PubMed 34405870
Karlsen TR, Kong XY, Holm S, Quiles-Jiménez A, Dahl TB, Yang K, Sagen EL, Skarpengland T, S Øgaard JD, Holm K, Vestad B, Olsen MB, Aukrust P, Bjørås M, Hov JR, Halvorsen B, Gregersen I (2021)
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0, PubMed 34611194
Kong XY, Huse C, Yang K, Øgaard J, Berges N, Vik ES, Nawaz MS, Quiles-Jiménez A, Abbas A, Gregersen I, Holm S, Bjerkli V, Rashidi A, Fladeby C, Suganthan R, Sagen EL, Skjelland M, Lång A, Bøe SO, Bjørås M, Aukrust P, Alseth I, Halvorsen B, Dahl TB (2021)
Endonuclease V Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration
J Am Heart Assoc, 10 (14), e020656
DOI 10.1161/JAHA.120.020656, PubMed 34259011
Kunath N, Bugaj AM, Bigonah P, Fernandez-Berrocal MS, Bjørås M, Ye J (2021)
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
iScience, 24 (12), 103470
DOI 10.1016/j.isci.2021.103470, PubMed 34988395
Lind A, Barlinn R, Landaas ET, Andresen LL, Jakobsen K, Fladeby C, Nilsen M, Bjørnstad PM, Sundaram AYM, Ribarska T, Müller F, Gilfillan GD, Holberg-Petersen M (2021)
Rapid SARS-CoV-2 variant monitoring using PCR confirmed by whole genome sequencing in a high-volume diagnostic laboratory
J Clin Virol, 141, 104906
DOI 10.1016/j.jcv.2021.104906, PubMed 34273860
Lobie TA, Roba AA, Booth JA, Kristiansen KI, Aseffa A, Skarstad K, Bjørås M (2021)
Antimicrobial resistance: A challenge awaiting the post-COVID-19 era
Int J Infect Dis, 111, 322-325
DOI 10.1016/j.ijid.2021.09.003, PubMed 34508864
Müller KE, Blomberg B, Tellevik MG, Jensenius M, Fladeby C, Lier T, Sand G, Hannula R, Langeland N, Mørch K (2021)
Leishmaniasis in Norway
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.19.0171, PubMed 33624958
Quan Z, Luo C, Zhu B, Zhao C, Yang M, Bjørås M, Zhu K, Kjøniksen AL (2021)
Synthesis and antimicrobial activities of chitosan/polypropylene carbonate-based nanoparticles
RSC Adv, 11 (17), 10121-10129
DOI 10.1039/d0ra09257f, PubMed 35423476
Quiles-Jiménez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygård S, Scheffler K, Prins J, Van der Veer E, Øgaard JD, Fløisand Y, Jørgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552
Roliński M, Montaldo NP, Aksu ME, Fordyce Martin SL, Brambilla A, Kunath N, Johansen J, Erlandsen SE, Liabbak NB, Rian K, Bjørås M, Sætrom P, van Loon B (2021)
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
Nucleic Acids Res, 49 (3), 1470-1484
DOI 10.1093/nar/gkaa1289, PubMed 33444446
Smith V, Nilssen IKB, Hegna IK, Dalhus B, Fagerlund A, Økstad OA (2021)
CdgL is a degenerate nucleotide cyclase domain protein affecting flagellin synthesis and motility in Bacillus thuringiensis
Res Microbiol, 172 (4-5), 103850
DOI 10.1016/j.resmic.2021.103850, PubMed 34082027
Xu KQ, Chatzitakis A, Backe PH, Ruan QS, Tang JW, Rise F, Bjoras M, Norby T (2021)
In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell
Appl. Catal. B-Environ., 296, 120349
DOI 10.1016/j.apcatb.2021.120349
Xu KQ, Chatzitakis A, Risbakk S, Yang MY, Backe PH, Grandcolas M, Bjoras M, Norby T (2021)
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catal. Today, 361, 57-62
DOI 10.1016/j.cattod.2019.12.031

Publications 2020

Ashuro AA, Lobie TA, Ye DQ, Leng RX, Li BZ, Pan HF, Fan YG (2020)
Review on the Alteration of Gut Microbiota: The Role of HIV Infection and Old Age
AIDS Res Hum Retroviruses, 36 (7), 556-565
DOI 10.1089/AID.2019.0282, PubMed 32323556
Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M (2020)
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390
Bjoras M (2020)
Nobel Prize for discovering how cells adapt to changing oxygen levels
Tidsskr. Nor. Laegeforen., 140 (1), 8
Booth JA, Špírek M, Lobie TA, Skarstad K, Krejci L, Bjørås M (2020)
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
Sci Rep, 10 (1), 19422
DOI 10.1038/s41598-020-76426-2, PubMed 33173044
Farooq A, Grønmyr S, Ali O, Rognes T, Scheffler K, Bjørås M, Wang J (2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148
Grøsvik K, Tesfahun AN, Muruzábal-Lecumberri I, Haugland GT, Leiros I, Ruoff P, Kvaløy JT, Knævelsrud I, Ånensen H, Alexeeva M, Sato K, Matsuda A, Alseth I, Klungland A, Bjelland S (2020)
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Front Microbiol, 11, 263
DOI 10.3389/fmicb.2020.00263, PubMed 32158436
Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667
Lobie TA, Woldeamanuel Y, Asrat D, Beyene D, Bjørås M, Aseffa A (2020)
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
PLoS One, 15 (4), e0231320
DOI 10.1371/journal.pone.0231320, PubMed 32267877
Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
Nedal A, Ræder SB, Dalhus B, Helgesen E, Forstrøm RJ, Lindland K, Sumabe BK, Martinsen JH, Kragelund BB, Skarstad K, Bjørås M, Otterlei M (2020)
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931
Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT (2020)
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072
Naas AE, MacKenzie AK, Dalhus B, Eijsink VGH, Pope PB (2020)
Author Correction: Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus
Sci Rep, 10 (1), 6287
DOI 10.1038/s41598-020-62786-2, PubMed 32269252
Połeć A, Rowe AD, Blicher P, Suganthan R, Bjørås M, Bøe SO (2020)
PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis
Genes (Basel), 11 (10)
DOI 10.3390/genes11101130, PubMed 32992884
Quiles-Jiménez A, Gregersen I, Mittelstedt Leal de Sousa M, Abbas A, Kong XY, Alseth I, Holm S, Dahl TB, Skagen K, Skjelland M, Aukrust P, Bjørås M, Halvorsen B (2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177
Rodriguez-Vargas JM, Martin-Hernandez K, Wang W, Kunath N, Suganthan R, Amé JC, Oliver FJ, Ye J, Bjørås M, Dantzer F (2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Cell Death Dis, 11 (11), 954
DOI 10.1038/s41419-020-03167-5, PubMed 33159039
Sahaf Naeini A, Farooq A, Bjørås M, Wang J (2020)
IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity
Comput Struct Biotechnol J, 18, 1270-1286
DOI 10.1016/j.csbj.2020.05.024, PubMed 32612751
Scheffler K, Jalland CMO, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA (2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
Free Radic Biol Med, 152, 348-354
DOI 10.1016/j.freeradbiomed.2020.03.030, PubMed 32259578
Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

