Inger Sandlie

  • Professor, group leader
  • +47 22854568/55784

Publications 2019

Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC (2019)
Complement C4 Prevents Viral Infection through Capsid Inactivation
Cell Host Microbe, 25 (4), 617-629.e7
DOI 10.1016/j.chom.2019.02.016, PubMed 30926239

Foss S, Bottermann M, Jonsson A, Sandlie I, James LC, Andersen JT (2019)
TRIM21-From Intracellular Immunity to Therapy
Front Immunol, 10, 2049
DOI 10.3389/fimmu.2019.02049, PubMed 31555278

Frick R, Gunnarsen KS, Dahal-Koirala S, Risnes LF, Sollid LM, Sandlie I, Høydahl LS, Løset GÅ (2019)
A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease
Eur J Immunol, 50 (1), 142-145
DOI 10.1002/eji.201948235, PubMed 31580480

Høydahl LS, Frick R, Sandlie I, Løset GÅ (2019)
Targeting the MHC Ligandome by Use of TCR-Like Antibodies
Antibodies (Basel), 8 (2)
DOI 10.3390/antib8020032, PubMed 31544838

Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS (2019)
The Neonatal Fc Receptor (FcRn): A Misnomer?
Front Immunol, 10, 1540
DOI 10.3389/fimmu.2019.01540, PubMed 31354709

Shaw A, Hoffecker IT, Smyrlaki I, Rosa J, Grevys A, Bratlie D, Sandlie I, Michaelsen TE, Andersen JT, Högberg B (2019)
Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies
Nat Nanotechnol, 14 (2), 184-190
DOI 10.1038/s41565-018-0336-3, PubMed 30643273

Shaw A, Hoffecker IT, Smyrlaki I, Rosa J, Grevys A, Bratlie D, Sandlie I, Michaelsen TE, Andersen JT, Högberg B (2019)
Publisher Correction: Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies
Nat Nanotechnol, 14 (4), 398
DOI 10.1038/s41565-019-0404-3, PubMed 30783200

Publications 2018

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT (2018)
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nat Commun, 9 (1), 621
DOI 10.1038/s41467-018-03061-x, PubMed 29434196

Gunnarsen KS, Høydahl LS, Neumann RS, Bjerregaard-Andersen K, Nilssen NR, Sollid LM, Sandlie I, Løset GÅ (2018)
Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system
PLoS One, 13 (4), e0195868
DOI 10.1371/journal.pone.0195868, PubMed 29649333

Høydahl LS, Richter L, Frick R, Snir O, Gunnarsen KS, Landsverk OJB, Iversen R, Jeliazkov JR, Gray JJ, Bergseng E, Foss S, Qiao SW, Lundin KEA, Jahnsen J, Jahnsen FL, Sandlie I, Sollid LM, Løset GÅ (2018)
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798

Nilsen J, Bern M, Sand KMK, Grevys A, Dalhus B, Sandlie I, Andersen JT (2018)
Human and mouse albumin bind their respective neonatal Fc receptors differently
Sci Rep, 8 (1), 14648
DOI 10.1038/s41598-018-32817-0, PubMed 30279529

Nilsen J, Sandlie I, Roopenian DC, Andersen JT (2018)
Animal models for evaluation of albumin-based therapeutics
Curr. Opin. Chem. Eng., 19, 68-76

Publications 2017

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC (2017)
Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 7, 45418
DOI 10.1038/srep45418, PubMed 28382939

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121

Michaelsen TE, Emilsen S, Sandin RH, Granerud BK, Bratlie D, Ihle O, Sandlie I (2017)
Human Secretory IgM Antibodies Activate Human Complement and Offer Protection at Mucosal Surface
Scand J Immunol, 85 (1), 43-50
DOI 10.1111/sji.12508, PubMed 27864913

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS (2017)
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Proc Natl Acad Sci U S A, 114 (14), E2862-E2871
DOI 10.1073/pnas.1618291114, PubMed 28330995

Publications 2016

Bottermann M, Lode HE, Watkinson RE, Foss S, Sandlie I, Andersen JT, James LC (2016)
Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 6, 37457
DOI 10.1038/srep37457, PubMed 27881870

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230

Høydahl LS, Nilssen NR, Gunnarsen KS, Pré MF, Iversen R, Roos N, Chen X, Michaelsen TE, Sollid LM, Sandlie I, Løset GÅ (2016)
Multivalent pIX phage display selects for distinct and improved antibody properties
Sci Rep, 6, 39066
DOI 10.1038/srep39066, PubMed 27966617

Publications 2015

Bern M, Sand KM, Nilsen J, Sandlie I, Andersen JT (2015)
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery
J Control Release, 211, 144-62
DOI 10.1016/j.jconrel.2015.06.006, PubMed 26055641

