Espen Stang
Position: Scientist
Phone: +47 23 07 14 83
Email:
 

Author network for Espen Stang by COREMINE medical


Publications 2017

Fosdahl AM, Dietrich M, Schink KO, Malik MS, Skeie M, Bertelsen V, Stang E (2017)
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Biochim Biophys Acta, 1864 (12), 2241-2252 (in press)
PubMed 28867611

Publications 2016

Kaasbøll OJ, Moe IT, Ahmed MS, Stang E, Hagelin EM, Attramadal H (2016)
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
PLoS One, 11 (2), e0149000
PubMed 26872261

Szymanska M, Fosdahl AM, Nikolaysen F, Pedersen MW, Grandal MM, Stang E, Bertelsen V (2016)
A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2
J Cell Mol Med, 20 (10), 1999-2011
PubMed 27469139

Szymanska M, Fosdahl AM, Raiborg C, Dietrich M, Liestøl K, Stang E, Bertelsen V (2016)
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim Biophys Acta, 1863 (6 Pt A), 1179-88
PubMed 26975582

Publications 2015

Rønning SB, Carlson CR, Stang E, Kolset SO, Hollung K, Pedersen ME (2015)
Syndecan-4 Regulates Muscle Differentiation and Is Internalized from the Plasma Membrane during Myogenesis
PLoS One, 10 (6), e0129288
PubMed 26068620

Publications 2014

Bertelsen V, Stang E (2014)
The Mysterious Ways of ErbB2/HER2 Trafficking
Membranes (Basel), 4 (3), 424-46
PubMed 25102001

Solberg LB, Stang E, Brorson SH, Andersson G, Reinholt FP (2014)
Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes
Histochem Cell Biol, 143 (2), 195-207
PubMed 25201349

Publications 2013

Sak MM, Szymanska M, Bertelsen V, Hasmann M, Madshus IH, Stang E (2013)
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3
Carcinogenesis, 34 (9), 2031-8
PubMed 23698633

Publications 2012

Berger C, Madshus IH, Stang E (2012)
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis
Exp Cell Res, 318 (20), 2578-91
PubMed 22975728

Hol J, Otterdal K, Breland UM, Stang E, Pedersen TM, Hagelsteen K, Ranheim T, Kasprzycka M, Halvorsen B, Haraldsen G, Aukrust P (2012)
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
PubMed 22815786

Hughes JB, Rødland MS, Hasmann M, Madshus IH, Stang E (2012)
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
Pharmaceuticals (Basel), 5 (7), 674-89
PubMed 24281706

Sak MM, Breen K, Rønning SB, Pedersen NM, Bertelsen V, Stang E, Madshus IH (2012)
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
PubMed 22436610

Vuong TT, Berger C, Bertelsen V, Rødland MS, Stang E, Madshus IH (2012)
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes
Exp Cell Res, 319 (3), 32-45
PubMed 23127513

Publications 2011

Berger C, Krengel U, Stang E, Moreno E, Madshus IH (2011)
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations
J Immunother, 34 (7), 550-5
PubMed 21760527

Bertelsen V, Sak MM, Breen K, Rødland MS, Johannessen LE, Traub LM, Stang E, Madshus IH (2011)
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner
Traffic, 12 (4), 507-20
PubMed 21226813

Rønning SB, Pedersen NM, Madshus IH, Stang E (2011)
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
PubMed 21635887

Publications 2010

Bredrup C, Stang E, Bruland O, Palka BP, Young RD, Haavik J, Knappskog PM, Rødahl E (2010)
Decorin accumulation contributes to the stromal opacities found in congenital stromal corneal dystrophy
Invest Ophthalmol Vis Sci, 51 (11), 5578-82
PubMed 20484579

Publications 2009

Hughes JB, Berger C, Rødland MS, Hasmann M, Stang E, Madshus IH (2009)
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
Mol Cancer Ther, 8 (7), 1885-92
PubMed 19584234

Madshus IH, Stang E (2009)
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking
J Cell Sci, 122 (Pt 19), 3433-9
PubMed 19759283

Pedersen NM, Breen K, Rødland MS, Haslekås C, Stang E, Madshus IH (2009)
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2
Mol Cancer Res, 7 (2), 275-84
PubMed 19208749

Publications 2008

Grøvdal LM, Johannessen LE, Rødland MS, Madshus IH, Stang E (2008)
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor
Exp Cell Res, 314 (6), 1292-300
PubMed 18262180

Kazazic M, Bertelsen V, Pedersen KW, Vuong TT, Grandal MV, Rødland MS, Traub LM, Stang E, Madshus IH (2008)
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
Traffic, 10 (2), 235-45
PubMed 19054389

Pedersen NM, Madshus IH, Haslekås C, Stang E (2008)
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent
Mol Cancer Res, 6 (3), 491-500
PubMed 18337455