Publications 2019

Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A (2019)
N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323
Ahmadi A, Rosnes I, Blicher P, Diekmann R, Schüttpelz M, Glette K, Tørresen J, Bjørås M, Dalhus B, Rowe AD (2019)
Publisher Correction: Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 10 (1), 1991
DOI 10.1038/s41467-019-10070-x, PubMed 31024006
Ahmadi A, Till K, Hafting Y, Schüttpelz M, Bjørås M, Glette K, Tørresen J, Rowe AD, Dalhus B (2019)
Additive manufacturing of laminar flow cells for single-molecule experiments
Sci Rep, 9 (1), 16784
DOI 10.1038/s41598-019-53151-z, PubMed 31727950
Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Kjelstrup H, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A (2019)
The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein
J Biol Chem, 294 (42), 15480-15494
DOI 10.1074/jbc.RA119.008318, PubMed 31484725
Berges N, Nawaz MS, Børresdatter Dahl T, Hagen L, Bjørås M, Laerdahl JK, Alseth I (2019)
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097
Blomberg B, Müller KE, Helgeland L, Fladeby C, Mørch K (2019)
A man in his 80s with arthritis and persistent fever
Tidsskr Nor Laegeforen, 139 (13)
DOI 10.4045/tidsskr.18.0546, PubMed 31556531
Ianevski A, Andersen PI, Merits A, Bjørås M, Kainov D (2019)
Expanding the activity spectrum of antiviral agents
Drug Discov Today, 24 (5), 1224-1228
DOI 10.1016/j.drudis.2019.04.006, PubMed 30980905
Madhuprakash J, Dalhus B, Vaaje-Kolstad G, Sakuda S, Podile AR, Eijsink VGH, Sørlie M (2019)
Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans
J Phys Chem B, 123 (10), 2270-2279
DOI 10.1021/acs.jpcb.8b11448, PubMed 30789732
Montaldo NP, Bordin DL, Brambilla A, Rösinger M, Fordyce Martin SL, Bjørås KØ, Bradamante S, Aas PA, Furrer A, Olsen LC, Kunath N, Otterlei M, Sætrom P, Bjørås M, Samson LD, van Loon B (2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Nat Commun, 10 (1), 5460
DOI 10.1038/s41467-019-13394-w, PubMed 31784530
Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca²⁺-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765
Rydning SL, Koht J, Sheng Y, Sowa P, Hjorthaug HS, Wedding IM, Erichsen AK, Hovden IA, Backe PH, Tallaksen CME, Vigeland MD, Selmer KK (2019)
Biallelic POLR3A variants confirmed as a frequent cause of hereditary ataxia and spastic paraparesis
Brain, 142 (4), e12
DOI 10.1093/brain/awz041, PubMed 30847471
Scheffler K, Bjørås KØ, Bjørås M (2019)
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
DNA Repair (Amst), 81, 102665
DOI 10.1016/j.dnarep.2019.102665, PubMed 31327582
Schwartz T, Jensenius M, Blomberg B, Fladeby C, Mæland A, Pettersen FO (2019)
Imported visceral leishmaniasis and immunosuppression in seven Norwegian patients
Trop Dis Travel Med Vaccines, 5, 16
DOI 10.1186/s40794-019-0092-x, PubMed 31463070
Ystgaard MB, Scheffler K, Suganthan R, Bjørås M, Ranheim T, Sagen EL, Halvorsen B, Saugstad OD, Yndestad A (2019)
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283
Zhang Z, Manaf A, Li Y, Perez SP, Suganthan R, Dahl JA, Bjørås M, Klungland A (2019)
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318

Publications 2018

Ahmadi A, Rosnes I, Blicher P, Diekmann R, Schüttpelz M, Glette K, Tørresen J, Bjørås M, Dalhus B, Rowe AD (2018)
Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 9 (1), 5381
DOI 10.1038/s41467-018-07797-4, PubMed 30568191
Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S (2018)
Excision of the doubly methylated base N⁴,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Philos Trans R Soc Lond B Biol Sci, 373 (1748)
DOI 10.1098/rstb.2017.0337, PubMed 29685966
Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L (2018)
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
Sci Rep, 8 (1), 9817
DOI 10.1038/s41598-018-27985-y, PubMed 29959348
Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L (2018)
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Dis Model Mech, 11 (10)
DOI 10.1242/dmm.035949, PubMed 30254085
Gago-Fuentes R, Xing M, Sæterstad S, Sarno A, Dewan A, Beck C, Bradamante S, Bjørås M, Oksenych V (2018)
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
FEBS Open Bio, 8 (3), 426-434
DOI 10.1002/2211-5463.12381, PubMed 29511619
Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619
Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271
Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A (2018)
Ythdf2-mediated m⁶A mRNA clearance modulates neural development in mice
Genome Biol, 19 (1), 69
DOI 10.1186/s13059-018-1436-y, PubMed 29855337
Madhuprakash J, Dalhus B, Rani TS, Podile AR, Eijsink VGH, Sørlie M (2018)
Key Residues Affecting Transglycosylation Activity in Family 18 Chitinases: Insights into Donor and Acceptor Subsites
Biochemistry, 57 (29), 4325-4337
DOI 10.1021/acs.biochem.8b00381, PubMed 29939724
Makrythanasis P, Maroofian R, Stray-Pedersen A, Musaev D, Zaki MS, Mahmoud IG, Selim L, Elbadawy A, Jhangiani SN, Coban Akdemir ZH, Gambin T, Sorte HS, Heiberg A, McEvoy-Venneri J, James KN, Stanley V, Belandres D, Guipponi M, Santoni FA, Ahangari N, Tara F, Doosti M, Iwaszkiewicz J, Zoete V, Backe PH et al. (2018)
Biallelic variants in KIF14 cause intellectual disability with microcephaly
Eur J Hum Genet, 26 (3), 330-339
DOI 10.1038/s41431-017-0088-9, PubMed 29343805
Rognlien AGW, Wollen EJ, Atneosen-Åsegg M, Suganthan R, Bjørås M, Saugstad OD (2018)
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
J Perinat Med, 47 (1), 114-124
DOI 10.1515/jpm-2018-0172, PubMed 30020889
Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE (2018)
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
Viruses, 10 (8)
DOI 10.3390/v10080423, PubMed 30103549

Publications 2017

Batmanov K, Wang W, Bjørås M, Delabie J, Wang J (2017)
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma
Sci Rep, 7 (1), 7040
DOI 10.1038/s41598-017-07226-4, PubMed 28765546
Bj Rås KØ, Sousa MML, Sharma A, Fonseca DM, S Gaard CK, Bj Rås M, Otterlei M (2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication
Nucleic Acids Res, 45 (14), 8291-8301
DOI 10.1093/nar/gkx476, PubMed 28575236
Forsberg Z, Bissaro B, Gullesen J, Dalhus B, Vaaje-Kolstad G, Eijsink VGH (2017)
Structural determinants of bacterial lytic polysaccharide monooxygenase functionality
J Biol Chem, 293 (4), 1397-1412
DOI 10.1074/jbc.M117.817130, PubMed 29222333
Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121
Kvisvik B, Morkrid L, Rosjo H, Cvancarova M, Rowe AD, Eek C, Bendz B, Edvardsen T, Gravning J (2017)
High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
Acta Bioquim. Clin. Latinoam., 51 (3), 395-407
Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
Ottesen AH, Carlson CR, Louch WE, Dahl MB, Sandbu RA, Johansen RF, Jarstadmarken H, Bjørås M, Høiseth AD, Brynildsen J, Sjaastad I, Stridsberg M, Omland T, Christensen G, Røsjø H (2017)
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis
Circ Heart Fail, 10 (2)
DOI 10.1161/CIRCHEARTFAILURE.116.003675, PubMed 28209766
Pawar T, Bjørås M, Klungland A, Eide L (2017)
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564
Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK (2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1031-1040
DOI 10.1093/hmg/ddw391, PubMed 28007905
Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK (2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1217-1218
DOI 10.1093/hmg/ddx072, PubMed 28334853
Scheffler K, Rachek L, You P, Rowe AD, Wang W, Kuśnierczyk A, Kittelsen L, Bjørås M, Eide L (2017)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315

Publications 2016

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholmen G, Ahmed MS, Sandvik L, Norgren S, Bjørås M, Baumbusch LO, Solberg R, Saugstad OD (2016)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671
Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377
Forsberg Z, Nelson CE, Dalhus B, Mekasha S, Loose JS, Crouch LI, Røhr ÅK, Gardner JG, Eijsink VG, Vaaje-Kolstad G (2016)
Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus
J Biol Chem, 291 (14), 7300-12
DOI 10.1074/jbc.M115.700161, PubMed 26858252
Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230
Jalland CM, Scheffler K, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA (2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase
Sci Rep, 6, 37844
DOI 10.1038/srep37844, PubMed 27886261
Kristiansen KI, Weel-Sneve R, Booth JA, Bjørås M (2016)
Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli
RNA, 22 (11), 1739-1749
DOI 10.1261/rna.058461.116, PubMed 27651528
Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L (2016)
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
PLoS Curr, 8
DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492
Nawaz MS, Vik ES, Berges N, Fladeby C, Bjørås M, Dalhus B, Alseth I (2016)
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
DOI 10.1074/jbc.M116.730911, PubMed 27573237
Nawaz MS, Vik ES, Ronander ME, Solvoll AM, Blicher P, Bjørås M, Alseth I, Dalhus B (2016)
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
DOI 10.1038/srep24979, PubMed 27108838
Palibrk V, Suganthan R, Scheffler K, Wang W, Bjørås M, Bøe SO (2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model
Cell Death Dis, 7 (7), e2320
DOI 10.1038/cddis.2016.223, PubMed 27468695
Petrova L, Gran C, Bjoras M, Doetsch PW (2016)
Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells
PLoS One, 11 (6), e0158581
DOI 10.1371/journal.pone.0158581, PubMed 27362559
Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Øyan AM, Zhang W, Kalland KH, Ke X (2016)
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Proc Natl Acad Sci U S A, 113 (33), 9339-44
DOI 10.1073/pnas.1604520113, PubMed 27482107
Schuermann D, Scheidegger SP, Weber AR, Bjørås M, Leumann CJ, Schär P (2016)
3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair
Nucleic Acids Res, 44 (5), 2187-98
DOI 10.1093/nar/gkv1520, PubMed 26733580
Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kuśnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, Folkersen L, Krohg-Sørensen K, Holm S, Bjørås M, Aukrust P, Halvorsen B (2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496
Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939
Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, Abrahamsen TG, Kittang OB, Øverland T, Jhangiani SN, Muzny DM, Vigeland MD, Samarakoon P, Gambin T, Akdemir ZH, Gibbs RA, Rødningen OK, Lyle R, Lupski JR, Stray-Pedersen A (2016)
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction
Mol Genet Genomic Med, 4 (6), 604-616
DOI 10.1002/mgg3.237, PubMed 27896283

