Genetic variation and ROS metabolism and signalling pathways in relation to response to treatment with radiation and chemotherapy.
Both radiation treatment and chemotherapy exert their therapeutic effect through the generation of reactive oxygen species (ROS). Ionising radiation stimulates hydrolyses of water and also generates a number of reactive oxygen species. ROS react often irreversible with cellular macromolecules like DNA, proteins and lipids. Genotype profiling of patients before administering therapy for breast cancer may help identify individuals with potentially severe side effects of given treatment. The patients genotyped in this project have received radiation therapy (RT) or chemotherapy, either as a sole mean of treatment or complimentary to surgery for their breast cancer. In retrospect, the women were evaluated for side effects of the treatment. By combining this information with their genotype profile we hope to find markers that can be used to design successful therapy strategies in the clinics.
Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN(2019) An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment Nat Commun, 10(1), 5499 DOI 10.1038/s41467-019-13329-5, PubMed 31796750
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EVet al.(2019) Publisher Correction: Shared heritability and functional enrichment across six solid cancers Nat Commun, 10(1), 4386 DOI 10.1038/s41467-019-12095-8, PubMed 31548585
Zhu Q, Tekpli X, Troyanskaya OG, Kristensen VN(2019) Subtype-Specific Transcriptional Regulators in Breast Tumors Subjected to Genetic and Epigenetic Alterations Bioinformatics(in press) DOI 10.1093/bioinformatics/btz709, PubMed 31529022