Roxrud I, Raiborg C, Pedersen NM, Stang E, Stenmark H (2008)
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor
J Cell Biol, 180 (6), 1205-18
PubMed 18362181

Publications 2007

Bertelsen V, Breen K, Sandvig K, Stang E, Madshus IH (2007)
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
PubMed 17382318

Publications 2006

Johannessen LE, Pedersen NM, Pedersen KW, Madshus IH, Stang E (2006)
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
PubMed 16382132

Kazazic M, Roepstorff K, Johannessen LE, Pedersen NM, van Deurs B, Stang E, Madshus IH (2006)
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
PubMed 16984407

Myromslien FD, Grøvdal LM, Raiborg C, Stenmark H, Madshus IH, Stang E (2006)
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
PubMed 16859684

Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damås JK (2006)
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes
Blood, 108 (3), 928-35
PubMed 16861346

Publications 2005

Haslekås C, Breen K, Pedersen KW, Johannessen LE, Stang E, Madshus IH (2005)
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane
Mol Biol Cell, 16 (12), 5832-42
PubMed 16207817

Longva KE, Pedersen NM, Haslekås C, Stang E, Madshus IH (2005)
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
PubMed 15800944

Publications 2004

Grøvdal LM, Stang E, Sorkin A, Madshus IH (2004)
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
Exp Cell Res, 300 (2), 388-95
PubMed 15475003

Stang E, Blystad FD, Kazazic M, Bertelsen V, Brodahl T, Raiborg C, Stenmark H, Madshus IH (2004)
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
PubMed 15194809

Publications 2003

Brede G, Solheim J, Stang E, Prydz H (2003)
Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus
Exp Cell Res, 291 (2), 299-312
PubMed 14644153

Publications 2002

Longva KE, Blystad FD, Stang E, Larsen AM, Johannessen LE, Madshus IH (2002)
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
J Cell Biol, 156 (5), 843-54
PubMed 11864992

Oksvold M, Huitfeldt H, Stang E, Madshus I (2002)
Localizing the EGF receptor
Nat Cell Biol, 4 (2), E22; author reply E22-3
PubMed 11835048

Raiborg C, Bache KG, Gillooly DJ, Madshus IH, Stang E, Stenmark H (2002)
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
PubMed 11988743

Richards AA, Stang E, Pepperkok R, Parton RG (2002)
Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection
Mol Biol Cell, 13 (5), 1750-64
PubMed 12006667

Ringerike T, Blystad FD, Levy FO, Madshus IH, Stang E (2002)
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae
J Cell Sci, 115 (Pt 6), 1331-40
PubMed 11884532

Publications 2001

Johannessen LE, Haugen KE, østvold AC, Stang E, Madshus IH (2001)
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms
Biochem J, 356 (Pt 1), 87-96
PubMed 11336639

Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (2001)
Hrs recruits clathrin to early endosomes
EMBO J, 20 (17), 5008-21
PubMed 11532964

Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H (2001)
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
J Cell Sci, 114 (Pt 12), 2255-63
PubMed 11493665

Publications 2000

Stang E, Johannessen LE, Knardal SL, Madshus IH (2000)
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
J Biol Chem, 275 (18), 13940-7
PubMed 10788520

Publications 1999

Deleuil F, Stang E, Escola J, Gorvel J (1999)
Characterization of a peptide-loading compartment by monoclonal antibodies
J Immunol Methods, 230 (1-2), 87-97
PubMed 10594356

Luetterforst R, Stang E, Zorzi N, Carozzi A, Way M, Parton RG (1999)
Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule
J Cell Biol, 145 (7), 1443-59
PubMed 10385524

Roy S, Luetterforst R, Harding A, Apolloni A, Etheridge M, Stang E, Rolls B, Hancock JF, Parton RG (1999)
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
Nat Cell Biol, 1 (2), 98-105
PubMed 10559881

Simonsen A, Pedersen KW, Nordeng TW, von der Lippe A, Stang E, Long EO, Bakke O (1999)
Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain
J Immunol, 163 (5), 2540-8
PubMed 10452991

Publications 1998

Haraldsen G, Sollid LM, Bakke O, Farstad IN, Kvale D, Molberg, Norstein J, Stang E, Brandtzaeg P (1998)
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells
Gastroenterology, 114 (4), 649-56
PubMed 9516385

Kobayashi T, Stang E, Fang KS, de Moerloose P, Parton RG, Gruenberg J (1998)
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
Nature, 392 (6672), 193-7
PubMed 9515966

Ringerike T, Stang E, Johannessen LE, Sandnes D, Levy FO, Madshus IH (1998)
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
J Biol Chem, 273 (27), 16639-42
PubMed 9642213