Czajkowsky DM, Andersen JT, Fuchs A, Wilson TJ, Mekhaiel D, Colonna M, He J, Shao Z, Mitchell DA, Wu G, Dell A, Haslam S, Lloyd KA, Moore SC, Sandlie I, Blundell PA, Pleass RJ (2015)
Developing the IVIG biomimetic, hexa-Fc, for drug and vaccine applications
Sci Rep, 5, 9526
DOI 10.1038/srep09526, PubMed 25912958

Foss S, Grevys A, Sand KMK, Bern M, Blundell P, Michaelsen TE, Pleass RJ, Sandlie I, Andersen JT (2015)
Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization
J Control Release, 223, 42-52
DOI 10.1016/j.jconrel.2015.12.033, PubMed 26718855

Foss S, Watkinson R, Sandlie I, James LC, Andersen JT (2015)
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity
Immunol Rev, 268 (1), 328-39
DOI 10.1111/imr.12363, PubMed 26497531

Grevys A, Bern M, Foss S, Bratlie DB, Moen A, Gunnarsen KS, Aase A, Michaelsen TE, Sandlie I, Andersen JT (2015)
Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions
J Immunol, 194 (11), 5497-508
DOI 10.4049/jimmunol.1401218, PubMed 25904551

Løset GÅ, Berntzen G, Frigstad T, Pollmann S, Gunnarsen KS, Sandlie I (2015)
Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions
Front Oncol, 4, 378
DOI 10.3389/fonc.2014.00378, PubMed 25629004

Sand KM, Bern M, Nilsen J, Noordzij HT, Sandlie I, Andersen JT (2015)
Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
Front Immunol, 5, 682
DOI 10.3389/fimmu.2014.00682, PubMed 25674083

Publications 2014

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290

Hallstensen RF, Bergseth G, Foss S, Jæger S, Gedde-Dahl T, Holt J, Christiansen D, Lau C, Brekke OL, Armstrong E, Stefanovic V, Andersen JT, Sandlie I, Mollnes TE (2014)
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
Immunobiology, 220 (4), 452-9
DOI 10.1016/j.imbio.2014.11.003, PubMed 25468724

Rahman MA, Kristiansen PE, Veiseth SV, Andersen JT, Yap KL, Zhou MM, Sandlie I, Thorstensen T, Aalen RB (2014)
The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure
Biochemistry, 53 (13), 2091-100
DOI 10.1021/bi401436h, PubMed 24625295

Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301

Publications 2013

Andersen JT, Cameron J, Plumridge A, Evans L, Sleep D, Sandlie I (2013)
Single-chain variable fragment albumin fusions bind the neonatal Fc receptor (FcRn) in a species-dependent manner: implications for in vivo half-life evaluation of albumin fusion therapeutics
J Biol Chem, 288 (33), 24277-85
DOI 10.1074/jbc.M113.463000, PubMed 23818524

Andersen JT, Gonzalez-Pajuelo M, Foss S, Landsverk OJ, Pinto D, Szyroki A, de Haard HJ, Saunders M, Vanlandschoot P, Sandlie I (2013)
Selection of nanobodies that target human neonatal Fc receptor
Sci Rep, 3, 1118
DOI 10.1038/srep01118, PubMed 23346375

Frigstad T, Løset GÅ, Sandlie I, Bogen B (2013)
A public T cell receptor recognized by a monoclonal antibody specific for the D-J junction of the β-chain
Scand J Immunol, 78 (4), 345-51
DOI 10.1111/sji.12098, PubMed 23841814

Gunnarsen KS, Kristinsson SG, Justesen S, Frigstad T, Buus S, Bogen B, Sandlie I, Løset GÅ (2013)
Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display
Sci Rep, 3, 1162
DOI 10.1038/srep01162, PubMed 23362461

Lau C, Gunnarsen KS, Høydahl LS, Andersen JT, Berntzen G, Pharo A, Lindstad JK, Ludviksen JK, Brekke OL, Barratt-Due A, Nielsen EW, Stokes CR, Espevik T, Sandlie I, Mollnes TE (2013)
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation
J Immunol, 191 (9), 4769-77
DOI 10.4049/jimmunol.1301653, PubMed 24062486

Mathiesen L, Nielsen LK, Andersen JT, Grevys A, Sandlie I, Michaelsen TE, Hedegaard M, Knudsen LE, Dziegiel MH (2013)
Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions
Blood, 122 (7), 1174-81
DOI 10.1182/blood-2012-12-473843, PubMed 23843496

Publications 2012

Andersen JT, Dalhus B, Cameron J, Daba MB, Plumridge A, Evans L, Brennan SO, Gunnarsen KS, Bjørås M, Sleep D, Sandlie I (2012)
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
DOI 10.1038/ncomms1607, PubMed 22215085

Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I (2012)
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
J Biol Chem, 287 (27), 22927-37
DOI 10.1074/jbc.M112.355131, PubMed 22570488