Publications 2015

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M (2015)
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Cell Rep, 13 (12), 2671-8
DOI 10.1016/j.celrep.2015.12.001, PubMed 26711335
Dalhus B, Alseth I, Bjørås M (2015)
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V
Prog Biophys Mol Biol, 117 (2-3), 134-142
DOI 10.1016/j.pbiomolbio.2015.03.005, PubMed 25824682
Fjaer R, Brodtkorb E, Øye AM, Sheng Y, Vigeland MD, Kvistad KA, Backe PH, Selmer KK (2015)
Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2
Eur J Med Genet, 58 (11), 624-8
DOI 10.1016/j.ejmg.2015.10.005, PubMed 26475232
Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
DOI 10.1371/journal.pone.0134954, PubMed 26248334
Hafver TL, Hodne K, Wanichawan P, Aronsen JM, Dalhus B, Lunde PK, Lunde M, Martinsen M, Enger UH, Fuller W, Sjaastad I, Louch WE, Sejersted OM, Carlson CR (2015)
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322
Heimdal K, Dalhus B, Rødningen OK, Kroken M, Eiklid K, Dheyauldeen S, Røysland T, Andersen R, Kulseth MA (2015)
Mutation analysis in Norwegian families with hereditary hemorrhagic telangiectasia: founder mutations in ACVRL1
Clin Genet, 89 (2), 182-6
DOI 10.1111/cge.12612, PubMed 25970827
Lundin KE, Hamasy A, Backe PH, Moens LN, Falk-Sörqvist E, Elgstøen KB, Mørkrid L, Bjørås M, Granert C, Norlin AC, Nilsson M, Christensson B, Stenmark S, Smith CI (2015)
Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene
Clin Immunol, 161 (2), 366-72
DOI 10.1016/j.clim.2015.10.002, PubMed 26482871
Mahajan TR, Ytre-Arne ME, Strøm-Andersen P, Dalhus B, Gundersen LL (2015)
Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1
Molecules, 20 (9), 15944-65
DOI 10.3390/molecules200915944, PubMed 26364627
Mekasha S, Forsberg Z, Dalhus B, Bacik JP, Choudhary S, Schmidt-Dannert C, Vaaje-Kolstad G, Eijsink VG (2015)
Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans
FEBS Lett, 590 (1), 34-42
DOI 10.1002/1873-3468.12025, PubMed 26763108
Naas AE, MacKenzie AK, Dalhus B, Eijsink VGH, Pope PB (2015)
Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus
Sci Rep, 5, 11666
DOI 10.1038/srep11666, PubMed 26133573
Ottesen AH, Louch WE, Carlson CR, Landsverk OJB, Kurola J, Johansen RF, Moe MK, Aronsen JM, Høiseth AD, Jarstadmarken H, Nygård S, Bjørås M, Sjaastad I, Pettilä V, Stridsberg M, Omland T, Christensen G, Røsjø H (2015)
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling
J Am Coll Cardiol, 65 (4), 339-351
DOI 10.1016/j.jacc.2014.10.065, PubMed 25634832
Skarpengland T, Laugsand LE, Janszky I, Luna L, Halvorsen B, Platou CG, Wang W, Vatten LJ, Damås JK, Aukrust P, Bjørås M, Åsvold BO (2015)
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study
DNA Repair (Amst), 28, 21-7
DOI 10.1016/j.dnarep.2015.01.013, PubMed 25703835
Xue JH, Xu GF, Gu TP, Chen GD, Han BB, Xu ZM, Bjørås M, Krokan HE, Xu GL, Du YR (2015)
Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation
J Biol Chem, 291 (2), 731-8
DOI 10.1074/jbc.M115.693861, PubMed 26620559
Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M (2015)
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
Sci Rep, 5, 17409
DOI 10.1038/srep17409, PubMed 26616534

Publications 2014

Alseth I, Dalhus B, Bjørås M (2014)
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738
Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290
Bliksøen M, Baysa A, Eide L, Bjørås M, Suganthan R, Vaage J, Stensløkken KO, Valen G (2014)
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179
Booth JA, Suganthan R, Gaustad P, Bjørås M (2014)
Development of DinQ from Escherichia coli as an anti-cell-envelope antibiotic
Int J Antimicrob Agents, 45 (2), 196-7
DOI 10.1016/j.ijantimicag.2014.10.005, PubMed 25465525
Bøyum A, Forstrøm RJ, Sefland I, Sand KL, Benestad HB (2014)
Intricacies of redoxome function demonstrated with a simple in vitro chemiluminescence method, with special reference to vitamin B12 as antioxidant
Scand J Immunol, 80 (6), 390-7
DOI 10.1111/sji.12220, PubMed 25345916
Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K (2014)
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716
DOI 10.1016/j.tetlet.2014.05.030
Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930
Palibrk V, Lång E, Lång A, Schink KO, Rowe AD, Bøe SO (2014)
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887
Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603
Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301
Strand JM, Scheffler K, Bjørås M, Eide L (2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126
Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662
Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, Sasa GS, Krance RA, Martinez CA, Abraham SM, Speckmann C, Ehl S, Hall P, Forbes LR, Merckoll E, Westvik J et al. (2014)
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394
Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L (2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950
Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645
Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Publications 2013

Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M (2013)
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
DOI 10.1016/j.jsb.2013.04.007, PubMed 23623903
Backe PH, Ytre-Arne M, Røhr AK, Brodtkorb E, Fowler B, Rootwelt H, Bjørås M, Mørkrid L (2013)
Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type
JIMD Rep, 11, 79-85
DOI 10.1007/8904_2013_225, PubMed 23580368
Booth JA, Thomassen GO, Rowe AD, Weel-Sneve R, Lagesen K, Kristiansen KI, Bjørås M, Rognes T, Lindvall JM (2013)
Tiling array study of MNNG treated Escherichia coli reveals a widespread transcriptional response
Sci Rep, 3, 3053
DOI 10.1038/srep03053, PubMed 24157950
Jalland CM, Benestad SL, Ersdal C, Scheffler K, Suganthan R, Nakabeppu Y, Eide L, Bjørås M, Tranulis MA (2013)
Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage
Free Radic Biol Med, 68, 1-7
DOI 10.1016/j.freeradbiomed.2013.11.013, PubMed 24296244
Krokan HE, Bjørås M (2013)
Base excision repair
Cold Spring Harb Perspect Biol, 5 (4), a012583
DOI 10.1101/cshperspect.a012583, PubMed 23545420
Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Fleming AM, Burrows CJ, Dalhus B, Bjørås M (2013)
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
DNA Repair (Amst), 12 (12), 1159-64
DOI 10.1016/j.dnarep.2013.04.026, PubMed 23755964
Rolseth V, Krokeide SZ, Kunke D, Neurauter CG, Suganthan R, Sejersted Y, Hildrestrand GA, Bjørås M, Luna L (2013)
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress
Biochim Biophys Acta, 1833 (5), 1157-64
DOI 10.1016/j.bbamcr.2012.12.024, PubMed 23305905
Rosnes I, Rowe AD, Vik ES, Forstrøm RJ, Alseth I, Bjørås M, Dalhus B (2013)
Structural basis of DNA loop recognition by endonuclease V
Structure, 21 (2), 257-65
DOI 10.1016/j.str.2012.12.007, PubMed 23313664
Vik ES, Nawaz MS, Strøm Andersen P, Fladeby C, Bjørås M, Dalhus B, Alseth I (2013)
Endonuclease V cleaves at inosines in RNA
Nat Commun, 4, 2271
DOI 10.1038/ncomms3271, PubMed 23912683
Weel-Sneve R, Kristiansen KI, Odsbu I, Dalhus B, Booth J, Rognes T, Skarstad K, Bjørås M (2013)
Single transmembrane peptide DinQ modulates membrane-dependent activities
PLoS Genet, 9 (2), e1003260
DOI 10.1371/journal.pgen.1003260, PubMed 23408903
Zhang X, Shi M, Bjørås M, Wang W, Zhang G, Han J, Liu Z, Zhang Y, Wang B, Chen J, Zhu Y, Xiong L, Zhao G (2013)
Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways
Front Pharmacol, 4, 152
DOI 10.3389/fphar.2013.00152, PubMed 24376419
Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM (2013)
TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy
Cell Rep, 5 (4), 1036-46
DOI 10.1016/j.celrep.2013.10.024, PubMed 24239358

