Research aims

Overall aim: To investigate mechanisms for individual variability in drug response and to establish principles for personalized dosing in selected pharmacotherapies, currently those related to immunosuppression, chemotherapy, anti-infectives and statins. 

This may be achieved by:

• The combination of pharmacokinetics (PK), pharmacodynamics (PD) and pharmacogenomics (PGx), sources for individual variability in the response of specific drugs.
• The identification of variant genotypes or altered gene expression affecting drug response. Biomarkers for the above.
• Models for decision support, including population PK/PD or machine learning based models plus integrative models for biomarkers. 

Current projects (and collaborations)

• Personalized statin treatment (Dept of Medicine, Drammen Hospital)
• Self collecting blood samples by patients; microsamples and home sampling 
• Meropenem -optimized administration in the ICU
• IMPRESS Norway - potential for dose individualization based on therapeutic drug monitroing and pharmacogenetics
• Tacrolimus new PK/PD principles for individualization (Dept of Transplant Medicine)
• Pediatric and adult hemato-oncology and transplantation, e.g. busulfan, glucocorticoids, tacrolimus (Dept of Pediatrics; Dept of Hematology)
• Pharmacogenetic panels; integration with high throughput screening (Dept of Genetics)
• Model informed precision dosing (MIPD) tools; pharmacometry models and machine learning 

Contact information

Stein Bergan, Professor II
Department of Pharmacology, Oslo University Hospital & School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo
Tel: +47 23071082; 93266214
E-mail: stein.bergan@farmasi.uio.no / sbergan@ous-hf.no