Phosphatidylinositol signaling & disease
We use the fruit fly, Drosophila melanogaster, as a genetic model system to investigate the relationship between cell signaling and intracellular vesicle trafficking pathways of importance in cancer and neurodegeneration.
We primarily study the biological functions of the phosphatidylinositol kinases (PIKs) and their effectors that regulate endocytosis and autophagy with the aim to understand the molecular mechanisms regulating these processes and how their abnormal function contribute to cancer and neurodegeneration.
To investigate these issues, we have generated and obtained mutants of PIKs and effector proteins. We are currently studying the function of these genes using a combination of targeted gene expression, conditional knock out, RNAi mediated knock down, electron microscopy, immunofluorescence and confocal microscopy.
Former lab member:
We collaborate with the research groups of:
- David Bilder, University of California, Berkeley, US
- Daniel StJohnston, Cambridge, UK
- Ragnhild Lothe, Centre for Cancer Biomedicine, The Norwegian Radium Hospital, Oslo, Norway
- John Poulton, University of North Carolina, Chapel Hill, USA
We are always looking for talented and motivated Post Docs and PhD students that wants to join the lab.
If you are interested please contact Tor Erik Rusten by email well in advance to be able to secure funding.
Post Doctoral fellowship:
Norwegian Research Council (2 years, June-start January)
The Norwegian Cancer Society (2years, June-start January)
Helse Sør-Øst (2 years, September-start January)
EMBO (2years, August-Start January)
HFSP (2 years, August-Start January)
FEBS (up to 3 years, bianually)
May 6, 2013
May 2, 2013
Tor Erik Rusten
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
Shaping development with ESCRTs
Nat Cell Biol, 14 (1), 38-45