Publications 2012

Andersen JT, Dalhus B, Cameron J, Daba MB, Plumridge A, Evans L, Brennan SO, Gunnarsen KS, Bjørås M, Sleep D, Sandlie I (2012)
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
DOI 10.1038/ncomms1607, PubMed 22215085
Bliksrud YT, Ellingsen A, Bjørås M (2012)
Fumarylacetoacetate inhibits the initial step of the base excision repair pathway: implication for the pathogenesis of tyrosinemia type I
J Inherit Metab Dis, 36 (5), 773-8
DOI 10.1007/s10545-012-9556-0, PubMed 23138988
Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall JM, Bjørås M, Meza-Zepeda LA, Enserink JM (2012)
Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes
Proc Natl Acad Sci U S A, 109 (26), 10450-5
DOI 10.1073/pnas.1200067109, PubMed 22689984
Fladeby C, Vik ES, Laerdahl JK, Gran Neurauter C, Heggelund JE, Thorgaard E, Strøm-Andersen P, Bjørås M, Dalhus B, Alseth I (2012)
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
DOI 10.1371/journal.pone.0047466, PubMed 23139746
Hereng TH, Backe PH, Kahmann J, Scheich C, Bjørås M, Skålhegg BS, Rosendal KR (2012)
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2
J Struct Biol, 178 (3), 300-10
DOI 10.1016/j.jsb.2012.03.013, PubMed 22504716
Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (2012)
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
Mol Cell, 49 (2), 339-45
DOI 10.1016/j.molcel.2012.11.010, PubMed 23246433
Korvald H, Falnes PØ, Laerdahl JK, Bjørås M, Alseth I (2012)
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity
DNA Repair (Amst), 11 (5), 453-62
DOI 10.1016/j.dnarep.2012.01.014, PubMed 22365419
Lång E, Grudic A, Pankiv S, Bruserud O, Simonsen A, Bjerkvig R, Bjørås M, Bøe SO (2012)
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling
Blood, 120 (4), 847-57
DOI 10.1182/blood-2011-10-388496, PubMed 22692509
Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A (2012)
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
Hum Mol Genet, 21 (22), 4939-47
DOI 10.1093/hmg/dds337, PubMed 22914735
Neurauter CG, Luna L, Bjørås M (2012)
Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway
DNA Repair (Amst), 11 (4), 401-9
DOI 10.1016/j.dnarep.2012.01.007, PubMed 22365498
Payne CM, Baban J, Horn SJ, Backe PH, Arvai AS, Dalhus B, Bjørås M, Eijsink VG, Sørlie M, Beckham GT, Vaaje-Kolstad G (2012)
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases
J Biol Chem, 287 (43), 36322-30
DOI 10.1074/jbc.M112.402149, PubMed 22952223
Ranneberg-Nilsen T, Rollag H, Slettebakk R, Backe PH, Olsen Ø, Luna L, Bjørås M (2012)
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
PLoS One, 7 (3), e34119
DOI 10.1371/journal.pone.0034119, PubMed 22479537
Vik ES, Alseth I, Forsbring M, Helle IH, Morland I, Luna L, Bjørås M, Dalhus B (2012)
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
DOI 10.1016/j.dnarep.2012.07.002, PubMed 22858590

Publications 2011

Belova NV, Dalhus B, Girichev GV, Giricheva NI, Haaland A, Kuzmima NP, Zhukova TA (2011)
The molecular structure of tris-2,2,6,6-tetramethyl-heptane-3,5-dione aluminium: gas-phase electron diffraction, quantum chemical calculations and X-ray crystallography
Struct. Chem., 22 (2), 393-399
DOI 10.1007/s11224-010-9729-0
Dalhus B, Forsbring M, Helle IH, Vik ES, Forstrøm RJ, Backe PH, Alseth I, Bjørås M (2011)
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
DOI 10.1016/j.str.2010.09.023, PubMed 21220122
Halsne R, Esbensen Y, Wang W, Scheffler K, Suganthan R, Bjørås M, Eide L (2011)
Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis
DNA Repair (Amst), 11 (3), 278-85
DOI 10.1016/j.dnarep.2011.12.001, PubMed 22209780
Hašplová K, Hudecová A, Magdolénová Z, Bjøras M, Gálová E, Miadoková E, Dušinská M (2011)
DNA alkylation lesions and their repair in human cells: modification of the comet assay with 3-methyladenine DNA glycosylase (AlkD)
Toxicol Lett, 208 (1), 76-81
DOI 10.1016/j.toxlet.2011.10.005, PubMed 22019460
Hereng TH, Elgstøen KB, Cederkvist FH, Eide L, Jahnsen T, Skålhegg BS, Rosendal KR (2011)
Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa
Hum Reprod, 26 (12), 3249-63
DOI 10.1093/humrep/der317, PubMed 21946930
Korvald H, Mølstad Moe AM, Cederkvist FH, Thiede B, Laerdahl JK, Bjørås M, Alseth I (2011)
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones
PLoS One, 6 (9), e25188
DOI 10.1371/journal.pone.0025188, PubMed 21949882
Myhre HA, Haug Dorenberg D, Kristiansen KI, Rollag H, Leivestad T, Asberg A, Hartmann A (2011)
Incidence and outcomes of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients
Transplantation, 92 (2), 217-23
DOI 10.1097/TP.0b013e31821fad25, PubMed 21685829
Nilsen L, Forstrøm RJ, Bjørås M, Alseth I (2011)
AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
Nucleic Acids Res, 40 (5), 2000-9
DOI 10.1093/nar/gkr933, PubMed 22084197
Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M (2011)
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Proc Natl Acad Sci U S A, 108 (46), 18802-7
DOI 10.1073/pnas.1106880108, PubMed 22065741
Vaaje-Kolstad G, Bøhle LA, Gåseidnes S, Dalhus B, Bjørås M, Mathiesen G, Eijsink VG (2011)
Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme
J Mol Biol, 416 (2), 239-54
DOI 10.1016/j.jmb.2011.12.033, PubMed 22210154
Wang W, Esbensen Y, Kunke D, Suganthan R, Rachek L, Bjørås M, Eide L (2011)
Mitochondrial DNA damage level determines neural stem cell differentiation fate
J Neurosci, 31 (26), 9746-51
DOI 10.1523/JNEUROSCI.0852-11.2011, PubMed 21715639
Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M (2011)
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366
Zimmermann C, Chymkowitch P, Eldholm V, Putnam CD, Lindvall JM, Omerzu M, Bjørås M, Kolodner RD, Enserink JM (2011)
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression
Proc Natl Acad Sci U S A, 108 (46), 18748-53
DOI 10.1073/pnas.1115885108, PubMed 22042866