Fredriksen AB, Sandlie I, Bogen B (2012)
Targeted DNA vaccines for enhanced induction of idiotype-specific B and T cells
Front Oncol, 2, 154
DOI 10.3389/fonc.2012.00154, PubMed 23115759

Jung ST, Kelton W, Kang TH, Ng DT, Andersen JT, Sandlie I, Sarkar CA, Georgiou G (2012)
Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity
ACS Chem Biol, 8 (2), 368-75
DOI 10.1021/cb300455f, PubMed 23030766

Løset GÅ, Sandlie I (2012)
Next generation phage display by use of pVII and pIX as display scaffolds
Methods, 58 (1), 40-6
DOI 10.1016/j.ymeth.2012.07.005, PubMed 22819858

Nilssen NR, Frigstad T, Pollmann S, Roos N, Bogen B, Sandlie I, Løset GÅ (2012)
DeltaPhage--a novel helper phage for high-valence pIX phagemid display
Nucleic Acids Res, 40 (16), e120
DOI 10.1093/nar/gks341, PubMed 22539265

Rasmussen IB, Oynebråten I, Høydahl LS, Flobakk M, Lunde E, Michaelsen TE, Bogen B, Sandlie I (2012)
CD40/APC-specific antibodies with three T-cell epitopes loaded in the constant domains induce CD4+ T-cell responses
Protein Eng Des Sel, 25 (3), 89-96
DOI 10.1093/protein/gzr063, PubMed 22233931

Yazaki PJ, Lee B, Channappa D, Cheung CW, Crow D, Chea J, Poku E, Li L, Andersen JT, Sandlie I, Orcutt KD, Wittrup KD, Shively JE, Raubitschek A, Colcher D (2012)
A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance
Protein Eng Des Sel, 26 (3), 187-93
DOI 10.1093/protein/gzs096, PubMed 23175797

Publications 2011

Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS (2011)
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells
Proc Natl Acad Sci U S A, 108 (24), 9927-32
DOI 10.1073/pnas.1019037108, PubMed 21628593

Løset GÅ, Bogen B, Sandlie I (2011)
Expanding the versatility of phage display I: efficient display of peptide-tags on protein VII of the filamentous phage
PLoS One, 6 (2), e14702
DOI 10.1371/journal.pone.0014702, PubMed 21390217

Løset GÅ, Roos N, Bogen B, Sandlie I (2011)
Expanding the versatility of phage display II: improved affinity selection of folded domains on protein VII and IX of the filamentous phage
PLoS One, 6 (2), e17433
DOI 10.1371/journal.pone.0017433, PubMed 21390283

Mekhaiel DN, Czajkowsky DM, Andersen JT, Shi J, El-Faham M, Doenhoff M, McIntosh RS, Sandlie I, He J, Hu J, Shao Z, Pleass RJ (2011)
Polymeric human Fc-fusion proteins with modified effector functions
Sci Rep, 1, 124
DOI 10.1038/srep00124, PubMed 22355641

Qiao SW, Ráki M, Gunnarsen KS, Løset GÅ, Lundin KE, Sandlie I, Sollid LM (2011)
Posttranslational modification of gluten shapes TCR usage in celiac disease
J Immunol, 187 (6), 3064-71
DOI 10.4049/jimmunol.1101526, PubMed 21849672

Stapleton NM, Andersen JT, Stemerding AM, Bjarnarson SP, Verheul RC, Gerritsen J, Zhao Y, Kleijer M, Sandlie I, de Haas M, Jonsdottir I, van der Schoot CE, Vidarsson G (2011)
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential
Nat Commun, 2, 599
DOI 10.1038/ncomms1608, PubMed 22186895

Wälchli S, Løset GÅ, Kumari S, Johansen JN, Yang W, Sandlie I, Olweus J (2011)
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
DOI 10.1371/journal.pone.0027930, PubMed 22132171

Publications 2010

Gunnarsen KS, Lunde E, Kristiansen PE, Bogen B, Sandlie I, Løset GÅ (2010)
Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA
BMC Biotechnol, 10, 8
DOI 10.1186/1472-6750-10-8, PubMed 20128915

Lunde E, Løset GÅ, Bogen B, Sandlie I (2010)
Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins
BMC Biotechnol, 10, 61
DOI 10.1186/1472-6750-10-61, PubMed 20735812

Publications 2009

Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I (2009)
Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
J Biol Chem, 285 (7), 4826-36
DOI 10.1074/jbc.M109.081828, PubMed 20018855

Andersen JT, Daba MB, Sandlie I (2009)
FcRn binding properties of an abnormal truncated analbuminemic albumin variant
Clin Biochem, 43 (4-5), 367-72
DOI 10.1016/j.clinbiochem.2009.12.001, PubMed 20006594

