Genetic variation and ROS metabolism and signalling pathways in relation to response to treatment with radiation and chemotherapy.
Both radiation treatment and chemotherapy exert their therapeutic effect through the generation of reactive oxygen species (ROS). Ionising radiation stimulates hydrolyses of water and also generates a number of reactive oxygen species. ROS react often irreversible with cellular macromolecules like DNA, proteins and lipids. Genotype profiling of patients before administering therapy for breast cancer may help identify individuals with potentially severe side effects of given treatment. The patients genotyped in this project have received radiation therapy (RT) or chemotherapy, either as a sole mean of treatment or complimentary to surgery for their breast cancer. In retrospect, the women were evaluated for side effects of the treatment. By combining this information with their genotype profile we hope to find markers that can be used to design successful therapy strategies in the clinics.
Zhang H, Ahearn TU, Lecarpentier J, Barnes D, Beesley J, Qi G, Jiang X, O'Mara TA, Zhao N, Bolla MK, Dunning AM, Dennis J, Wang Q, Ful ZA, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Arun BK, Auer PL, Azzollini J, Barrowdale D, Becher H, Beckmann MWet al.(2020) Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses Nat Genet(in press) DOI 10.1038/s41588-020-0609-2, PubMed 32424353
Egeland NG, Jonsdottir K, Aure MR, Sahlberg K, Kristensen VN, Cronin-Fenton D, Skaland I, Gudlaugsson E, Baak JPA, Janssen EAM(2020) MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers BMC Cancer, 20(1), 377 DOI 10.1186/s12885-020-06857-7, PubMed 32370743
Pladsen AV, Nilsen G, Rueda OM, Aure MR, Borgan Ø, Liestøl K, Vitelli V, Frigessi A, Langerød A, Mathelier A, OSBREAC, Engebråten O, Kristensen V, Wedge DC, Van Loo P, Caldas C, Børresen-Dale AL, Russnes HG, Lingjærde OC(2020) DNA copy number motifs are strong and independent predictors of survival in breast cancer Commun Biol, 3(1), 153 DOI 10.1038/s42003-020-0884-6, PubMed 32242091