Genetic variation and ROS metabolism and signalling pathways in relation to response to treatment with radiation and chemotherapy.
Both radiation treatment and chemotherapy exert their therapeutic effect through the generation of reactive oxygen species (ROS). Ionising radiation stimulates hydrolyses of water and also generates a number of reactive oxygen species. ROS react often irreversible with cellular macromolecules like DNA, proteins and lipids. Genotype profiling of patients before administering therapy for breast cancer may help identify individuals with potentially severe side effects of given treatment. The patients genotyped in this project have received radiation therapy (RT) or chemotherapy, either as a sole mean of treatment or complimentary to surgery for their breast cancer. In retrospect, the women were evaluated for side effects of the treatment. By combining this information with their genotype profile we hope to find markers that can be used to design successful therapy strategies in the clinics.
Kramer I, Hooning MJ, Mavaddat N, Hauptmann M, Keeman R, Steyerberg EW, Giardiello D, Antoniou AC, Pharoah PDP, Canisius S, Abu-Ful Z, Andrulis IL, Anton-Culver H, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Brauch Het al.(2020) Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk Am J Hum Genet(in press) DOI 10.1016/j.ajhg.2020.09.001, PubMed 33022221
Tahiri A, Tekpli X, Satheesh SV, DeWijn R, Lüders T, Bukholm IR, Hurtado A, Geisler J, Kristensen VN(2020) Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer Breast Cancer Res Treat, 183(3), 585-598 DOI 10.1007/s10549-020-05763-7, PubMed 32710281
Bergholtz H, Kumar S, Wärnberg F, Lüders T, Kristensen V, Sørlie T(2020) Comparable cancer-relevant mutation profiles in synchronous ductal carcinoma in situ and invasive breast cancer Cancer Rep (Hoboken), 3(3), e1248 DOI 10.1002/cnr2.1248, PubMed 32671987