Andersen JT, Sandlie I (2009)
The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics
Drug Metab Pharmacokinet, 24 (4), 318-32
DOI 10.2133/dmpk.24.318, PubMed 19745559

Ghumra A, Shi J, Mcintosh RS, Rasmussen IB, Braathen R, Johansen FE, Sandlie I, Mongini PK, Areschoug T, Lindahl G, Lewis MJ, Woof JM, Pleass RJ (2009)
Structural requirements for the interaction of human IgM and IgA with the human Fcalpha/mu receptor
Eur J Immunol, 39 (4), 1147-56
DOI 10.1002/eji.200839184, PubMed 19266484

Jung ST, Reddy ST, Kang TH, Borrok MJ, Sandlie I, Tucker PW, Georgiou G (2009)
Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells
Proc Natl Acad Sci U S A, 107 (2), 604-9
DOI 10.1073/pnas.0908590107, PubMed 20080725

Michaelsen TE, Sandlie I, Bratlie DB, Sandin RH, Ihle O (2009)
Structural difference in the complement activation site of human IgG1 and IgG3
Scand J Immunol, 70 (6), 553-64
DOI 10.1111/j.1365-3083.2009.02338.x, PubMed 19906198

Publications 2008

Andersen JT, Justesen S, Fleckenstein B, Michaelsen TE, Berntzen G, Kenanova VE, Daba MB, Lauvrak V, Buus S, Sandlie I (2008)
Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues
FEBS J, 275 (16), 4097-110
DOI 10.1111/j.1742-4658.2008.06551.x, PubMed 18637944

Berntzen G, Andersen JT, Ustgård K, Michaelsen TE, Mousavi SA, Qian JD, Kristiansen PE, Lauvrak V, Sandlie I (2008)
Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation
J Biol Chem, 284 (2), 1126-35
DOI 10.1074/jbc.M803584200, PubMed 18957413

Flobakk M, Rasmussen IB, Lunde E, Frigstad T, Berntzen G, Michaelsen TE, Bogen B, Sandlie I (2008)
Processing of an antigenic sequence from IgG constant domains for presentation by MHC class II
J Immunol, 181 (10), 7062-72
DOI 10.4049/jimmunol.181.10.7062, PubMed 18981126

Ghumra A, Semblat JP, McIntosh RS, Raza A, Rasmussen IB, Braathen R, Johansen FE, Sandlie I, Mongini PK, Rowe JA, Pleass RJ (2008)
Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
J Immunol, 181 (3), 1988-2000
DOI 10.4049/jimmunol.181.3.1988, PubMed 18641336

Løset GÅ, Kristinsson SG, Sandlie I (2008)
Reliable titration of filamentous bacteriophages independent of pIII fusion moiety and genome size by using trypsin to restore wild-type pIII phenotype
Biotechniques, 44 (4), 551-2, 554
DOI 10.2144/000112724, PubMed 18476820

Tunheim G, Schjetne KW, Rasmussen IB, Sollid LM, Sandlie I, Bogen B (2008)
Recombinant antibodies for delivery of antigen: a single loop between beta-strands in the constant region can accommodate long, complex and tandem T cell epitopes
Int Immunol, 20 (3), 295-306
DOI 10.1093/intimm/dxm141, PubMed 18252695

Publications 2007

Andersen JT, Justesen S, Berntzen G, Michaelsen TE, Lauvrak V, Fleckenstein B, Buus S, Sandlie I (2007)
A strategy for bacterial production of a soluble functional human neonatal Fc receptor
J Immunol Methods, 331 (1-2), 39-49
DOI 10.1016/j.jim.2007.11.003, PubMed 18155020

Andersen JT, Sandlie I (2007)
A receptor-mediated mechanism to support clinical observation of altered albumin variants
Clin Chem, 53 (12), 2216
DOI 10.1373/clinchem.2007.097071, PubMed 18267931

Lu Y, Harding SE, Michaelsen TE, Longman E, Davis KG, Ortega A, Grossmann JG, Sandlie I, García de la Torre J (2007)
Solution conformation of wild-type and mutant IgG3 and IgG4 immunoglobulins using crystallohydrodynamics: possible implications for complement activation
Biophys J, 93 (11), 3733-44
DOI 10.1529/biophysj.107.108993, PubMed 17704171

Løset GÅ, Lunde E, Bogen B, Brekke OH, Sandlie I (2007)
Functional phage display of two murine alpha/beta T-cell receptors is strongly dependent on fusion format, mode and periplasmic folding assistance
Protein Eng Des Sel, 20 (9), 461-72
DOI 10.1093/protein/gzm044, PubMed 17925331

Nielsen LK, Green TH, Norderhaug L, Sandlie I, Dziegiel MH (2007)
Functional in vitro studies of recombinant human immunoglobulin G and immunoglobulin A anti-D
Transfusion, 47 (2), 306-15
DOI 10.1111/j.1537-2995.2007.01107.x, PubMed 17302778

