Ingrun Alseth

  • Research scientist (Group leader); PhD
  • 230 74069
Yeast group
 

Original articles

Berges N, Nawaz MS, Børresdatter Dahl T, Hagen L, Bjørås M, Laerdahl JK, Alseth I (2019)
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 11698-11711
DOI 10.1093/nar/gky846, PubMed 30247619

Nawaz MS, Vik ES, Berges N, Fladeby C, Bjørås M, Dalhus B, Alseth I (2016)
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
DOI 10.1074/jbc.M116.730911, PubMed 27573237

Nawaz MS, Vik ES, Ronander ME, Solvoll AM, Blicher P, Bjørås M, Alseth I, Dalhus B (2016)
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
DOI 10.1038/srep24979, PubMed 27108838

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Alseth I, Dalhus B, Bjørås M (2014)
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738

Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M (2013)
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
DOI 10.1016/j.jsb.2013.04.007, PubMed 23623903

Rosnes I, Rowe AD, Vik ES, Forstrøm RJ, Alseth I, Bjørås M, Dalhus B (2013)
Structural basis of DNA loop recognition by endonuclease V
Structure, 21 (2), 257-65
DOI 10.1016/j.str.2012.12.007, PubMed 23313664

Vik ES, Nawaz MS, Strøm Andersen P, Fladeby C, Bjørås M, Dalhus B, Alseth I (2013)
Endonuclease V cleaves at inosines in RNA
Nat Commun, 4, 2271
DOI 10.1038/ncomms3271, PubMed 23912683

Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray CT, Alseth I, Tainer JA, Bjørås M (2012)
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2
Structure, 21 (1), 154-166
DOI 10.1016/j.str.2012.11.004, PubMed 23245849

Vik ES, Alseth I, Forsbring M, Helle IH, Morland I, Luna L, Bjørås M, Dalhus B (2012)
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
DOI 10.1016/j.dnarep.2012.07.002, PubMed 22858590

Korvald H, Falnes PØ, Laerdahl JK, Bjørås M, Alseth I (2012)
The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity
DNA Repair (Amst), 11 (5), 453-62
DOI 10.1016/j.dnarep.2012.01.014, PubMed 22365419

Fladeby C, Vik ES, Laerdahl JK, Gran Neurauter C, Heggelund JE, Thorgaard E, Strøm-Andersen P, Bjørås M, Dalhus B, Alseth I (2012)
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
DOI 10.1371/journal.pone.0047466, PubMed 23139746

Nilsen L, Forstrøm RJ, Bjørås M, Alseth I (2011)
AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
Nucleic Acids Res, 40 (5), 2000-9
DOI 10.1093/nar/gkr933, PubMed 22084197

Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M (2011)
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366

Dalhus B, Forsbring M, Helle IH, Vik ES, Forstrøm RJ, Backe PH, Alseth I, Bjørås M (2011)
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
DOI 10.1016/j.str.2010.09.023, PubMed 21220122

Korvald H, Mølstad Moe AM, Cederkvist FH, Thiede B, Laerdahl JK, Bjørås M, Alseth I (2011)
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones
PLoS One, 6 (9), e25188
DOI 10.1371/journal.pone.0025188, PubMed 21949882

Laerdahl JK, Korvald H, Nilsen L, Dahl-Michelsen K, Rognes T, Bjørås M, Alseth I (2010)
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1
DNA Repair (Amst), 10 (3), 296-305
DOI 10.1016/j.dnarep.2010.11.014, PubMed 21193357

Olsen I, Balasingham SV, Davidsen T, Debebe E, Rødland EA, van Soolingen D, Kremer K, Alseth I, Tønjum T (2009)
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol Med Microbiol, 56 (2), 151-61
DOI 10.1111/j.1574-695X.2009.00562.x, PubMed 19496823

Forsbring M, Vik ES, Dalhus B, Karlsen TH, Bergquist A, Schrumpf E, Bjørås M, Boberg KM, Alseth I (2009)
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
DOI 10.1093/carcin/bgp118, PubMed 19443904

Dalhus B, Arvai AS, Rosnes I, Olsen ØE, Backe PH, Alseth I, Gao H, Cao W, Tainer JA, Bjørås M (2009)
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
DOI 10.1038/nsmb.1538, PubMed 19136958

Dalhus B, Helle IH, Backe PH, Alseth I, Rognes T, Bjørås M, Laerdahl JK (2007)
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
DOI 10.1093/nar/gkm039, PubMed 17395642

