Hiroko Kato Solvang
Position: Researcher
Phone: +47 22 78 13 70

Hiroko Kato Solvang’s CV



  • 1995  Ph.D.(A study of multivariate mean-nonstatinary time series model for estimating mutual relationship) in Statistical Science, The Institute of Statistical Mathematics with Professor Makio Ishiguro and Professor Genshiro Kitagawa
  • 1988  MS in Educational Physics and Computer Physics, Tokyo Gakugei University
  • 1986  BS in Macromolecular Physics, Japan Women’s University

Professional experience

  • 2007-present Researcher, Dept. Genetics, Inst. Cancer Research, Rikshospitalet-Radiumhospitalet
  • 1998-2007  Research Scientist, NTT Communication Science Laboratories http://www.kecl.ntt.co.jp/rps/index.html
  • 1996-1998  Research Associate, Dept. Applied Mathematics, Faculty of Engineering, Hiroshima University http://www.hiroshima-u.ac.jp/index.html
  • 1995-1996  Research Associate, Advanced Telecommunication Research http://www.atr.jp
  • 1989-1993  Research Assistant, Dept. Physics, Japan Women’s University
  • 1998-1992  Lecturer of Physics, Senior high-school affiliated Japan Women’s University



  • Statistical methodology: Multivariate statistical system analysis, Time series analysis for non-linear, non-stationary and non-Gaussian data, Spatial (time) data modelling, Bayesian influence, Discriminant analysis, Machine learning
  • Applications: Biomedical signal processing, Speech signal processing, Economic time series data

Academic society


  • IEEE, American Statistical Association, Institute of Mathematical Statistics, Japan Statistical Society

Publications (referred paper)

  • Discriminant analysis:

1. Solvang, K, H., Taniguchi, M., Nakatani, T., Amano, S., 2007, Classification and similarity analysis for fundamental frequency patterns in infant spoken language acquisition, Statistical Methodology.

2. Ishizuka, K., Mugitani, R., Kato, H., Amano, S., 2007, Longitudinal developmental changes in the spectral peaks of vowels in a Japanese infants, The Journal of the Acoustical Society of America, 121, 4, 2272-2282.

3. Ishizuka, K., Mugitani, R., Kato, H., Amano, S., 2005, A longitudinal analysis of the spectral peaks of vowels for a Japanese infant”, The 9th European Conference on Speech Communication and Technology (Interspeech2005-Eurospeech), 1169-1172.

Independent component analysis:

4. Kato, H., Nagahara, Y., Araki, S., Sawada, H., Makino, S., 2006, A parametric Pearson approach based independent component analysis for frequency domain blind speech separation, EUSIPC2006, CD-ROM.

  • Bayesian time series modeling, Multivariate time series analysis:

5. Osu,R., Franklin,D.W., Kato,H., Gomi,H., Domen,K., Yoshioka,T., Kawato,M. 2002, Short-and Long-term changes in joint co-contraction associated with motor learning as revealed from surface EMG, J. Neurophysiol, 88, 991-1004

6. Kato,H., Kawahara,H. 1998, An application of the Bayesian time series model and statistical system analysis for F0 control, J. Speech Communication, 24, 4, 325-339.

7. Kato, H. 1996, A statistical system analysis for nonstationary biometric time series, Japanese J. Medical Electronics and Biological Engineering, 10, 4, 36-42 (in Japanese).

8.  Kato,H., Naniwa,S., Ishiguro,M. 1996, A Bayesian multivariate nonstationary time series model for estimating mutual relationships among variables, J. Econometrics, 75, 147-161.

9. Ishiguro,M., Kato,H. 1995, Economic system analysis, Mathematical Science, 389, 50-57 (in Japanese).

10. Kato,H., Naniwa,S., Ishiguro,M. 1995, A multivariate stochastic model with non-stationary trend component, Applied Stochastic Models and Data Analysis, 11, 1, 77-95.

11. Kato,H., Wada,T., Ishiguro,M 1994, A study of human body balance by new multivariate feedback models with common low frequency components, Japanese J. Biometrics, 15, 41-57.