Nielsen LK, Green TH, Sandlie I, Michaelsen TE, Dziegiel MH (2007)
In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn
Transfusion, 48 (1), 12-9
DOI 10.1111/j.1537-2995.2007.01474.x, PubMed 17764508

Publications 2006

Andersen JT, Dee Qian J, Sandlie I (2006)
The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
Eur J Immunol, 36 (11), 3044-51
DOI 10.1002/eji.200636556, PubMed 17048273

Berntzen G, Brekke OH, Mousavi SA, Andersen JT, Michaelsen TE, Berg T, Sandlie I, Lauvrak V (2006)
Characterization of an FcgammaRI-binding peptide selected by phage display
Protein Eng Des Sel, 19 (3), 121-8
DOI 10.1093/protein/gzj011, PubMed 16423844

Braathen R, Sandvik A, Berntzen G, Hammerschmidt S, Fleckenstein B, Sandlie I, Brandtzaeg P, Johansen FE, Lauvrak V (2006)
Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
J Biol Chem, 281 (11), 7075-81
DOI 10.1074/jbc.M508509200, PubMed 16423833

Fredriksen AB, Sandlie I, Bogen B (2006)
DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells
Mol Ther, 13 (4), 776-85
DOI 10.1016/j.ymthe.2005.10.019, PubMed 16414309

Michaelsen TE, Thommesen JE, Ihle O, Gregers TF, Sandin RH, Brekke OH, Sandlie I (2006)
A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells
Eur J Immunol, 36 (1), 129-38
DOI 10.1002/eji.200535178, PubMed 16323243

Nielsen LK, Norderhaug L, Sandlie I, Dziegiel MH (2006)
In vitro functional test of two subclasses of an anti-RhD antibody produced by transient expression in COS cells
APMIS, 114 (5), 345-51
DOI 10.1111/j.1600-0463.2006.apm_381.x, PubMed 16725010

Publications 2005

Berntzen G, Lunde E, Flobakk M, Andersen JT, Lauvrak V, Sandlie I (2005)
Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
J Immunol Methods, 298 (1-2), 93-104
DOI 10.1016/j.jim.2005.01.002, PubMed 15847800

Schjetne KW, Thommesen JE, Fredriksen AB, Lunde E, Sandlie I, Bogen B (2005)
Induction of central T cell tolerance: recombinant antibodies deliver peptides for deletion of antigen-specific (CD4+)8+ thymocytes
Eur J Immunol, 35 (11), 3142-52
DOI 10.1002/eji.200425947, PubMed 16184515

Publications 2004

Lauvrak V, Berntzen G, Heggelund U, Herstad TK, Sandin RH, Dalseg R, Rosenqvist E, Sandlie I, Michaelsen TE (2004)
Selection and characterization of cyclic peptides that bind to a monoclonal antibody against meningococcal L3,7,9 lipopolysaccharides
Scand J Immunol, 59 (4), 373-84
DOI 10.1111/j.1365-3083.2004.01400.x, PubMed 15049781

Løset GÅ, Roux KH, Zhu P, Michaelsen TE, Sandlie I (2004)
Differential segmental flexibility and reach dictate the antigen binding mode of chimeric IgD and IgM: implications for the function of the B cell receptor
J Immunol, 172 (5), 2925-34
DOI 10.4049/jimmunol.172.5.2925, PubMed 14978095

Tjelle TE, Corthay A, Lunde E, Sandlie I, Michaelsen TE, Mathiesen I, Bogen B (2004)
Monoclonal antibodies produced by muscle after plasmid injection and electroporation
Mol Ther, 9 (3), 328-36
DOI 10.1016/j.ymthe.2003.12.007, PubMed 15006599

Tunheim G, Schjetne KW, Fredriksen AB, Sandlie I, Bogen B (2004)
Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes
J Leukoc Biol, 77 (3), 303-10
DOI 10.1189/jlb.0804480, PubMed 15576418

Publications 2003

Brekke OH, Sandlie I (2003)
Therapeutic antibodies for human diseases at the dawn of the twenty-first century
Nat Rev Drug Discov, 2 (1), 52-62
DOI 10.1038/nrd984, PubMed 12509759

Gregers TF, Fleckenstein B, Vartdal F, Roepstorff P, Bakke O, Sandlie I (2003)
MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation
Int Immunol, 15 (11), 1291-9
DOI 10.1093/intimm/dxg128, PubMed 14565927

Gregers TF, Nordeng TW, Birkeland HC, Sandlie I, Bakke O (2003)
The cytoplasmic tail of invariant chain modulates antigen processing and presentation
Eur J Immunol, 33 (2), 277-86
DOI 10.1002/immu.200310001, PubMed 12548558

