GAP-1 serum

GAP1, or Global Action Plan 1, is a global program which aims to optimalize yields by bringing together the best from biobanks and registers world-wide. At the same time, across-the-border collaborations between researchers will ensure a great collective competence. 

Link to the project's website

Members of the GAP1-Serum project: William Watson (Dublin), Lorelei Mucci (Boston), Kenneth Evans (Toronto), Kristin Austlid Taskén (Oslo), GAP1-Unique TMA (Oslo University Hospital (Viktor Berge (PI), Olov Øgren (project coordinator), Johns Hopkins School of Medicine, University of Washington, Helsinki University Central Hospital, Emory University, Université de Montréal, University of Montreal Hospital Research Center, The University of Mississippi Medical Center, Jonsson Comprehensive Cancer Center, Cedars-Sinai Medical Center, Duke University).

 

Metabolite biomarkers for treatment failure

Although radical prostatectomy normally is administered with curative intent, 20-30% of men experience prostate cancer recurrence following surgery. Adjuvant therapy has been shown to be beneficial in terms of recurrence-free, metastasis-free, and overall survival, but is associated with more comorbidities than PSA-monitoring alone. Thus, novel prognostic biomarkers capable of distinguishing non-recurrent from recurrent prostate cancers will improve  prostate cancer care.

Tissue and clinicopathological data from men radically operated for PCa at Oslo University Hospital and St. Olavs Hospital are being metabolically fingerprinted using High Resolution Magic Angle Spinning  1H Magnetic Resonance Spectroscopy (1H HR-MAS MRS). We investigate the association between metabolite levels and development of recurrence.

Importantly, the translational potential of ex vivo MRS to in vivo MRS imaging (MRSI) may be exploited preoperatively for risk prediction. Together, an enhanced diagnostic and prognostic accuracy through performing MRS and MRSI on prostate cancer patients can help uro-oncologists consider tailored adjuvant therapy and/or closer monitoring of high-risk patients, as well as possibly prevent over-treatment of patients with low-risk disease.

Publications:

Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence, British Journal of Cancer (2017)

Project members: Braadland, P.R (OUS), Giskeødegård, G. (NTNU) Sandsmark, E.(NTNU), Bertilsson, H. (NTNU/St.Olavs), Euceda, L.G. (NTNU), Hansen, A.F. (NTNU), Katz, B.(OUS), Svindland, A.(OUS), Grytli, H.H, (OUS), Berge, V. (OUS) Eri, L.M. (OUS/UIO), Nygård, S. (OUS), Bathen T.F. (NTNU), Taskén, K.A. (OUS/UIO), Tessem M.B. (NTNU).

 

Non-invasive biomarkers for improved treatment stratification

Evaluating risk of progression and disease-related mortality is an essential first step for all patients with newly diagnosed prostate cancer.

Our goal is to improve the current risk stratification model through developing non-invasive tests that enhances the accuracy in predicting the likely course of the disease. Through careful analysis of serum from patients we have identified several new proteins that is improving current prediction models for aggressive prostate cancer.

One of the candidate biomarkers has been validated in several independent cohorts and we are currently exploring how this biomarker can aid therapy selection.

In parallel we are investigating how this serum protein is affecting tumour tissue, and how this knowledge can improve and individualize patient care.

Project members: Ingrid J. Guldvik, Ian G. Mills (Oxford/Belfast)

 

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