Publications 2010

Bøyum A, Skrede KK, Myhre O, Tennfjord VA, Neurauter CG, Tolleshaug H, Knudsen E, Opstad PK, Bjørås M, Benestad HB (2010)
Calprotectin (S100A8/S100A9) and myeloperoxidase: co-regulators of formation of reactive oxygen species
Toxins (Basel), 2 (1), 95-115
DOI 10.3390/toxins2010095, PubMed 22069549
Duri K, Gumbo FZ, Kristiansen KI, Kurewa NE, Mapingure MP, Rusakaniko S, Chirenje MZ, Muller F, Stray-Pedersen B (2010)
Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting
Virol J, 7, 176
DOI 10.1186/1743-422X-7-176, PubMed 20678190
Görbitz CH, Backe PH (2010)
L-isoleucyl-L-asparagine 1.094-hydrate: a hybrid hydrogen-bonding pattern
Acta Crystallogr C, 66 (Pt 7), o349-52
DOI 10.1107/S0108270110020895, PubMed 20603563
Görbitz CH, Dalhus B, Day GM (2010)
Pseudoracemic amino acid complexes: blind predictions for flexible two-component crystals
Phys Chem Chem Phys, 12 (30), 8466-77
DOI 10.1039/c004055j, PubMed 20461256
Isakson P, Bjørås M, Bøe SO, Simonsen A (2010)
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein
Blood, 116 (13), 2324-31
DOI 10.1182/blood-2010-01-261040, PubMed 20574048
Johnsen L, Flåtten I, Morigen, Dalhus B, Bjørås M, Waldminghaus T, Skarstad K (2010)
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication
Mol Microbiol, 79 (2), 433-46
DOI 10.1111/j.1365-2958.2010.07453.x, PubMed 21219462
Laerdahl JK, Korvald H, Nilsen L, Dahl-Michelsen K, Rognes T, Bjørås M, Alseth I (2010)
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1
DNA Repair (Amst), 10 (3), 296-305
DOI 10.1016/j.dnarep.2010.11.014, PubMed 21193357
Thomassen GO, Weel-Sneve R, Rowe AD, Booth JA, Lindvall JM, Lagesen K, Kristiansen KI, Bjørås M, Rognes T (2010)
Tiling array analysis of UV treated Escherichia coli predicts novel differentially expressed small peptides
PLoS One, 5 (12), e15356
DOI 10.1371/journal.pone.0015356, PubMed 21203457
Wang W, Osenbroch P, Skinnes R, Esbensen Y, Bjørås M, Eide L (2010)
Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells
Stem Cells, 28 (12), 2195-204
DOI 10.1002/stem.542, PubMed 20954243

Publications 2009

Dalhus B, Arvai AS, Rosnes I, Olsen ØE, Backe PH, Alseth I, Gao H, Cao W, Tainer JA, Bjørås M (2009)
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
DOI 10.1038/nsmb.1538, PubMed 19136958
Dalhus B, Laerdahl JK, Backe PH, Bjørås M (2009)
DNA base repair--recognition and initiation of catalysis
FEMS Microbiol Rev, 33 (6), 1044-78
DOI 10.1111/j.1574-6976.2009.00188.x, PubMed 19659577
Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
DOI 10.1093/carcin/bgp118, PubMed 19443904
Hildrestrand GA, Duggal S, Bjørås M, Luna L, Brinchmann JE (2009)
Modulation of DNA glycosylase activities in mesenchymal stem cells
Exp Cell Res, 315 (15), 2558-67
DOI 10.1016/j.yexcr.2009.05.017, PubMed 19477173
Hol J, Küchler AM, Johansen FE, Dalhus B, Haraldsen G, Oynebråten I (2009)
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies
J Biol Chem, 284 (35), 23532-9
DOI 10.1074/jbc.M900874200, PubMed 19578117
Kats ES, Enserink JM, Martinez S, Kolodner RD (2009)
The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants
Mol Cell Biol, 29 (19), 5226-37
DOI 10.1128/MCB.00894-09, PubMed 19635810
Olsen I, Balasingham SV, Davidsen T, Debebe E, Rødland EA, van Soolingen D, Kremer K, Alseth I, Tønjum T (2009)
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol Med Microbiol, 56 (2), 151-61
DOI 10.1111/j.1574-695X.2009.00562.x, PubMed 19496823
Sejersted Y, Aasland AL, Bjørås M, Eide L, Saugstad OD (2009)
Accumulation of 8-oxoguanine in liver DNA during hyperoxic resuscitation of newborn mice
Pediatr Res, 66 (5), 533-8
DOI 10.1203/PDR.0b013e3181ba1a42, PubMed 19668103
Yndestad A, Neurauter CG, Oie E, Forstrøm RJ, Vinge LE, Eide L, Luna L, Aukrust P, Bjørås M (2009)
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat Res, 666 (1-2), 32-8
DOI 10.1016/j.mrfmmm.2009.03.008, PubMed 19481677

Publications 2008

Allunans J, Kristiansen KI, Assalkhou R, Bjørås M (2008)
Bacteriocins (meningocins) in Norwegian isolates of Neisseria meningitidis: possible role in the course of a meningococcal epidemic
APMIS, 116 (5), 333-44
DOI 10.1111/j.1600-0463.2008.00850.x, PubMed 18452423
Bernardes de Jesus BM, Bjørås M, Coin F, Egly JM (2008)
Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC
Mol Cell Biol, 28 (23), 7225-35
DOI 10.1128/MCB.00781-08, PubMed 18809580
Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Björas M, Cunningham RP, Tainer JA (2008)
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV
Nat Struct Mol Biol, 15 (5), 515-22
DOI 10.1038/nsmb.1414, PubMed 18408731
Krokeide SZ, Bolstad N, Laerdahl JK, Bjørås M, Luna L (2008)
Expression and purification of NEIL3, a human DNA glycosylase homolog
Protein Expr Purif, 65 (2), 160-4
DOI 10.1016/j.pep.2008.11.014, PubMed 19121397
Nyombi BM, Holm-Hansen C, Kristiansen KI, Bjune G, Müller F (2008)
Prevalence of reverse transcriptase and protease mutations associated with antiretroviral drug resistance among drug-naïve HIV-1 infected pregnant women in Kagera and Kilimanjaro regions, Tanzania
AIDS Res Ther, 5, 13
DOI 10.1186/1742-6405-5-13, PubMed 18570675
Nyombi BM, Kristiansen KI, Bjune G, Müller F, Holm-Hansen C (2008)
Diversity of human immunodeficiency virus type 1 subtypes in Kagera and Kilimanjaro regions, Tanzania
AIDS Res Hum Retroviruses, 24 (6), 761-9
DOI 10.1089/aid.2007.0311, PubMed 18507522
Nyombi BM, Nkya W, Barongo L, Bjune G, Kristiansen KI, Müller F, Holm-Hansen C (2008)
Evolution of human immunodeficiency virus type 1 serotypes in northern Tanzania: a retrospective study
APMIS, 116 (6), 507-14
DOI 10.1111/j.1600-0463.2008.00996.x, PubMed 18754325
Ranneberg-Nilsen T, Dale HA, Luna L, Slettebakk R, Sundheim O, Rollag H, Bjørås M (2008)
Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44)
J Mol Biol, 381 (2), 276-88
DOI 10.1016/j.jmb.2008.05.028, PubMed 18599070

Publications 2007

Dalhus B, Helle IH, Backe PH, Alseth I, Rognes T, Bjørås M, Laerdahl JK (2007)
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
DOI 10.1093/nar/gkm039, PubMed 17395642
Davidsen T, Tuven HK, Bjørås M, Rødland EA, Tønjum T (2007)
Genetic interactions of DNA repair pathways in the pathogen Neisseria meningitidis
J Bacteriol, 189 (15), 5728-37
DOI 10.1128/JB.00161-07, PubMed 17513474
Hildrestrand GA, Diep DB, Kunke D, Bolstad N, Bjørås M, Krauss S, Luna L (2007)
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
DOI 10.1016/j.dnarep.2006.12.008, PubMed 17236821
Hildrestrand GA, Rolseth V, Bjørås M, Luna L (2007)
Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis
DNA Repair (Amst), 6 (10), 1425-33
DOI 10.1016/j.dnarep.2007.04.008, PubMed 17556049
Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT (2007)
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Nature, 447 (7143), 447-52
DOI 10.1038/nature05778, PubMed 17450122