Publications 2002

Braathen R, Sorensen V, Brandtzaeg P, Sandlie I, Johansen FE (2002)
The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
J Biol Chem, 277 (45), 42755-62
DOI 10.1074/jbc.M205502200, PubMed 12213814

Furebring C, Speckner A, Mach M, Sandlie I, Norderhaug L, Borrebaeck CA, Turesson H, Ohlin M (2002)
Antibody-mediated neutralization of cytomegalovirus: modulation of efficacy induced through the IgG constant region
Mol Immunol, 38 (11), 833-40
DOI 10.1016/s0161-5890(01)00119-5, PubMed 11922941

Furebring C, Speckner A, Mach M, Sandlie I, Norderhaug L, Borrebaeck CAK, Turesson H, Ohlin M (2002)
Antibody-mediated neutralization of cytomegalovirus: modulation of efficacy induced through the IgG constant region (vol 38, pg 833, 2002)
Mol. Immunol., 39 (1-2), PII S0161-5890(02)00053-6-121

Lunde E, Lauvrak V, Rasmussen IB, Schjetne KW, Thompson KM, Michaelsen TE, Brekke OH, Sollid LM, Bogen B, Sandlie I (2002)
Troybodies and pepbodies
Biochem Soc Trans, 30 (4), 500-6
DOI 10.1042/bst0300500, PubMed 12196123

Lunde E, Western KH, Rasmussen IB, Sandlie I, Bogen B (2002)
Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies
J Immunol, 168 (5), 2154-62
DOI 10.4049/jimmunol.168.5.2154, PubMed 11859101

Norderhaug L, Johansen FE, Sandlie I (2002)
Balanced expression of single subunits in a multisubunit protein, achieved by cell fusion of individual transfectants
Eur J Biochem, 269 (13), 3205-10
DOI 10.1046/j.1432-1033.2002.03000.x, PubMed 12084060

Publications 2001

Choi I, De Ines C, Kürschner T, Cochlovius B, Sörensen V, Olafsen T, Sandlie I, Little M (2001)
Recombinant chimeric OKT3 scFv IgM antibodies mediate immune suppression while reducing T cell activation in vitro
Eur J Immunol, 31 (1), 94-106
DOI 10.1002/1521-4141(200101)31:1<94::aid-immu94>;2-j, PubMed 11169443

Lund E, Rasmussen IB, Western KH, Eidem JK, Sandlie I, Bogen B (2001)
"Troy-bodies": recombinant antibodies that target T cell epitopes to antigen presenting cells
Int Rev Immunol, 20 (5), 647-73
DOI 10.3109/08830180109045583, PubMed 11890617

Lunde E, Rasmussen IB, Eidem JK, Gregers TF, Western KH, Bogen B, Sandlie I (2001)
'Troy-bodies': antibodies as vector proteins for T cell epitopes
Biomol Eng, 18 (3), 109-16
DOI 10.1016/s1389-0344(01)00091-0, PubMed 11566602

McAdam SN, Fleckenstein B, Rasmussen IB, Schmid DG, Sandlie I, Bogen B, Viner NJ, Sollid LM (2001)
T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation
J Exp Med, 193 (11), 1239-46
DOI 10.1084/jem.193.11.1239, PubMed 11390431

Rasmussen IB, Lunde E, Michaelsen TE, Bogen B, Sandlie I (2001)
The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination
Proc Natl Acad Sci U S A, 98 (18), 10296-301
DOI 10.1073/pnas.181336898, PubMed 11517321

Publications 2000

Eidem JK, Rasmussen IB, Lunde E, Gregers TF, Rees AR, Bogen B, Sandlie I (2000)
Recombinant antibodies as carrier proteins for sub-unit vaccines: influence of mode of fusion on protein production and T-cell activation
J Immunol Methods, 245 (1-2), 119-31
DOI 10.1016/s0022-1759(00)00274-x, PubMed 11042289

Sørensen V, Rasmussen IB, Sundvold V, Michaelsen TE, Sandlie I (2000)
Structural requirements for incorporation of J chain into human IgM and IgA
Int Immunol, 12 (1), 19-27
DOI 10.1093/intimm/12.1.19, PubMed 10607746

Thommesen JE, Michaelsen TE, Løset GÅ, Sandlie I, Brekke OH (2000)
Lysine 322 in the human IgG3 C(H)2 domain is crucial for antibody dependent complement activation
Mol Immunol, 37 (16), 995-1004
DOI 10.1016/s0161-5890(01)00010-4, PubMed 11395138

Publications 1999

Johansen FE, Natvig Norderhaug I, Røe M, Sandlie I, Brandtzaeg P (1999)
Recombinant expression of polymeric IgA: incorporation of J chain and secretory component of human origin
Eur J Immunol, 29 (5), 1701-8
DOI 10.1002/(SICI)1521-4141(199905)29:05<1701::AID-IMMU1701>3.0.CO;2-Z, PubMed 10359125

