Quian Peng

Photodynamic Therapy and Photodetection

 
Quian Peng<br>Group leader
Quian Peng
Group leader

Photodynamic therapy (PDT) is a two-step therapeutic technology in which the topical or systemic delivery of a lesion-localising photosensitising drug is followed by local irradiation with visible light. The light-activated photosensitiser then transfers the energy to molecular oxygen, generating reactive oxygen species (ROS). The subsequent ROS-mediated oxidation of lipids, amino-acids and proteins induces cell necrosis and apoptosis. The absorbed energy of the photosensitiser can also be released via fluorescence, which can be utilised for tumour photodetection (PD). PDT/PD is already an established modality for clinical practice. This group focuses mainly on the development of new photosensitisers, mechanistic studies of PDT effects and clinical applications of PDT/PD with optical spectroscopy and imaging systems.

Projects

  • Mechanism of PDT-mediated apoptosis
  • PDT-mediated anti-tumour immunity
  • PDT in combination with nanotechnology
  • Clinical PDT of oral and genital erosive lichen planus
  • Clinical PDT of skin diseases

Contact information:
Qian Peng, Dr.med., senior scientist, Department of Pathology, Oslo University Hospital, Radiumhospitalet, Montebello 0310, Oslo E-mail: Qian.Peng@rr-research.no