Publications 2006

Alseth I, Rognes T, Lindbäck T, Solberg I, Robertsen K, Kristiansen KI, Mainieri D, Lillehagen L, Kolstø AB, Bjørås M (2006)
A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD
Mol Microbiol, 59 (5), 1602-9
DOI 10.1111/j.1365-2958.2006.05044.x, PubMed 16468998
D'Errico M, Parlanti E, Teson M, de Jesus BM, Degan P, Calcagnile A, Jaruga P, Bjørås M, Crescenzi M, Pedrini AM, Egly JM, Zambruno G, Stefanini M, Dizdaroglu M, Dogliotti E (2006)
New functions of XPC in the protection of human skin cells from oxidative damage
EMBO J, 25 (18), 4305-15
DOI 10.1038/sj.emboj.7601277, PubMed 16957781
Falnes PØ, Klungland A, Alseth I (2006)
Repair of methyl lesions in DNA and RNA by oxidative demethylation
Neuroscience, 145 (4), 1222-32
DOI 10.1016/j.neuroscience.2006.11.018, PubMed 17175108
Hoell IA, Dalhus B, Heggset EB, Aspmo SI, Eijsink VG (2006)
Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes
FEBS J, 273 (21), 4889-900
DOI 10.1111/j.1742-4658.2006.05487.x, PubMed 17010167
Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A (2006)
Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice
Oncogene, 25 (17), 2425-32
DOI 10.1038/sj.onc.1209284, PubMed 16369492
Nakken S, Alseth I, Rognes T (2006)
Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes
Neuroscience, 145 (4), 1273-9
DOI 10.1016/j.neuroscience.2006.09.004, PubMed 17055652
Ranneberg-Nilsen T, Bjørås M, Luna L, Slettebakk R, Dale HA, Seeberg E, Rollag H (2006)
Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells
Virology, 348 (2), 389-97
DOI 10.1016/j.virol.2006.01.001, PubMed 16476462
Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G (2006)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
EMBO J, 25 (14), 3389-97
DOI 10.1038/sj.emboj.7601219, PubMed 16858410
Walberg M, Mørk C, Sandven P, Jorde AT, Bjørås M, Gaustad P (2006)
18S rDNA polymerase chain reaction and sequencing in onychomycosis diagnostics
Acta Derm Venereol, 86 (3), 223-6
DOI 10.2340/00015555-0077, PubMed 16710579

Publications 2005

Alseth I, Osman F, Korvald H, Tsaneva I, Whitby MC, Seeberg E, Bjørås M (2005)
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 33 (3), 1123-31
DOI 10.1093/nar/gki259, PubMed 15722486
Aukrust P, Luna L, Ueland T, Johansen RF, Müller F, Frøland SS, Seeberg EC, Bjørås M (2005)
Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients
Blood, 105 (12), 4730-5
DOI 10.1182/blood-2004-11-4272, PubMed 15705786
Davidsen T, Bjørås M, Seeberg EC, Tønjum T (2005)
Antimutator role of DNA glycosylase MutY in pathogenic Neisseria species
J Bacteriol, 187 (8), 2801-9
DOI 10.1128/JB.187.8.2801-2809.2005, PubMed 15805527
Heggelund L, Mollnes TE, Espevik T, Müller F, Kristiansen KI, Aukrust P, Frøland SS (2005)
Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection
Eur J Clin Invest, 35 (12), 765-70
DOI 10.1111/j.1365-2362.2005.01579.x, PubMed 16313253
Johnsen L, Dalhus B, Leiros I, Nissen-Meyer J (2005)
1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A
J Biol Chem, 280 (19), 19045-50
DOI 10.1074/jbc.M501386200, PubMed 15753083
Luna L, Rolseth V, Hildrestrand GA, Otterlei M, Dantzer F, Bjørås M, Seeberg E (2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant
Nucleic Acids Res, 33 (6), 1813-24
DOI 10.1093/nar/gki325, PubMed 15800211
Morland I, Luna L, Gustad E, Seeberg E, Bjørås M (2005)
Product inhibition and magnesium modulate the dual reaction mode of hOgg1
DNA Repair (Amst), 4 (3), 381-7
DOI 10.1016/j.dnarep.2004.11.002, PubMed 15661661
Olsen PA, Randøl M, Luna L, Brown T, Krauss S (2005)
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
J Gene Med, 7 (12), 1534-44
DOI 10.1002/jgm.804, PubMed 16025558
Saetrom P, Sneve R, Kristiansen KI, Snøve O, Grünfeld T, Rognes T, Seeberg E (2005)
Predicting non-coding RNA genes in Escherichia coli with boosted genetic programming
Nucleic Acids Res, 33 (10), 3263-70
DOI 10.1093/nar/gki644, PubMed 15942029

Publications 2004

Alseth I, Korvald H, Osman F, Seeberg E, Bjørås M (2004)
A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 32 (17), 5119-25
DOI 10.1093/nar/gkh851, PubMed 15452279
Davidsen T, Rødland EA, Lagesen K, Seeberg E, Rognes T, Tønjum T (2004)
Biased distribution of DNA uptake sequences towards genome maintenance genes
Nucleic Acids Res, 32 (3), 1050-8
DOI 10.1093/nar/gkh255, PubMed 14960717
Falnes PØ, Bjørås M, Aas PA, Sundheim O, Seeberg E (2004)
Substrate specificities of bacterial and human AlkB proteins
Nucleic Acids Res, 32 (11), 3456-61
DOI 10.1093/nar/gkh655, PubMed 15229293
Heggelund L, Müller F, Lien E, Yndestad A, Ueland T, Kristiansen KI, Espevik T, Aukrust P, Frøland SS (2004)
Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication
Clin Infect Dis, 39 (2), 264-9
DOI 10.1086/421780, PubMed 15307037
Ougland R, Zhang CM, Liiv A, Johansen RF, Seeberg E, Hou YM, Remme J, Falnes PØ (2004)
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
Mol Cell, 16 (1), 107-16
DOI 10.1016/j.molcel.2004.09.002, PubMed 15469826
Trushina E, Dyer RB, Badger JD, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT (2004)
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Mol Cell Biol, 24 (18), 8195-209
DOI 10.1128/MCB.24.18.8195-8209.2004, PubMed 15340079
Tønjum T, Håvarstein LS, Koomey M, Seeberg E (2004)
Transformation and DNA repair: linkage by DNA recombination
Trends Microbiol, 12 (1), 1-4
DOI 10.1016/j.tim.2003.11.008, PubMed 14700543
Ulbert S, Eide L, Seeberg E, Borst P (2004)
Base J, found in nuclear DNA of Trypanosoma brucei, is not a target for DNA glycosylases
DNA Repair (Amst), 3 (2), 145-54
DOI 10.1016/j.dnarep.2003.10.009, PubMed 14706348
Aamodt RM, Falnes PØ, Johansen RF, Seeberg E, Bjørås M (2004)
The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates
J Biol Chem, 279 (14), 13601-6
DOI 10.1074/jbc.M314277200, PubMed 14729667

Publications 2003

Barone F, Dogliotti E, Cellai L, Giordano C, Bjørås M, Mazzei F (2003)
Influence of DNA torsional rigidity on excision of 7,8-dihydro-8-oxo-2'-deoxyguanosine in the presence of opposing abasic sites by human OGG1 protein
Nucleic Acids Res, 31 (7), 1897-903
DOI 10.1093/nar/gkg289, PubMed 12655006
Baynton K, Otterlei M, Bjørås M, von Kobbe C, Bohr VA, Seeberg E (2003)
WRN interacts physically and functionally with the recombination mediator protein RAD52
J Biol Chem, 278 (38), 36476-86
DOI 10.1074/jbc.M303885200, PubMed 12750383
Bjelland S, Seeberg E (2003)
Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
Mutat Res, 531 (1-2), 37-80
DOI 10.1016/j.mrfmmm.2003.07.002, PubMed 14637246
Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E (2003)
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
DOI 10.1016/s1568-7864(03)00041-7, PubMed 12767349
Larsen E, Gran C, Saether BE, Seeberg E, Klungland A (2003)
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
Mol Cell Biol, 23 (15), 5346-53
DOI 10.1128/MCB.23.15.5346-5353.2003, PubMed 12861020
Liu Y, Reichelt WH, Luna L, Elgjo K, Reichelt KL (2003)
The effects of a growth-inhibiting tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), on gene expression and cell cycle progression of two lymphoma cell lines
Anticancer Res, 23 (4), 3159-65
PubMed 12926049
Maclean MJ, Aamodt R, Harris N, Alseth I, Seeberg E, Bjørås M, Piper PW (2003)
Base excision repair activities required for yeast to attain a full chronological life span
Aging Cell, 2 (2), 93-104
DOI 10.1046/j.1474-9728.2003.00041.x, PubMed 12882322
Ménissier de Murcia J, Ricoul M, Tartier L, Niedergang C, Huber A, Dantzer F, Schreiber V, Amé JC, Dierich A, LeMeur M, Sabatier L, Chambon P, de Murcia G (2003)
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
EMBO J, 22 (9), 2255-63
DOI 10.1093/emboj/cdg206, PubMed 12727891
Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjørås M, Seeberg E, Rognes T, Klungland A (2003)
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V
Nucleic Acids Res, 31 (14), 3893-900
DOI 10.1093/nar/gkg472, PubMed 12853604
Olsen AK, Duale N, Bjørås M, Larsen CT, Wiger R, Holme JA, Seeberg EC, Brunborg G (2003)
Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells
Nucleic Acids Res, 31 (4), 1351-63
DOI 10.1093/nar/gkg216, PubMed 12582255
Osman F, Bjørås M, Alseth I, Morland I, McCready S, Seeberg E, Tsaneva I (2003)
A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage
Mol Microbiol, 48 (2), 465-80
DOI 10.1046/j.1365-2958.2003.03440.x, PubMed 12675805
Seeberg E, Klungland A (2003)
Better late than never for repair of miscoding lesions within a transcribed template
Mol Cell, 12 (4), 799-800
DOI 10.1016/s1097-2765(03)00403-9, PubMed 14580331
Winter DB, Phung QH, Zeng X, Seeberg E, Barnes DE, Lindahl T, Gearhart PJ (2003)
Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase
J Immunol, 170 (11), 5558-62
DOI 10.4049/jimmunol.170.11.5558, PubMed 12759433
Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE (2003)
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Nature, 421 (6925), 859-63
DOI 10.1038/nature01363, PubMed 12594517