Lunde E, Munthe LA, Vabø A, Sandlie I, Bogen B (1999)
Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells
Nat Biotechnol, 17 (7), 670-5
DOI 10.1038/10883, PubMed 10404160

Olafsen T, Bruland O, Zalutsky M, Sandlie I (1999)
Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Location of lysine residues and implications for radiolabeling (vol 22, pg 765, 1995)
Nucl. Med. Biol., 26 (5), 599

Olafsen T, Munthe Lund CK, Bruland OS, Sandlie I, Michaelsen TE (1999)
Complement-mediated lysis of cultured osteosarcoma cell lines using chimeric mouse/human TP-1 IgG1 and IgG3 antibodies
Cancer Immunol Immunother, 48 (7), 411-8
DOI 10.1007/s002620050594, PubMed 10501855

Sørensen V, Sundvold V, Michaelsen TE, Sandlie I (1999)
Polymerization of IgA and IgM: roles of Cys309/Cys414 and the secretory tailpiece
J Immunol, 162 (6), 3448-55
PubMed 10092800

Publications 1998

Michaelsen TE, Brekke OH, Sandin RH, Sparstad T, Sandlie I (1998)
Blocking of harmful antibodies by mutant antibodies devoid of effector functions

Olafsen T, Rasmussen IB, Norderhaug L, Bruland OS, Sandlie I (1998)
IgM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells
Immunotechnology, 4 (2), 141-53
DOI 10.1016/s1380-2933(98)00014-1, PubMed 9853955

Redpath S, Michaelsen T, Sandlie I, Clark MR (1998)
Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52
Immunology, 93 (4), 595-600
DOI 10.1046/j.1365-2567.1998.00472.x, PubMed 9659234

Redpath S, Michaelsen TE, Sandlie I, Clark MR (1998)
The influence of the hinge region length in binding of human IgG to human Fcgamma receptors
Hum Immunol, 59 (11), 720-7
DOI 10.1016/s0198-8859(98)00075-5, PubMed 9796740

Roux KH, Strelets L, Brekke OH, Sandlie I, Michaelsen TE (1998)
Comparisons of the ability of human IgG3 hinge mutants, IgM, IgE, and IgA2, to form small immune complexes: a role for flexibility and geometry
J Immunol, 161 (8), 4083-90
PubMed 9780179

Publications 1997

Lunde E, Bogen B, Sandlie I (1997)
Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells
Mol Immunol, 34 (16-17), 1167-76
DOI 10.1016/s0161-5890(97)00143-0, PubMed 9566764

Norderhaug L, Olafsen T, Michaelsen TE, Sandlie I (1997)
Versatile vectors for transient and stable expression of recombinant antibody molecules in mammalian cells
J Immunol Methods, 204 (1), 77-87
DOI 10.1016/s0022-1759(97)00034-3, PubMed 9202712

Publications 1996

Brekke OH, Michaelsen TE, Sandlin R, Sandlie I (1996)
Activation of complement by an IgG molecule without a genetic hinge
Nature, 383 (6595), 103
DOI 10.1038/383103a0, PubMed 8779724

Olafsen T, Bruland OS, Zalutsky MR, Sandlie I (1996)
Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling
Acta Oncol, 35 (3), 297-301
DOI 10.3109/02841869609101644, PubMed 8679259

Sørensen V, Rasmussen IB, Norderhaug L, Natvig I, Michaelsen TE, Sandlie I (1996)
Effect of the IgM and IgA secretory tailpieces on polymerization and secretion of IgM and IgG
J Immunol, 156 (8), 2858-65
PubMed 8609405

Publications 1995

Brekke OH, Michaelsen TE, Sandlie I (1995)
The structural requirements for complement activation by IgG: does it hinge on the hinge?
Immunol Today, 16 (2), 85-90
DOI 10.1016/0167-5699(95)80094-8, PubMed 7888072

Fc-receptor mediated endocytosis of immune complexes in cells of the hepatic sinusoid

Olafsen T, Bruland OS, Zalutsky MR, Sandlie I (1995)
Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling
Nucl Med Biol, 22 (6), 765-71
DOI 10.1016/0969-8051(95)00014-o, PubMed 8535337

Publications 1994

Brekke OH, Michaelsen TE, Aase A, Sandin RH, Sandlie I (1994)
Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis
Eur J Immunol, 24 (10), 2542-7
DOI 10.1002/eji.1830241042, PubMed 7925582

Michaelsen TE, Brekke OH, Aase A, Sandin RH, Bremnes B, Sandlie I (1994)
One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge
Proc Natl Acad Sci U S A, 91 (20), 9243-7
DOI 10.1073/pnas.91.20.9243, PubMed 7937748

