Clinical immunology and infectious diseases
The research group focus on immunopathogenesis in primary and secondary immunodeficiency (such as CVID and HIV) and selected infectious diseases, in particular the study of chronic inflammation characterising these disorders. The aim is to improve the understanding of disease mechanisms and to discover new targets for therapeutic intervention. The group works in a translational setting combining close contact to the clinic, in particular Section of Clinical Immunology and Infectious Diseases at OUS, with access to a wide range of immunological methods through extensive collaboration with other groups.
Chronic inflammation is a common feature of both immunodeficiencies and many infectious disorders. While inflammation is vital to the clearance of both invading microbes and potentially malignant cells a continued or exaggerated response will further compromise the patients health. Identifying the factors leading to such an exaggerated response will potentially enable clinicians to modify the inflammatory response of the individual patient with agents targeting anything from intracellular signalling pathways to intercellular cytokine networks and microbiota.
From left: Kari Otterdal, Jan-Cato Holter, Børre Fevang, Elisabeth Astrup, William Siljan, Magnhild Eide Macpherson, Liv Hesstvedt, Silje Jørgensen, Ingvild Nordøy
Early phase drug development: From idea to concept
Feb 3, 2017
Feb 2, 2017
Oncolytic peptide LTX-315; the road from basic science to clinical trials
Jan 26, 2017
CVID and Celiac Disease
Am J Gastroenterol, 112 (2), 393
Liver transplantation in patients with primary antibody deficiency
J Allergy Clin Immunol (in press)