Skarpen E, Johannessen LE, Bjerk K, Fasteng H, Guren TK, Lindeman B, Thoresen GH, Christoffersen T, Stang E, Huitfeldt HS, Madshus IH (1998)
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1
Exp Cell Res, 243 (1), 161-72
PubMed 9716460

Stang E, Guerra CB, Amaya M, Paterson Y, Bakke O, Mellins ED (1998)
DR/CLIP (class II-associated invariant chain peptides) and DR/peptide complexes colocalize in prelysosomes in human B lymphoblastoid cells
J Immunol, 160 (10), 4696-707
PubMed 9590215

Publications 1997

Parton RG, Way M, Zorzi N, Stang E (1997)
Caveolin-3 associates with developing T-tubules during muscle differentiation
J Cell Biol, 136 (1), 137-54
PubMed 9008709

Rojo M, Pepperkok R, Emery G, Kellner R, Stang E, Parton RG, Gruenberg J (1997)
Involvement of the transmembrane protein p23 in biosynthetic protein transport
J Cell Biol, 139 (5), 1119-35
PubMed 9382861

Simonsen A, Stang E, Bremnes B, Røe M, Prydz K, Bakke O (1997)
Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells
J Cell Sci, 110 ( Pt 5), 597-609
PubMed 9092942

Stang E, Bakke O (1997)
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study
Exp Cell Res, 235 (1), 79-92
PubMed 9281355

Stang E, Kartenbeck J, Parton RG (1997)
Major histocompatibility complex class I molecules mediate association of SV40 with caveolae
Mol Biol Cell, 8 (1), 47-57
PubMed 9017594

Publications 1996

Escola JM, Deleuil F, Stang E, Boretto J, Chavrier P, Gorvel JP (1996)
Characterization of a lysozyme-major histocompatibility complex class II molecule-loading compartment as a specialized recycling endosome in murine B lymphocytes
J Biol Chem, 271 (44), 27360-5
PubMed 8910313

Publications 1995

Gorvel JP, Escola JM, Stang E, Bakke O (1995)
Invariant chain induces a delayed transport from early to late endosomes
J Biol Chem, 270 (6), 2741-6
PubMed 7852345

Publications 1993

Brech A, Magnusson S, Stang E, Berg T, Roos N (1993)
Receptor-mediated endocytosis of ricin in rat liver endothelial cells. An immunocytochemical study
Eur J Cell Biol, 60 (1), 154-62
PubMed 8462592

Leyshon-Sørland K, Stang E (1993)
The ultrastructural localization of metallothionein in cadmium exposed rat liver
Histochem J, 25 (12), 857-64
PubMed 8113097

Roche PA, Teletski CL, Stang E, Bakke O, Long EO (1993)
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
Proc Natl Acad Sci U S A, 90 (18), 8581-5
PubMed 8397411

Senoo H, Smeland S, Malaba L, Bjerknes T, Stang E, Roos N, Berg T, Norum KR, Blomhoff R (1993)
Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells
Proc Natl Acad Sci U S A, 90 (8), 3616-20
PubMed 8386378

Publications 1992

Stang E, Krause J, Seydel W, Berg T, Roos N (1992)
Endocytosis and intracellular processing of tissue-type plasminogen activator by rat liver cells in vivo
Biochem J, 282 ( Pt 3), 841-51
PubMed 1554369

Stang E, Roos N, Schlüter M, Berg T, Krause J (1992)
Evidence for carbohydrate-independent endocytosis of tissue-type plasminogen activator by liver cells
Biochem J, 285 ( Pt 3), 799-804
PubMed 1323274

Publications 1991

Seydel W, Stang E, Roos N, Krause J (1991)
Endocytosis of the recombinant tissue plasminogen activator alteplase by hepatic endothelial cells
Arzneimittelforschung, 41 (2), 182-6
PubMed 1904231

Tanswell P, Seifried E, Stang E, Krause J (1991)
Pharmacokinetics and hepatic catabolism of tissue-type plasminogen activator
Arzneimittelforschung, 41 (12), 1310-9
PubMed 1815534

Publications 1990

Kindberg GM, Stang E, Andersen KJ, Roos N, Berg T (1990)
Intracellular transport of endocytosed proteins in rat liver endothelial cells
Biochem J, 270 (1), 205-11
PubMed 2396981

Senoo H, Stang E, Nilsson A, Kindberg GM, Berg T, Roos N, Norum KR, Blomhoff R (1990)
Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver
J Lipid Res, 31 (7), 1229-39
PubMed 2401856

Stang E, Kindberg GM, Berg T, Roos N (1990)
Endocytosis mediated by the mannose receptor in liver endothelial cells. An immunocytochemical study
Eur J Cell Biol, 52 (1), 67-76
PubMed 2387309