Publications 1993

Brekke OH, Bremnes B, Sandin R, Aase A, Michaelsen TE, Sandlie I (1993)
Human IgG3 can adopt the disulfide bond pattern characteristic for IgG1 without resembling it in complement mediated cell lysis
Mol Immunol, 30 (16), 1419-25
DOI 10.1016/0161-5890(93)90103-i, PubMed 8232327

Brekke OH, Michaelsen TE, Sandin R, Sandlie I (1993)
Activation of complement by an IgG molecule without a genetic hinge
Nature, 363 (6430), 628-30
DOI 10.1038/363628a0, PubMed 8510754

Aase A, Sandlie I, Norderhaug L, Brekke OH, Michaelsen TE (1993)
The extended hinge region of IgG3 is not required for high phagocytic capacity mediated by Fc gamma receptors, but the heavy chains must be disulfide bonded
Eur J Immunol, 23 (7), 1546-51
DOI 10.1002/eji.1830230723, PubMed 8325331

Publications 1992

Michaelsen TE, Aase A, Norderhaug L, Sandlie I (1992)
Antibody dependent cell-mediated cytotoxicity induced by chimeric mouse-human IgG subclasses and IgG3 antibodies with altered hinge region
Mol Immunol, 29 (3), 319-26
DOI 10.1016/0161-5890(92)90018-s, PubMed 1557042

Publications 1991

Alfsen GC, Beiske K, Holte H, Hovig E, Deggerdal A, Sandlie I, Widing E, Slørdahl S, Klepper LK, Sizoo W (1991)
T-cell receptor tau delta +/CD3+4-8-T- cell acute lymphoblastic leukemias: a distinct subgroup of leukemias in children. A report of five cases
Blood, 77 (9), 2023-30
PubMed 1826854

Norderhaug L, Brekke OH, Bremnes B, Sandin R, Aase A, Michaelsen TE, Sandlie I (1991)
Chimeric mouse human IgG3 antibodies with an IgG4-like hinge region induce complement-mediated lysis more efficiently than IgG3 with normal hinge
Eur J Immunol, 21 (10), 2379-84
DOI 10.1002/eji.1830211013, PubMed 1915551

Sandlie I, Michaelsen TE (1991)
Engineering monoclonal antibodies to determine the structural requirements for complement activation and complement mediated lysis
Mol Immunol, 28 (12), 1361-8
DOI 10.1016/0161-5890(91)90038-l, PubMed 1749385

Publications 1990

Michaelsen TE, Aase A, Westby C, Sandlie I (1990)
Enhancement of complement activation and cytolysis of human IgG3 by deletion of hinge exons
Scand J Immunol, 32 (5), 517-28
DOI 10.1111/j.1365-3083.1990.tb03192.x, PubMed 2125362

Publications 1989

Sandlie I, Aase A, Westby C, Michaelsen TE (1989)
C1q binding to chimeric monoclonal IgG3 antibodies consisting of mouse variable regions and human constant regions with shortened hinge containing 15 to 47 amino acids
Eur J Immunol, 19 (9), 1599-603
DOI 10.1002/eji.1830190912, PubMed 2792180

Publications 1988

Dickstein R, Huh ND, Sandlie I, Grossman L (1988)
The expression of the Escherichia coli uvrA gene in human cells
Mutat Res, 193 (1), 75-86
DOI 10.1016/0167-8817(88)90009-0, PubMed 2827013

Publications 1987

Alfsen GC, Sandlie I (1987)
[DNA probes. An important aid in the diagnosis of lymphoma]
Tidsskr Nor Laegeforen, 107 (19-21), 1669-71
PubMed 3629576

Alfsen GC, Sandlie I, Marton P (1987)
[The T-cell antigen receptor. Structure, gene rearranging and function]
Tidsskr Nor Laegeforen, 107 (19-21), 1665-8
PubMed 3629575

Publications 1983

Sandlie I, Lossius I, Sjåstad K, Kleppe K (1983)
Mechanism of caffeine-induced inhibition of DNA synthesis in escherichia coli
FEBS Lett, 151 (2), 237-42
DOI 10.1016/0014-5793(83)80077-5, PubMed 6339273

Publications 1982

Sandlie I, Kleppe K (1982)
Effect of caffeine on nucleotide pools in Escherichia coli
Chem Biol Interact, 40 (2), 141-8
DOI 10.1016/0009-2797(82)90096-5, PubMed 7044577

Publications 1980

Sandlie I, Kleppe K (1980)
Mechanism of inhibition of thymidine kinase from Escherichia coli by caffeine
FEBS Lett, 110 (2), 223-6
DOI 10.1016/0014-5793(80)80078-0, PubMed 6989634

Sandlie I, Solberg K, Kleppe K (1980)
The effect of caffeine on cell growth and metabolism of thymidine in Escherichia coli
Mutat Res, 73 (1), 29-41
DOI 10.1016/0027-5107(80)90133-5, PubMed 7019679

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