Publications 2002

Birkeland NK, Anensen H, Knaevelsrud I, Kristoffersen W, Bjørås M, Robb FT, Klungland A, Bjelland S (2002)
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus
Biochemistry, 41 (42), 12697-705
DOI 10.1021/bi020334w, PubMed 12379112
Bjørås M, Seeberg E, Luna L, Pearl LH, Barrett TE (2002)
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
J Mol Biol, 317 (2), 171-7
DOI 10.1006/jmbi.2002.5400, PubMed 11902834
Dantzer F, Luna L, Bjørås M, Seeberg E (2002)
Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo
Nucleic Acids Res, 30 (11), 2349-57
DOI 10.1093/nar/30.11.2349, PubMed 12034821
Falnes PØ, Johansen RF, Seeberg E (2002)
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
Nature, 419 (6903), 178-82
DOI 10.1038/nature01048, PubMed 12226668
Morland I, Rolseth V, Luna L, Rognes T, Bjørås M, Seeberg E (2002)
Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA
Nucleic Acids Res, 30 (22), 4926-36
DOI 10.1093/nar/gkf618, PubMed 12433996
Pascucci B, Maga G, Hübscher U, Bjoras M, Seeberg E, Hickson ID, Villani G, Giordano C, Cellai L, Dogliotti E (2002)
Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins
Nucleic Acids Res, 30 (10), 2124-30
DOI 10.1093/nar/30.10.2124, PubMed 12000832

Publications 2001

Allunans J, Bøvre K (2001)
Unusual antineisserial activity expressed by a systemic isolate of Neisseria meningitidis. antimeningococcal effect and properties
Scand J Infect Dis, 33 (7), 516-22
DOI 10.1080/00365540110026610, PubMed 11515762
Anensen H, Provan F, Lian AT, Reinertsen SH, Ueno Y, Matsuda A, Seeberg E, Bjelland S (2001)
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine
Mutat Res, 476 (1-2), 99-107
DOI 10.1016/s0027-5107(01)00086-0, PubMed 11336987
Bjelland S, Anensen H, Knaevelsrud I, Seeberg E (2001)
Cellular effects of 5-formyluracil in DNA
Mutat Res, 486 (2), 147-54
DOI 10.1016/s0921-8777(01)00085-4, PubMed 11425519
de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA (2001)
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice
Cancer Res, 61 (14), 5378-81
PubMed 11454679
Degré M, Kristiansen KI, Rollag H, Holter E, Nordal KP (2001)
Detection of human cytomegalovirus (HCMV) pp67-mRNA and pp65 antigenemia in relation to development of clinical HCMV disease in renal transplant recipients
Clin Microbiol Infect, 7 (5), 254-60
DOI 10.1046/j.1198-743x.2001.00251.x, PubMed 11422252
Eide L, Fosberg E, Hoff E, Seeberg E (2001)
Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate
FEBS Lett, 491 (1-2), 59-62
DOI 10.1016/s0014-5793(01)02156-1, PubMed 11226419
Eide L, Luna L, Gustad EC, Henderson PT, Essigmann JM, Demple B, Seeberg E (2001)
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA
Biochemistry, 40 (22), 6653-9
DOI 10.1021/bi0028901, PubMed 11380260
Klungland A, Paulsen R, Rolseth V, Yamada Y, Ueno Y, Wiik P, Matsuda A, Seeberg E, Bjelland S (2001)
5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism
Toxicol Lett, 119 (1), 71-8
DOI 10.1016/s0378-4274(00)00308-8, PubMed 11275423
Olsen AK, Bjørtuft H, Wiger R, Holme J, Seeberg E, Bjørås M, Brunborg G (2001)
Highly efficient base excision repair (BER) in human and rat male germ cells
Nucleic Acids Res, 29 (8), 1781-90
DOI 10.1093/nar/29.8.1781, PubMed 11292851
Tønjum T, Seeberg E (2001)
Microbial fitness and genome dynamics
Trends Microbiol, 9 (8), 356-8
DOI 10.1016/s0966-842x(01)02099-6, PubMed 11519528

Publications 2000

Luna L, Bjørås M, Hoff E, Rognes T, Seeberg E (2000)
Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA
Mutat Res, 460 (2), 95-104
DOI 10.1016/s0921-8777(00)00015-x, PubMed 10882850
Mehl A, Rolseth V, Gordon S, Bjøraas M, Seeberg E, Fonnum F (2000)
Brain hypoplasia caused by exposure to trichlorfon and dichlorvos during development can be ascribed to DNA alkylation damage and inhibition of DNA alkyltransferase repair
Neurotoxicology, 21 (1-2), 165-73
PubMed 10794396
Rognes T, Seeberg E (2000)
Six-fold speed-up of Smith-Waterman sequence database searches using parallel processing on common microprocessors
Bioinformatics, 16 (8), 699-706
DOI 10.1093/bioinformatics/16.8.699, PubMed 11099256
Seeberg E, Luna L, Morland I, Eide L, Johnsen B, Larsen E, Alseth I, Dantzer F, Baynton K, Aamodt R, Kristiansen KI, Rognes T, Klungland A, Bjørås M (2000)
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028

Publications 1999

Alseth I, Eide L, Pirovano M, Rognes T, Seeberg E, Bjørås M (1999)
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
Mol Cell Biol, 19 (5), 3779-87
DOI 10.1128/MCB.19.5.3779, PubMed 10207101
Cascinu S, Frontini L, Comella G, Barni S, Labianca R, Battelli N, Casaretti R, Zonato S, Pirovano M, Catalano G, Cellerino R (1999)
Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)
Br J Cancer, 79 (3-4), 491-4
DOI 10.1038/sj.bjc.6690076, PubMed 10027318
Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, Seeberg E, Lindahl T, Barnes DE (1999)
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Proc Natl Acad Sci U S A, 96 (23), 13300-5
DOI 10.1073/pnas.96.23.13300, PubMed 10557315
Luna L, Bjoras M, Berdal KG, Alseth I, Eide L, Rognes T, Seeberg E (1999)
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283
Maltoni M, Nanni O, Pirovano M, Scarpi E, Indelli M, Martini C, Monti M, Arnoldi E, Piva L, Ravaioli A, Cruciani G, Labianca R, Amadori D (1999)
Successful validation of the palliative prognostic score in terminally ill cancer patients. Italian Multicenter Study Group on Palliative Care
J Pain Symptom Manage, 17 (4), 240-7
DOI 10.1016/s0885-3924(98)00146-8, PubMed 10203876