  • Non-linear and non-Gaussian time series modeling:

12. Solvang, K.H., Ishizuka, K., Fujimoto, M., 2007, A voice activity detection based on an AR-GARCH model, The Institute of Electronics, Information and Communication Engineers, D-II.

13. Ishizuka,K., Kato, H., 2006, A feature for voice activity detection derived from speech analysis with the exponential autoregressive model, ICASSP 2006, 1, 789-792.

14. Ishizuka,K., Kato,H., Nakatani,T. 2005, Speech signal analysis with exponential autoregressive model, Proc. the 30th International Conference of Acoustics, Speech and Signal Processing, 1, 225-228.

15.  Kato,H, Taniguchi, M., Honda, M. 2005, Statistical analysis for multiplicatively modulated nonlinear autoregressive model and its application to electrophysiological signal analysis in human, IEEE Transactions, Signal Processing, 54, 9, 3414-3425.

16. Kato,H., Honda,M. 2005, Multiplicatively modulated exponential autoregressive model for corticomuscular functional coupling, Signal Processing, 85, 7, 1287-1300.

17. Kato,H., Ozaki,T. 2002, Adding data process feedback to the nonlinear autoregressive model, Signal Processing, 82, 1189-1204.

  • Nonparametric time series modeling:

18. Zolfagari,P., Kato,H., Minami,Y., Nakamura,A., Katagiri,S., 2004, Model selection for mixture of Gaussian based spectral modeling, IEEE International Workshop on Machine Learning for Signal Processing, 335-345.

  •  Test:

19. Kato,H., Abe,K., Terakado,H., Konno,N. 1991, Time series analysis of EEG: local weak stationary, self similarity, normality, The Institute of Electronics, Information and Communication Engineers D-II J74-D-II, 10, 1466-1471.

  • Software

20. Ishiguro,M., Kato,H., Akaike,H. 1999, ARDOCK, An auto-regressive model analyzer, Computer Science Monographs, The Institute of Statistical Mathematics, 30.


Author network for Hiroko Kato Solvang by COREMINE medical

Publications 2017

Malde K, Seliussen BB, Quintela M, Dahle G, Besnier F, Skaug HJ, Øien N, Solvang HK, Haug T, Skern-Mauritzen R, Kanda N, Pastene LA, Jonassen I, Glover KA (2017)
Whole genome resequencing reveals diagnostic markers for investigating global migration and hybridization between minke whale species
BMC Genomics, 18 (1), 76
PubMed 28086785

Solvang HK, Yanagihara H, Oien N, Haug T (2017)
Temporal and geographical variation in body condition of common minke whales (Balaenoptera acutorostrata acutorostrata) in the Northeast Atlantic
Polar Biol., 40 (3), 667-683

Publications 2016

Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK (2016)
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16 (1), 913
PubMed 27876019

Solvang HK, Frigessi A, Kaveh F, Riis ML, Lüders T, Bukholm IR, Kristensen VN, Andreassen BK (2016)
Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer
EURASIP J Bioinform Syst Biol, 2016 (1), 6
PubMed 26900390

Publications 2015

Borge KS, Nord S, Van Loo P, Lingjærde OC, Gunnes G, Alnæs GI, Solvang HK, Lüders T, Kristensen VN, Børresen-Dale AL, Lingaas F (2015)
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN
PLoS One, 10 (5), e0126371
PubMed 25955013

Publications 2014

Fleischer T, Edvardsen H, Solvang HK, Daviaud C, Naume B, Børresen-Dale AL, Kristensen VN, Tost J (2014)
Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
Int J Cancer, 134 (11), 2615-25
PubMed 24395279

Quintela M, Skaug HJ, Øien N, Haug T, Seliussen BB, Solvang HK, Pampoulie C, Kanda N, Pastene LA, Glover KA (2014)
Investigating population genetic structure in a highly mobile marine organism: the minke whale Balaenoptera acutorostrata acutorostrata in the North East Atlantic
PLoS One, 9 (9), e108640
PubMed 25268591

Publications 2013

Klajic J, Fleischer T, Dejeux E, Edvardsen H, Warnberg F, Bukholm I, Lønning PE, Solvang H, Børresen-Dale AL, Tost J, Kristensen VN (2013)
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
BMC Cancer, 13, 456
PubMed 24093668