Falnes PØ, Klungland A, Alseth I (2006)
Repair of methyl lesions in DNA and RNA by oxidative demethylation
Neuroscience, 145 (4), 1222-32
DOI 10.1016/j.neuroscience.2006.11.018, PubMed 17175108

Nakken S, Alseth I, Rognes T (2006)
Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes
Neuroscience, 145 (4), 1273-9
DOI 10.1016/j.neuroscience.2006.09.004, PubMed 17055652

Alseth I, Rognes T, Lindbäck T, Solberg I, Robertsen K, Kristiansen KI, Mainieri D, Lillehagen L, Kolstø AB, Bjørås M (2006)
A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD
Mol Microbiol, 59 (5), 1602-9
DOI 10.1111/j.1365-2958.2006.05044.x, PubMed 16468998

Alseth I, Osman F, Korvald H, Tsaneva I, Whitby MC, Seeberg E, Bjørås M (2005)
Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 33 (3), 1123-31
DOI 10.1093/nar/gki259, PubMed 15722486

Alseth I, Korvald H, Osman F, Seeberg E, Bjørås M (2004)
A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces pombe
Nucleic Acids Res, 32 (17), 5119-25
DOI 10.1093/nar/gkh851, PubMed 15452279

Osman F, Bjørås M, Alseth I, Morland I, McCready S, Seeberg E, Tsaneva I (2003)
A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage
Mol Microbiol, 48 (2), 465-80
DOI 10.1046/j.1365-2958.2003.03440.x, PubMed 12675805

Maclean MJ, Aamodt R, Harris N, Alseth I, Seeberg E, Bjørås M, Piper PW (2003)
Base excision repair activities required for yeast to attain a full chronological life span
Aging Cell, 2 (2), 93-104
DOI 10.1046/j.1474-9728.2003.00041.x, PubMed 12882322

Seeberg E, Luna L, Morland I, Eide L, Johnsen B, Larsen E, Alseth I, Dantzer F, Baynton K, Aamodt R, Kristiansen KI, Rognes T, Klungland A, Bjørås M (2000)
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028

Alseth I, Eide L, Pirovano M, Rognes T, Seeberg E, Bjørås M (1999)
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
Mol Cell Biol, 19 (5), 3779-87
DOI 10.1128/mcb.19.5.3779, PubMed 10207101

Luna L, Bjoras M, Berdal KG, Alseth I, Eide L, Rognes T, Seeberg E (1999)
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283

Eide L, Bjørås M, Pirovano M, Alseth I, Berdal KG, Seeberg E (1996)
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli
Proc Natl Acad Sci U S A, 93 (20), 10735-40
DOI 10.1073/pnas.93.20.10735, PubMed 8855249

Mol CD, Arvai AS, Slupphaug G, Kavli B, Alseth I, Krokan HE, Tainer JA (1995)
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis
Cell, 80 (6), 869-78
DOI 10.1016/0092-8674(95)90290-2, PubMed 7697717

Slupphaug G, Alseth I, Eftedal I, Volden G, Krokan HE (1993)
Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplifications
Anal Biochem, 211 (1), 164-9
DOI 10.1006/abio.1993.1248, PubMed 8323030

Review articles

Dalhus B, Alseth I, Bjørås M (2015)
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V
Prog Biophys Mol Biol, 117 (2-3), 134-142
DOI 10.1016/j.pbiomolbio.2015.03.005, PubMed 25824682

Other articles

Herrera MC, Chymkowitch P, Robertson JM, Eriksson J, Bøe SO, Alseth I, Enserink JM (2018)
Corrigendum: Cdk1 gates cell cycle-dependent tRNA synthesis by regulating RNA polymerase III activity
Nucleic Acids Res, 46 (22), 12188-12189
DOI 10.1093/nar/gky1102, PubMed 30395271

Theses

Alseth I (1999)
Enzymatic removal of oxidized and alkylated base residuesfrom DNA
Institute of Medical Microbiology, Department of Molecular Biology, The National Hospital, [Oslo], 1 b. (flere pag.)
BIBSYS 991255992, ISBN 82-7633-132-7

Alseth I (1993)
Studier av human uracil-DNA glykosylase ved sete-spesifikkmutagenese
[Trondheim], 1 b. (flere pag.)
BIBSYS 940086239

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