Publications 1998

Allunans J, Bjørås M, Seeberg E, Bøvre K (1998)
Production, isolation and purification of bacteriocins expressed by two strains of Neisseria meningitidis
APMIS, 106 (12), 1181-7
DOI 10.1111/j.1699-0463.1998.tb00275.x, PubMed 10052727
Berdal KG, Johansen RF, Seeberg E (1998)
Release of normal bases from intact DNA by a native DNA repair enzyme
EMBO J, 17 (2), 363-7
DOI 10.1093/emboj/17.2.363, PubMed 9430628
Gran C, Bøyum A, Johansen RF, Løvhaug D, Seeberg EC (1998)
Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein
Blood, 91 (11), 4127-35
DOI 10.1182/blood.V91.11.4127.411k42_4127_4135, PubMed 9596658
Holme JA, Bjørge C, Trbojevic M, Olsen AK, Brunborg G, Søderlund EJ, Bjørås M, Seeberg E, Scholz T, Dybing E, Wiger R (1998)
Effects of chemical-induced DNA damage on male germ cells
Arch Toxicol Suppl, 20, 151-60
DOI 10.1007/978-3-642-46856-8_14, PubMed 9442290
Levy LM, Attwell D, Hoover F, Ash JF, Bjoras M, Danbolt NC (1998)
Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake (vol 422, pg 339, 1998)
FEBS Lett., 427 (1), 152
DOI 10.1016/S0014-5793(98)00345-7
Levy LM, Attwell D, Hoover F, Ash JF, Bjørås M, Danbolt NC (1998)
Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake
FEBS Lett, 422 (3), 339-42
DOI 10.1016/s0014-5793(98)00036-2, PubMed 9498811
Rognes T, Seeberg E (1998)
SALSA: improved protein database searching by a new algorithm for assembly of sequence fragments into gapped alignments
Bioinformatics, 14 (10), 839-45
DOI 10.1093/bioinformatics/14.10.839, PubMed 9927712

Publications 1997

Bjorâs M, Luna L, Johnsen B, Hoff E, Haug T, Rognes T, Seeberg E (1997)
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites
EMBO J, 16 (20), 6314-22
DOI 10.1093/emboj/16.20.6314, PubMed 9321410
Maltoni M, Pirovano M, Nanni O, Marinari M, Indelli M, Gramazio A, Terzoli E, Luzzani M, De Marinis F, Caraceni A, Labianca R (1997)
Biological indices predictive of survival in 519 Italian terminally ill cancer patients. Italian Multicenter Study Group on Palliative Care
J Pain Symptom Manage, 13 (1), 1-9
DOI 10.1016/s0885-3924(96)00265-5, PubMed 9029856
Marsteinstredet U, Brunborg G, Bjørås M, Søderlund E, Seeberg E, Kronberg L, Holme JA (1997)
DNA damage induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in HL-60 cells and purified DNA in vitro
Mutat Res, 390 (1-2), 171-8
DOI 10.1016/s0165-1218(97)00016-5, PubMed 9150766

Publications 1996

Allunans J, Bøvre K (1996)
Bacteriocins in Neisseria meningitidis. Screening of systemic patient strains and pharyngeal isolates from healthy carriers
APMIS, 104 (3), 206-12
DOI 10.1111/j.1699-0463.1996.tb00709.x, PubMed 8611195
Bjelland S, Seeberg E (1996)
Different efficiencies of the Tag and AlkA DNA glycosylases from Escherichia coli in the removal of 3-methyladenine from single-stranded DNA
FEBS Lett, 397 (1), 127-9
DOI 10.1016/s0014-5793(96)01166-0, PubMed 8941728
Bjørås M, Gjesdal O, Erickson JD, Torp R, Levy LM, Ottersen OP, Degree M, Storm-Mathisen J, Seeberg E, Danbolt NC (1996)
Cloning and expression of a neuronal rat brain glutamate transporter
Brain Res Mol Brain Res, 36 (1), 163-8
DOI 10.1016/0169-328x(95)00279-2, PubMed 9011753
Eide L, Bjørås M, Pirovano M, Alseth I, Berdal KG, Seeberg E (1996)
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
Proc Natl Acad Sci U S A, 93 (20), 10735-40
DOI 10.1073/pnas.93.20.10735, PubMed 8855249
Labianca R, Pessi A, Facendola G, Pirovano M, Luporini G (1996)
Modulated 5-fluorouracil (5-FU) regimens in advanced colorectal cancer: a critical review of comparative studies
Eur J Cancer, 32A Suppl 5, S7-12
DOI 10.1016/s0959-8049(96)00330-9, PubMed 8958036
Lehmann AR, Bridges BA, Hanawalt PC, Johnson RT, Kanaar R, Krokan HE, Kyrtopoulos S, Lambert B, Melton DW, Moustacchi E, Natarajan AT, Radman M, Sarasin A, Seeberg E, Smerdon MJ, Smith CA, Smith PJ, Thacker J, Thomale J, Waters R, Weeda G, West SC, van Zeeland AA, Zdzienicka MZ (1996)
Workshop on processing of DNA damage
Mutat Res, 364 (3), 245-70
DOI 10.1016/s0921-8777(96)00037-7, PubMed 8960136
Maltoni M, Pirovano M, Nanni O, Scarpi E (1996)
Studies signaling the prognostic factors of terminally ill phases
J Pain Symptom Manage, 12 (4), 205
DOI 10.1016/0885-3924(96)00143-1, PubMed 8898499
Zamparelli G, Pancera G, Pessi MA, Dallavalle G, Pirovano M, Valsecchi R, Labianca R, Samori G, Luporini G (1996)
[Locoregional chemotherapy of liver metastasis from colorectal carcinoma]
Ann Ital Chir, 67 (6), 793-7
PubMed 9214270
Zaniboni A, Labianca R, Martignoni G, Barni S, Vinci M, Vaghi M, Pirovano M, Facendola G, Marini G, Luporini G (1996)
Sequential methotrexate and 5-fluorouracil as second-line chemotherapy for advanced colorectal cancer patients pretreated with 5-fluorouracil and leucovorin: a GISCAD study
J Chemother, 8 (1), 82-4
DOI 10.1179/joc.1996.8.1.82, PubMed 8835115

Publications 1995

Bjelland S, Eide L, Time RW, Stote R, Eftedal I, Volden G, Seeberg E (1995)
Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts
Biochemistry, 34 (45), 14758-64
DOI 10.1021/bi00045a017, PubMed 7578084
Bjørås M, Klungland A, Johansen RF, Seeberg E (1995)
Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae
Biochemistry, 34 (14), 4577-82
DOI 10.1021/bi00014a010, PubMed 7718559
Klungland A, Laake K, Hoff E, Seeberg E (1995)
Spectrum of mutations induced by methyl and ethyl methanesulfonate at the hprt locus of normal and tag expressing Chinese hamster fibroblasts
Carcinogenesis, 16 (6), 1281-5
DOI 10.1093/carcin/16.6.1281, PubMed 7788844
Seeberg E, Eide L, Bjørås M (1995)
The base excision repair pathway
Trends Biochem Sci, 20 (10), 391-7
DOI 10.1016/s0968-0004(00)89086-6, PubMed 8533150

Publications 1984

Jyssum K, Allunans J (1984)
Inhibitory spectrum of bacteriocin-like agents from Neisseria meningitidis
Acta Pathol Microbiol Immunol Scand B, 92 (3), 159-63
DOI 10.1111/j.1699-0463.1984.tb02812.x, PubMed 6435390
Jyssum K, Allunans J (1984)
Activity of bacteriocin-like agents from Neisseria meningitidis on strains isolated from patients and carriers
Acta Pathol Microbiol Immunol Scand B, 92 (3), 165-70
DOI 10.1111/j.1699-0463.1984.tb02813.x, PubMed 6435391

Publications 1983

Jyssum K, Allunans J (1983)
Expression of bacteriocin-like activity in batch cultures of Neisseria meningitidis and consequences for genetic recombination
Acta Pathol Microbiol Immunol Scand B, 91 (2), 107-11
DOI 10.1111/j.1699-0463.1983.tb00018.x, PubMed 6408888
Jyssum K, Allunans J (1983)
Influence of blood cells on the expression of bacteriocin-like activity in Neisseria meningitidis
Acta Pathol Microbiol Immunol Scand B, 91 (4), 245-50
DOI 10.1111/j.1699-0463.1983.tb00041.x, PubMed 6414242

Publications 1982

Jyssum K, Allunans J (1982)
Three types of growth inhibition among strains of Neisseria meningitidis isolated from patients in Norway
Acta Pathol Microbiol Immunol Scand B, 90 (5), 335-40
DOI 10.1111/j.1699-0463.1982.tb00128.x, PubMed 6816008
JYSSUM K, ALLUNANS J (1982)
3 TYPES OF GROWTH-INHIBITION AMONG STRAINS OF NEISSERIA-MENINGITIDIS ISOLATED FROM PATIENTS IN NORWAY
ACTA PATH MICRO IM B, 90 (5), 335-340

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