Olaussen M, Holmedal O, Lindbaek M, Brage S, Solvang H (2013)
Treating lateral epicondylitis with corticosteroid injections or non-electrotherapeutical physiotherapy: a systematic review
BMJ Open, 3 (10), e003564
PubMed 24171937

Riis ML, Zhao X, Kaveh F, Vollan HS, Nesbakken AJ, Solvang HK, Lüders T, Bukholm IR, Kristensen VN (2013)
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways
ISRN Oncol, 2013, 924971
PubMed 23533813

Publications 2012

Kim J, Villadsen R, Sørlie T, Fogh L, Grønlund SZ, Fridriksdottir AJ, Kuhn I, Rank F, Wielenga VT, Solvang H, Edwards PA, Børresen-Dale AL, Rønnov-Jessen L, Bissell MJ, Petersen OW (2012)
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
Proc Natl Acad Sci U S A, 109 (16), 6124-9
PubMed 22454501

Kjersem JB, Ikdahl T, Guren T, Skovlund E, Sorbye H, Hamfjord J, Pfeiffer P, Glimelius B, Kersten C, Solvang H, Tveit KM, Kure EH (2012)
Let-7 miRNA-binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/- cetuximab
BMC Cancer, 12, 534
PubMed 23167843

Publications 2011

Kaveh F, Edvardsen H, Børresen-Dale AL, N Kristensen V, Solvang HK (2011)
Allele-specific disparity in breast cancer
BMC Med Genomics, 4, 85
PubMed 22188678

Solvang HK, Lingjærde OC, Frigessi A, Børresen-Dale AL, Kristensen VN (2011)
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
BMC Bioinformatics, 12, 197
PubMed 21609452

Publications 2010

Biong M, Gram IT, Brill I, Johansen F, Solvang HK, Alnaes GI, Fagerheim T, Bremnes Y, Chanock SJ, Burdett L, Yeager M, Ursin G, Kristensen VN (2010)
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
BMC Med Genomics, 3, 9
PubMed 20302654

Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J (2010)
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
Mol Cancer, 9, 68
PubMed 20338046

Edvardsen H, Brunsvig PF, Solvang H, Tsalenko A, Andersen A, Syvanen AC, Yakhini Z, Børresen-Dale AL, Olsen H, Aamdal S, Kristensen VN (2010)
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance
Pharmacogenomics J, 10 (6), 513-23
PubMed 20157331

Haakensen VD, Biong M, Lingjærde OC, Holmen MM, Frantzen JO, Chen Y, Navjord D, Romundstad L, Lüders T, Bukholm IK, Solvang HK, Kristensen VN, Ursin G, Børresen-Dale AL, Helland A (2010)
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
Breast Cancer Res, 12 (4), R65
PubMed 20799965

Muggerud AA, Rønneberg JA, Wärnberg F, Botling J, Busato F, Jovanovic J, Solvang H, Bukholm I, Børresen-Dale AL, Kristensen VN, Sørlie T, Tost J (2010)
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
Breast Cancer Res, 12 (1), R3
PubMed 20056007

Rønneberg JA, Fleischer T, Solvang HK, Nordgard SH, Edvardsen H, Potapenko I, Nebdal D, Daviaud C, Gut I, Bukholm I, Naume B, Børresen-Dale AL, Tost J, Kristensen V (2010)
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer
Mol Oncol, 5 (1), 61-76
PubMed 21212030

Publications 2009

Solvang HK, Nagahara Y, Araki S, Sawada H, Makino S (2009)
Frequency-Domain Pearson Distribution Approach for Independent Component Analysis (FD-Pearson-ICA) in Blind Source Separation
IEEE Trans. Audio Speech Lang. Process., 17 (4), 639-649

Publications 2008

Rønneberg JA, Tost J, Solvang HK, Alnaes GI, Johansen FE, Brendeford EM, Yakhini Z, Gut IG, Lønning PE, Børresen-Dale AL, Gabrielsen OS, Kristensen VN (2008)
GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas
Cancer Res, 68 (14), 5562-71
PubMed 18632608

Solvang HK, Ishizuka K, Fujimoto M (2008)
Voice activity detection based on adjustable linear prediction and GARCH models
Speech Commun., 50 (6), 476-486